Compile Data Set for Download or QSAR

Found 112 hits Enz. Inhib. hit(s) with all data for entry = 122   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180912 (US9676721, 28 2-cyano-1-({4-[(3,4-difluorobenzene)...) Show SMILES Fc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C20H15F2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180103 (US9676721, 32 2-cyano-1-({4-[(3,5-difluorobenzene)...) Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 |w:26.27| Show InChI InChI=1S/C20H15F2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180915 (US9676721, 21 1-{2-[4-(benzenesulfonyl)phenyl]ethy...) Show SMILES O=S(=O)(c1ccccc1)c1ccc(CCN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C21H19N5O2S/c22-16-25-21(26-18-11-13-23-14-12-18)24-15-10-17-6-8-20(9-7-17)29(27,28)19-4-2-1-3-5-19/h1-9,11-14H,10,15H2,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180921 (US9676721, 79 2-cyano-1-{[4-(1-methyl-1H-indazole-...) Show SMILES Cn1ncc2ccc(cc12)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C22H19N7O2S/c1-29-21-12-20(7-4-17(21)14-27-29)32(30,31)19-5-2-16(3-6-19)13-25-22(26-15-23)28-18-8-10-24-11-9-18/h2-12,14H,13H2,1H3,(H2,24,25,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180067 (US9676721, 17 1-[(4-{[4-chloro-3-(trifluoromethyl)...) Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:28.30| Show InChI InChI=1S/C21H15ClF3N5O2S/c22-19-6-5-17(11-18(19)21(23,24)25)33(31,32)16-3-1-14(2-4-16)12-28-20(29-13-26)30-15-7-9-27-10-8-15/h1-11H,12H2,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180928 (US9676721, 97 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...) Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cnc2ccccc2c1 |w:17.18| Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-9-11-25-12-10-19)27-14-17-5-7-20(8-6-17)32(30,31)21-13-18-3-1-2-4-22(18)26-15-21/h1-13,15H,14H2,(H2,25,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180918 (US9676721, 36 2-cyano-1-({4-[(3-fluoro-4-methoxybe...) Show SMILES COc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:26.28| Show InChI InChI=1S/C21H18FN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181033 (US9676721, 41 2-cyano-1-({4-[(3-methoxy-4-methylbe...) Show SMILES COc1cc(ccc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:26.28| Show InChI InChI=1S/C22H21N5O3S/c1-16-3-6-20(13-21(16)30-2)31(28,29)19-7-4-17(5-8-19)14-25-22(26-15-23)27-18-9-11-24-12-10-18/h3-13H,14H2,1-2H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180064 (US9676721, 64 2-cyano-1-[(4-{[3-(dimethylsulfamoyl...) Show SMILES CN(C)S(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:29.31| Show InChI InChI=1S/C22H22N6O4S2/c1-28(2)34(31,32)21-5-3-4-20(14-21)33(29,30)19-8-6-17(7-9-19)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,15H2,1-2H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180081 (US9676721, 88 2-cyano-1-{[4-(6-methylpyridine-3-su...) Show SMILES Cc1ccc(cn1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:24.26| Show InChI InChI=1S/C20H18N6O2S/c1-15-2-5-19(13-23-15)29(27,28)18-6-3-16(4-7-18)12-24-20(25-14-21)26-17-8-10-22-11-9-17/h2-11,13H,12H2,1H3,(H2,22,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180272 (US9676721, 42 2-cyano-1-({4-[(3-methoxybenzene)sul...) Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C21H19N5O3S/c1-29-18-3-2-4-20(13-18)30(27,28)19-7-5-16(6-8-19)14-24-21(25-15-22)26-17-9-11-23-12-10-17/h2-13H,14H2,1H3,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181032 (US9676721, 75 2-cyano-1-[(4-{[4-(morpholin-4-yl)be...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C24H24N6O3S/c25-18-28-24(29-20-9-11-26-12-10-20)27-17-19-1-5-22(6-2-19)34(31,32)23-7-3-21(4-8-23)30-13-15-33-16-14-30/h1-12H,13-17H2,(H2,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180257 (US9676721, 78 2-cyano-1-{[4-({3-[(morpholin-4-yl)c...) Show SMILES O=C(N1CCOCC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:31.34| Show InChI InChI=1S/C25H24N6O4S/c26-18-29-25(30-21-8-10-27-11-9-21)28-17-19-4-6-22(7-5-19)36(33,34)23-3-1-2-20(16-23)24(32)31-12-14-35-15-13-31/h1-11,16H,12-15,17H2,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180786 (US9676721, 34 2-cyano-1-({4-[(3-cyanobenzene)sulfo...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc(c1)C#N |w:18.18| Show InChI InChI=1S/C21H16N6O2S/c22-13-17-2-1-3-20(12-17)30(28,29)19-6-4-16(5-7-19)14-25-21(26-15-23)27-18-8-10-24-11-9-18/h1-12H,14H2,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180095 (US9676721, 27 2-cyano-1-({4-[(3,4-dichlorobenzene)...) Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 |w:26.27| Show InChI InChI=1S/C20H15Cl2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180920 (US9676721, 39 2-cyano-1-({4-[(3-fluoro-5-methylben...) Show SMILES Cc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C21H18FN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180101 (US9676721, 20 1-{[4-(2H-1,3-benzodioxole-5-sulfony...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc2OCOc2c1 |w:18.18| Show InChI InChI=1S/C21H17N5O4S/c22-13-25-21(26-16-7-9-23-10-8-16)24-12-15-1-3-17(4-2-15)31(27,28)18-5-6-19-20(11-18)30-14-29-19/h1-11H,12,14H2,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180049 (US9676721, 65 2-cyano-1-[(4-{[3-(ethanesulfonyl)be...) Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:28.30| Show InChI InChI=1S/C22H21N5O4S2/c1-2-32(28,29)20-4-3-5-21(14-20)33(30,31)19-8-6-17(7-9-19)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180260 (US9676721, 4 1-({4-[(3-chloro-4-methylbenzene)sulf...) Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C21H18ClN5O2S/c1-15-2-5-19(12-20(15)22)30(28,29)18-6-3-16(4-7-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180089 (US9676721, 57 2-cyano-1-({4-[6-(morpholin-4-yl)pyr...) Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(nc1)N1CCOCC1 |w:17.18| Show InChI InChI=1S/C23H23N7O3S/c24-17-28-23(29-19-7-9-25-10-8-19)27-15-18-1-3-20(4-2-18)34(31,32)21-5-6-22(26-16-21)30-11-13-33-14-12-30/h1-10,16H,11-15H2,(H2,25,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180253 (US9676721, 90 2-cyano-3-({4-[(4-fluorobenzene)sulf...) Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C20H16FN5O2S/c21-16-3-7-19(8-4-16)29(27,28)18-5-1-15(2-6-18)13-24-20(25-14-22)26-17-9-11-23-12-10-17/h1-12H,13H2,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181022 (US9676721, 108 3-{[4-(benzenesulfonyl)phenyl]methy...) Show SMILES O=S(=O)(c1ccccc1)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C20H17N5O2S/c21-15-24-20(25-17-10-12-22-13-11-17)23-14-16-6-8-19(9-7-16)28(26,27)18-4-2-1-3-5-18/h1-13H,14H2,(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181671 (US9676721, 11 1-({4-[(4-chloro-3-fluorobenzene)sul...) Show SMILES Fc1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C20H15ClFN5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181024 (US9676721, 80 2-cyano-1-{[4-(1-methyl-1H-indole-2-...) Show SMILES Cn1c(cc2ccccc12)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:27.30| Show InChI InChI=1S/C23H20N6O2S/c1-29-21-5-3-2-4-18(21)14-22(29)32(30,31)20-8-6-17(7-9-20)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h2-14H,15H2,1H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180854 (US9676721, 69 2-cyano-1-[(4-{[3-(propane-1-sulfona...) Show SMILES CCCS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:30.32| Show InChI InChI=1S/C23H24N6O4S2/c1-2-14-34(30,31)29-20-4-3-5-22(15-20)35(32,33)21-8-6-18(7-9-21)16-26-23(27-17-24)28-19-10-12-25-13-11-19/h3-13,15,29H,2,14,16H2,1H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180083 (US9676721, 30 2-cyano-1-({4-[(3,4-dimethylbenzene)...) Show SMILES Cc1ccc(cc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C22H21N5O2S/c1-16-3-6-21(13-17(16)2)30(28,29)20-7-4-18(5-8-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180868 (US9676721, 106 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...) Show SMILES O=C(NC1CC1)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:29.32| Show InChI InChI=1S/C24H22N6O3S/c25-16-28-24(30-20-10-12-26-13-11-20)27-15-17-4-8-21(9-5-17)34(32,33)22-3-1-2-18(14-22)23(31)29-19-6-7-19/h1-5,8-14,19H,6-7,15H2,(H,29,31)(H2,26,27,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180122 (US9676721, 85 2-cyano-1-{[4-(4-methylpyridine-3-su...) Show SMILES Cc1ccncc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:24.26| Show InChI InChI=1S/C20H18N6O2S/c1-15-6-9-23-13-19(15)29(27,28)18-4-2-16(3-5-18)12-24-20(25-14-21)26-17-7-10-22-11-8-17/h2-11,13H,12H2,1H3,(H2,22,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180255 (US9676721, 38 2-cyano-1-({4-[(3-fluoro-5-methoxybe...) Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:26.28| Show InChI InChI=1S/C21H18FN5O3S/c1-30-18-10-16(22)11-20(12-18)31(28,29)19-4-2-15(3-5-19)13-25-21(26-14-23)27-17-6-8-24-9-7-17/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181669 (US9676721, 23 2-cyano-1-({4-[(2,4-dimethylbenzene)...) Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C22H21N5O2S/c1-16-3-8-21(17(2)13-16)30(28,29)20-6-4-18(5-7-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181031 (US9676721, 92 2-cyano-3-(pyridin-4-yl)-1-[(4-{[3-(...) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C21H16F3N5O2S/c22-21(23,24)16-2-1-3-19(12-16)32(30,31)18-6-4-15(5-7-18)13-27-20(28-14-25)29-17-8-10-26-11-9-17/h1-12H,13H2,(H2,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180922 (US9676721, 53 2-cyano-1-({4-[(4-methylbenzene)sulf...) Show SMILES Cc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C21H19N5O2S/c1-16-2-6-19(7-3-16)29(27,28)20-8-4-17(5-9-20)14-24-21(25-15-22)26-18-10-12-23-13-11-18/h2-13H,14H2,1H3,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180919 (US9676721, 109 3-chloro-5-[(4-{[2-cyano-3-(pyridin...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C26H21N5O2S/c27-19-30-26(31-23-14-16-28-17-15-23)29-18-20-6-10-24(11-7-20)34(32,33)25-12-8-22(9-13-25)21-4-2-1-3-5-21/h1-17H,18H2,(H2,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180065 (US9676721, 1 (E)-3-({4-[(3-chlorobenzene)sulfonyl]...) Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C20H16ClN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180091 (US9676721, 3 1-({4-[(3-chloro-4-methoxybenzene)sul...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 |w:27.28| Show InChI InChI=1S/C21H18ClN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180094 (US9676721, 77 2-cyano-1-[(4-{[4-(propan-2-yloxy)be...) Show SMILES CC(C)Oc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 |w:28.29| Show InChI InChI=1S/C23H23N5O3S/c1-17(2)31-20-5-9-22(10-6-20)32(29,30)21-7-3-18(4-8-21)15-26-23(27-16-24)28-19-11-13-25-14-12-19/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180092 (US9676721, 67 2-cyano-1-[(4-{[3-(propan-2-yl)benze...) Show SMILES CC(C)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:26.28| Show InChI InChI=1S/C23H23N5O2S/c1-17(2)19-4-3-5-22(14-19)31(29,30)21-8-6-18(7-9-21)15-26-23(27-16-24)28-20-10-12-25-13-11-20/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180102 (US9676721, 99 2-cyano-3-(pyridin-4-yl)-1-{[4-(quin...) Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc2cccnc12 |w:18.18| Show InChI InChI=1S/C23H18N6O2S/c24-16-28-23(29-19-10-13-25-14-11-19)27-15-17-6-8-20(9-7-17)32(30,31)21-5-1-3-18-4-2-12-26-22(18)21/h1-14H,15H2,(H2,25,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181028 (US9676721, 63 2-cyano-1-[(4-{[3-(3,5-dimethyl-1H-p...) Show SMILES Oc1cc(O)n(n1)-c1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C23H19N7O4S/c24-15-27-23(28-17-8-10-25-11-9-17)26-14-16-4-6-19(7-5-16)35(33,34)20-3-1-2-18(12-20)30-22(32)13-21(31)29-30/h1-13,32H,14H2,(H,29,31)(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180259 (US9676721, 10 1-({4-[(4-chloro-2-methoxybenzene)su...) Show SMILES COc1cc(Cl)ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:26.28| Show InChI InChI=1S/C21H18ClN5O3S/c1-30-19-12-16(22)4-7-20(19)31(28,29)18-5-2-15(3-6-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180917 (US9676721, 100 2-cyano-3-[(4-{8-oxa-3-azabicyclo[3...) Show SMILES O=S(=O)(N1CC2CCC(C1)O2)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1 Show InChI InChI=1S/C20H22N6O3S/c21-14-24-20(25-16-7-9-22-10-8-16)23-11-15-1-5-19(6-2-15)30(27,28)26-12-17-3-4-18(13-26)29-17/h1-2,5-10,17-18H,3-4,11-13H2,(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180258 (US9676721, 49 2-cyano-1-({4-[(4-fluoro-3-methylben...) Show SMILES Cc1cc(ccc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C21H18FN5O2S/c1-15-12-19(6-7-20(15)22)30(28,29)18-4-2-16(3-5-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180126 (US9676721, 68 2-cyano-1-[(4-{[3-(propan-2-yloxy)be...) Show SMILES CC(C)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:27.29| Show InChI InChI=1S/C23H23N5O3S/c1-17(2)31-20-4-3-5-22(14-20)32(29,30)21-8-6-18(7-9-21)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h3-14,17H,15H2,1-2H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180927 (US9676721, 40 2-cyano-1-({4-[(3-fluorobenzene)sulf...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:24.26| Show InChI InChI=1S/C20H16FN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180256 (US9676721, 33 2-cyano-1-({4-[(3,5-dimethylbenzene)...) Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C22H21N5O2S/c1-16-11-17(2)13-21(12-16)30(28,29)20-5-3-18(4-6-20)14-25-22(26-15-23)27-19-7-9-24-10-8-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180254 (US9676721, 8 1-({4-[(3-chloro-5-methylbenzene)sulf...) Show SMILES Cc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27| Show InChI InChI=1S/C21H18ClN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180252 (US9676721, 74 2-cyano-1-[(4-{[4-(1H-pyrazol-1-yl)b...) Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(cc1)-n1cccn1 |w:17.18| Show InChI InChI=1S/C23H19N7O2S/c24-17-27-23(29-19-10-13-25-14-11-19)26-16-18-2-6-21(7-3-18)33(31,32)22-8-4-20(5-9-22)30-15-1-12-28-30/h1-15H,16H2,(H2,25,26,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM181670 (US9676721, 16 1-[(4-{[3-chloro-5-(trifluoromethyl)...) Show SMILES FC(F)(F)c1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:28.30| Show InChI InChI=1S/C21H15ClF3N5O2S/c22-16-9-15(21(23,24)25)10-19(11-16)33(31,32)18-3-1-14(2-4-18)12-28-20(29-13-26)30-17-5-7-27-8-6-17/h1-11H,12H2,(H2,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180123 (US9676721, 104 3-[(4-{[2-cyano-3-(pyridin-4-yl)car...) Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:28.30| Show InChI InChI=1S/C23H22N6O3S/c1-29(2)22(30)18-4-3-5-21(14-18)33(31,32)20-8-6-17(7-9-20)15-26-23(27-16-24)28-19-10-12-25-13-11-19/h3-14H,15H2,1-2H3,(H2,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM180106 (US9676721, 15 1-({4-[3-chloro-2-(morpholin-4-yl)py...) Show SMILES Clc1c(ccnc1N1CCOCC1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:30.33| Show InChI InChI=1S/C23H22ClN7O3S/c24-21-20(7-10-27-22(21)31-11-13-34-14-12-31)35(32,33)19-3-1-17(2-4-19)15-28-23(29-16-25)30-18-5-8-26-9-6-18/h1-10H,11-15H2,(H2,26,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	7.5	25
FORMA TM, LLC US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US9676721 (2017) BindingDB Entry DOI: 10.7270/Q2VD6WMM
					More data for this Ligand-Target Pair

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