Found 86 hits Enz. Inhib. hit(s) with all data for entry = 50015281 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153786
(4-((5-((4-cyanophenoxy)methyl)-1H-imidazol-1-yl)me...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-9-12-26(13-10-21)34-19-25-17-32-20-33(25)18-22-8-11-24(16-31)29(14-22)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153802
(3'',4''-Dichloro-6-[3-(4-cyano-benzyl)-3H-imidazol...)Show SMILES Clc1ccc(cc1Cl)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H18Cl2N4O/c27-25-8-7-21(10-26(25)28)24-9-20(12-30)5-6-22(24)15-33-16-23-13-31-17-32(23)14-19-3-1-18(11-29)2-4-19/h1-10,13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153166
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153785
(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153176
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153172
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153776
(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C27H23N5O2/c1-2-34-26-5-3-4-22(11-26)27-10-20(12-28)6-8-23(27)17-33-18-25-15-30-19-32(25)16-21-7-9-24(13-29)31-14-21/h3-11,14-15,19H,2,16-18H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153782
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES Cc1ccc(cc1C)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O/c1-20-3-9-25(11-21(20)2)28-12-24(14-30)8-10-26(28)17-33-18-27-15-31-19-32(27)16-23-6-4-22(13-29)5-7-23/h3-12,15,19H,16-18H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153779
(4-((5-(((3',5-dichlorobiphenyl-2-yl)methoxy)methyl...)Show SMILES Clc1cccc(c1)-c1cc(Cl)ccc1COCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c26-22-3-1-2-20(10-22)25-11-23(27)9-8-21(25)15-31-16-24-13-29-17-30(24)14-19-6-4-18(12-28)5-7-19/h1-11,13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126335
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153774
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methylamin...)Show SMILES N#Cc1ccc(Cn2cncc2CNCc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H23N5/c31-15-22-8-10-23(11-9-22)20-35-21-34-19-27(35)18-33-17-24-12-13-26(16-32)30(14-24)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,19,21,33H,17-18,20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153174
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153784
(3-(benzo[d][1,3]dioxol-4-yl)-4-(((1-(4-cyanobenzyl...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2cccc3OCOc23)C#N)cc1 Show InChI InChI=1S/C27H20N4O3/c28-11-19-4-6-20(7-5-19)14-31-17-30-13-23(31)16-32-15-22-9-8-21(12-29)10-25(22)24-2-1-3-26-27(24)34-18-33-26/h1-10,13,17H,14-16,18H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153778
(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1 Show InChI InChI=1S/C28H19N5O/c29-13-21-9-11-28(32-15-21)34-18-24-16-31-19-33(24)17-20-8-10-23(14-30)27(12-20)26-7-3-5-22-4-1-2-6-25(22)26/h1-12,15-16,19H,17-18H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153777
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3ccccc3c2)C#N)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-5-7-23(8-6-22)18-34-21-33-17-29(34)20-35-19-28-10-9-24(16-32)13-30(28)27-12-11-25-3-1-2-4-26(25)14-27/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153781
(4-((5-((4-cyanobenzyloxy)methyl)-1H-imidazol-1-yl)...)Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(cc2-c2cccc3ccccc23)C#N)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-8-10-23(11-9-22)19-35-20-27-17-33-21-34(27)18-26-13-12-24(16-32)14-30(26)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153165
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES CCOc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-11-9-24(10-12-27)28-13-23(15-30)7-8-25(28)18-33-19-26-16-31-20-32(26)17-22-5-3-21(14-29)4-6-22/h3-13,16,20H,2,17-19H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153792
(4''-Acetyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)Show SMILES CC(=O)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H22N4O2/c1-20(33)24-8-10-25(11-9-24)28-12-23(14-30)6-7-26(28)17-34-18-27-15-31-19-32(27)16-22-4-2-21(13-29)3-5-22/h2-12,15,19H,16-18H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153793
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2cccc3ccccc23)C#N)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-8-10-23(11-9-22)18-34-21-33-17-27(34)20-35-19-26-13-12-24(16-32)14-30(26)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153796
(6-(((1-(4-chlorobenzyl)-1H-imidazol-5-yl)methoxy)m...)Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(Cl)cc1)C#N Show InChI InChI=1S/C27H24ClN3O2/c1-2-33-26-5-3-4-22(13-26)27-12-21(14-29)6-9-23(27)17-32-18-25-15-30-19-31(25)16-20-7-10-24(28)11-8-20/h3-13,15,19H,2,16-18H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153803
(5-((5-(((5-cyano-3'-methoxybiphenyl-2-yl)methoxy)m...)Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C26H21N5O2/c1-32-25-4-2-3-21(10-25)26-9-19(11-27)5-7-22(26)16-33-17-24-14-29-18-31(24)15-20-6-8-23(12-28)30-13-20/h2-10,13-14,18H,15-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153789
(6-((5-(((3'-chloro-5-cyanobiphenyl-2-yl)methoxy)me...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cn1)C#N)C#N Show InChI InChI=1S/C25H18ClN5O/c26-22-3-1-2-20(9-22)25-8-18(10-27)4-6-21(25)15-32-16-24-13-29-17-31(24)14-23-7-5-19(11-28)12-30-23/h1-9,12-13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153775
(6-(((1-(4-chlorobenzyl)-1H-imidazol-5-yl)methoxy)m...)Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(Cl)cc1)C#N Show InChI InChI=1S/C26H22ClN3O2/c1-31-25-4-2-3-21(12-25)26-11-20(13-28)5-8-22(26)16-32-17-24-14-29-18-30(24)15-19-6-9-23(27)10-7-19/h2-12,14,18H,15-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153806
(5-((5-(((3'-chloro-5-cyanobiphenyl-2-yl)methoxy)me...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(nc1)C#N)C#N Show InChI InChI=1S/C25H18ClN5O/c26-22-3-1-2-20(9-22)25-8-18(10-27)4-6-21(25)15-32-16-24-13-29-17-31(24)14-19-5-7-23(11-28)30-12-19/h1-9,12-13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153783
(5-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(nc2)C#N)c(c1)-c1ccc2OCOc2c1 Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-19-2-5-22(10-28)30-11-19/h1-8,11-12,16H,13-15,17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153780
(4-((5-((3',5-dichlorobiphenyl-2-yloxy)methyl)-1H-i...)Show SMILES Clc1cccc(c1)-c1cc(Cl)ccc1OCc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C24H17Cl2N3O/c25-20-3-1-2-19(10-20)23-11-21(26)8-9-24(23)30-15-22-13-28-16-29(22)14-18-6-4-17(12-27)5-7-18/h1-11,13,16H,14-15H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153797
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O/c28-27(29,30)24-9-7-22(8-10-24)26-11-21(13-32)5-6-23(26)16-35-17-25-14-33-18-34(25)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153788
(4-(3-Chloro-phenyl)-5-[3-(4-cyano-benzyl)-3H-imida...)Show SMILES Clc1cccc(c1)-c1cc(ncc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C25H18ClN5O/c26-22-3-1-2-20(8-22)25-9-23(11-28)30-12-21(25)15-32-16-24-13-29-17-31(24)14-19-6-4-18(10-27)5-7-19/h1-9,12-13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153798
(6-((5-(((5-cyano-3'-methoxybiphenyl-2-yl)methoxy)m...)Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cn1)C#N)C#N Show InChI InChI=1S/C26H21N5O2/c1-32-25-4-2-3-21(10-25)26-9-19(11-27)5-7-22(26)16-33-17-24-14-29-18-31(24)15-23-8-6-20(12-28)13-30-23/h2-10,13-14,18H,15-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153791
(6-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)nc1 Show InChI InChI=1S/C26H19N5O3/c27-9-18-1-3-21(24(7-18)20-4-6-25-26(8-20)34-17-33-25)14-32-15-23-12-29-16-31(23)13-22-5-2-19(10-28)11-30-22/h1-8,11-12,16H,13-15,17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153799
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-8-10-23(11-9-22)18-34-21-33-17-27(34)20-35-19-24-12-13-26(16-32)30(14-24)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153790
(3-(benzo[d][1,3]dioxol-5-yl)-4-(((1-(4-cyano-2-(na...)Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(cc2-c2cccc3ccccc23)C#N)c(c1)-c1ccc2OCOc2c1 Show InChI InChI=1S/C37H26N4O3/c38-17-25-9-11-30(34(14-25)28-12-13-36-37(16-28)44-24-43-36)21-42-22-31-19-40-23-41(31)20-29-10-8-26(18-39)15-35(29)33-7-3-5-27-4-1-2-6-32(27)33/h1-16,19,23H,20-22,24H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153804
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES COc1ccc(cn1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H21N5O2/c1-32-26-9-8-22(13-30-26)25-10-21(12-28)6-7-23(25)16-33-17-24-14-29-18-31(24)15-20-4-2-19(11-27)3-5-20/h2-10,13-14,18H,15-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153794
(3-(benzo[d][1,3]dioxol-5-yl)-4-(((1-(4-chlorobenzy...)Show SMILES Clc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1 Show InChI InChI=1S/C26H20ClN3O3/c27-22-6-2-18(3-7-22)13-30-16-29-12-23(30)15-31-14-21-4-1-19(11-28)9-24(21)20-5-8-25-26(10-20)33-17-32-25/h1-10,12,16H,13-15,17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153805
(3'-chloro-6-(((1-((3'-chloro-5-cyanobiphenyl-2-yl)...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1-c1cccc(Cl)c1)C#N)C#N Show InChI InChI=1S/C32H22Cl2N4O/c33-28-5-1-3-24(13-28)31-11-22(15-35)7-9-26(31)18-38-21-37-17-30(38)20-39-19-27-10-8-23(16-36)12-32(27)25-4-2-6-29(34)14-25/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153800
(CHEMBL434146 | N-(5'-cyano-2'-(((1-(4-cyanobenzyl)...)Show SMILES CC(=O)Nc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H23N5O2/c1-20(34)32-26-4-2-3-24(12-26)28-11-23(14-30)9-10-25(28)17-35-18-27-15-31-19-33(27)16-22-7-5-21(13-29)6-8-22/h2-12,15,19H,16-18H2,1H3,(H,32,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153805
(3'-chloro-6-(((1-((3'-chloro-5-cyanobiphenyl-2-yl)...)Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1-c1cccc(Cl)c1)C#N)C#N Show InChI InChI=1S/C32H22Cl2N4O/c33-28-5-1-3-24(13-28)31-11-22(15-35)7-9-26(31)18-38-21-37-17-30(38)20-39-19-27-10-8-23(16-36)12-32(27)25-4-2-6-29(34)14-25/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153795
(3''-Chloro-6-[3-(4-methanesulfonyl-benzyl)-3H-imid...)Show SMILES CS(=O)(=O)c1ccc(Cn2cncc2COCc2ccc(cc2-c2cccc(Cl)c2)C#N)cc1 Show InChI InChI=1S/C26H22ClN3O3S/c1-34(31,32)25-9-6-19(7-10-25)15-30-18-29-14-24(30)17-33-16-22-8-5-20(13-28)11-26(22)21-3-2-4-23(27)12-21/h2-12,14,18H,15-17H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153774
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methylamin...)Show SMILES N#Cc1ccc(Cn2cncc2CNCc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H23N5/c31-15-22-8-10-23(11-9-22)20-35-21-34-19-27(35)18-33-17-24-12-13-26(16-32)30(14-24)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,19,21,33H,17-18,20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153785
(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)Show SMILES N#Cc1ccc(Cn2cncc2COc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-8-10-22(11-9-21)18-33-20-32-17-25(33)19-34-26-13-12-24(16-31)29(14-26)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153787
(3-(benzo[d][1,3]dioxol-5-yl)-4-(((1-(2-(benzo[d][1...)Show SMILES N#Cc1ccc(COCc2cncn2Cc2ccc(cc2-c2ccc3OCOc3c2)C#N)c(c1)-c1ccc2OCOc2c1 Show InChI InChI=1S/C34H24N4O5/c35-13-22-1-3-26(29(9-22)24-5-7-31-33(11-24)42-20-40-31)16-38-19-37-15-28(38)18-39-17-27-4-2-23(14-36)10-30(27)25-6-8-32-34(12-25)43-21-41-32/h1-12,15,19H,16-18,20-21H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine farnesyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153778
(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1 Show InChI InChI=1S/C28H19N5O/c29-13-21-9-11-28(32-15-21)34-18-24-16-31-19-33(24)17-20-8-10-23(14-30)27(12-20)26-7-3-5-22-4-1-2-6-25(22)26/h1-12,15-16,19H,17-18H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153786
(4-((5-((4-cyanophenoxy)methyl)-1H-imidazol-1-yl)me...)Show SMILES N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C29H20N4O/c30-15-21-9-12-26(13-10-21)34-19-25-17-32-20-33(25)18-22-8-11-24(16-31)29(14-22)28-7-3-5-23-4-1-2-6-27(23)28/h1-14,17,20H,18-19H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153802
(3'',4''-Dichloro-6-[3-(4-cyano-benzyl)-3H-imidazol...)Show SMILES Clc1ccc(cc1Cl)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C26H18Cl2N4O/c27-25-8-7-21(10-26(25)28)24-9-20(12-30)5-6-22(24)15-33-16-23-13-31-17-32(23)14-19-3-1-18(11-29)2-4-19/h1-10,13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153788
(4-(3-Chloro-phenyl)-5-[3-(4-cyano-benzyl)-3H-imida...)Show SMILES Clc1cccc(c1)-c1cc(ncc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C25H18ClN5O/c26-22-3-1-2-20(8-22)25-9-23(11-28)30-12-21(25)15-32-16-24-13-29-17-31(24)14-19-6-4-18(10-27)5-7-19/h1-9,12-13,17H,14-16H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153176
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153172
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126335
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153799
(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(C#N)c(c2)-c2cccc3ccccc23)cc1 Show InChI InChI=1S/C30H22N4O/c31-15-22-8-10-23(11-9-22)18-34-21-33-17-27(34)20-35-19-24-12-13-26(16-32)30(14-24)29-7-3-5-25-4-1-2-6-28(25)29/h1-14,17,21H,18-20H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50153174
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyltransferase |
Bioorg Med Chem Lett 14: 5371-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.011
BindingDB Entry DOI: 10.7270/Q2J102N8 |
More data for this
Ligand-Target Pair | |
Search and Browse
