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Compile Data Set for Download or QSAR

Found 154 hits with Last Name = 'dawson' and Initial = 'es'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50402788
PNG
(CHEMBL2208408)
Show SMILES CS(=O)(=O)N(CC(=O)Nc1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C15H15ClN2O3S/c1-22(20,21)18(14-10-6-5-9-13(14)16)11-15(19)17-12-7-3-2-4-8-12/h2-10H,11H2,1H3,(H,17,19)
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>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 22: 7388-92 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.068
BindingDB Entry DOI: 10.7270/Q2H996BR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM44464
PNG
(2-(2-chloro-N-mesyl-anilino)-N-(3-chlorophenyl)ace...)
Show SMILES CS(=O)(=O)N(CC(=O)Nc1cccc(Cl)c1)c1ccccc1Cl
Show InChI InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19(14-8-3-2-7-13(14)17)10-15(20)18-12-6-4-5-11(16)9-12/h2-9H,10H2,1H3,(H,18,20)
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>1.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 22: 7388-92 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.068
BindingDB Entry DOI: 10.7270/Q2H996BR
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50402787
PNG
(CHEMBL2208405)
Show SMILES CS(=O)(=O)N(CC(=O)NCC1CC1)c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C14H16ClF3N2O3S/c1-24(22,23)20(8-13(21)19-7-9-2-3-9)12-6-10(14(16,17)18)4-5-11(12)15/h4-6,9H,2-3,7-8H2,1H3,(H,19,21)
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>3.00E+4n/an/an/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]-methoxyPEPy from rat mGlu5 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 22: 7388-92 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.068
BindingDB Entry DOI: 10.7270/Q2H996BR
More data for this
Ligand-Target Pair
Cholecystokinin receptor type A


(RAT)		BDBM50181434
PNG
((S)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C41H37N5O6/c1-27(2)45(32-21-23-33(52-3)24-22-32)36(47)26-44-34-19-10-11-20-35(34)46(31-17-8-5-9-18-31)40(50)37(39(44)49)43-41(51)42-30-16-12-15-29(25-30)38(48)28-13-6-4-7-14-28/h4-25,27,37H,26H2,1-3H3,(H2,42,43,51)/t37-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells

J Med Chem 49: 850-63 (2006)


Article DOI: 10.1021/jm049072h
BindingDB Entry DOI: 10.7270/Q28S4PHJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor type A


(RAT)		BDBM50181435
PNG
((R)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C39H33N5O6/c1-42(29-20-22-31(50-2)23-21-29)34(45)25-43-32-18-9-10-19-33(32)44(30-16-7-4-8-17-30)38(48)35(37(43)47)41-39(49)40-28-15-11-14-27(24-28)36(46)26-12-5-3-6-13-26/h3-24,35H,25H2,1-2H3,(H2,40,41,49)/t35-/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells

J Med Chem 49: 850-63 (2006)


Article DOI: 10.1021/jm049072h
BindingDB Entry DOI: 10.7270/Q28S4PHJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor type A


(RAT)		BDBM50181433
PNG
((S)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C39H33N5O6/c1-42(29-20-22-31(50-2)23-21-29)34(45)25-43-32-18-9-10-19-33(32)44(30-16-7-4-8-17-30)38(48)35(37(43)47)41-39(49)40-28-15-11-14-27(24-28)36(46)26-12-5-3-6-13-26/h3-24,35H,25H2,1-2H3,(H2,40,41,49)/t35-/m0/s1
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n/an/a 490n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells

J Med Chem 49: 850-63 (2006)


Article DOI: 10.1021/jm049072h
BindingDB Entry DOI: 10.7270/Q28S4PHJ
More data for this
Ligand-Target Pair
Cholecystokinin receptor type A


(RAT)		BDBM50181436
PNG
((R)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C41H37N5O6/c1-27(2)45(32-21-23-33(52-3)24-22-32)36(47)26-44-34-19-10-11-20-35(34)46(31-17-8-5-9-18-31)40(50)37(39(44)49)43-41(51)42-30-16-12-15-29(25-30)38(48)28-13-6-4-7-14-28/h4-25,27,37H,26H2,1-3H3,(H2,42,43,51)/t37-/m1/s1
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n/an/a 710n/an/an/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Displacement of [125I-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat CCK receptor expressed in CHO cells

J Med Chem 49: 850-63 (2006)


Article DOI: 10.1021/jm049072h
BindingDB Entry DOI: 10.7270/Q28S4PHJ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50402787
PNG
(CHEMBL2208405)
Show SMILES CS(=O)(=O)N(CC(=O)NCC1CC1)c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C14H16ClF3N2O3S/c1-24(22,23)20(8-13(21)19-7-9-2-3-9)12-6-10(14(16,17)18)4-5-11(12)15/h4-6,9H,2-3,7-8H2,1H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 22: 7388-92 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.068
BindingDB Entry DOI: 10.7270/Q2H996BR
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088534
PNG
(CHEMBL3576929 | US10189805, Compound 5)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1CN1CCOCC1)C(O)=O |r|
Show InChI InChI=1S/C16H23N3O4/c17-13(16(21)22)5-6-15(20)18-14-4-2-1-3-12(14)11-19-7-9-23-10-8-19/h1-4,13H,5-11,17H2,(H,18,20)(H,21,22)/t13-/m0/s1
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n/an/a 3.12E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088535
PNG
(CHEMBL3576928 | US10189805, Compound 4)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1-c1nc2ccccc2s1)C(O)=O |r|
Show InChI InChI=1S/C18H17N3O3S/c19-12(18(23)24)9-10-16(22)20-13-6-2-1-5-11(13)17-21-14-7-3-4-8-15(14)25-17/h1-8,12H,9-10,19H2,(H,20,22)(H,23,24)/t12-/m0/s1
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n/an/a 4.36E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088536
PNG
(CHEMBL3576927 | US10189805, Compound 3)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1N1CCOCC1)C(O)=O |r|
Show InChI InChI=1S/C15H21N3O4/c16-11(15(20)21)5-6-14(19)17-12-3-1-2-4-13(12)18-7-9-22-10-8-18/h1-4,11H,5-10,16H2,(H,17,19)(H,20,21)/t11-/m0/s1
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n/an/a 6.64E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088531
PNG
(CHEMBL3576943 | US10189805, Compound 19)
Show SMILES N[C@@H](CCC(=O)NCc1ccccc1CS(=O)(=O)N1CCOCC1)C(O)=O |r|
Show InChI InChI=1S/C17H25N3O6S/c18-15(17(22)23)5-6-16(21)19-11-13-3-1-2-4-14(13)12-27(24,25)20-7-9-26-10-8-20/h1-4,15H,5-12,18H2,(H,19,21)(H,22,23)/t15-/m0/s1
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n/an/a 6.77E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088530
PNG
(CHEMBL3576944 | US10189805, Compound 20)
Show SMILES CN1CCN(Cc2ccccc2CNC(=O)CC[C@H](N)C(O)=O)CC1 |r|
Show InChI InChI=1S/C18H28N4O3/c1-21-8-10-22(11-9-21)13-15-5-3-2-4-14(15)12-20-17(23)7-6-16(19)18(24)25/h2-5,16H,6-13,19H2,1H3,(H,20,23)(H,24,25)/t16-/m0/s1
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n/an/a 6.97E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088533
PNG
(CHEMBL3576936 | US10189805, Compound 12)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C16H23N3O3/c17-12(16(21)22)8-9-15(20)18-13-6-2-3-7-14(13)19-10-4-1-5-11-19/h2-3,6-7,12H,1,4-5,8-11,17H2,(H,18,20)(H,21,22)/t12-/m0/s1
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n/an/a 7.76E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088532
PNG
(CHEMBL3576940 | US10189805, Compound 16)
Show SMILES N[C@@H](CCC(=O)Nc1ccccc1CCc1ccncc1)C(O)=O |r|
Show InChI InChI=1S/C18H21N3O3/c19-15(18(23)24)7-8-17(22)21-16-4-2-1-3-14(16)6-5-13-9-11-20-12-10-13/h1-4,9-12,15H,5-8,19H2,(H,21,22)(H,23,24)/t15-/m0/s1
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n/an/a 8.32E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Neutral amino acid transporter B(0)


(Homo sapiens (Human))		BDBM50088537
PNG
(CHEMBL6251 | US10189805, Compound 1)
Show SMILES N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C11H13N3O5/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1
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n/an/a 9.54E+5n/an/an/an/an/an/a



Vanderbilt University Institute of Imaging Science (VUIIS)

Curated by ChEMBL


Assay Description
Inhibition of ASCT2-mediated [3H]glutamine uptake in HEK293 cells after 15 mins by Live-cell glutamine uptake assay

Bioorg Med Chem Lett 25: 113-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.098
BindingDB Entry DOI: 10.7270/Q2CZ38X7
More data for this
Ligand-Target Pair
Cholecystokinin receptor type A


(RAT)		BDBM50181434
PNG
((S)-2-{3-[3-(4-Benzoylphenyl)ureido]-2,4-dioxo-5-p...)
Show SMILES COc1ccc(cc1)N(C(C)C)C(=O)CN1c2ccccc2N(c2ccccc2)C(=O)[C@@H](NC(=O)Nc2cccc(c2)C(=O)c2ccccc2)C1=O
Show InChI InChI=1S/C41H37N5O6/c1-27(2)45(32-21-23-33(52-3)24-22-32)36(47)26-44-34-19-10-11-20-35(34)46(31-17-8-5-9-18-31)40(50)37(39(44)49)43-41(51)42-30-16-12-15-29(25-30)38(48)28-13-6-4-7-14-28/h4-25,27,37H,26H2,1-3H3,(H2,42,43,51)/t37-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



Mayo Clinic

Curated by ChEMBL


Assay Description
Intrinsic agonistic activity at CCK receptor in SD rat at 1uM expressed in pancreatic acinar cell line

J Med Chem 49: 850-63 (2006)


Article DOI: 10.1021/jm049072h
BindingDB Entry DOI: 10.7270/Q28S4PHJ
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393277
PNG
(CHEMBL2152032)
Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1
Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)
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n/an/an/an/a 2.24E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393278
PNG
(CHEMBL2141631)
Show SMILES N(c1cnc2ccccc2n1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H15N7/c1-2-8-15(9-3-1)20-22(27-21(29-28-20)18-12-6-7-13-23-18)26-19-14-24-16-10-4-5-11-17(16)25-19/h1-14H,(H,25,26,27,29)
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n/an/an/an/a 7.64E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393279
PNG
(CHEMBL600512 | GNF-Pf-100)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C21H17N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h1-14H,15H2,(H,23,24,26)
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n/an/an/an/a 7.74E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393280
PNG
(CHEMBL2134094)
Show SMILES Cc1ccccc1CNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-16-9-5-6-12-18(16)15-24-22-20(17-10-3-2-4-11-17)26-27-21(25-22)19-13-7-8-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 6.67E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393281
PNG
(CHEMBL2139973)
Show SMILES Cc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5/c1-16-8-7-9-17(14-16)15-24-22-20(18-10-3-2-4-11-18)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 5.41E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393282
PNG
(CHEMBL2139663)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5/c1-16-10-12-17(13-11-16)15-24-22-20(18-7-3-2-4-8-18)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.58E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393283
PNG
(CHEMBL2144203)
Show SMILES C[C@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m0/s1
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n/an/an/an/a 4.17E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393284
PNG
(CHEMBL2132069)
Show SMILES C[C@@H](Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C22H25N5/c1-16(17-10-4-2-5-11-17)24-22-20(18-12-6-3-7-13-18)26-27-21(25-22)19-14-8-9-15-23-19/h3,6-9,12-17H,2,4-5,10-11H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/an/an/a 6.73E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393285
PNG
(CHEMBL2140836)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCOCC1
Show InChI InChI=1S/C20H21N5O/c1-2-6-16(7-3-1)18-20(22-14-15-9-12-26-13-10-15)23-19(25-24-18)17-8-4-5-11-21-17/h1-8,11,15H,9-10,12-14H2,(H,22,23,25)
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n/an/an/an/a 2.95E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393286
PNG
(CHEMBL2130848)
Show SMILES C(Cc1ccccc1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C22H19N5/c1-3-9-17(10-4-1)14-16-24-22-20(18-11-5-2-6-12-18)26-27-21(25-22)19-13-7-8-15-23-19/h1-13,15H,14,16H2,(H,24,25,27)
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n/an/an/an/a 3.63E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393287
PNG
(CHEMBL2134352)
Show SMILES C(Cc1ccccn1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C21H18N6/c1-2-8-16(9-3-1)19-21(24-15-12-17-10-4-6-13-22-17)25-20(27-26-19)18-11-5-7-14-23-18/h1-11,13-14H,12,15H2,(H,24,25,27)
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n/an/an/an/a 1.75E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393288
PNG
(CHEMBL2142554)
Show SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1C
Show InChI InChI=1S/C23H21N5/c1-16-11-12-18(14-17(16)2)15-25-23-21(19-8-4-3-5-9-19)27-28-22(26-23)20-10-6-7-13-24-20/h3-14H,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a 2.96E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393289
PNG
(CHEMBL2137226)
Show SMILES Clc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C21H16ClN5/c22-17-10-6-7-15(13-17)14-24-21-19(16-8-2-1-3-9-16)26-27-20(25-21)18-11-4-5-12-23-18/h1-13H,14H2,(H,24,25,27)
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n/an/an/an/a 2.33E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393290
PNG
(CHEMBL2131991)
Show SMILES COc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5O/c1-28-18-12-10-16(11-13-18)15-24-22-20(17-7-3-2-4-8-17)26-27-21(25-22)19-9-5-6-14-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.74E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393291
PNG
(CHEMBL2140244)
Show SMILES COc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1
Show InChI InChI=1S/C22H19N5O/c1-28-18-11-7-8-16(14-18)15-24-22-20(17-9-3-2-4-10-17)26-27-21(25-22)19-12-5-6-13-23-19/h2-14H,15H2,1H3,(H,24,25,27)
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n/an/an/an/a 4.15E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393292
PNG
(CHEMBL2138065 | cid_46742345)
Show SMILES CC(C)(C)c1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H25N5/c1-25(2,3)20-14-12-18(13-15-20)17-27-24-22(19-9-5-4-6-10-19)29-30-23(28-24)21-11-7-8-16-26-21/h4-16H,17H2,1-3H3,(H,27,28,30)
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n/an/an/an/a 1.71E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393293
PNG
(CHEMBL2152106)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccnc1
Show InChI InChI=1S/C20H16N6/c1-2-8-16(9-3-1)18-20(23-14-15-7-6-11-21-13-15)24-19(26-25-18)17-10-4-5-12-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 2.60E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393294
PNG
(CHEMBL2136245)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C20H16N6/c1-2-8-15(9-3-1)18-20(23-14-16-10-4-6-12-21-16)24-19(26-25-18)17-11-5-7-13-22-17/h1-13H,14H2,(H,23,24,26)
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n/an/an/an/a 2.78E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393295
PNG
(CHEMBL2135309)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-11-21(12-4-1)23-15-9-10-20(18-23)19-29-27-25(22-13-5-2-6-14-22)31-32-26(30-27)24-16-7-8-17-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 2.49E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393296
PNG
(CHEMBL2144958)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5/c1-3-9-21(10-4-1)22-16-14-20(15-17-22)19-29-27-25(23-11-5-2-6-12-23)31-32-26(30-27)24-13-7-8-18-28-24/h1-18H,19H2,(H,29,30,32)
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n/an/an/an/a 1.12E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM49766
PNG
(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Show SMILES O=C(NCCCn1ccnc1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-16(18-7-4-9-20-10-8-17-12-20)14-11-15(22-19-14)13-5-2-1-3-6-13/h1-3,5-6,8,10-12H,4,7,9H2,(H,18,21)
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n/an/an/an/a 7.72E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393297
PNG
(CHEMBL2152027)
Show SMILES OCCCCNC(=O)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H16N2O3/c17-9-5-4-8-15-14(18)12-10-13(19-16-12)11-6-2-1-3-7-11/h1-3,6-7,10,17H,4-5,8-9H2,(H,15,18)
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n/an/an/an/a 3.04E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393298
PNG
(CHEMBL2152028)
Show SMILES O=C(NCC1CC1)c1cc(on1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O2/c17-14(15-9-10-6-7-10)12-8-13(18-16-12)11-4-2-1-3-5-11/h1-5,8,10H,6-7,9H2,(H,15,17)
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n/an/an/an/a 1.66E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48250
PNG
(6-phenyl-N-prop-2-enyl-3-(2-pyridinyl)-1,2,4-triaz...)
Show SMILES C=CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H15N5/c1-2-11-19-17-15(13-8-4-3-5-9-13)21-22-16(20-17)14-10-6-7-12-18-14/h2-10,12H,1,11H2,(H,19,20,22)
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n/an/an/an/a 4.62E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM48235
PNG
(MLS000541553 | N,N-dimethyl-6-phenyl-3-(2-pyridiny...)
Show SMILES CN(C)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C16H15N5/c1-21(2)16-14(12-8-4-3-5-9-12)19-20-15(18-16)13-10-6-7-11-17-13/h3-11H,1-2H3
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n/an/an/an/a 9.82E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393299
PNG
(CHEMBL2141772)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CC1
Show InChI InChI=1S/C18H17N5/c1-2-6-14(7-3-1)16-18(20-12-13-9-10-13)21-17(23-22-16)15-8-4-5-11-19-15/h1-8,11,13H,9-10,12H2,(H,20,21,23)
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n/an/an/an/a 4.27E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393300
PNG
(CHEMBL2130568)
Show SMILES C(Nc1nc(nnc1-c1ccccc1)-c1ccccn1)C1CCCCC1
Show InChI InChI=1S/C21H23N5/c1-3-9-16(10-4-1)15-23-21-19(17-11-5-2-6-12-17)25-26-20(24-21)18-13-7-8-14-22-18/h2,5-8,11-14,16H,1,3-4,9-10,15H2,(H,23,24,26)
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n/an/an/an/a 2.46E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393301
PNG
(CHEMBL2141722)
Show SMILES CC(C)(C)CCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H23N5/c1-20(2,3)12-14-22-19-17(15-9-5-4-6-10-15)24-25-18(23-19)16-11-7-8-13-21-16/h4-11,13H,12,14H2,1-3H3,(H,22,23,25)
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n/an/an/an/a 3.82E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393302
PNG
(CHEMBL2140280)
Show SMILES OCCCNc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C17H17N5O/c23-12-6-11-19-17-15(13-7-2-1-3-8-13)21-22-16(20-17)14-9-4-5-10-18-14/h1-5,7-10,23H,6,11-12H2,(H,19,20,22)
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n/an/an/an/a 1.05E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393303
PNG
(CHEMBL2152029)
Show SMILES C(CN1CCOCC1)Nc1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H22N6O/c1-2-6-16(7-3-1)18-20(22-10-11-26-12-14-27-15-13-26)23-19(25-24-18)17-8-4-5-9-21-17/h1-9H,10-15H2,(H,22,23,25)
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n/an/an/an/a 9.08E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393304
PNG
(CHEMBL2152030)
Show SMILES C(CNc1nc(nnc1-c1ccccc1)-c1ccccn1)CN1CCOCC1
Show InChI InChI=1S/C21H24N6O/c1-2-7-17(8-3-1)19-21(23-11-6-12-27-13-15-28-16-14-27)24-20(26-25-19)18-9-4-5-10-22-18/h1-5,7-10H,6,11-16H2,(H,23,24,26)
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n/an/an/an/a 6.27E+3n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393305
PNG
(CHEMBL2131608)
Show SMILES OCC1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O/c26-14-15-9-12-25(13-10-15)20-18(16-6-2-1-3-7-16)23-24-19(22-20)17-8-4-5-11-21-17/h1-8,11,15,26H,9-10,12-14H2
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n/an/an/an/a 1.16E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50393306
PNG
(CHEMBL2152031)
Show SMILES CN1CCN(CC1)c1nc(nnc1-c1ccccc1)-c1ccccn1
Show InChI InChI=1S/C19H20N6/c1-24-11-13-25(14-12-24)19-17(15-7-3-2-4-8-15)22-23-18(21-19)16-9-5-6-10-20-16/h2-10H,11-14H2,1H3
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n/an/an/an/a 1.02E+4n/an/an/an/a



The Broad Institute Probe Development Center

Curated by ChEMBL


Assay Description
Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay

Bioorg Med Chem Lett 22: 76-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.077
BindingDB Entry DOI: 10.7270/Q2XD12SN
More data for this
Ligand-Target Pair
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