Found 170 hits with Last Name = 'radinsky' and Initial = 'r' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340122
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340126
(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-31-22-15-18(6-7-21(22)30-10-12-32-13-11-30)28-24-25-9-8-23(29-24)27-19-14-17-4-2-3-5-20(17)26-16-19/h2-9,14-16H,10-13H2,1H3,(H2,25,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of INSR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340128
(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4ncccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-12-16(13-19(29-2)21(18)30-3)26-22-24-10-8-20(27-22)25-15-6-7-17-14(11-15)5-4-9-23-17/h4-13H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340144
(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1OCCCN1CCCCC1 Show InChI InChI=1S/C28H32N6O2/c1-35-26-19-22(10-11-25(26)36-17-7-16-34-14-5-2-6-15-34)32-28-29-13-12-27(33-28)31-23-18-21-8-3-4-9-24(21)30-20-23/h3-4,8-13,18-20H,2,5-7,14-17H2,1H3,(H2,29,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340127
(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-17-11-16(12-18(29-2)21(17)30-3)25-22-23-9-8-19(27-22)26-20-10-14-6-4-5-7-15(14)13-24-20/h4-13H,1-3H3,(H2,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Mus musculus) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340126
(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1N1CCOCC1 Show InChI InChI=1S/C24H24N6O2/c1-31-22-15-18(6-7-21(22)30-10-12-32-13-11-30)28-24-25-9-8-23(29-24)27-19-14-17-4-2-3-5-20(17)26-16-19/h2-9,14-16H,10-13H2,1H3,(H2,25,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326206
(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1 Show InChI InChI=1S/C29H24N6O2/c1-30-29-32-19-17-26(35-29)24-11-7-18-31-28(24)37-22-15-13-21(14-16-22)34-27(36)23-10-5-6-12-25(23)33-20-8-3-2-4-9-20/h2-19,33H,1H3,(H,34,36)(H,30,32,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340120
(CHEMBL1760034 | N2-(naphthalen-2-yl)-N4-(3,4,5-tri...)Show SMILES COc1cc(Nc2ncnc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-17(12-19(29-2)20(18)30-3)26-22-24-13-23-21(27-22)25-16-9-8-14-6-4-5-7-15(14)10-16/h4-13H,1-3H3,(H2,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340127
(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4cn3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-17-11-16(12-18(29-2)21(17)30-3)25-22-23-9-8-19(27-22)26-20-10-14-6-4-5-7-15(14)13-24-20/h4-13H,1-3H3,(H2,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326208
(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326204
(CHEMBL1243137 | N-(3-Methyl-4-(3-(2-(methylamino)p...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1C Show InChI InChI=1S/C30H26N6O2/c1-20-19-22(35-28(37)23-11-6-7-13-25(23)34-21-9-4-3-5-10-21)14-15-27(20)38-29-24(12-8-17-32-29)26-16-18-33-30(31-2)36-26/h3-19,34H,1-2H3,(H,35,37)(H,31,33,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340135
(CHEMBL1760049 | N2-(3,4-dimethoxyphenyl)-N4-(quino...)Show InChI InChI=1S/C21H19N5O2/c1-27-18-8-7-15(12-19(18)28-2)25-21-22-10-9-20(26-21)24-16-11-14-5-3-4-6-17(14)23-13-16/h3-13H,1-2H3,(H2,22,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340143
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1 Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340136
(CHEMBL1760050 | N2-(3,5-dimethoxyphenyl)-N4-(quino...)Show InChI InChI=1S/C21H19N5O2/c1-27-17-10-15(11-18(12-17)28-2)25-21-22-8-7-20(26-21)24-16-9-14-5-3-4-6-19(14)23-13-16/h3-13H,1-2H3,(H2,22,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340142
(CHEMBL1760056 | N2-(4-morpholinophenyl)-N4-(quinol...)Show SMILES C1CN(CCO1)c1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1 Show InChI InChI=1S/C23H22N6O/c1-2-4-21-17(3-1)15-19(16-25-21)26-22-9-10-24-23(28-22)27-18-5-7-20(8-6-18)29-11-13-30-14-12-29/h1-10,15-16H,11-14H2,(H2,24,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326207
(CHEMBL1243294 | N-(4-(3-(2-(Methylamino)pyrimidin-...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1 Show InChI InChI=1S/C30H23N7O/c1-31-30-33-19-17-26(35-30)25-12-7-18-32-29(25)38-22-15-13-21(14-16-22)34-28-24-11-6-5-10-23(24)27(36-37-28)20-8-3-2-4-9-20/h2-19H,1H3,(H,34,37)(H,31,33,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50340143
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1 Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of INSR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340118
(CHEMBL1760048 | N4-(3-(trifluoromethoxy)phenyl)-N2...)Show SMILES COc1cc(Nc2nccc(Nc3cccc(OC(F)(F)F)c3)n2)cc(OC)c1OC Show InChI InChI=1S/C20H19F3N4O4/c1-28-15-10-13(11-16(29-2)18(15)30-3)26-19-24-8-7-17(27-19)25-12-5-4-6-14(9-12)31-20(21,22)23/h4-11H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340131
(CHEMBL1760044 | N4-(1H-indazol-5-yl)-N2-(3,4,5-tri...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4[nH]ncc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-14(10-17(28-2)19(16)29-3)24-20-21-7-6-18(25-20)23-13-4-5-15-12(8-13)11-22-26-15/h4-11H,1-3H3,(H,22,26)(H2,21,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340144
(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)ccc1OCCCN1CCCCC1 Show InChI InChI=1S/C28H32N6O2/c1-35-26-19-22(10-11-25(26)36-17-7-16-34-14-5-2-6-15-34)32-28-29-13-12-27(33-28)31-23-18-21-8-3-4-9-24(21)30-20-23/h3-4,8-13,18-20H,2,5-7,14-17H2,1H3,(H2,29,31,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340141
(CHEMBL1760055 | N2-(3-chloro-4-methoxyphenyl)-N4-(...)Show InChI InChI=1S/C20H16ClN5O/c1-27-18-7-6-14(11-16(18)21)25-20-22-9-8-19(26-20)24-15-10-13-4-2-3-5-17(13)23-12-15/h2-12H,1H3,(H2,22,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340128
(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4ncccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-12-16(13-19(29-2)21(18)30-3)26-22-24-10-8-20(27-22)25-15-6-7-17-14(11-15)5-4-9-23-17/h4-13H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340138
(CHEMBL1760052 | N2-(3-methoxyphenyl)-N4-(quinolin-...)Show InChI InChI=1S/C20H17N5O/c1-26-17-7-4-6-15(12-17)24-20-21-10-9-19(25-20)23-16-11-14-5-2-3-8-18(14)22-13-16/h2-13H,1H3,(H2,21,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340119
(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)Show SMILES COc1cc(Nc2ncnc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C21H20N6O3/c1-28-17-9-14(10-18(29-2)19(17)30-3)25-20-23-12-24-21(27-20)26-15-8-13-6-4-5-7-16(13)22-11-15/h4-12H,1-3H3,(H2,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340140
(CHEMBL1760054 | N2-(3-chlorophenyl)-N4-(quinolin-3...)Show InChI InChI=1S/C19H14ClN5/c20-14-5-3-6-15(11-14)24-19-21-9-8-18(25-19)23-16-10-13-4-1-2-7-17(13)22-12-16/h1-12H,(H2,21,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340123
(CHEMBL1760037 | N4-(2-methylquinolin-3-yl)-N2-(3,4...)Show SMILES COc1cc(Nc2nccc(Nc3cc4ccccc4nc3C)n2)cc(OC)c1OC Show InChI InChI=1S/C23H23N5O3/c1-14-18(11-15-7-5-6-8-17(15)25-14)27-21-9-10-24-23(28-21)26-16-12-19(29-2)22(31-4)20(13-16)30-3/h5-13H,1-4H3,(H2,24,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50131840
(CHEMBL3633142)Show SMILES COc1cc(ccc1Nc1ncc2ccc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1 Show InChI InChI=1S/C28H29N7O3/c1-4-25(36)30-20-6-5-7-22(16-20)35-26(37)11-8-19-18-29-28(32-27(19)35)31-23-10-9-21(17-24(23)38-3)34-14-12-33(2)13-15-34/h4-11,16-18H,1,12-15H2,2-3H3,(H,30,36)(H,29,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Binding affinity against delta opioid receptor in mouse hot plate test |
ACS Med Chem Lett 6: 987-92 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00193
BindingDB Entry DOI: 10.7270/Q21C1ZPN |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340137
(CHEMBL1760051 | N2-(4-methoxyphenyl)-N4-(quinolin-...)Show InChI InChI=1S/C20H17N5O/c1-26-17-8-6-15(7-9-17)24-20-21-11-10-19(25-20)23-16-12-14-4-2-3-5-18(14)22-13-16/h2-13H,1H3,(H2,21,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326202
(CHEMBL1243042 | N-(3-Methyl-4-(3-(2-(methylamino)p...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Oc2ccccc2)cc1C Show InChI InChI=1S/C30H25N5O3/c1-20-19-21(34-28(36)24-11-6-7-13-27(24)37-22-9-4-3-5-10-22)14-15-26(20)38-29-23(12-8-17-32-29)25-16-18-33-30(31-2)35-25/h3-19H,1-2H3,(H,34,36)(H,31,33,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340129
(CHEMBL1760042 | N4-(quinoxalin-6-yl)-N2-(3,4,5-tri...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4nccnc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C21H20N6O3/c1-28-17-11-14(12-18(29-2)20(17)30-3)26-21-24-7-6-19(27-21)25-13-4-5-15-16(10-13)23-9-8-22-15/h4-12H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326198
(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C Show InChI InChI=1S/C25H20F3N5O2/c1-15-13-18(32-22(34)16-5-3-6-17(14-16)25(26,27)28)8-9-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340143
(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)Show SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1 Show InChI InChI=1S/C27H30N6O/c1-4-15-33(16-5-1)17-6-18-34-24-11-9-22(10-12-24)31-27-28-14-13-26(32-27)30-23-19-21-7-2-3-8-25(21)29-20-23/h2-3,7-14,19-20H,1,4-6,15-18H2,(H2,28,30,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM24773
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ... |
Cancer Res 66: 8715-21 (2006)
Article DOI: 10.1158/0008-5472.CAN-05-4665
BindingDB Entry DOI: 10.7270/Q2057D73 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340122
(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C23H22N4O3/c1-28-19-13-18(14-20(29-2)22(19)30-3)26-23-24-11-10-21(27-23)25-17-9-8-15-6-4-5-7-16(15)12-17/h4-14H,1-3H3,(H2,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50340121
(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)Show SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H21N5O3/c1-28-18-11-15(12-19(29-2)21(18)30-3)26-22-23-9-8-20(27-22)25-16-10-14-6-4-5-7-17(14)24-13-16/h4-13H,1-3H3,(H2,23,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340130
(CHEMBL1760043 | N4-(1H-indazol-6-yl)-N2-(3,4,5-tri...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4cn[nH]c4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-14(10-17(28-2)19(16)29-3)24-20-21-7-6-18(25-20)23-13-5-4-12-11-22-26-15(12)8-13/h4-11H,1-3H3,(H,22,26)(H2,21,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50326205
(CHEMBL1243167 | N-(2-Methyl-4-(3-(2-(methylamino)p...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)c(C)c1 Show InChI InChI=1S/C30H26N6O2/c1-20-19-22(38-29-24(12-8-17-32-29)27-16-18-33-30(31-2)36-27)14-15-25(20)35-28(37)23-11-6-7-13-26(23)34-21-9-4-3-5-10-21/h3-19,34H,1-2H3,(H,35,37)(H,31,33,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B by HTRF assay |
J Med Chem 53: 6368-77 (2010)
Article DOI: 10.1021/jm100394y
BindingDB Entry DOI: 10.7270/Q2C829H0 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340133
(CHEMBL1760046 | N4-(3,3-dimethylindolin-6-yl)-N2-(...)Show SMILES COc1cc(Nc2nccc(Nc3ccc4c(NCC4(C)C)c3)n2)cc(OC)c1OC Show InChI InChI=1S/C23H27N5O3/c1-23(2)13-25-17-10-14(6-7-16(17)23)26-20-8-9-24-22(28-20)27-15-11-18(29-3)21(31-5)19(12-15)30-4/h6-12,25H,13H2,1-5H3,(H2,24,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340119
(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)Show SMILES COc1cc(Nc2ncnc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C21H20N6O3/c1-28-17-9-14(10-18(29-2)19(17)30-3)25-20-23-12-24-21(27-20)26-15-8-13-6-4-5-7-16(13)22-11-15/h4-12H,1-3H3,(H2,23,24,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340142
(CHEMBL1760056 | N2-(4-morpholinophenyl)-N4-(quinol...)Show SMILES C1CN(CCO1)c1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1 Show InChI InChI=1S/C23H22N6O/c1-2-4-21-17(3-1)15-19(16-25-21)26-22-9-10-24-23(28-22)27-18-5-7-20(8-6-18)29-11-13-30-14-12-29/h1-10,15-16H,11-14H2,(H2,24,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340139
(CHEMBL1760053 | N4-(quinolin-3-yl)-N2-(3-(trifluor...)Show SMILES FC(F)(F)Oc1cccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)c1 Show InChI InChI=1S/C20H14F3N5O/c21-20(22,23)29-16-6-3-5-14(11-16)27-19-24-9-8-18(28-19)26-15-10-13-4-1-2-7-17(13)25-12-15/h1-12H,(H2,24,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human IGF1R |
Bioorg Med Chem Lett 21: 2394-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.075
BindingDB Entry DOI: 10.7270/Q28G8M0D |
More data for this
Ligand-Target Pair | |
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