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Compile Data Set for Download or QSAR

Found 85 hits with Last Name = 'yamanada' and Initial = 'n'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264847
PNG
(CHEMBL4096902)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C#N)n1
Show InChI InChI=1S/C25H23N9OS2/c1-14-22(37-15(2)30-14)20-13-36-25(31-20)32-21-6-3-17(10-27-21)23(35)34-18-4-5-19(34)12-33(11-18)24-28-8-16(7-26)9-29-24/h3,6,8-10,13,18-19H,4-5,11-12H2,1-2H3,(H,27,31,32)
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n/an/a 0.180n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256209
PNG
(CHEMBL4101768)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8O2S2/c1-13-21(40-14(2)32-13)19-12-39-24(33-19)34-20-4-3-15(5-29-20)22(37)36-17-8-35(9-18(36)11-38-10-17)23-30-6-16(7-31-23)25(26,27)28/h3-7,12,17-18H,8-11H2,1-2H3,(H,29,33,34)
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n/an/a 0.190n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264846
PNG
(CHEMBL4066531)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(Br)cn2)n1
Show InChI InChI=1S/C24H23BrN8OS2/c1-13-21(36-14(2)29-13)19-12-35-24(30-19)31-20-6-3-15(7-26-20)22(34)33-17-4-5-18(33)11-32(10-17)23-27-8-16(25)9-28-23/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,26,30,31)
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n/an/a 0.210n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192809
PNG
(CHEMBL3941914)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)36-17-4-5-18(36)11-35(10-17)23-30-8-16(9-31-23)25(26,27)28/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 0.220n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256228
PNG
(CHEMBL4099293)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CCN(CC2C(F)(F)F)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C24H20F6N8OS2/c1-12-19(41-13(2)34-12)16-11-40-22(35-16)36-18-4-3-14(7-31-18)20(39)38-6-5-37(10-17(38)24(28,29)30)21-32-8-15(9-33-21)23(25,26)27/h3-4,7-9,11,17H,5-6,10H2,1-2H3,(H,31,35,36)
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n/an/a 0.290n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192811
PNG
(CHEMBL3971502)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(Cl)cn2)n1
Show InChI InChI=1S/C24H23ClN8OS2/c1-13-21(36-14(2)29-13)19-12-35-24(30-19)31-20-6-3-15(7-26-20)22(34)33-17-4-5-18(33)11-32(10-17)23-27-8-16(25)9-28-23/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,26,30,31)
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n/an/a 0.300n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264858
PNG
(CHEMBL4077638)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(F)cn2)n1
Show InChI InChI=1S/C24H23FN8OS2/c1-13-21(36-14(2)29-13)19-12-35-24(30-19)31-20-6-3-15(7-26-20)22(34)33-17-4-5-18(33)11-32(10-17)23-27-8-16(25)9-28-23/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,26,30,31)
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n/an/a 0.310n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264859
PNG
(CHEMBL4078117)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C25H26N8O3S3/c1-14-22(38-15(2)29-14)20-13-37-25(30-20)31-21-7-4-16(8-26-21)23(34)33-17-5-6-18(33)12-32(11-17)24-27-9-19(10-28-24)39(3,35)36/h4,7-10,13,17-18H,5-6,11-12H2,1-3H3,(H,26,30,31)
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n/an/a 0.390n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192809
PNG
(CHEMBL3941914)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)36-17-4-5-18(36)11-35(10-17)23-30-8-16(9-31-23)25(26,27)28/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 0.400n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264845
PNG
(CHEMBL4095552)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncccn2)n1
Show InChI InChI=1S/C24H24N8OS2/c1-14-21(35-15(2)28-14)19-13-34-24(29-19)30-20-7-4-16(10-27-20)22(33)32-17-5-6-18(32)12-31(11-17)23-25-8-3-9-26-23/h3-4,7-10,13,17-18H,5-6,11-12H2,1-2H3,(H,27,29,30)
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n/an/a 0.5n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256212
PNG
(CHEMBL4060956)
Show SMILES C[C@H]1CN(CCN1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1)c1ncc(cn1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(22-29-9-17(10-30-22)24(25,26)27)6-7-35(13)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264848
PNG
(CHEMBL4062935)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(CO)cn2)n1
Show InChI InChI=1S/C25H26N8O2S2/c1-14-22(37-15(2)29-14)20-13-36-25(30-20)31-21-6-3-17(9-26-21)23(35)33-18-4-5-19(33)11-32(10-18)24-27-7-16(12-34)8-28-24/h3,6-9,13,18-19,34H,4-5,10-12H2,1-2H3,(H,26,30,31)
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n/an/a 0.650n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264857
PNG
(CHEMBL4090714)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2cnc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-22(39-14(2)32-13)18-12-38-24(33-18)34-20-6-3-15(7-30-20)23(37)36-16-4-5-17(36)11-35(10-16)21-9-29-19(8-31-21)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,30,33,34)
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n/an/a 0.710n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264856
PNG
(CHEMBL4084992)
Show SMILES Cc1nn(C)cc1-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H24F3N9OS/c1-14-19(12-35(2)34-14)20-13-39-24(32-20)33-21-6-3-15(7-29-21)22(38)37-17-4-5-18(37)11-36(10-17)23-30-8-16(9-31-23)25(26,27)28/h3,6-9,12-13,17-18H,4-5,10-11H2,1-2H3,(H,29,32,33)
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n/an/a 0.870n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256230
PNG
(CHEMBL4083772)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CC3CCC(C2)N3c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)35-10-17-4-5-18(11-35)36(17)23-30-8-16(9-31-23)25(26,27)28/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 0.970n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264855
PNG
(CHEMBL4091558)
Show SMILES C[C@@H]1CN(CCN1c1ncc(cn1)C(F)(F)F)C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r|
Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(6-7-35(13)22-29-9-17(10-30-22)24(25,26)27)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m1/s1
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n/an/a 0.990n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264844
PNG
(CHEMBL4069724)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ccc(nn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-22(39-14(2)30-13)18-12-38-24(31-18)32-20-7-3-15(9-29-20)23(37)36-16-4-5-17(36)11-35(10-16)21-8-6-19(33-34-21)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,29,31,32)
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n/an/a 1.30n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256210
PNG
(CHEMBL4080527)
Show SMILES Cc1cc(-c2csc(Nc3ccc(cn3)C(=O)N3C4CCC3CN(C4)c3ncc(cn3)C(F)(F)F)n2)n(C)n1
Show InChI InChI=1S/C25H24F3N9OS/c1-14-7-20(35(2)34-14)19-13-39-24(32-19)33-21-6-3-15(8-29-21)22(38)37-17-4-5-18(37)12-36(11-17)23-30-9-16(10-31-23)25(26,27)28/h3,6-10,13,17-18H,4-5,11-12H2,1-2H3,(H,29,32,33)
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n/an/a 1.30n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50263440
PNG
(CHEMBL4083195)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ccc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C26H24F3N7OS2/c1-14-23(39-15(2)32-14)20-13-38-25(33-20)34-21-7-3-16(9-30-21)24(37)36-18-5-6-19(36)12-35(11-18)22-8-4-17(10-31-22)26(27,28)29/h3-4,7-10,13,18-19H,5-6,11-12H2,1-2H3,(H,30,33,34)
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n/an/a 1.40n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256211
PNG
(CHEMBL4077429)
Show SMILES CC(O)c1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C26H25F3N8O2S2/c1-13-21(41-22(33-13)14(2)38)19-12-40-25(34-19)35-20-6-3-15(7-30-20)23(39)37-17-4-5-18(37)11-36(10-17)24-31-8-16(9-32-24)26(27,28)29/h3,6-9,12,14,17-18,38H,4-5,10-11H2,1-2H3,(H,30,34,35)
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n/an/a 1.80n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 1.80n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced activation

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256229
PNG
(CHEMBL4063752)
Show SMILES C[C@H]1CN(CCN1c1ncc(cn1)C(F)(F)F)C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r|
Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(6-7-35(13)22-29-9-17(10-30-22)24(25,26)27)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264844
PNG
(CHEMBL4069724)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ccc(nn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-22(39-14(2)30-13)18-12-38-24(31-18)32-20-7-3-15(9-29-20)23(37)36-16-4-5-17(36)11-35(10-16)21-8-6-19(33-34-21)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,29,31,32)
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n/an/a 2.20n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50263440
PNG
(CHEMBL4083195)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ccc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C26H24F3N7OS2/c1-14-23(39-15(2)32-14)20-13-38-25(33-20)34-21-7-3-16(9-30-21)24(37)36-18-5-6-19(36)12-35(11-18)22-8-4-17(10-31-22)26(27,28)29/h3-4,7-10,13,18-19H,5-6,11-12H2,1-2H3,(H,30,33,34)
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n/an/a 2.20n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256213
PNG
(CHEMBL4082835)
Show SMILES C[C@@H]1CN(CCN1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1)c1ncc(cn1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(22-29-9-17(10-30-22)24(25,26)27)6-7-35(13)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264857
PNG
(CHEMBL4090714)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2cnc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-22(39-14(2)32-13)18-12-38-24(33-18)34-20-6-3-15(7-30-20)23(37)36-16-4-5-17(36)11-35(10-16)21-9-29-19(8-31-21)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,30,33,34)
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n/an/a 2.60n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192823
PNG
(CHEMBL3906074)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1
Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25)
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n/an/a 3.10n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of hypotonic solution-induced calcium mobilization by F...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264868
PNG
(CHEMBL4075898)
Show SMILES Cc1nc(C)c(s1)-c1nsc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C24H22F3N9OS2/c1-12-19(38-13(2)31-12)20-33-23(39-34-20)32-18-6-3-14(7-28-18)21(37)36-16-4-5-17(36)11-35(10-16)22-29-8-15(9-30-22)24(25,26)27/h3,6-9,16-17H,4-5,10-11H2,1-2H3,(H,28,32,33,34)
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n/an/a 3.70n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50263438
PNG
(CHEMBL4077357)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ccc(cc2)C(F)(F)F)n1
Show InChI InChI=1S/C27H25F3N6OS2/c1-15-24(39-16(2)32-15)22-14-38-26(33-22)34-23-10-3-17(11-31-23)25(37)36-20-8-9-21(36)13-35(12-20)19-6-4-18(5-7-19)27(28,29)30/h3-7,10-11,14,20-21H,8-9,12-13H2,1-2H3,(H,31,33,34)
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n/an/a 3.90n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264860
PNG
(CHEMBL4069627)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(N)=O)n1
Show InChI InChI=1S/C25H25N9O2S2/c1-13-21(38-14(2)30-13)19-12-37-25(31-19)32-20-6-3-15(7-27-20)23(36)34-17-4-5-18(34)11-33(10-17)24-28-8-16(9-29-24)22(26)35/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H2,26,35)(H,27,31,32)
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n/an/a 4.20n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)		BDBM50256209
PNG
(CHEMBL4101768)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8O2S2/c1-13-21(40-14(2)32-13)19-12-39-24(33-19)34-20-4-3-15(5-29-20)22(37)36-17-8-35(9-18(36)11-38-10-17)23-30-6-16(7-31-23)25(26,27)28/h3-7,12,17-18H,8-11H2,1-2H3,(H,29,33,34)
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n/an/a 4.40n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256231
PNG
(CHEMBL4077790)
Show SMILES Cc1nn(C)cc1-c1nsc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C24H23F3N10OS/c1-13-18(12-35(2)33-13)20-32-23(39-34-20)31-19-6-3-14(7-28-19)21(38)37-16-4-5-17(37)11-36(10-16)22-29-8-15(9-30-22)24(25,26)27/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,28,31,32,34)
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n/an/a 6.20n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256208
PNG
(CHEMBL4103303)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2cnc(nc2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)36-16-4-5-17(36)11-35(10-16)18-8-30-23(31-9-18)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 6.30n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195055
PNG
(CHEMBL3954949)
Show SMILES CC1CCCC(C)N1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1
Show InChI InChI=1S/C21H25N5OS2/c1-12-6-5-7-13(2)26(12)20(27)16-8-9-18(22-10-16)25-21-24-17(11-28-21)19-14(3)23-15(4)29-19/h8-13H,5-7H2,1-4H3,(H,22,24,25)
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n/an/a 6.30n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50264850
PNG
(CHEMBL4090643)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CCN(CC2)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C23H21F3N8OS2/c1-13-19(37-14(2)30-13)17-12-36-22(31-17)32-18-4-3-15(9-27-18)20(35)33-5-7-34(8-6-33)21-28-10-16(11-29-21)23(24,25)26/h3-4,9-12H,5-8H2,1-2H3,(H,27,31,32)
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n/an/a 6.80n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)		BDBM50256228
PNG
(CHEMBL4099293)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2CCN(CC2C(F)(F)F)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C24H20F6N8OS2/c1-12-19(41-13(2)34-12)16-11-40-22(35-16)36-18-4-3-14(7-31-18)20(39)38-6-5-37(10-17(38)24(28,29)30)21-32-8-15(9-33-21)23(25,26)27/h3-4,7-9,11,17H,5-6,10H2,1-2H3,(H,31,35,36)
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Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)		BDBM50192809
PNG
(CHEMBL3941914)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)36-17-4-5-18(36)11-35(10-17)23-30-8-16(9-31-23)25(26,27)28/h3,6-9,12,17-18H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 8.60n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195058
PNG
(CHEMBL3979286)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)Nc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C20H16ClN5OS2/c1-11-18(29-12(2)23-11)16-10-28-20(25-16)26-17-8-3-13(9-22-17)19(27)24-15-6-4-14(21)5-7-15/h3-10H,1-2H3,(H,24,27)(H,22,25,26)
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n/an/a 9.5n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM65888
PNG
((2',4'-Dimethyl-[4,5']bithiazolyl-2-yl...)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccccn2)n1
Show InChI InChI=1S/C13H12N4S2/c1-8-12(19-9(2)15-8)10-7-18-13(16-10)17-11-5-3-4-6-14-11/h3-7H,1-2H3,(H,14,16,17)
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n/an/a 10n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195059
PNG
(CHEMBL3932523)
Show SMILES CCOC(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1
Show InChI InChI=1S/C16H16N4O2S2/c1-4-22-15(21)11-5-6-13(17-7-11)20-16-19-12(8-23-16)14-9(2)18-10(3)24-14/h5-8H,4H2,1-3H3,(H,17,19,20)
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n/an/a 11n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192823
PNG
(CHEMBL3906074)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3COCC2CC(=O)C3)n1
Show InChI InChI=1S/C21H21N5O3S2/c1-11-19(31-12(2)23-11)17-10-30-21(24-17)25-18-4-3-13(7-22-18)20(28)26-14-5-16(27)6-15(26)9-29-8-14/h3-4,7,10,14-15H,5-6,8-9H2,1-2H3,(H,22,24,25)
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n/an/a 19n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)		BDBM50256212
PNG
(CHEMBL4060956)
Show SMILES C[C@H]1CN(CCN1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1)c1ncc(cn1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N8OS2/c1-13-11-34(22-29-9-17(10-30-22)24(25,26)27)6-7-35(13)21(36)16-4-5-19(28-8-16)33-23-32-18(12-37-23)20-14(2)31-15(3)38-20/h4-5,8-10,12-13H,6-7,11H2,1-3H3,(H,28,32,33)/t13-/m0/s1
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Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195141
PNG
(CHEMBL3900585)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C#N)n1
Show InChI InChI=1S/C14H11N5S2/c1-8-13(21-9(2)17-8)11-7-20-14(18-11)19-12-4-3-10(5-15)6-16-12/h3-4,6-7H,1-2H3,(H,16,18,19)
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Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195142
PNG
(CHEMBL3925315)
Show SMILES COc1cccc(Nc2nc(cs2)-c2sc(C)nc2C)n1
Show InChI InChI=1S/C14H14N4OS2/c1-8-13(21-9(2)15-8)10-7-20-14(16-10)18-11-5-4-6-12(17-11)19-3/h4-7H,1-3H3,(H,16,17,18)
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n/an/a 23n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50256208
PNG
(CHEMBL4103303)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2cnc(nc2)C(F)(F)F)n1
Show InChI InChI=1S/C25H23F3N8OS2/c1-13-21(39-14(2)32-13)19-12-38-24(33-19)34-20-6-3-15(7-29-20)22(37)36-16-4-5-17(36)11-35(10-16)18-8-30-23(31-9-18)25(26,27)28/h3,6-9,12,16-17H,4-5,10-11H2,1-2H3,(H,29,33,34)
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n/an/a 23n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192802
PNG
(CHEMBL3927993)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CC(=O)C3)n1
Show InChI InChI=1S/C21H21N5O2S2/c1-11-19(30-12(2)23-11)17-10-29-21(24-17)25-18-6-3-13(9-22-18)20(28)26-14-4-5-15(26)8-16(27)7-14/h3,6,9-10,14-15H,4-5,7-8H2,1-2H3,(H,22,24,25)
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n/an/a 24n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195056
PNG
(CHEMBL3975583)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)NC2CCCCC2)n1
Show InChI InChI=1S/C20H23N5OS2/c1-12-18(28-13(2)22-12)16-11-27-20(24-16)25-17-9-8-14(10-21-17)19(26)23-15-6-4-3-5-7-15/h8-11,15H,3-7H2,1-2H3,(H,23,26)(H,21,24,25)
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n/an/a 29n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50192821
PNG
(CHEMBL2133556)
Show SMILES Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
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n/an/a 29n/an/an/an/an/an/a



Shionogi& Co., Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...

Bioorg Med Chem 25: 2177-2190 (2017)


Article DOI: 10.1016/j.bmc.2017.02.047
BindingDB Entry DOI: 10.7270/Q2N58PT9
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195092
PNG
(CHEMBL3977499)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccccc2)n1
Show InChI InChI=1S/C14H13N3S2/c1-9-13(19-10(2)15-9)12-8-18-14(17-12)16-11-6-4-3-5-7-11/h3-8H,1-2H3,(H,16,17)
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n/an/a 31n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM50195220
PNG
(CHEMBL424708)
Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(Br)cc2)n1
Show InChI InChI=1S/C14H12BrN3S2/c1-8-13(20-9(2)16-8)12-7-19-14(18-12)17-11-5-3-10(15)4-6-11/h3-7H,1-2H3,(H,17,18)
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n/an/a 34n/an/an/an/an/an/a



Shionogi& Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...

Bioorg Med Chem Lett 26: 4930-4935 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.013
BindingDB Entry DOI: 10.7270/Q2BC41H5
More data for this
Ligand-Target Pair
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