Compile Data Set for Download or QSAR

Found 1196 hits with Last Name = 'lehmann-lintz' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30645 (US8853193, 32-28) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C16H10ClN3O2S3/c17-13-7-8-14(23-13)25(21,22)20-11-5-3-10(4-6-11)15-19-12-2-1-9-18-16(12)24-15/h1-9,20H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279238 ((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136194 (US8853193, 23-3) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(N)=O Show InChI InChI=1S/C17H15F3N4O2S/c1-8-13-16(22-7-23-17(13)27-14(8)15(21)25)24-11-3-2-9(20)4-12(11)26-10(5-18)6-19/h2-4,7,10H,5-6H2,1H3,(H2,21,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM98036 (US8486953, 19) Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279080 ((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136277 (US8853193, 32.7) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H15F2N3O3S/c1-8(6-18)25-12-5-10(19)3-4-11(12)22-15-13-9(2)14(17(23)24)26-16(13)21-7-20-15/h3-5,7-8H,6H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279080 ((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279267 ((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM98040 (US8486953, 53) Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279237 ((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136283 (US8853193, 32-44) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12 Show InChI InChI=1S/C24H29F2N5O2S/c1-15(13-25)33-19-12-17(26)6-7-18(19)30-22-20-16(2)21(34-24(20)29-14-28-22)23(32)27-8-5-11-31-9-3-4-10-31/h6-7,12,14-15H,3-5,8-11,13H2,1-2H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136193 (US8853193, 23-2) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(O)=O Show InChI InChI=1S/C17H14F3N3O3S/c1-8-13-15(21-7-22-16(13)27-14(8)17(24)25)23-11-3-2-9(20)4-12(11)26-10(5-18)6-19/h2-4,7,10H,5-6H2,1H3,(H,24,25)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279236 ((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136262 (US8853193, 53) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCC#N Show InChI InChI=1S/C20H16F2N6O2S/c1-11-16-18(26-10-27-20(16)31-17(11)19(29)25-5-4-23)28-14-3-2-12(9-24)6-15(14)30-13(7-21)8-22/h2-3,6,10,13H,5,7-8H2,1H3,(H,25,29)(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279236 ((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279082 ((Z)-6-Nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phen...) Show SMILES [O-][N+](=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:9.9| Show InChI InChI=1S/C27H26N4O3/c32-27-25(23-14-13-22(31(33)34)17-24(23)29-27)26(20-7-3-1-4-8-20)28-21-11-9-19(10-12-21)18-30-15-5-2-6-16-30/h1,3-4,7-14,17,25H,2,5-6,15-16,18H2,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279238 ((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30642 (US8853193, 32-27) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12 Show InChI InChI=1S/C16H12N2O2/c19-15-11-12-16(20)18(15)17(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-12H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136201 (US8853193, 23-10) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCCN1CCCC1 Show InChI InChI=1S/C24H28F3N5O2S/c1-15-20-22(31-18-6-5-16(27)11-19(18)34-17(12-25)13-26)29-14-30-24(20)35-21(15)23(33)28-7-4-10-32-8-2-3-9-32/h5-6,11,14,17H,2-4,7-10,12-13H2,1H3,(H,28,33)(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136202 (US8853193, 24) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NS(C)(=O)=O Show InChI InChI=1S/C18H17F3N4O4S2/c1-9-14-16(22-8-23-18(14)30-15(9)17(26)25-31(2,27)28)24-12-4-3-10(21)5-13(12)29-11(6-19)7-20/h3-5,8,11H,6-7H2,1-2H3,(H,25,26)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30641 (US8853193, 32-26) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12 Show InChI InChI=1S/C28H23ClN4O2/c1-18-15-20(19(2)33(18)22-13-11-21(29)12-14-22)16-30-31-27(34)17-32-25-9-5-3-7-23(25)28(35)24-8-4-6-10-26(24)32/h3-16H,17H2,1-2H3,(H,31,34)/b30-16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136200 (US8853193, 23-9) Show SMILES CN(C)CC#CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C23H24F3N5O2S/c1-14-19-21(30-17-7-6-15(26)10-18(17)33-16(11-24)12-25)28-13-29-23(19)34-20(14)22(32)27-8-4-5-9-31(2)3/h6-7,10,13,16H,8-9,11-12H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136258 (US8853193, 49) Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C Show InChI InChI=1S/C23H26F2N6O2S/c1-14-19-21(30-17-6-5-15(12-26)9-18(17)33-16(10-24)11-25)28-13-29-23(19)34-20(14)22(32)27-7-4-8-31(2)3/h5-6,9,13,16H,4,7-8,10-11H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279236 ((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279267 ((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279237 ((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136175 (US8853193, 16-2) Show SMILES CC(CCN)Oc1ncccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H19N5O3S/c1-9(5-6-18)25-15-11(4-3-7-19-15)22-14-12-10(2)13(17(23)24)26-16(12)21-8-20-14/h3-4,7-9H,5-6,18H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136199 (US8853193, 23-8) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCO Show InChI InChI=1S/C19H19F3N4O3S/c1-10-15-17(24-9-25-19(15)30-16(10)18(28)23-4-5-27)26-13-3-2-11(22)6-14(13)29-12(7-20)8-21/h2-3,6,9,12,27H,4-5,7-8H2,1H3,(H,23,28)(H,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136275 (US8853193, 32-5) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12)C(O)=O Show InChI InChI=1S/C18H14F3N3O3S/c1-8-13-15(22-7-23-16(13)28-14(8)17(25)26)24-11-3-2-10(19)4-12(11)27-6-9-5-18(9,20)21/h2-4,7,9H,5-6H2,1H3,(H,25,26)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM30636 (US8853193, 32-21) Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC3CC3(F)F)c12)C(N)=O Show InChI InChI=1S/C16H12N2O2/c19-15-11-12-16(20)18(15)17(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-12H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM31312 (US8853193, 32-37) Show SMILES COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C18H19FN4O3S/c1-9(7-25-3)26-13-6-11(19)4-5-12(13)23-17-14-10(2)15(16(20)24)27-18(14)22-8-21-17/h4-6,8-9H,7H2,1-3H3,(H2,20,24)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136195 (US8853193, 23-4) Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C18H17F3N4O2S/c1-9-14-16(23-8-24-18(14)28-15(9)17(26)22-2)25-12-4-3-10(21)5-13(12)27-11(6-19)7-20/h3-5,8,11H,6-7H2,1-2H3,(H,22,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279238 ((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279237 ((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136260 (US8853193, 51) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCO Show InChI InChI=1S/C20H19F2N5O3S/c1-11-16-18(25-10-26-20(16)31-17(11)19(29)24-4-5-28)27-14-3-2-12(9-23)6-15(14)30-13(7-21)8-22/h2-3,6,10,13,28H,4-5,7-8H2,1H3,(H,24,29)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136197 (US8853193, 23-6) Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C Show InChI InChI=1S/C22H26F3N5O2S/c1-13-18-20(29-16-6-5-14(25)9-17(16)32-15(10-23)11-24)27-12-28-22(18)33-19(13)21(31)26-7-4-8-30(2)3/h5-6,9,12,15H,4,7-8,10-11H2,1-3H3,(H,26,31)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279268 ((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50279045 ((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR3				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136263 (US8853193, 54) Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C#N Show InChI InChI=1S/C17H14FN5O2S/c1-8(6-19)25-12-5-10(18)3-4-11(12)23-16-13-9(2)14(15(20)24)26-17(13)22-7-21-16/h3-5,7-8H,1-2H3,(H2,20,24)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279269 ((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136284 (US8853193, 32-45) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NC3CCN(C)CC3)c(C)c12 Show InChI InChI=1S/C23H27F2N5O2S/c1-13(11-24)32-18-10-15(25)4-5-17(18)29-21-19-14(2)20(33-23(19)27-12-26-21)22(31)28-16-6-8-30(3)9-7-16/h4-5,10,12-13,16H,6-9,11H2,1-3H3,(H,28,31)(H,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136219 (US8853193, 31-5) Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C19H20FN5O3S/c1-4-22-18(27)10(3)28-13-7-11(20)5-6-12(13)25-17-14-9(2)15(16(21)26)29-19(14)24-8-23-17/h5-8,10H,4H2,1-3H3,(H2,21,26)(H,22,27)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136185 (US8853193, 21-3) Show SMILES CC(Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C(F)(F)F Show InChI InChI=1S/C16H14F3N5O2S/c1-7-10-13(22-6-23-15(10)27-11(7)12(20)25)24-9-4-3-5-21-14(9)26-8(2)16(17,18)19/h3-6,8H,1-2H3,(H2,20,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136257 (US8853193, 48) Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCCN1CCCC1 Show InChI InChI=1S/C25H28F2N6O2S/c1-16-21-23(32-19-6-5-17(14-28)11-20(19)35-18(12-26)13-27)30-15-31-25(21)36-22(16)24(34)29-7-4-10-33-8-2-3-9-33/h5-6,11,15,18H,2-4,7-10,12-13H2,1H3,(H,29,34)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50279268 ((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human PDGFRalpha				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279267 ((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...) Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells				J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136188 (US8853193, 21-6) Show SMILES CNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C(F)(F)F)c2c1C Show InChI InChI=1S/C17H16F3N5O2S/c1-8-11-13(23-7-24-16(11)28-12(8)14(26)21-3)25-10-5-4-6-22-15(10)27-9(2)17(18,19)20/h4-7,9H,1-3H3,(H,21,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM32187 (US8853193, 32-42) Show SMILES CC(CC(F)(F)F)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12 Show InChI InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136281 (US8853193, 32-12) Show SMILES CC(F)COc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H15F2N3O3S/c1-8(18)6-25-12-5-10(19)3-4-11(12)22-15-13-9(2)14(17(23)24)26-16(13)21-7-20-15/h3-5,7-8H,6H2,1-2H3,(H,23,24)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM136282 (US8853193, 32-43) Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCC3CCN(C)C3)c(C)c12 Show InChI InChI=1S/C24H29F2N5O2S/c1-14(11-25)33-19-10-17(26)4-5-18(19)30-22-20-15(2)21(34-24(20)29-13-28-22)23(32)27-8-6-16-7-9-31(3)12-16/h4-5,10,13-14,16H,6-9,11-12H2,1-3H3,(H,27,32)(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	30
Boehringer Ingelheim International GmbH US Patent					Assay Description Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...				US Patent US8853193 (2014) BindingDB Entry DOI: 10.7270/Q2GX4983
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 1196 total )  |  Next  |  Last  >>

Jump to: