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Compile Data Set for Download or QSAR

Found 217 hits with Last Name = 'ballantine' and Initial = 's'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415001
PNG
(CHEMBL570015 | GSK-256066 | GSK-256066 (3))
Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1
Show InChI InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)
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n/an/a 0.00794n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414999
PNG
(CHEMBL569791)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1
Show InChI InChI=1S/C26H24N4O5S/c1-30(2)26(32)16-6-4-9-19(12-16)36(33,34)20-10-11-23-21(14-20)24(22(15-28-23)25(27)31)29-17-7-5-8-18(13-17)35-3/h4-15H,1-3H3,(H2,27,31)(H,28,29)
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n/an/a 0.0100n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415009
PNG
(CHEMBL571381)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1cc(C)c2ncc(C(N)=O)c(Nc3cccc(OC)c3)c2c1
Show InChI InChI=1S/C25H23N3O5S/c1-15-11-20(34(30,31)19-9-7-17(32-2)8-10-19)13-21-23(15)27-14-22(25(26)29)24(21)28-16-5-4-6-18(12-16)33-3/h4-14H,1-3H3,(H2,26,29)(H,27,28)
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n/an/a 0.0200n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415008
PNG
(CHEMBL584327)
Show SMILES COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C24H21N3O4S/c1-15-11-19(32(29,30)18-9-4-3-5-10-18)13-20-22(15)26-14-21(24(25)28)23(20)27-16-7-6-8-17(12-16)31-2/h3-14H,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 0.100n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414998
PNG
(CHEMBL569556)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc2ncc(C(N)=O)c(Nc3cccc(OC)c3)c2c1
Show InChI InChI=1S/C24H21N3O5S/c1-31-16-6-8-18(9-7-16)33(29,30)19-10-11-22-20(13-19)23(21(14-26-22)24(25)28)27-15-4-3-5-17(12-15)32-2/h3-14H,1-2H3,(H2,25,28)(H,26,27)
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n/an/a 0.126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM14774
PNG
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
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n/an/a 0.398n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415007
PNG
(CHEMBL571171)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)c2ccc(cc2)C(C)(C)C)C(N)=O)c1
Show InChI InChI=1S/C27H27N3O4S/c1-27(2,3)17-8-10-20(11-9-17)35(32,33)21-12-13-24-22(15-21)25(23(16-29-24)26(28)31)30-18-6-5-7-19(14-18)34-4/h5-16H,1-4H3,(H2,28,31)(H,29,30)
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n/an/a 0.631n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414992
PNG
(CHEMBL576479)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)N(C)C)C(N)=O)c1
Show InChI InChI=1S/C19H20N4O4S/c1-23(2)28(25,26)14-7-8-17-15(10-14)18(16(11-21-17)19(20)24)22-12-5-4-6-13(9-12)27-3/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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n/an/a 0.794n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50413291
PNG
(CHEMBL515240)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)c2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C23H19N3O4S/c1-30-16-7-5-6-15(12-16)26-22-19-13-18(31(28,29)17-8-3-2-4-9-17)10-11-21(19)25-14-20(22)23(24)27/h2-14H,1H3,(H2,24,27)(H,25,26)
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n/an/a 1.58n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415000
PNG
(CHEMBL570029)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)c2ccc(cc2)-c2ccoc2)C(N)=O)c1
Show InChI InChI=1S/C27H21N3O5S/c1-34-20-4-2-3-19(13-20)30-26-23-14-22(9-10-25(23)29-15-24(26)27(28)31)36(32,33)21-7-5-17(6-8-21)18-11-12-35-16-18/h2-16H,1H3,(H2,28,31)(H,29,30)
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n/an/a 1.58n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415004
PNG
(CHEMBL571593)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)N2CCOCC2)C(N)=O)c1
Show InChI InChI=1S/C21H22N4O5S/c1-29-15-4-2-3-14(11-15)24-20-17-12-16(31(27,28)25-7-9-30-10-8-25)5-6-19(17)23-13-18(20)21(22)26/h2-6,11-13H,7-10H2,1H3,(H2,22,26)(H,23,24)
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415006
PNG
(CHEMBL585528)
Show SMILES NC(=O)c1cnc2ccc(cc2c1Nc1ccc2ncsc2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H16N4O3S2/c24-23(28)18-12-25-19-9-7-16(32(29,30)15-4-2-1-3-5-15)11-17(19)22(18)27-14-6-8-20-21(10-14)31-13-26-20/h1-13H,(H2,24,28)(H,25,27)
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n/an/a 2.51n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412414
PNG
(CHEMBL521203)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C21H25N5O2/c1-2-26-20-17(14-24-26)19(25-16-8-10-28-11-9-16)18(13-22-20)21(27)23-12-15-6-4-3-5-7-15/h3-7,13-14,16H,2,8-12H2,1H3,(H,22,25)(H,23,27)
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414994
PNG
(CHEMBL571386)
Show SMILES NC(=O)c1cnc2ccc(cc2c1Nc1cccc(c1)C#N)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C23H16N4O3S/c24-13-15-5-4-6-16(11-15)27-22-19-12-18(31(29,30)17-7-2-1-3-8-17)9-10-21(19)26-14-20(22)23(25)28/h1-12,14H,(H2,25,28)(H,26,27)
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414989
PNG
(CHEMBL585937)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)C2CCCC2)C(N)=O)c1
Show InChI InChI=1S/C22H23N3O4S/c1-29-15-6-4-5-14(11-15)25-21-18-12-17(30(27,28)16-7-2-3-8-16)9-10-20(18)24-13-19(21)22(23)26/h4-6,9-13,16H,2-3,7-8H2,1H3,(H2,23,26)(H,24,25)
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n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50413298
PNG
(CHEMBL462150)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)S(C)(=O)=O)C(N)=O)c1
Show InChI InChI=1S/C18H17N3O4S/c1-25-12-5-3-4-11(8-12)21-17-14-9-13(26(2,23)24)6-7-16(14)20-10-15(17)18(19)22/h3-10H,1-2H3,(H2,19,22)(H,20,21)
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n/an/a 3.98n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415005
PNG
(CHEMBL569352)
Show SMILES NC(=O)c1cnc2ccc(cc2c1Nc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H17N3O3S/c23-22(26)19-14-24-20-12-11-17(29(27,28)16-9-5-2-6-10-16)13-18(20)21(19)25-15-7-3-1-4-8-15/h1-14H,(H2,23,26)(H,24,25)
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412405
PNG
(CHEMBL488634)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H31N5O2/c1-2-26-20-17(14-24-26)19(25-16-8-10-28-11-9-16)18(13-22-20)21(27)23-12-15-6-4-3-5-7-15/h13-16H,2-12H2,1H3,(H,22,25)(H,23,27)
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n/an/a 7.94n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31647
PNG
(tetrahydrobenzothiophene (THBT), 21)
Show SMILES CCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C18H19N3O4S/c1-2-10-7-8-12-14(9-10)26-18(15(12)16(19)22)20-17(23)11-5-3-4-6-13(11)21(24)25/h3-6,10H,2,7-9H2,1H3,(H2,19,22)(H,20,23)
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n/an/a 10n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412394
PNG
(CHEMBL511488)
Show SMILES CCOC(=O)c1cnc2n(CC)ncc2c1NC1CCCCC1
Show InChI InChI=1S/C17H24N4O2/c1-3-21-16-13(11-19-21)15(20-12-8-6-5-7-9-12)14(10-18-16)17(22)23-4-2/h10-12H,3-9H2,1-2H3,(H,18,20)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414993
PNG
(CHEMBL571594)
Show SMILES CCc1cccc(Nc2c(cnc3ccc(cc23)S(=O)(=O)c2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C24H21N3O3S/c1-2-16-7-6-8-17(13-16)27-23-20-14-19(31(29,30)18-9-4-3-5-10-18)11-12-22(20)26-15-21(23)24(25)28/h3-15H,2H2,1H3,(H2,25,28)(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414997
PNG
(CHEMBL569555)
Show SMILES Cc1coc2CCCC(Nc3c(cnc4ccc(cc34)S(=O)(=O)c3ccccc3)C(N)=O)c12
Show InChI InChI=1S/C25H23N3O4S/c1-15-14-32-22-9-5-8-21(23(15)22)28-24-18-12-17(33(30,31)16-6-3-2-4-7-16)10-11-20(18)27-13-19(24)25(26)29/h2-4,6-7,10-14,21H,5,8-9H2,1H3,(H2,26,29)(H,27,28)
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412411
PNG
(CHEMBL538659)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H22FN5O2/c1-2-26-19-16(12-23-26)18(24-15-7-9-28-10-8-15)17(11-22-19)20(27)25-14-5-3-13(21)4-6-14/h3-6,11-12,15H,2,7-10H2,1H3,(H,22,24)(H,25,27)
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n/an/a 12.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412393
PNG
(CHEMBL506982)
Show SMILES CCOC(=O)c1cnc2n(CC)ncc2c1NC1CCOCC1
Show InChI InChI=1S/C16H22N4O3/c1-3-20-15-12(10-18-20)14(19-11-5-7-22-8-6-11)13(9-17-15)16(21)23-4-2/h9-11H,3-8H2,1-2H3,(H,17,19)
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412393
PNG
(CHEMBL506982)
Show SMILES CCOC(=O)c1cnc2n(CC)ncc2c1NC1CCOCC1
Show InChI InChI=1S/C16H22N4O3/c1-3-20-15-12(10-18-20)14(19-11-5-7-22-8-6-11)13(9-17-15)16(21)23-4-2/h9-11H,3-8H2,1-2H3,(H,17,19)
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412392
PNG
(CHEMBL519588)
Show SMILES CCOC(=O)c1cnc2n(CC)ncc2c1NCC(C)C
Show InChI InChI=1S/C15H22N4O2/c1-5-19-14-11(9-18-19)13(16-7-10(3)4)12(8-17-14)15(20)21-6-2/h8-10H,5-7H2,1-4H3,(H,16,17)
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n/an/a 15.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412412
PNG
(CHEMBL488290)
Show SMILES CCC(CC)CNC(=O)c1cnc2n(CC)ncc2c1NC1CCOCC1
Show InChI InChI=1S/C20H31N5O2/c1-4-14(5-2)11-22-20(26)17-12-21-19-16(13-23-25(19)6-3)18(17)24-15-7-9-27-10-8-15/h12-15H,4-11H2,1-3H3,(H,21,24)(H,22,26)
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31648
PNG
(tetrahydrobenzothiophene (THBT), 22)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-13-15(10-11)28-19(16(13)17(21)24)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)
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n/an/a 25n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414991
PNG
(CHEMBL569790)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)C(=O)N2CCOCC2)C(N)=O)c1
Show InChI InChI=1S/C22H22N4O4/c1-29-16-4-2-3-15(12-16)25-20-17-11-14(22(28)26-7-9-30-10-8-26)5-6-19(17)24-13-18(20)21(23)27/h2-6,11-13H,7-10H2,1H3,(H2,23,27)(H,24,25)
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412410
PNG
(CHEMBL486443)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(N)=O
Show InChI InChI=1S/C14H19N5O2/c1-2-19-14-11(8-17-19)12(10(7-16-14)13(15)20)18-9-3-5-21-6-4-9/h7-9H,2-6H2,1H3,(H2,15,20)(H,16,18)
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n/an/a 25.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50415003
PNG
(CHEMBL570956)
Show SMILES COc1cccc(Nc2c(cnc3ccc(cc23)C(=O)N(C)C)C(N)=O)c1
Show InChI InChI=1S/C20H20N4O3/c1-24(2)20(26)12-7-8-17-15(9-12)18(16(11-22-17)19(21)25)23-13-5-4-6-14(10-13)27-3/h4-11H,1-3H3,(H2,21,25)(H,22,23)
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414995
PNG
(CHEMBL585537)
Show SMILES NC(=O)c1cnc2ccc(cc2c1NC1CCCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H23N3O3S/c23-22(26)19-14-24-20-12-11-17(29(27,28)16-9-5-2-6-10-16)13-18(20)21(19)25-15-7-3-1-4-8-15/h2,5-6,9-15H,1,3-4,7-8H2,(H2,23,26)(H,24,25)
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414996
PNG
(CHEMBL571170)
Show SMILES NC(=O)c1cnc2ccc(cc2c1Nc1cccnc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C21H16N4O3S/c22-21(26)18-13-24-19-9-8-16(29(27,28)15-6-2-1-3-7-15)11-17(19)20(18)25-14-5-4-10-23-12-14/h1-13H,(H2,22,26)(H,24,25)
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31644
PNG
(tetrahydrobenzothiophene (THBT), 23)
Show SMILES CC1(C)CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C18H19N3O4S/c1-18(2)8-7-11-13(9-18)26-17(14(11)15(19)22)20-16(23)10-5-3-4-6-12(10)21(24)25/h3-6H,7-9H2,1-2H3,(H2,19,22)(H,20,23)
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n/an/a 50n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31637
PNG
(tetrahydrobenzothiophene (THBT), 6)
Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-11-13(8-9)25-17(14(11)15(18)21)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)
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n/an/a 50n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412408
PNG
(CHEMBL488632)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)NC1CCCC1
Show InChI InChI=1S/C19H27N5O2/c1-2-24-18-15(12-21-24)17(22-14-7-9-26-10-8-14)16(11-20-18)19(25)23-13-5-3-4-6-13/h11-14H,2-10H2,1H3,(H,20,22)(H,23,25)
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412413
PNG
(CHEMBL486442)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C22H27N5O2/c1-3-27-21-18(14-24-27)20(25-17-9-11-29-12-10-17)19(13-23-21)22(28)26(2)15-16-7-5-4-6-8-16/h4-8,13-14,17H,3,9-12,15H2,1-2H3,(H,23,25)
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412396
PNG
(CHEMBL471738)
Show SMILES CCOC(=O)c1cnc2n(CC)ncc2c1NC1CCCC1
Show InChI InChI=1S/C16H22N4O2/c1-3-20-15-12(10-18-20)14(19-11-7-5-6-8-11)13(9-17-15)16(21)22-4-2/h9-11H,3-8H2,1-2H3,(H,17,19)
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n/an/a 63.1n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31638
PNG
(tetrahydrobenzothiophene (THBT), 13a)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1c(F)cccc1F)c2C(N)=O
Show InChI InChI=1S/C20H22F2N2O2S/c1-20(2,3)10-7-8-11-14(9-10)27-19(15(11)17(23)25)24-18(26)16-12(21)5-4-6-13(16)22/h4-6,10H,7-9H2,1-3H3,(H2,23,25)(H,24,26)
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n/an/a 79n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412406
PNG
(CHEMBL528772)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H23N5O2/c1-2-22-16-13(10-19-22)15(20-12-5-7-24-8-6-12)14(9-18-16)17(23)21-11-3-4-11/h9-12H,2-8H2,1H3,(H,18,20)(H,21,23)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412402
PNG
(CHEMBL488487)
Show SMILES CCCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)OCC
Show InChI InChI=1S/C17H24N4O3/c1-3-7-21-16-13(11-19-21)15(20-12-5-8-23-9-6-12)14(10-18-16)17(22)24-4-2/h10-12H,3-9H2,1-2H3,(H,18,20)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50334942
PNG
(1-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-in...)
Show SMILES CC(=O)c1ccc(cc1)-n1nc(c2CCCCc12)C(F)(F)F
Show InChI InChI=1S/C16H15F3N2O/c1-10(22)11-6-8-12(9-7-11)21-14-5-3-2-4-13(14)15(20-21)16(17,18)19/h6-9H,2-5H2,1H3
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n/an/a 100n/an/an/an/an/an/a



University of Sussex

Curated by ChEMBL


Assay Description
Inhibition of human CYP1A2 by fluorescence assay

J Med Chem 54: 78-94 (2011)


Article DOI: 10.1021/jm100679e
BindingDB Entry DOI: 10.7270/Q21C1XVG
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM31649
PNG
(tetrahydrobenzothiophene (THBT), 24)
Show SMILES CCCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C19H21N3O4S/c1-2-5-11-8-9-13-15(10-11)27-19(16(13)17(20)23)21-18(24)12-6-3-4-7-14(12)22(25)26/h3-4,6-7,11H,2,5,8-10H2,1H3,(H2,20,23)(H,21,24)
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n/an/a 100n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412407
PNG
(CHEMBL488633)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)NC1CCN(CC1)C(C)=O
Show InChI InChI=1S/C21H30N6O3/c1-3-27-20-17(13-23-27)19(24-16-6-10-30-11-7-16)18(12-22-20)21(29)25-15-4-8-26(9-5-15)14(2)28/h12-13,15-16H,3-11H2,1-2H3,(H,22,24)(H,25,29)
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM31648
PNG
(tetrahydrobenzothiophene (THBT), 22)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-13-15(10-11)28-19(16(13)17(21)24)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)
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n/an/a 126n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D


(Homo sapiens (Human))		BDBM31647
PNG
(tetrahydrobenzothiophene (THBT), 21)
Show SMILES CCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C18H19N3O4S/c1-2-10-7-8-12-14(9-10)26-18(15(12)16(19)22)20-17(23)11-5-3-4-6-13(11)21(24)25/h3-6,10H,2,7-9H2,1H3,(H2,19,22)(H,20,23)
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n/an/a 126n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...

Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50414990
PNG
(CHEMBL571383)
Show SMILES COc1cccc(Nc2c(cnc3ccc(Sc4ccccc4)cc23)C(N)=O)c1
Show InChI InChI=1S/C23H19N3O2S/c1-28-16-7-5-6-15(12-16)26-22-19-13-18(29-17-8-3-2-4-9-17)10-11-21(19)25-14-20(22)23(24)27/h2-14H,1H3,(H2,24,27)(H,25,26)
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay

Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412409
PNG
(CHEMBL528771)
Show SMILES CCn1ncc2c(NC3CCOCC3)c(cnc12)C(=O)N1CCCC1
Show InChI InChI=1S/C18H25N5O2/c1-2-23-17-14(12-20-23)16(21-13-5-9-25-10-6-13)15(11-19-17)18(24)22-7-3-4-8-22/h11-13H,2-10H2,1H3,(H,19,21)
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50412398
PNG
(CHEMBL488467)
Show SMILES CCOC(=O)c1cnc2n(CCO)ncc2c1NC1CCOCC1
Show InChI InChI=1S/C16H22N4O4/c1-2-24-16(22)13-9-17-15-12(10-18-20(15)5-6-21)14(13)19-11-3-7-23-8-4-11/h9-11,21H,2-8H2,1H3,(H,17,19)
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human PDE4B in Sf9 cells

Bioorg Med Chem Lett 18: 4237-41 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.052
BindingDB Entry DOI: 10.7270/Q2ZP47B3
More data for this
Ligand-Target Pair
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