Compile Data Set for Download or QSAR

Found 727 hits with Last Name = 'moskey' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50201303 (1-(4-(4-amino-7-(pyrimidin-5-yl)thieno[3,2-c]pyrid...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cncnc2)c1 Show InChI InChI=1S/C25H20N6OS/c1-15-3-2-4-19(9-15)31-25(32)30-18-7-5-16(6-8-18)21-13-33-23-20(12-29-24(26)22(21)23)17-10-27-14-28-11-17/h2-14H,1H3,(H2,26,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR phosphorylation in NIH3T3 cells				Bioorg Med Chem Lett 17: 1246-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.015 BindingDB Entry DOI: 10.7270/Q28K78RS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50187995 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C19H16N6OS/c1-11-3-2-4-14(9-11)24-19(26)23-13-7-5-12(6-8-13)16-15-17(20)21-10-22-18(15)27-25-16/h2-10H,1H3,(H2,20,21,22)(H2,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by cellular assay				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by cellular assay				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT1				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207507 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-p-tolylure...) Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)cc1 Show InChI InChI=1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207484 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylure...) Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2[nH]nc(N)c12 Show InChI InChI=1S/C21H19N5O/c1-13-5-2-3-7-17(13)24-21(27)23-15-11-9-14(10-12-15)16-6-4-8-18-19(16)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207473 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-chlorop...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C20H16ClN5O/c21-13-3-1-4-15(11-13)24-20(27)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)26-25-17/h1-11H,(H3,22,25,26)(H2,23,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT1 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of CSF1R by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207509 (1-(4-(3-amino-7-methyl-1H-indazol-4-yl)phenyl)-3-m...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(C)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C22H21N5O/c1-13-4-3-5-17(12-13)25-22(28)24-16-9-7-15(8-10-16)18-11-6-14(2)20-19(18)21(23)27-26-20/h3-12H,1-2H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50187997 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Nc1ncnc2snc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C19H13F3N6OS/c20-19(21,22)11-2-1-3-13(8-11)27-18(29)26-12-6-4-10(5-7-12)15-14-16(23)24-9-25-17(14)30-28-15/h1-9H,(H2,23,24,25)(H2,26,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT4				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207499 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-m-tolylure...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H19N5O/c1-13-4-2-5-16(12-13)24-21(27)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8870 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50187997 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Nc1ncnc2snc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C19H13F3N6OS/c20-19(21,22)11-2-1-3-13(8-11)27-18(29)26-12-6-4-10(5-7-12)15-14-16(23)24-9-25-17(14)30-28-15/h1-9H,(H2,23,24,25)(H2,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50201323 (1-(4-(4-amino-7-(pyridin-3-yl)thieno[3,2-c]pyridin...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cccnc2)c1 Show InChI InChI=1S/C26H21N5OS/c1-16-4-2-6-20(12-16)31-26(32)30-19-9-7-17(8-10-19)22-15-33-24-21(14-29-25(27)23(22)24)18-5-3-11-28-13-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR phosphorylation in NIH3T3 cells				Bioorg Med Chem Lett 17: 1246-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.015 BindingDB Entry DOI: 10.7270/Q28K78RS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50201330 (1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccncc2)c1 Show InChI InChI=1S/C26H21N5OS/c1-16-3-2-4-20(13-16)31-26(32)30-19-7-5-17(6-8-19)22-15-33-24-21(14-29-25(27)23(22)24)18-9-11-28-12-10-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR phosphorylation in NIH3T3 cells				Bioorg Med Chem Lett 17: 1246-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.015 BindingDB Entry DOI: 10.7270/Q28K78RS
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21090 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-met...) Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1 Show InChI InChI=1S/C21H18N4O2/c1-13-5-9-15(10-6-13)23-21(26)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)25-27-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM21085 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-met...) Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)c1 Show InChI InChI=1S/C21H18N4O3/c1-27-16-5-2-4-15(12-16)24-21(26)23-14-10-8-13(9-11-14)17-6-3-7-18-19(17)20(22)25-28-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Homo sapiens (Human))	BDBM50187995 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C19H16N6OS/c1-11-3-2-4-14(9-11)24-19(26)23-13-7-5-12(6-8-13)16-15-17(20)21-10-22-18(15)27-25-16/h2-10H,1H3,(H2,20,21,22)(H2,23,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT4				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207474 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...) Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21093 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-flu...) Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12 Show InChI InChI=1S/C20H15FN4O2/c21-13-6-10-15(11-7-13)24-20(26)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207475 (1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(F)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207498 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(thiophen-...) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccsc4)cc3)c12 Show InChI InChI=1S/C18H15N5OS/c19-17-16-14(2-1-3-15(16)22-23-17)11-4-6-12(7-5-11)20-18(24)21-13-8-9-25-10-13/h1-10H,(H3,19,22,23)(H2,20,21,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50207475 (1-(4-(3-amino-7-fluoro-1H-indazol-4-yl)phenyl)-3-m...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2ccc(F)c3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-3-2-4-15(11-12)25-21(28)24-14-7-5-13(6-8-14)16-9-10-17(22)19-18(16)20(23)27-26-19/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Kit by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50188000 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H18N6OS/c1-2-12-4-3-5-15(10-12)25-20(27)24-14-8-6-13(7-9-14)17-16-18(21)22-11-23-19(16)28-26-17/h3-11H,2H2,1H3,(H2,21,22,23)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM21092 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-met...) Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1 Show InChI InChI=1S/C21H18N4O3/c1-27-16-11-9-15(10-12-16)24-21(26)23-14-7-5-13(6-8-14)17-3-2-4-18-19(17)20(22)25-28-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21079 (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21086 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-nit...) Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c12 Show InChI InChI=1S/C20H15N5O4/c21-19-18-16(5-2-6-17(18)29-24-19)12-7-9-13(10-8-12)22-20(26)23-14-3-1-4-15(11-14)25(27)28/h1-11H,(H2,21,24)(H2,22,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50187997 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Nc1ncnc2snc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C19H13F3N6OS/c20-19(21,22)11-2-1-3-13(8-11)27-18(29)26-12-6-4-10(5-7-12)15-14-16(23)24-9-25-17(14)30-28-15/h1-9H,(H2,23,24,25)(H2,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by cellular assay				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50188000 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H18N6OS/c1-2-12-4-3-5-15(10-12)25-20(27)24-14-8-6-13(7-9-14)17-16-18(21)22-11-23-19(16)28-26-17/h3-11H,2H2,1H3,(H2,21,22,23)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by cellular assay				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM21090 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-met...) Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1 Show InChI InChI=1S/C21H18N4O2/c1-13-5-9-15(10-6-13)23-21(26)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)25-27-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50201330 (1-(4-(4-amino-7-(pyridin-4-yl)thieno[3,2-c]pyridin...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2ccncc2)c1 Show InChI InChI=1S/C26H21N5OS/c1-16-3-2-4-20(13-16)31-26(32)30-19-7-5-17(6-8-19)22-15-33-24-21(14-29-25(27)23(22)24)18-9-11-28-12-10-18/h2-15H,1H3,(H2,27,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 17: 1246-9 (2007) Article DOI: 10.1016/j.bmcl.2006.12.015 BindingDB Entry DOI: 10.7270/Q28K78RS
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50209158 (2-(4-methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-pro...) Show SMILES CN1CCN(CC(=O)Nc2cccc-3c2Cc2c-3n[nH]c2-c2csc(c2)C#CCOc2ccccc2)CC1 Show InChI InChI=1S/C30H29N5O2S/c1-34-12-14-35(15-13-34)19-28(36)31-27-11-5-10-24-25(27)18-26-29(32-33-30(24)26)21-17-23(38-20-21)9-6-16-37-22-7-3-2-4-8-22/h2-5,7-8,10-11,17,20H,12-16,18-19H2,1H3,(H,31,36)(H,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Flt1 by HTRF assay				Bioorg Med Chem Lett 17: 3136-40 (2007) Article DOI: 10.1016/j.bmcl.2007.03.031 BindingDB Entry DOI: 10.7270/Q2VD6Z3Q
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50207491 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(3-ethylph...) Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C22H21N5O/c1-2-14-5-3-6-17(13-14)25-22(28)24-16-11-9-15(10-12-16)18-7-4-8-19-20(18)21(23)27-26-19/h3-13H,2H2,1H3,(H3,23,26,27)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21089 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chl...) Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C20H15ClN4O2/c21-13-3-1-4-15(11-13)24-20(26)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8813 (3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...) Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM8826 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of CKIT				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50207474 (1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(4-fluoro-...) Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F Show InChI InChI=1S/C21H18FN5O/c1-12-11-15(9-10-17(12)22)25-21(28)24-14-7-5-13(6-8-14)16-3-2-4-18-19(16)20(23)27-26-18/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of FLT3 by HTRF assay				J Med Chem 50: 1584-97 (2007) Article DOI: 10.1021/jm061280h BindingDB Entry DOI: 10.7270/Q2DJ5F95
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50187996 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C19H15FN6OS/c1-10-2-7-13(20)14(8-10)25-19(27)24-12-5-3-11(4-6-12)16-15-17(21)22-9-23-18(15)28-26-16/h2-9H,1H3,(H2,21,22,23)(H2,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of CKIT				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM21080 (3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-phenyl...) Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 Show InChI InChI=1S/C20H16N4O2/c21-19-18-16(7-4-8-17(18)26-24-19)13-9-11-15(12-10-13)23-20(25)22-14-5-2-1-3-6-14/h1-12H,(H2,21,24)(H2,22,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 51: 1231-41 (2008) Article DOI: 10.1021/jm701096v BindingDB Entry DOI: 10.7270/Q2HX19Z7
					More data for this Ligand-Target Pair

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