Found 151 hits with Last Name = 'kingery-wood' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091927
(1-(2,6-Dichloro-phenyl)-1-(4'-fluoro-6-hydroxymeth...)Show SMILES Cc1cc(F)ccc1-c1cc(ccc1CO)N(C(N)=O)c1c(Cl)cccc1Cl Show InChI InChI=1S/C21H17Cl2FN2O2/c1-12-9-14(24)6-8-16(12)17-10-15(7-5-13(17)11-27)26(21(25)28)20-18(22)3-2-4-19(20)23/h2-10,27H,11H2,1H3,(H2,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095409
(5-tert-Butyl-3-[3-(2,3-dichloro-phenyl)-ureido]-1H...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C Show InChI InChI=1S/C17H19Cl2N3O3/c1-17(2,3)12-8-11(14(22-12)15(23)25-4)21-16(24)20-10-7-5-6-9(18)13(10)19/h5-8,22H,1-4H3,(H2,20,21,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139601
(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16BrF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50358043
(CHEMBL1794051 | GW-5074)Show InChI InChI=1S/C15H10Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,15,19-21H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory concentration against raf kinase. |
Bioorg Med Chem Lett 11: 2775-8 (2001)
BindingDB Entry DOI: 10.7270/Q2NS0VD5 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095390
(5-tert-Butyl-3-(3-naphthalen-1-yl-ureido)-1H-pyrro...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C Show InChI InChI=1S/C21H23N3O3/c1-21(2,3)17-12-16(18(24-17)19(25)27-4)23-20(26)22-15-11-7-9-13-8-5-6-10-14(13)15/h5-12,24H,1-4H3,(H2,22,23,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139614
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C22H18ClF3N4O3/c1-2-27-20(31)19-12-16(9-10-28-19)33-15-6-3-13(4-7-15)29-21(32)30-14-5-8-18(23)17(11-14)22(24,25)26/h3-12H,2H2,1H3,(H,27,31)(H2,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139618
(4-{4-[3-(4-Bromo-3-trifluoromethyl-phenyl)-ureido]...)Show SMILES CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C22H18BrF3N4O3/c1-2-27-20(31)19-12-16(9-10-28-19)33-15-6-3-13(4-7-15)29-21(32)30-14-5-8-18(23)17(11-14)22(24,25)26/h3-12H,2H2,1H3,(H,27,31)(H2,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095392
(5-tert-Butyl-3-[3-(3-chloro-phenyl)-ureido]-1H-pyr...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1cccc(Cl)c1)C(C)(C)C Show InChI InChI=1S/C17H20ClN3O3/c1-17(2,3)13-9-12(14(21-13)15(22)24-4)20-16(23)19-11-7-5-6-10(18)8-11/h5-9,21H,1-4H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095415
(5-tert-Butyl-3-(3-naphthalen-1-yl-ureido)-1H-pyrro...)Show SMILES CNC(=O)c1[nH]c(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C Show InChI InChI=1S/C21H24N4O2/c1-21(2,3)17-12-16(18(25-17)19(26)22-4)24-20(27)23-15-11-7-9-13-8-5-6-10-14(13)15/h5-12,25H,1-4H3,(H,22,26)(H2,23,24,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095402
(5-tert-Butyl-3-(3-p-tolyl-ureido)-furan-2-carboxyl...)Show InChI InChI=1S/C18H23N3O3/c1-11-6-8-12(9-7-11)20-17(23)21-13-10-14(18(2,3)4)24-15(13)16(22)19-5/h6-10H,1-5H3,(H,19,22)(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095429
(5-tert-Butyl-3-[3-(2,3-dichloro-phenyl)-ureido]-fu...)Show SMILES COC(=O)c1oc(cc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C Show InChI InChI=1S/C17H18Cl2N2O4/c1-17(2,3)12-8-11(14(25-12)15(22)24-4)21-16(23)20-10-7-5-6-9(18)13(10)19/h5-8H,1-4H3,(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095428
(5-tert-Butyl-3-(3-p-tolyl-ureido)-1H-pyrrole-2-car...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C18H23N3O3/c1-11-6-8-12(9-7-11)19-17(23)20-13-10-14(18(2,3)4)21-15(13)16(22)24-5/h6-10,21H,1-5H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095403
(1-(5-tert-butyl-2-(methylcarbamoyl)thiophen-3-yl)-...)Show InChI InChI=1S/C18H23N3O2S/c1-11-6-8-12(9-7-11)20-17(23)21-13-10-14(18(2,3)4)24-15(13)16(22)19-5/h6-10H,1-5H3,(H,19,22)(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibition of Mitogen-activated protein kinase p38 alpha 2 |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091919
(1-(3-tert-Butyl-isoxazol-5-yl)-3-(2,3-dichloro-phe...)Show InChI InChI=1S/C14H15Cl2N3O2/c1-14(2,3)10-7-11(21-19-10)18-13(20)17-9-6-4-5-8(15)12(9)16/h4-7H,1-3H3,(H2,17,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139621
(4-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-pheno...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)ccn1 Show InChI InChI=1S/C21H23N5O4/c1-21(2,3)17-12-18(26-30-17)25-20(28)24-13-5-7-14(8-6-13)29-15-9-10-23-16(11-15)19(27)22-4/h5-12H,1-4H3,(H,22,27)(H2,24,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095398
(5-tert-Butyl-3-[3-(4-fluoro-phenyl)-ureido]-1H-pyr...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(F)cc1)C(C)(C)C Show InChI InChI=1S/C17H20FN3O3/c1-17(2,3)13-9-12(14(21-13)15(22)24-4)20-16(23)19-11-7-5-10(18)6-8-11/h5-9,21H,1-4H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095407
(5-tert-Butyl-3-[3-(4-chloro-phenyl)-ureido]-1H-pyr...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C Show InChI InChI=1S/C17H20ClN3O3/c1-17(2,3)13-9-12(14(21-13)15(22)24-4)20-16(23)19-11-7-5-10(18)6-8-11/h5-9,21H,1-4H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095426
(5-tert-Butyl-3-(3-phenyl-ureido)-1H-pyrrole-2-carb...)Show InChI InChI=1S/C17H21N3O3/c1-17(2,3)13-10-12(14(20-13)15(21)23-4)19-16(22)18-11-8-6-5-7-9-11/h5-10,20H,1-4H3,(H2,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095397
(5-tert-Butyl-3-[3-(2,3-dichloro-phenyl)-ureido]-1H...)Show SMILES CNC(=O)c1[nH]c(cc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C Show InChI InChI=1S/C17H20Cl2N4O2/c1-17(2,3)12-8-11(14(23-12)15(24)20-4)22-16(25)21-10-7-5-6-9(18)13(10)19/h5-8,23H,1-4H3,(H,20,24)(H2,21,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139626
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)Nc3cccnc3)cc2)ccc1Cl Show InChI InChI=1S/C26H18ClF3N4O3/c27-23-11-8-18(14-22(23)26(28,29)30)34-25(36)33-17-6-9-20(10-7-17)37-21-5-1-3-16(13-21)24(35)32-19-4-2-12-31-15-19/h1-15H,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139620
(5-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES CNC(=O)c1cncc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)12-8-16(11-27-10-12)32-15-5-2-13(3-6-15)28-20(31)29-14-4-7-18(22)17(9-14)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139597
(4-(4-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureid...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3OC)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C22H19F3N4O4/c1-26-20(30)18-12-16(9-10-27-18)33-15-6-4-14(5-7-15)28-21(31)29-17-11-13(22(23,24)25)3-8-19(17)32-2/h3-12H,1-2H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091923
(1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-(2,3-d...)Show InChI InChI=1S/C15H18Cl2N4O/c1-15(2,3)11-8-12(21(4)20-11)19-14(22)18-10-7-5-6-9(16)13(10)17/h5-8H,1-4H3,(H2,18,19,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095401
(5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carb...)Show SMILES Cc1ccc(NC(=O)Nc2cc(sc2C(=O)OCCCO)C(C)(C)C)cc1 Show InChI InChI=1S/C20H26N2O4S/c1-13-6-8-14(9-7-13)21-19(25)22-15-12-16(20(2,3)4)27-17(15)18(24)26-11-5-10-23/h6-9,12,23H,5,10-11H2,1-4H3,(H2,21,22,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibition of Mitogen-activated protein kinase p38 alpha 2 |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095412
(5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carb...)Show SMILES Cc1ccc(NC(=O)Nc2cc(sc2C(=O)OCCO)C(C)(C)C)cc1 Show InChI InChI=1S/C19H24N2O4S/c1-12-5-7-13(8-6-12)20-18(24)21-14-11-15(19(2,3)4)26-16(14)17(23)25-10-9-22/h5-8,11,22H,9-10H2,1-4H3,(H2,20,21,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibition of Mitogen-activated protein kinase p38 alpha 2 |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091917
(1-(5-tert-Butyl-isoxazol-3-yl)-3-(2,3-dichloro-phe...)Show InChI InChI=1S/C14H15Cl2N3O2/c1-14(2,3)10-7-11(19-21-10)18-13(20)17-9-6-4-5-8(15)12(9)16/h4-7H,1-3H3,(H2,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095424
(5-tert-Butyl-3-[3-(2-chloro-phenyl)-ureido]-1H-pyr...)Show SMILES COC(=O)c1[nH]c(cc1NC(=O)Nc1ccccc1Cl)C(C)(C)C Show InChI InChI=1S/C17H20ClN3O3/c1-17(2,3)13-9-12(14(21-13)15(22)24-4)20-16(23)19-11-8-6-5-7-10(11)18/h5-9,21H,1-4H3,(H2,19,20,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139623
(4-{4-[3-(4-Bromo-3-trifluoromethyl-phenyl)-ureido]...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)C(=O)NCCN3CCOCC3)cc2)ccc1Br Show InChI InChI=1S/C26H25BrF3N5O4/c27-22-6-3-18(15-21(22)26(28,29)30)34-25(37)33-17-1-4-19(5-2-17)39-20-7-8-31-23(16-20)24(36)32-9-10-35-11-13-38-14-12-35/h1-8,15-16H,9-14H2,(H,32,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139627
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(4-(5-(m...)Show SMILES CNC(=O)c1cncc(Oc2ccc(NC(=O)Nc3cc(ccc3OC)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C22H19F3N4O4/c1-26-20(30)13-9-17(12-27-11-13)33-16-6-4-15(5-7-16)28-21(31)29-18-10-14(22(23,24)25)3-8-19(18)32-2/h3-12H,1-2H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139602
(5-{4-[3-(2-Methoxy-5-trifluoromethyl-phenyl)-ureid...)Show SMILES COc1ccc(cc1NC(=O)Nc1ccc(Oc2cncc(c2)C(=O)NCCN2CCOCC2)cc1)C(F)(F)F Show InChI InChI=1S/C27H28F3N5O5/c1-38-24-7-2-19(27(28,29)30)15-23(24)34-26(37)33-20-3-5-21(6-4-20)40-22-14-18(16-31-17-22)25(36)32-8-9-35-10-12-39-13-11-35/h2-7,14-17H,8-13H2,1H3,(H,32,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095408
(5-tert-Butyl-3-(3-p-tolyl-ureido)-1H-pyrrole-2-car...)Show SMILES CNC(=O)c1[nH]c(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C18H24N4O2/c1-11-6-8-12(9-7-11)20-17(24)21-13-10-14(18(2,3)4)22-15(13)16(23)19-5/h6-10,22H,1-5H3,(H,19,23)(H2,20,21,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139598
(3-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-pheno...)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)Nc3cccnc3)cc2)no1 Show InChI InChI=1S/C26H25N5O4/c1-26(2,3)22-15-23(31-35-22)30-25(33)29-18-9-11-20(12-10-18)34-21-8-4-6-17(14-21)24(32)28-19-7-5-13-27-16-19/h4-16H,1-3H3,(H,28,32)(H2,29,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139635
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)NCCN3CCOCC3)cc2)ccc1Cl Show InChI InChI=1S/C27H26ClF3N4O4/c28-24-9-6-20(17-23(24)27(29,30)31)34-26(37)33-19-4-7-21(8-5-19)39-22-3-1-2-18(16-22)25(36)32-10-11-35-12-14-38-15-13-35/h1-9,16-17H,10-15H2,(H,32,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095396
(5-tert-Butyl-3-(3-p-tolyl-ureido)-furan-2-carboxyl...)Show InChI InChI=1S/C18H22N2O4/c1-11-6-8-12(9-7-11)19-17(22)20-13-10-14(18(2,3)4)24-15(13)16(21)23-5/h6-10H,1-5H3,(H2,19,20,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139596
(4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)C(=O)NCCN3CCOCC3)cc2)ccc1Cl Show InChI InChI=1S/C26H25ClF3N5O4/c27-22-6-3-18(15-21(22)26(28,29)30)34-25(37)33-17-1-4-19(5-2-17)39-20-7-8-31-23(16-20)24(36)32-9-10-35-11-13-38-14-12-35/h1-8,15-16H,9-14H2,(H,32,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139628
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)NCCN3CCCCC3)cc2)ccc1Cl Show InChI InChI=1S/C28H28ClF3N4O3/c29-25-12-9-21(18-24(25)28(30,31)32)35-27(38)34-20-7-10-22(11-8-20)39-23-6-4-5-19(17-23)26(37)33-13-16-36-14-2-1-3-15-36/h4-12,17-18H,1-3,13-16H2,(H,33,37)(H2,34,35,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095391
(5-tert-Butyl-3-[3-(4-fluoro-phenyl)-ureido]-thioph...)Show InChI InChI=1S/C17H20FN3O2S/c1-17(2,3)13-9-12(14(24-13)15(22)19-4)21-16(23)20-11-7-5-10(18)6-8-11/h5-9H,1-4H3,(H,19,22)(H2,20,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091929
(2-[3-(3,4-Dichloro-phenyl)-ureido]-benzamide | CHE...)Show InChI InChI=1S/C14H11Cl2N3O2/c15-10-6-5-8(7-11(10)16)18-14(21)19-12-4-2-1-3-9(12)13(17)20/h1-7H,(H2,17,20)(H2,18,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139611
(3-{4-[3-(2-Methoxy-5-trifluoromethyl-phenyl)-ureid...)Show SMILES COc1ccc(cc1NC(=O)Nc1ccc(Oc2cccc(c2)C(=O)Nc2cccnc2)cc1)C(F)(F)F Show InChI InChI=1S/C27H21F3N4O4/c1-37-24-12-7-18(27(28,29)30)15-23(24)34-26(36)33-19-8-10-21(11-9-19)38-22-6-2-4-17(14-22)25(35)32-20-5-3-13-31-16-20/h2-16H,1H3,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139606
(CHEMBL168049 | N-(2-Dimethylamino-ethyl)-5-{4-[3-(...)Show SMILES COc1ccc(cc1NC(=O)Nc1ccc(Oc2cncc(c2)C(=O)NCCN(C)C)cc1)C(F)(F)F Show InChI InChI=1S/C25H26F3N5O4/c1-33(2)11-10-30-23(34)16-12-20(15-29-14-16)37-19-7-5-18(6-8-19)31-24(35)32-21-13-17(25(26,27)28)4-9-22(21)36-3/h4-9,12-15H,10-11H2,1-3H3,(H,30,34)(H2,31,32,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139629
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES COCCNC(=O)c1cccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C24H21ClF3N3O4/c1-34-12-11-29-22(32)15-3-2-4-19(13-15)35-18-8-5-16(6-9-18)30-23(33)31-17-7-10-21(25)20(14-17)24(26,27)28/h2-10,13-14H,11-12H2,1H3,(H,29,32)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50095422
(5-tert-Butyl-3-[3-(4-ethyl-phenyl)-ureido]-thiophe...)Show SMILES CCc1ccc(NC(=O)Nc2cc(sc2C(=O)NC)C(C)(C)C)cc1 Show InChI InChI=1S/C19H25N3O2S/c1-6-12-7-9-13(10-8-12)21-18(24)22-14-11-15(19(2,3)4)25-16(14)17(23)20-5/h7-11H,6H2,1-5H3,(H,20,23)(H2,21,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coli |
Bioorg Med Chem Lett 11: 9-12 (2001)
BindingDB Entry DOI: 10.7270/Q2JM28WH |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091920
(1-(5-tert-Butyl-thiophen-2-yl)-3-(2,3-dichloro-phe...)Show InChI InChI=1S/C15H16Cl2N2OS/c1-15(2,3)11-7-8-12(21-11)19-14(20)18-10-6-4-5-9(16)13(10)17/h4-8H,1-3H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091916
(1-(2,3-Dichloro-phenyl)-3-[3-(1,1-dimethyl-propyl)...)Show InChI InChI=1S/C15H17Cl2N3O2/c1-4-15(2,3)11-8-12(22-20-11)19-14(21)18-10-7-5-6-9(16)13(10)17/h5-8H,4H2,1-3H3,(H2,18,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139609
(3-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenoxy)...)Show SMILES CNC(=O)c1cccc(Oc2ccc(NC(=O)Nc3cc(on3)C(C)(C)C)cc2)c1 Show InChI InChI=1S/C22H24N4O4/c1-22(2,3)18-13-19(26-30-18)25-21(28)24-15-8-10-16(11-9-15)29-17-7-5-6-14(12-17)20(27)23-4/h5-13H,1-4H3,(H,23,27)(H2,24,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50091913
(1-(2,3-Dichloro-phenyl)-3-[3-(2,2-dimethyl-propyl)...)Show InChI InChI=1S/C15H17Cl2N3O2/c1-15(2,3)8-9-7-12(22-20-9)19-14(21)18-11-6-4-5-10(16)13(11)17/h4-7H,8H2,1-3H3,(H2,18,19,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli. |
Bioorg Med Chem Lett 10: 2047-50 (2000)
BindingDB Entry DOI: 10.7270/Q2FB526H |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50139605
(3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido...)Show SMILES COc1ccncc1NC(=O)c1cccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c1 Show InChI InChI=1S/C27H20ClF3N4O4/c1-38-24-11-12-32-15-23(24)35-25(36)16-3-2-4-20(13-16)39-19-8-5-17(6-9-19)33-26(37)34-18-7-10-22(28)21(14-18)27(29,30)31/h2-15H,1H3,(H,35,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Raf-1 kinase |
Bioorg Med Chem Lett 14: 783-6 (2004)
BindingDB Entry DOI: 10.7270/Q2TM79JT |
More data for this
Ligand-Target Pair | |
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