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Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with all data for entry = 50011981   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112911
PNG
((2-Chloro-6-methyl-phenyl)-(6,7-dimethoxy-imidazo[...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cncn23)c1OC
Show InChI InChI=1S/C19H17ClN4O2/c1-11-5-4-6-12(20)16(11)22-19-14-9-21-10-24(14)13-7-8-15(25-2)18(26-3)17(13)23-19/h4-10H,1-3H3,(H,22,23)
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n/an/a 2n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112947
PNG
((6,7-Dimethoxy-imidazo[1,5-a]quinoxalin-4-yl)-(2,6...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3C)c3cncn23)c1OC
Show InChI InChI=1S/C20H20N4O2/c1-12-6-5-7-13(2)17(12)22-20-15-10-21-11-24(15)14-8-9-16(25-3)19(26-4)18(14)23-20/h5-11H,1-4H3,(H,22,23)
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n/an/a 2.40n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112938
PNG
((E)-4-(2-chloro-6-methylphenylamino)-6,7-dimethoxy...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(CN=O)n23)c1OC
Show InChI InChI=1S/C20H18ClN5O3/c1-11-5-4-6-12(21)17(11)24-20-14-9-22-16(10-23-27)26(14)13-7-8-15(28-2)19(29-3)18(13)25-20/h4-9H,10H2,1-3H3,(H,24,25)
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n/an/a 4.30n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112948
PNG
((4-(2-chloro-6-methylphenylamino)-6,7-dimethoxyimi...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(CO)n23)c1OC
Show InChI InChI=1S/C20H19ClN4O3/c1-11-5-4-6-12(21)17(11)23-20-14-9-22-16(10-26)25(14)13-7-8-15(27-2)19(28-3)18(13)24-20/h4-9,26H,10H2,1-3H3,(H,23,24)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112926
PNG
((2-Chloro-6-methyl-phenyl)-(6,7-dimethoxy-1-methyl...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(C)n23)c1OC
Show InChI InChI=1S/C20H19ClN4O2/c1-11-6-5-7-13(21)17(11)23-20-15-10-22-12(2)25(15)14-8-9-16(26-3)19(27-4)18(14)24-20/h5-10H,1-4H3,(H,23,24)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112920
PNG
((2-Chloro-6-methyl-phenyl)-imidazo[1,5-a]quinoxali...)
Show SMILES Cc1cccc(Cl)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C17H13ClN4/c1-11-5-4-6-12(18)16(11)21-17-15-9-19-10-22(15)14-8-3-2-7-13(14)20-17/h2-10H,1H3,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112931
PNG
((2,6-Dichloro-phenyl)-imidazo[1,5-a]quinoxalin-4-y...)
Show SMILES Clc1cccc(Cl)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H10Cl2N4/c17-10-4-3-5-11(18)15(10)21-16-14-8-19-9-22(14)13-7-2-1-6-12(13)20-16/h1-9H,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112956
PNG
(4-(2-Chloro-6-methyl-phenylamino)-6,7-dimethoxy-im...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(C=O)n23)c1OC
Show InChI InChI=1S/C20H17ClN4O3/c1-11-5-4-6-12(21)17(11)23-20-14-9-22-16(10-26)25(14)13-7-8-15(27-2)19(28-3)18(13)24-20/h4-10H,1-3H3,(H,23,24)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112925
PNG
((2,6-Dimethyl-phenyl)-imidazo[1,5-a]quinoxalin-4-y...)
Show SMILES Cc1cccc(C)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C18H16N4/c1-12-6-5-7-13(2)17(12)21-18-16-10-19-11-22(16)15-9-4-3-8-14(15)20-18/h3-11H,1-2H3,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112935
PNG
((2-Chloro-4,6-dimethyl-phenyl)-imidazo[1,5-a]quino...)
Show SMILES Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(Cl)c1
Show InChI InChI=1S/C18H15ClN4/c1-11-7-12(2)17(13(19)8-11)22-18-16-9-20-10-23(16)15-6-4-3-5-14(15)21-18/h3-10H,1-2H3,(H,21,22)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112934
PNG
((2-Chloro-phenyl)-(3-methyl-imidazo[1,5-a]quinoxal...)
Show SMILES Cc1ncn2c1c(Nc1ccccc1Cl)nc1ccccc21
Show InChI InChI=1S/C17H13ClN4/c1-11-16-17(20-13-7-3-2-6-12(13)18)21-14-8-4-5-9-15(14)22(16)10-19-11/h2-10H,1H3,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112921
PNG
(CHEMBL25969 | Imidazo[1,5-a]quinoxalin-4-yl-(2,4,6...)
Show SMILES Cc1cc(C)c(Nc2nc3ccccc3n3cncc23)c(C)c1
Show InChI InChI=1S/C19H18N4/c1-12-8-13(2)18(14(3)9-12)22-19-17-10-20-11-23(17)16-7-5-4-6-15(16)21-19/h4-11H,1-3H3,(H,21,22)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112919
PNG
((2,6-Dibromo-phenyl)-imidazo[1,5-a]quinoxalin-4-yl...)
Show SMILES Brc1cccc(Br)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H10Br2N4/c17-10-4-3-5-11(18)15(10)21-16-14-8-19-9-22(14)13-7-2-1-6-12(13)20-16/h1-9H,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112914
PNG
(1-(4-(2-chloro-6-methylphenylamino)-6,7-dimethoxyi...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(C(C)O)n23)c1OC
Show InChI InChI=1S/C21H21ClN4O3/c1-11-6-5-7-13(22)17(11)24-20-15-10-23-21(12(2)27)26(15)14-8-9-16(28-3)19(29-4)18(14)25-20/h5-10,12,27H,1-4H3,(H,24,25)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112913
PNG
(2-Bromo-N-imidazo[1,5-a]quinoxalin-4-yl-benzamide ...)
Show SMILES Brc1ccccc1C(=O)Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C17H11BrN4O/c18-12-6-2-1-5-11(12)17(23)21-16-15-9-19-10-22(15)14-8-4-3-7-13(14)20-16/h1-10H,(H,20,21,23)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112936
PNG
((2-Chloro-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-am...)
Show SMILES Clc1ccccc1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H11ClN4/c17-11-5-1-2-6-12(11)19-16-15-9-18-10-21(15)14-8-4-3-7-13(14)20-16/h1-10H,(H,19,20)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112939
PNG
(3-(4-(2-chloro-6-methylphenylamino)-6,7-dimethoxyi...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(CCCO)n23)c1OC
Show InChI InChI=1S/C22H23ClN4O3/c1-13-6-4-7-14(23)19(13)25-22-16-12-24-18(8-5-11-28)27(16)15-9-10-17(29-2)21(30-3)20(15)26-22/h4,6-7,9-10,12,28H,5,8,11H2,1-3H3,(H,25,26)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112918
PNG
((2-Bromo-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-ami...)
Show SMILES Brc1ccccc1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H11BrN4/c17-11-5-1-2-6-12(11)19-16-15-9-18-10-21(15)14-8-4-3-7-13(14)20-16/h1-10H,(H,19,20)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112953
PNG
((2-Bromo-phenyl)-(1-methyl-imidazo[1,5-a]quinoxali...)
Show SMILES Cc1ncc2c(Nc3ccccc3Br)nc3ccccc3n12
Show InChI InChI=1S/C17H13BrN4/c1-11-19-10-16-17(20-13-7-3-2-6-12(13)18)21-14-8-4-5-9-15(14)22(11)16/h2-10H,1H3,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112944
PNG
(1-(4-(2-chloro-6-methylphenylamino)-6,7-dimethoxyi...)
Show SMILES COc1ccc2c(nc(Nc3c(C)cccc3Cl)c3cnc(C(O)C(C)C)n23)c1OC
Show InChI InChI=1S/C23H25ClN4O3/c1-12(2)20(29)23-25-11-16-22(26-18-13(3)7-6-8-14(18)24)27-19-15(28(16)23)9-10-17(30-4)21(19)31-5/h6-12,20,29H,1-5H3,(H,26,27)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112933
PNG
((2-Chloro-4-methyl-phenyl)-imidazo[1,5-a]quinoxali...)
Show SMILES Cc1ccc(Nc2nc3ccccc3n3cncc23)c(Cl)c1
Show InChI InChI=1S/C17H13ClN4/c1-11-6-7-13(12(18)8-11)20-17-16-9-19-10-22(16)15-5-3-2-4-14(15)21-17/h2-10H,1H3,(H,20,21)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112943
PNG
((2,6-Difluoro-phenyl)-imidazo[1,5-a]quinoxalin-4-y...)
Show SMILES Fc1cccc(F)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H10F2N4/c17-10-4-3-5-11(18)15(10)21-16-14-8-19-9-22(14)13-7-2-1-6-12(13)20-16/h1-9H,(H,20,21)
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n/an/a 360n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112949
PNG
((2-Fluoro-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-am...)
Show SMILES Fc1ccccc1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H11FN4/c17-11-5-1-2-6-12(11)19-16-15-9-18-10-21(15)14-8-4-3-7-13(14)20-16/h1-10H,(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112927
PNG
(4-(2-Chloro-6-methyl-phenylamino)-6,7-dimethoxy-im...)
Show SMILES CCNC(=O)c1ncc2c(Nc3c(C)cccc3Cl)nc3c(OC)c(OC)ccc3n12
Show InChI InChI=1S/C22H22ClN5O3/c1-5-24-22(29)21-25-11-15-20(26-17-12(2)7-6-8-13(17)23)27-18-14(28(15)21)9-10-16(30-3)19(18)31-4/h6-11H,5H2,1-4H3,(H,24,29)(H,26,27)
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n/an/a 665n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112912
PNG
(2,6-Dichloro-N-imidazo[1,5-a]quinoxalin-4-yl-benza...)
Show SMILES Clc1cccc(Cl)c1C(=O)Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C17H10Cl2N4O/c18-10-4-3-5-11(19)15(10)17(24)22-16-14-8-20-9-23(14)13-7-2-1-6-12(13)21-16/h1-9H,(H,21,22,24)
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n/an/a 810n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112945
PNG
(CHEMBL29531 | Imidazo[1,5-a]quinoxalin-4-yl-pyridi...)
Show SMILES N(c1cccnc1)c1nc2ccccc2n2cncc12
Show InChI InChI=1S/C15H11N5/c1-2-6-13-12(5-1)19-15(14-9-17-10-20(13)14)18-11-4-3-7-16-8-11/h1-10H,(H,18,19)
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n/an/a 820n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112946
PNG
(CHEMBL29856 | Imidazo[1,5-a]quinoxalin-4-yl-phenyl...)
Show SMILES N(c1ccccc1)c1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H12N4/c1-2-6-12(7-3-1)18-16-15-10-17-11-20(15)14-9-5-4-8-13(14)19-16/h1-11H,(H,18,19)
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n/an/a 890n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112930
PNG
((3-Fluoro-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-am...)
Show SMILES Fc1cccc(Nc2nc3ccccc3n3cncc23)c1
Show InChI InChI=1S/C16H11FN4/c17-11-4-3-5-12(8-11)19-16-15-9-18-10-21(15)14-7-2-1-6-13(14)20-16/h1-10H,(H,19,20)
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n/an/a 1.33E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112941
PNG
((2,6-Diethyl-phenyl)-imidazo[1,5-a]quinoxalin-4-yl...)
Show SMILES CCc1cccc(CC)c1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C20H20N4/c1-3-14-8-7-9-15(4-2)19(14)23-20-18-12-21-13-24(18)17-11-6-5-10-16(17)22-20/h5-13H,3-4H2,1-2H3,(H,22,23)
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n/an/a 1.69E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112932
PNG
(CHEMBL29462 | Imidazo[1,5-a]quinoxalin-4-yl-propyl...)
Show SMILES CCCNc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C13H14N4/c1-2-7-15-13-12-8-14-9-17(12)11-6-4-3-5-10(11)16-13/h3-6,8-9H,2,7H2,1H3,(H,15,16)
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n/an/a 2.68E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112951
PNG
(CHEMBL418580 | Cyclohexyl-imidazo[1,5-a]quinoxalin...)
Show SMILES C1CCC(CC1)Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H18N4/c1-2-6-12(7-3-1)18-16-15-10-17-11-20(15)14-9-5-4-8-13(14)19-16/h4-5,8-12H,1-3,6-7H2,(H,18,19)
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n/an/a 3.17E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112950
PNG
(CHEMBL286032 | Cyclopropyl-imidazo[1,5-a]quinoxali...)
Show SMILES C1CC1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C13H12N4/c1-2-4-11-10(3-1)16-13(15-9-5-6-9)12-7-14-8-17(11)12/h1-4,7-9H,5-6H2,(H,15,16)
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n/an/a 3.17E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112922
PNG
(4-(2-Bromo-phenoxy)-imidazo[1,5-a]quinoxaline | 4-...)
Show SMILES Brc1ccccc1Oc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H10BrN3O/c17-11-5-1-4-8-15(11)21-16-14-9-18-10-20(14)13-7-3-2-6-12(13)19-16/h1-10H
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n/an/a 3.70E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112929
PNG
(CHEMBL30023 | N-(3-chlorophenethyl)imidazo[1,5-a]q...)
Show SMILES Clc1cccc(CCNc2nc3ccccc3n3cncc23)c1
Show InChI InChI=1S/C18H15ClN4/c19-14-5-3-4-13(10-14)8-9-21-18-17-11-20-12-23(17)16-7-2-1-6-15(16)22-18/h1-7,10-12H,8-9H2,(H,21,22)
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n/an/a 4.39E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112915
PNG
(CHEMBL29764 | Imidazo[1,5-a]quinoxalin-4-yl-(2-met...)
Show SMILES COc1ccccc1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C17H14N4O/c1-22-16-9-5-3-7-13(16)20-17-15-10-18-11-21(15)14-8-4-2-6-12(14)19-17/h2-11H,1H3,(H,19,20)
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n/an/a 5.52E+3n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112952
PNG
(4-(2,6-Dimethyl-phenyl)-imidazo[1,5-a]quinoxaline ...)
Show SMILES Cc1cccc(C)c1-c1nc2ccccc2n2cncc12 |(10.14,-7.28,;11.48,-6.52,;12.82,-7.3,;14.17,-6.53,;14.17,-4.97,;12.84,-4.19,;12.84,-2.66,;11.49,-4.97,;10.16,-4.18,;8.81,-4.95,;7.49,-4.18,;6.16,-4.95,;4.83,-4.18,;4.83,-2.64,;6.16,-1.87,;7.49,-2.64,;8.81,-1.87,;9.14,-.37,;10.67,-.22,;11.31,-1.61,;10.16,-2.64,)|
Show InChI InChI=1S/C18H15N3/c1-12-6-5-7-13(2)17(12)18-16-10-19-11-21(16)15-9-4-3-8-14(15)20-18/h3-11H,1-2H3
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n/an/a>1.25E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112954
PNG
(CHEMBL283215 | Imidazo[1,5-a]quinoxalin-4-yl-pyrid...)
Show SMILES N(c1ccncc1)c1nc2ccccc2n2cncc12
Show InChI InChI=1S/C15H11N5/c1-2-4-13-12(3-1)19-15(14-9-17-10-20(13)14)18-11-5-7-16-8-6-11/h1-10H,(H,16,18,19)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112916
PNG
(CHEMBL30222 | Hexyl-imidazo[1,5-a]quinoxalin-4-yl-...)
Show SMILES CCCCCCNc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H20N4/c1-2-3-4-7-10-18-16-15-11-17-12-20(15)14-9-6-5-8-13(14)19-16/h5-6,8-9,11-12H,2-4,7,10H2,1H3,(H,18,19)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112940
PNG
(CHEMBL281722 | N-Imidazo[1,5-a]quinoxalin-4-yl-2-m...)
Show SMILES Cc1ccccc1C(=O)Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C18H14N4O/c1-12-6-2-3-7-13(12)18(23)21-17-16-10-19-11-22(16)15-9-5-4-8-14(15)20-17/h2-11H,1H3,(H,20,21,23)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112937
PNG
((2-Chloro-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-me...)
Show SMILES CN(c1ccccc1Cl)c1nc2ccccc2n2cncc12
Show InChI InChI=1S/C17H13ClN4/c1-21(14-8-4-2-6-12(14)18)17-16-10-19-11-22(16)15-9-5-3-7-13(15)20-17/h2-11H,1H3
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112955
PNG
(Benzyl-imidazo[1,5-a]quinoxalin-4-yl-amine | CHEMB...)
Show SMILES C(Nc1nc2ccccc2n2cncc12)c1ccccc1
Show InChI InChI=1S/C17H14N4/c1-2-6-13(7-3-1)10-19-17-16-11-18-12-21(16)15-9-5-4-8-14(15)20-17/h1-9,11-12H,10H2,(H,19,20)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112923
PNG
((4-Bromo-phenyl)-imidazo[1,5-a]quinoxalin-4-yl-ami...)
Show SMILES Brc1ccc(Nc2nc3ccccc3n3cncc23)cc1
Show InChI InChI=1S/C16H11BrN4/c17-11-5-7-12(8-6-11)19-16-15-9-18-10-21(15)14-4-2-1-3-13(14)20-16/h1-10H,(H,19,20)
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112924
PNG
(4-(2-Bromo-phenylsulfanyl)-imidazo[1,5-a]quinoxali...)
Show SMILES Brc1ccccc1Sc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H10BrN3S/c17-11-5-1-4-8-15(11)21-16-14-9-18-10-20(14)13-7-3-2-6-12(13)19-16/h1-10H
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Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112917
PNG
(CHEMBL29936 | Imidazo[1,5-a]quinoxalin-4-yl-(2-nit...)
Show SMILES [O-][N+](=O)c1ccccc1Nc1nc2ccccc2n2cncc12
Show InChI InChI=1S/C16H11N5O2/c22-21(23)14-8-4-2-6-12(14)19-16-15-9-17-10-20(15)13-7-3-1-5-11(13)18-16/h1-10H,(H,18,19)
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n/an/a>1.25E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112928
PNG
((2-Bromo-phenyl)-(3-phenyl-imidazo[1,5-a]quinoxali...)
Show SMILES Brc1ccccc1Nc1nc2ccccc2n2cnc(-c3ccccc3)c12
Show InChI InChI=1S/C22H15BrN4/c23-16-10-4-5-11-17(16)25-22-21-20(15-8-2-1-3-9-15)24-14-27(21)19-13-7-6-12-18(19)26-22/h1-14H,(H,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
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n/an/a>1.25E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))		BDBM50112942
PNG
((2-Bromo-phenyl)-imidazo[1,2-a]quinoxalin-4-yl-ami...)
Show SMILES Brc1ccccc1Nc1nc2ccccc2n2ccnc12
Show InChI InChI=1S/C16H11BrN4/c17-11-5-1-2-6-12(11)19-15-16-18-9-10-21(16)14-8-4-3-7-13(14)20-15/h1-10H,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
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UniChem

Similars
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant p56 Lck tyrosine kinase expressed as a His-tagged protein in insect cells using a baculovirus expression syst...

Bioorg Med Chem Lett 12: 1361-4 (2002)


BindingDB Entry DOI: 10.7270/Q2R78DJ1
More data for this
Ligand-Target Pair