Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 7405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193022 (US9193726, 10) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(c(F)c1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)18-3-4-19-24(36)33(7-8-34(19)23(18)35)14(2)20-5-6-21(37-20)15-9-16(26)22(17(27)10-15)25(28,29)30/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.34	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193067 (US9193726, 55) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)c(F)c1)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C24H23ClF2N4O3/c1-13-11-29(12-28-13)18-3-4-19-24(33)30(7-8-31(19)23(18)32)14(2)20-5-6-21(34-20)15-9-16(26)22(25)17(27)10-15/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.48	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193079 (US9193726, 67) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)c(Cl)c1)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C24H23Cl2FN4O3/c1-13-11-29(12-28-13)18-3-4-19-24(33)30(7-8-31(19)23(18)32)14(2)20-5-6-21(34-20)15-9-16(25)22(26)17(27)10-15/h3-4,9-12,14,20-21H,5-8H2,1-2H3/t14-,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.78	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193081 (US9193726, 69) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-18(27)17(26)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.84	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193063 (US9193726, 51) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H24F4N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)16-3-4-17(18(26)11-16)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.35	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193021 (US9193726, 9) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H24ClF3N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(26)11-18(17)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193082 (US9193726, 70) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)c(F)c1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)17-5-6-18-24(36)33(9-10-34(18)23(17)35)14(2)19-7-8-20(37-19)15-3-4-16(26)22(27)21(15)25(28,29)30/h3-6,11-12,14,19-20H,7-10H2,1-2H3/t14-,19-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193062 (US9193726, 50) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1F)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)17-5-6-18-24(36)33(9-10-34(18)23(17)35)14(2)19-7-8-20(37-19)15-3-4-16(25(28,29)30)22(27)21(15)26/h3-6,11-12,14,19-20H,7-10H2,1-2H3/t14-,19-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193069 (US9193726, 57) Show SMILES COc1cc(Cl)c(F)cc1[C@H]1CC[C@H](O1)[C@H](C)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H26ClFN4O4/c1-14-12-29(13-28-14)19-4-5-20-25(33)30(8-9-31(20)24(19)32)15(2)21-6-7-22(35-21)16-10-18(27)17(26)11-23(16)34-3/h4-5,10-13,15,21-22H,6-9H2,1-3H3/t15-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.1	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193066 (US9193726, 54) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)cc1F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C24H23ClF2N4O3/c1-13-11-29(12-28-13)19-3-4-20-24(33)30(7-8-31(20)23(19)32)14(2)21-5-6-22(34-21)15-9-18(27)16(25)10-17(15)26/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193074 (US9193726, 62) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cc(F)c(Cl)c(F)c3)CCn2c1=O Show InChI InChI=1S/C23H21ClF2N4O3/c1-13-10-29(12-27-13)18-3-4-19-22(31)28(6-7-30(19)23(18)32)11-15-2-5-20(33-15)14-8-16(25)21(24)17(26)9-14/h3-4,8-10,12,15,20H,2,5-7,11H2,1H3/t15-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193020 (US9193726, 8) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(cc1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H25F3N4O3/c1-15-13-30(14-29-15)19-7-8-20-24(34)31(11-12-32(20)23(19)33)16(2)21-9-10-22(35-21)17-3-5-18(6-4-17)25(26,27)28/h3-8,13-14,16,21-22H,9-12H2,1-2H3/t16-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193070 (US9193726, 58) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1OC(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H24ClF3N4O4/c1-14-12-31(13-30-14)18-5-6-19-24(35)32(9-10-33(19)23(18)34)15(2)20-7-8-21(36-20)17-4-3-16(26)11-22(17)37-25(27,28)29/h3-6,11-13,15,20-21H,7-10H2,1-2H3/t15-,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193064 (US9193726, 52) Show SMILES COc1cc(ccc1[C@H]1CC[C@H](O1)[C@H](C)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)C(F)(F)F Show InChI InChI=1S/C26H27F3N4O4/c1-15-13-31(14-30-15)19-6-7-20-25(35)32(10-11-33(20)24(19)34)16(2)21-8-9-22(37-21)18-5-4-17(26(27,28)29)12-23(18)36-3/h4-7,12-14,16,21-22H,8-11H2,1-3H3/t16-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193059 (US9193726, 47) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(c(F)c3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-31(13-29-14)19-5-6-20-22(33)30(8-9-32(20)23(19)34)12-16-3-7-21(35-16)15-2-4-17(18(25)10-15)24(26,27)28/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3/t16-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.7	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193030 (US9193726, 18) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cc(F)c(c(F)c3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H21F5N4O3/c1-13-10-32(12-30-13)18-3-4-19-22(34)31(6-7-33(19)23(18)35)11-15-2-5-20(36-15)14-8-16(25)21(17(26)9-14)24(27,28)29/h3-4,8-10,12,15,20H,2,5-7,11H2,1H3/t15-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193085 (US9193726, 73) Show SMILES C[C@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-30(14-29-15)20-8-9-21-24(34)31(16(2)12-32(21)23(20)33)13-19-7-10-22(35-19)17-3-5-18(6-4-17)25(26,27)28/h3-6,8-9,11,14,16,19,22H,7,10,12-13H2,1-2H3/t16-,19+,22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.8	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193061 (US9193726, 49) Show SMILES COc1cc(Cl)ccc1[C@H]1CC[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O1 Show InChI InChI=1S/C24H25ClN4O4/c1-15-12-28(14-26-15)19-6-7-20-23(30)27(9-10-29(20)24(19)31)13-17-4-8-21(33-17)18-5-3-16(25)11-22(18)32-2/h3,5-7,11-12,14,17,21H,4,8-10,13H2,1-2H3/t17-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193080 (US9193726, 68) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(F)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H24F4N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(26)11-18(17)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.2	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193073 (US9193726, 61) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1OC(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H25ClF2N4O4/c1-14-12-30(13-29-14)18-5-6-19-24(34)31(9-10-32(19)23(18)33)15(2)20-7-8-21(35-20)17-4-3-16(26)11-22(17)36-25(27)28/h3-6,11-13,15,20-21,25H,7-10H2,1-2H3/t15-,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193018 (US9193726, 6) Show SMILES C[C@H]1C[C@@H](O[C@@H]1CN1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-21(17-3-5-18(6-4-17)25(26,27)28)35-22(15)13-30-9-10-32-20(23(30)33)8-7-19(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,21-22H,9-11,13H2,1-2H3/t15-,21+,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193057 (US9193726, 45) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)S(F)(F)(F)(F)F)CCn2c1=O Show InChI InChI=1S/C23H23F5N4O3S/c1-15-12-31(14-29-15)19-7-8-20-22(33)30(10-11-32(20)23(19)34)13-17-4-9-21(35-17)16-2-5-18(6-3-16)36(24,25,26,27)28/h2-3,5-8,12,14,17,21H,4,9-11,13H2,1H3/t17-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193077 (US9193726, 65) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(Cl)cc3C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H22ClF3N4O3/c1-14-11-31(13-29-14)19-5-6-20-22(33)30(8-9-32(20)23(19)34)12-16-3-7-21(35-16)17-4-2-15(25)10-18(17)24(26,27)28/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3/t16-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26.8	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193055 (US9193726, 43) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-18-6-9-21(34-18)16-2-4-17(5-3-16)24(25,26)27/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193065 (US9193726, 53) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(cc1Cl)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H24ClF3N4O3/c1-14-12-31(13-30-14)19-5-6-20-24(35)32(9-10-33(20)23(19)34)15(2)21-7-8-22(36-21)17-4-3-16(11-18(17)26)25(27,28)29/h3-6,11-13,15,21-22H,7-10H2,1-2H3/t15-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.1	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193027 (US9193726, 15) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CCC[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-9-10-21-23(33)30(11-12-32(21)24(20)34)14-19-3-2-4-22(35-19)17-5-7-18(8-6-17)25(26,27)28/h5-10,13,15,19,22H,2-4,11-12,14H2,1H3/t19-,22-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.9	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193078 (US9193726, 66) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(F)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-17(26)18(27)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193029 (US9193726, 17) Show SMILES C[C@H]1C[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O[C@H]1c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-19(35-22(15)17-3-5-18(6-4-17)25(26,27)28)13-30-9-10-32-21(23(30)33)8-7-20(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,19,22H,9-11,13H2,1-2H3/t15-,19-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38.4	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193023 (US9193726, 11) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@](C)(O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-7-8-21-22(33)30(11-12-32(21)23(20)34)14-19-9-10-24(2,35-19)17-3-5-18(6-4-17)25(26,27)28/h3-8,13,15,19H,9-12,14H2,1-2H3/t19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193084 (US9193726, 72) Show SMILES C[C@@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-30(14-29-15)20-8-9-21-24(34)31(16(2)12-32(21)23(20)33)13-19-7-10-22(35-19)17-3-5-18(6-4-17)25(26,27)28/h3-6,8-9,11,14,16,19,22H,7,10,12-13H2,1-2H3/t16-,19-,22+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46.4	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193056 (US9193726, 44) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(Cl)cc3)CCn2c1=O Show InChI InChI=1S/C23H23ClN4O3/c1-15-12-27(14-25-15)19-7-8-20-22(29)26(10-11-28(20)23(19)30)13-18-6-9-21(31-18)16-2-4-17(24)5-3-16/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	52.1	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193083 (US9193726, 71) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(s1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C23H23F3N4O3S/c1-13-11-28(12-27-13)15-3-4-16-22(32)29(9-10-30(16)21(15)31)14(2)17-5-6-18(33-17)19-7-8-20(34-19)23(24,25)26/h3-4,7-8,11-12,14,17-18H,5-6,9-10H2,1-2H3/t14-,17-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	52.4	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193058 (US9193726, 46) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(OC(F)(F)F)cc3)CCn2c1=O Show InChI InChI=1S/C24H23F3N4O4/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-18-6-9-21(34-18)16-2-4-17(5-3-16)35-24(25,26)27/h2-5,7-8,12,14,18,21H,6,9-11,13H2,1H3/t18-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193015 (US9193726, 3) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2cc(F)c(F)cc12 Show InChI InChI=1S/C26H22F2N4O3/c1-15-13-30(14-29-15)21-5-6-22-26(34)31(9-10-32(22)25(21)33)20-7-8-24(20)35-23-4-2-3-16-11-18(27)19(28)12-17(16)23/h2-6,11-14,20,24H,7-10H2,1H3/t20-,24-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193060 (US9193726, 48) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C3CC3)CCn2c1=O Show InChI InChI=1S/C26H28N4O3/c1-17-14-29(16-27-17)22-9-10-23-25(31)28(12-13-30(23)26(22)32)15-21-8-11-24(33-21)20-6-4-19(5-7-20)18-2-3-18/h4-7,9-10,14,16,18,21,24H,2-3,8,11-13,15H2,1H3/t21-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63.8	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193075 (US9193726, 63) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccccc3C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-7-8-20-22(32)29(10-11-31(20)23(19)33)13-16-6-9-21(34-16)17-4-2-3-5-18(17)24(25,26)27/h2-5,7-8,12,14,16,21H,6,9-11,13H2,1H3/t16-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193072 (US9193726, 60) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(C)(F)F)CCn2c1=O Show InChI InChI=1S/C25H26F2N4O3/c1-16-13-30(15-28-16)20-8-9-21-23(32)29(11-12-31(21)24(20)33)14-19-7-10-22(34-19)17-3-5-18(6-4-17)25(2,26)27/h3-6,8-9,13,15,19,22H,7,10-12,14H2,1-2H3/t19-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193076 (US9193726, 64) Show SMILES C[C@@H]1C[C@@H](CN2CCn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)O[C@H]1c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-19(35-22(15)17-3-5-18(6-4-17)25(26,27)28)13-30-9-10-32-21(23(30)33)8-7-20(24(32)34)31-12-16(2)29-14-31/h3-8,12,14-15,19,22H,9-11,13H2,1-2H3/t15-,19+,22-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193019 (US9193726, 7) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3C[C@@H](F)[C@@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H22F4N4O3/c1-14-11-31(13-29-14)19-6-7-20-22(33)30(8-9-32(20)23(19)34)12-17-10-18(25)21(35-17)15-2-4-16(5-3-15)24(26,27)28/h2-7,11,13,17-18,21H,8-10,12H2,1H3/t17-,18+,21-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193041 (US9193726, 29) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CCC[C@@H](C3)c3ccc(Cl)cc3)CCn2c1=O Show InChI InChI=1S/C25H27ClN4O2/c1-17-14-29(16-27-17)22-9-10-23-24(31)28(11-12-30(23)25(22)32)15-18-3-2-4-20(13-18)19-5-7-21(26)8-6-19/h5-10,14,16,18,20H,2-4,11-13,15H2,1H3/t18-,20+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193068 (US9193726, 56) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3cccc(c3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C24H23F3N4O3/c1-15-12-30(14-28-15)19-6-7-20-22(32)29(9-10-31(20)23(19)33)13-18-5-8-21(34-18)16-3-2-4-17(11-16)24(25,26)27/h2-4,6-7,11-12,14,18,21H,5,8-10,13H2,1H3/t18-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	81.2	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193028 (US9193726, 16) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@H]3CCC[C@H](O3)c3ccc(cc3)C(F)(F)F)CCn2c1=O Show InChI InChI=1S/C25H25F3N4O3/c1-16-13-31(15-29-16)20-9-10-21-23(33)30(11-12-32(21)24(20)34)14-19-3-2-4-22(35-19)17-5-7-18(8-6-17)25(26,27)28/h5-10,13,15,19,22H,2-4,11-12,14H2,1H3/t19-,22+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	96.6	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193035 (US9193726, 23) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CCCC(C3)c3ccc(Cl)cc3)CCn2c1=O Show InChI InChI=1S/C25H27ClN4O2/c1-17-14-29(16-27-17)22-9-10-23-24(31)28(11-12-30(23)25(22)32)15-18-3-2-4-20(13-18)19-5-7-21(26)8-6-19/h5-10,14,16,18,20H,2-4,11-13,15H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193051 (US9193726, 39) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2ccc(F)cc12 Show InChI InChI=1S/C26H23FN4O3/c1-16-14-29(15-28-16)21-7-8-22-26(33)30(11-12-31(22)25(21)32)20-9-10-24(20)34-23-4-2-3-17-5-6-18(27)13-19(17)23/h2-8,13-15,20,24H,9-12H2,1H3/t20-,24-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193054 (US9193726, 42) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CC3CCC(O3)c3ccc(Cl)c(Cl)c3)CCn2c1=O Show InChI InChI=1S/C23H22Cl2N4O3/c1-14-11-28(13-26-14)19-5-6-20-22(30)27(8-9-29(20)23(19)31)12-16-3-7-21(32-16)15-2-4-17(24)18(25)10-15/h2,4-6,10-11,13,16,21H,3,7-9,12H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193046 (US9193726, 34) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(Cl)cc1C(F)(F)F Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-11-29(12-28-13)17-3-4-18-22(33)30(8-9-31(18)21(17)32)16-5-7-20(16)34-19-6-2-14(24)10-15(19)23(25,26)27/h2-4,6,10-12,16,20H,5,7-9H2,1H3/t16-,20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193017 (US9193726, 5) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Oc1ccc(F)cc1C(F)(F)F Show InChI InChI=1S/C24H22F4N4O3/c1-14-12-30(13-29-14)18-6-7-19-23(34)31(9-10-32(19)22(18)33)17-3-2-4-21(17)35-20-8-5-15(25)11-16(20)24(26,27)28/h5-8,11-13,17,21H,2-4,9-10H2,1H3/t17-,21+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193048 (US9193726, 36) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(F)c(Cl)c1C Show InChI InChI=1S/C23H22ClFN4O3/c1-13-11-27(12-26-13)17-4-5-18-23(31)28(9-10-29(18)22(17)30)16-6-8-20(16)32-19-7-3-15(25)21(24)14(19)2/h3-5,7,11-12,16,20H,6,8-10H2,1-2H3/t16-,20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193052 (US9193726, 40) Show SMILES CC(C)c1c(F)cccc1O[C@@H]1CC[C@H]1N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H27FN4O3/c1-15(2)23-17(26)5-4-6-22(23)33-21-10-9-18(21)29-11-12-30-20(25(29)32)8-7-19(24(30)31)28-13-16(3)27-14-28/h4-8,13-15,18,21H,9-12H2,1-3H3/t18-,21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM193053 (US9193726, 41) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C23H20ClF3N4O3/c1-13-11-29(12-28-13)16-5-6-17-22(33)30(9-10-31(17)21(16)32)15-7-8-18(15)34-19-4-2-3-14(20(19)24)23(25,26)27/h2-6,11-12,15,18H,7-10H2,1H3/t15-,18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair

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