Found 86 hits with Last Name = 'karle' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine protease 1
(Homo sapiens (Human)) | BDBM50092660
(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)Show InChI InChI=1S/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Trypsin-3
(Homo sapiens (Human)) | BDBM50092660
(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)Show InChI InChI=1S/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50092660
(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)Show InChI InChI=1S/C7H9N3/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H3,9,10) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Trypsin-3
(Homo sapiens (Human)) | BDBM50387180
(CHEMBL2047998)Show InChI InChI=1S/C12H14N4O3S/c1-2-19-10(18)6-16-8-4-3-7(17)5-9(8)20-12(16)15-11(13)14/h3-5,17H,2,6H2,1H3,(H3,13,14)/b15-12+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.68E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50387180
(CHEMBL2047998)Show InChI InChI=1S/C12H14N4O3S/c1-2-19-10(18)6-16-8-4-3-7(17)5-9(8)20-12(16)15-11(13)14/h3-5,17H,2,6H2,1H3,(H3,13,14)/b15-12+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Trypsin-3
(Homo sapiens (Human)) | BDBM50387183
(CHEMBL2048000)Show SMILES [#7]\[#6](-[#7])=[#7]\c1nc2cc(Cl)c(-[#8])cc2s1 Show InChI InChI=1S/C8H7ClN4OS/c9-3-1-4-6(2-5(3)14)15-8(12-4)13-7(10)11/h1-2,14H,(H4,10,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 4.76E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50387180
(CHEMBL2047998)Show InChI InChI=1S/C12H14N4O3S/c1-2-19-10(18)6-16-8-4-3-7(17)5-9(8)20-12(16)15-11(13)14/h3-5,17H,2,6H2,1H3,(H3,13,14)/b15-12+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 4.81E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Serine protease 1
(Homo sapiens (Human)) | BDBM50387183
(CHEMBL2048000)Show SMILES [#7]\[#6](-[#7])=[#7]\c1nc2cc(Cl)c(-[#8])cc2s1 Show InChI InChI=1S/C8H7ClN4OS/c9-3-1-4-6(2-5(3)14)15-8(12-4)13-7(10)11/h1-2,14H,(H4,10,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 6.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Trypsin-3
(Homo sapiens (Human)) | BDBM50387182
(CHEMBL2048003)Show SMILES [#6]-c1cc(-[#8])cc2sc(\[#7]=[#6](/[#7])-[#7])nc12 Show InChI InChI=1S/C9H10N4OS/c1-4-2-5(14)3-6-7(4)12-9(15-6)13-8(10)11/h2-3,14H,1H3,(H4,10,11,12,13) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 7.94E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Trypsin-3
(Homo sapiens (Human)) | BDBM50387181
(CHEMBL2047999)Show InChI InChI=1S/C12H15N5O2S/c1-2-15-10(19)6-17-8-4-3-7(18)5-9(8)20-12(17)16-11(13)14/h3-5,18H,2,6H2,1H3,(H3,13,14)(H,15,19)/b16-12+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 1.09E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50387181
(CHEMBL2047999)Show InChI InChI=1S/C12H15N5O2S/c1-2-15-10(19)6-17-8-4-3-7(18)5-9(8)20-12(17)16-11(13)14/h3-5,18H,2,6H2,1H3,(H3,13,14)(H,15,19)/b16-12+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 2.73E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometry |
Bioorg Med Chem Lett 22: 4839-43 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.046 BindingDB Entry DOI: 10.7270/Q2QV3NKC |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020035
(CHEMBL3287849)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@@H](Cc2ccccc2)C1 |r| Show InChI InChI=1S/C15H18N2O2/c18-15-10-14(19-17-15)12-6-7-16-13(9-12)8-11-4-2-1-3-5-11/h1-5,10,12-13,16H,6-9H2,(H,17,18)/t12-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Plasminogen
(Homo sapiens (Human)) | BDBM50020042
(CHEMBL3287856)Show SMILES Fc1cccc(C[C@H]2C[C@H](CCN2)c2cc(=O)[nH]o2)c1 |r| Show InChI InChI=1S/C15H17FN2O2/c16-12-3-1-2-10(6-12)7-13-8-11(4-5-17-13)14-9-15(19)18-20-14/h1-3,6,9,11,13,17H,4-5,7-8H2,(H,18,19)/t11-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020037
(CHEMBL3287854)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@@H](CCc2ccccc2)C1 |r| Show InChI InChI=1S/C16H20N2O2/c19-16-11-15(20-18-16)13-8-9-17-14(10-13)7-6-12-4-2-1-3-5-12/h1-5,11,13-14,17H,6-10H2,(H,18,19)/t13-,14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020036
(CHEMBL3287851)Show SMILES CC(C)(C)C[C@H]1C[C@H](CCN1)c1cc(=O)[nH]o1 |r| Show InChI InChI=1S/C13H22N2O2/c1-13(2,3)8-10-6-9(4-5-14-10)11-7-12(16)15-17-11/h7,9-10,14H,4-6,8H2,1-3H3,(H,15,16)/t9-,10+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020036
(CHEMBL3287851)Show SMILES CC(C)(C)C[C@H]1C[C@H](CCN1)c1cc(=O)[nH]o1 |r| Show InChI InChI=1S/C13H22N2O2/c1-13(2,3)8-10-6-9(4-5-14-10)11-7-12(16)15-17-11/h7,9-10,14H,4-6,8H2,1-3H3,(H,15,16)/t9-,10+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020043
(CHEMBL3287857)Show SMILES Fc1ccc(C[C@H]2C[C@H](CCN2)c2cc(=O)[nH]o2)cc1 |r| Show InChI InChI=1S/C15H17FN2O2/c16-12-3-1-10(2-4-12)7-13-8-11(5-6-17-13)14-9-15(19)18-20-14/h1-4,9,11,13,17H,5-8H2,(H,18,19)/t11-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020033
(CHEMBL3287847)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@H](Cc2ccccc2)C1 |r| Show InChI InChI=1S/C15H18N2O2/c18-15-10-14(19-17-15)12-6-7-16-13(9-12)8-11-4-2-1-3-5-11/h1-5,10,12-13,16H,6-9H2,(H,17,18)/t12-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020039
(CHEMBL3287852)Show SMILES CC(C)(C)CC[C@H]1C[C@H](CCN1)c1cc(=O)[nH]o1 |r| Show InChI InChI=1S/C14H24N2O2/c1-14(2,3)6-4-11-8-10(5-7-15-11)12-9-13(17)16-18-12/h9-11,15H,4-8H2,1-3H3,(H,16,17)/t10-,11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50032954
(5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...)Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020035
(CHEMBL3287849)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@@H](Cc2ccccc2)C1 |r| Show InChI InChI=1S/C15H18N2O2/c18-15-10-14(19-17-15)12-6-7-16-13(9-12)8-11-4-2-1-3-5-11/h1-5,10,12-13,16H,6-9H2,(H,17,18)/t12-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Plasminogen
(Homo sapiens (Human)) | BDBM50020038
(CHEMBL3287850)Show InChI InChI=1S/C12H20N2O2/c1-8(2)5-10-6-9(3-4-13-10)11-7-12(15)14-16-11/h7-10,13H,3-6H2,1-2H3,(H,14,15)/t9-,10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020040
(CHEMBL3287853)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@@H](CC2CCCCC2)C1 |r| Show InChI InChI=1S/C15H24N2O2/c18-15-10-14(19-17-15)12-6-7-16-13(9-12)8-11-4-2-1-3-5-11/h10-13,16H,1-9H2,(H,17,18)/t12-,13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020041
(CHEMBL3287855)Show SMILES Fc1ccccc1C[C@H]1C[C@H](CCN1)c1cc(=O)[nH]o1 |r| Show InChI InChI=1S/C15H17FN2O2/c16-13-4-2-1-3-10(13)7-12-8-11(5-6-17-12)14-9-15(19)18-20-14/h1-4,9,11-12,17H,5-8H2,(H,18,19)/t11-,12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50201426
(dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-c...)Show SMILES NC[C@H]1CC[C@]2(CC1)OO[C@@]1(O2)C2CC3CC(C2)CC1C3 |w:14.15,16.18,12.14,19.21,wU:10.10,5.8,2.1,TLB:17:12:15.16.18:20,THB:11:10:15.16.18:20,9:10:15.16.18:20,10:12:15:18.19.20,10:19:15:13.17.12,TEB:17:16:20:13.12.10,18:19:13:15.16.17,(13.45,-13.89,;13.42,-12.35,;12.07,-11.6,;10.75,-12.4,;9.41,-11.66,;9.37,-10.12,;10.69,-9.32,;12.04,-10.06,;9.17,-8.58,;7.66,-8.3,;6.92,-9.66,;7.98,-10.78,;5.82,-10.73,;4.59,-9.98,;4.01,-8.7,;2.26,-8.74,;3.61,-9.51,;4.2,-10.91,;4.73,-8.39,;6.34,-8.26,;5.06,-7.64,)| Show InChI InChI=1S/C17H27NO3/c18-10-11-1-3-16(4-2-11)19-17(21-20-16)14-6-12-5-13(8-14)9-15(17)7-12/h11-15H,1-10,18H2/t11-,12?,13?,14?,15?,16+,17- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hERG by patch clamp assay |
Bioorg Med Chem Lett 17: 1260-5 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.007 BindingDB Entry DOI: 10.7270/Q2N017B8 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020029
(CHEMBL144416)Show InChI InChI=1S/C9H14N2O2/c1-6-8(13-11-9(6)12)7-2-4-10-5-3-7/h7,10H,2-5H2,1H3,(H,11,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020031
(CHEMBL3287844)Show InChI InChI=1S/C9H14N2O2/c1-6-4-7(2-3-10-6)8-5-9(12)11-13-8/h5-7,10H,2-4H2,1H3,(H,11,12)/t6-,7-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50201425
(2-({dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1...)Show SMILES NC(=O)CNC[C@H]1CC[C@]2(CC1)OO[C@@]1(O2)C2CC3CC(C2)CC1C3 |w:18.19,20.22,16.18,23.25,wU:14.14,9.12,6.5,TLB:21:16:19.20.22:24,THB:15:14:19.20.22:24,13:14:19.20.22:24,14:16:19:22.23.24,14:23:19:17.21.16,TEB:21:20:24:17.16.14,22:23:17:19.20.21,(25.77,-11.15,;27.09,-10.36,;28.44,-11.11,;27.07,-8.82,;25.73,-8.06,;25.71,-6.52,;24.36,-5.77,;23.04,-6.56,;21.7,-5.81,;21.68,-4.27,;23,-3.47,;24.34,-4.23,;21.49,-2.73,;19.98,-2.44,;19.23,-3.79,;20.28,-4.92,;18.12,-4.85,;16.9,-4.09,;16.32,-2.81,;14.58,-2.84,;15.92,-3.62,;16.5,-5.02,;17.05,-2.51,;18.66,-2.39,;17.38,-1.76,)| Show InChI InChI=1S/C19H30N2O4/c20-17(22)11-21-10-12-1-3-18(4-2-12)23-19(25-24-18)15-6-13-5-14(8-15)9-16(19)7-13/h12-16,21H,1-11H2,(H2,20,22)/t12-,13?,14?,15?,16?,18+,19- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hERG by patch clamp assay |
Bioorg Med Chem Lett 17: 1260-5 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.007 BindingDB Entry DOI: 10.7270/Q2N017B8 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50032954
(5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...)Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020033
(CHEMBL3287847)Show SMILES O=c1cc(o[nH]1)[C@H]1CCN[C@H](Cc2ccccc2)C1 |r| Show InChI InChI=1S/C15H18N2O2/c18-15-10-14(19-17-15)12-6-7-16-13(9-12)8-11-4-2-1-3-5-11/h1-5,10,12-13,16H,6-9H2,(H,17,18)/t12-,13+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50428067
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:5.8,wD:2.1,(1.2,4.21,;-.14,3.44,;-.14,1.9,;-1.47,1.13,;-1.47,-.41,;-.14,-1.18,;1.2,-.41,;1.2,1.13,;-.14,-2.72,;-1.47,-3.49,;1.2,-3.49,)| Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Plasminogen
(Homo sapiens (Human)) | BDBM50020029
(CHEMBL144416)Show InChI InChI=1S/C9H14N2O2/c1-6-8(13-11-9(6)12)7-2-4-10-5-3-7/h7,10H,2-5H2,1H3,(H,11,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020031
(CHEMBL3287844)Show InChI InChI=1S/C9H14N2O2/c1-6-4-7(2-3-10-6)8-5-9(12)11-13-8/h5-7,10H,2-4H2,1H3,(H,11,12)/t6-,7-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50428067
(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)Show SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:5.8,wD:2.1,(1.2,4.21,;-.14,3.44,;-.14,1.9,;-1.47,1.13,;-1.47,-.41,;-.14,-1.18,;1.2,-.41,;1.2,1.13,;-.14,-2.72,;-1.47,-3.49,;1.2,-3.49,)| Show InChI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Plasminogen
(Homo sapiens (Human)) | BDBM50032956
(3-Piperidin-4-yl-isoxazol-5-ol | CHEMBL110210)Show InChI InChI=1S/C8H12N2O2/c11-8-5-7(10-12-8)6-1-3-9-4-2-6/h5-6,9-10H,1-4H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408762
(DESETHYLCHLOROQUINE | Desethyl chloroquine)Show InChI InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408763
(CHEMBL343728)Show InChI InChI=1S/C19H28ClN3/c1-5-23(6-2)11-7-8-15(4)22-19-14(3)13-21-18-12-16(20)9-10-17(18)19/h9-10,12-13,15H,5-8,11H2,1-4H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)Show InChI InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM23300
(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)Show InChI InChI=1S/C9H7ClN2/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-5H,(H2,11,12) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408770
(CHEMBL143042 | TCMDC-124246)Show InChI InChI=1S/C19H28ClN3/c1-5-23(6-2)11-7-8-14(3)21-18-12-15(4)22-19-13-16(20)9-10-17(18)19/h9-10,12-14H,5-8,11H2,1-4H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408760
(CHEMBL139984)Show InChI InChI=1S/C16H22ClN3/c1-4-20(5-2)11-12(3)19-15-8-9-18-16-10-13(17)6-7-14(15)16/h6-10,12H,4-5,11H2,1-3H3,(H,18,19) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408771
(CHEMBL344599)Show InChI InChI=1S/C18H26BrN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408766
(CHEMBL342499)Show InChI InChI=1S/C19H27ClN2/c1-4-15(5-2)8-6-7-14(3)22-18-11-12-21-19-13-16(20)9-10-17(18)19/h9-15H,4-8H2,1-3H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020028
(CHEMBL3287843)Show InChI InChI=1S/C9H14N2O2/c1-11-9(12)6-8(13-11)7-2-4-10-5-3-7/h6-7,10H,2-5H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50357211
(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)Show InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
| DrugBank PDB Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Plasminogen
(Homo sapiens (Human)) | BDBM50020028
(CHEMBL3287843)Show InChI InChI=1S/C9H14N2O2/c1-11-9(12)6-8(13-11)7-2-4-10-5-3-7/h6-7,10H,2-5H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPA |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408768
(CHEMBL423184)Show InChI InChI=1S/C19H28ClN3/c1-4-23(5-2)13-7-6-8-15(3)22-18-11-12-21-19-14-16(20)9-10-17(18)19/h9-12,14-15H,4-8,13H2,1-3H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408764
(CHEMBL143439)Show InChI InChI=1S/C11H11ClN2/c1-2-13-10-5-6-14-11-7-8(12)3-4-9(10)11/h3-7H,2H2,1H3,(H,13,14) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50408761
(CHEMBL143522)Show SMILES CCN(CC)CCCC(C)Nc1ccnc2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C18H26N4O2/c1-4-21(5-2)12-6-7-14(3)20-17-10-11-19-18-13-15(22(23)24)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,19,20) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description Inhibition of hematin polymerization |
J Med Chem 42: 4630-9 (1999)
BindingDB Entry DOI: 10.7270/Q2DV1M34 |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50020027
(CHEMBL3287842)Show InChI InChI=1S/C9H14N2O2/c1-11-4-2-7(3-5-11)8-6-9(12)10-13-8/h6-7H,2-5H2,1H3,(H,10,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b... |
ACS Med Chem Lett 5: 538-43 (2014)
Article DOI: 10.1021/ml400526d BindingDB Entry DOI: 10.7270/Q2QJ7JV4 |
More data for this Ligand-Target Pair | |