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Compile Data Set for Download or QSAR

Found 56 hits Enz. Inhib. hit(s) with all data for entry = 50021402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224221
PNG
(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCC1
Show InChI InChI=1S/C14H15FN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17)
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5.30n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224216
PNG
(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
Show SMILES Oc1nc(Nc2ccccc2Cl)sc1C1CCCC1
Show InChI InChI=1S/C14H15ClN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17)
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6.30n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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7n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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7.20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224208
PNG
(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2Cl)nc1O
Show InChI InChI=1S/C12H13ClN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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7.20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224203
PNG
(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2Cl)sc1C1CCCCC1
Show InChI InChI=1S/C15H17ClN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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11n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224217
PNG
(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2cc(F)ccc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-5-7(13)3-4-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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12n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224205
PNG
(2-(2,6-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2c(Cl)cccc2Cl)nc1O
Show InChI InChI=1S/C12H12Cl2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-7(13)4-3-5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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13n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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17n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224222
PNG
(2-(2,4-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(Cl)cc2Cl)nc1O
Show InChI InChI=1S/C12H12Cl2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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18n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224212
PNG
(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Show SMILES CC(C)c1sc(Nc2ccccc2C(F)(F)F)nc1O
Show InChI InChI=1S/C13H13F3N2OS/c1-7(2)10-11(19)18-12(20-10)17-9-6-4-3-5-8(9)13(14,15)16/h3-7,19H,1-2H3,(H,17,18)
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23n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224200
PNG
(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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26n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224213
PNG
(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Show SMILES CC(C)c1sc(Nc2ccccc2C)nc1O
Show InChI InChI=1S/C13H16N2OS/c1-8(2)11-12(16)15-13(17-11)14-10-7-5-4-6-9(10)3/h4-8,16H,1-3H3,(H,14,15)
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27n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224211
PNG
(5-isopropyl-2-(isoquinolin-5-ylamino)thiazol-4(5H)...)
Show SMILES CC(C)c1sc(Nc2cccc3cnccc23)nc1O
Show InChI InChI=1S/C15H15N3OS/c1-9(2)13-14(19)18-15(20-13)17-12-5-3-4-10-8-16-7-6-11(10)12/h3-9,19H,1-2H3,(H,17,18)
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32n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224206
PNG
(5-isopropyl-2-(phenylamino)thiazol-4(5H)-one | CHE...)
Show SMILES CC(C)c1sc(Nc2ccccc2)nc1O
Show InChI InChI=1S/C12H14N2OS/c1-8(2)10-11(15)14-12(16-10)13-9-6-4-3-5-7-9/h3-8,15H,1-2H3,(H,13,14)
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110n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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140n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224215
PNG
(2-(1H-indol-4-ylamino)-5-isopropylthiazol-4(5H)-on...)
Show SMILES CC(C)c1sc(Nc2cccc3[nH]ccc23)nc1O
Show InChI InChI=1S/C14H15N3OS/c1-8(2)12-13(18)17-14(19-12)16-11-5-3-4-10-9(11)6-7-15-10/h3-8,15,18H,1-2H3,(H,16,17)
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210n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224223
PNG
(5-isopropyl-2-(4-phenoxyphenylamino)thiazol-4(5H)-...)
Show SMILES CC(C)c1sc(Nc2ccc(Oc3ccccc3)cc2)nc1O
Show InChI InChI=1S/C18H18N2O2S/c1-12(2)16-17(21)20-18(23-16)19-13-8-10-15(11-9-13)22-14-6-4-3-5-7-14/h3-12,21H,1-2H3,(H,19,20)
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220n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224201
PNG
(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-5-3-8(13)4-6-9/h3-7,16H,1-2H3,(H,14,15)
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340n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224220
PNG
(2-(2-chlorophenylamino)-5-methylthiazol-4(5H)-one ...)
Show SMILES Cc1sc(Nc2ccccc2Cl)nc1O
Show InChI InChI=1S/C10H9ClN2OS/c1-6-9(14)13-10(15-6)12-8-5-3-2-4-7(8)11/h2-5,14H,1H3,(H,12,13)
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350n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224225
PNG
(5-isopropyl-2-(2-methylbenzo[d]thiazol-5-ylamino)t...)
Show SMILES CC(C)c1sc(Nc2ccc3sc(C)nc3c2)nc1O
Show InChI InChI=1S/C14H15N3OS2/c1-7(2)12-13(18)17-14(20-12)16-9-4-5-11-10(6-9)15-8(3)19-11/h4-7,18H,1-3H3,(H,16,17)
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510n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224210
PNG
(2-(4-cyclohexylphenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(cc2)C2CCCCC2)nc1O
Show InChI InChI=1S/C18H24N2OS/c1-12(2)16-17(21)20-18(22-16)19-15-10-8-14(9-11-15)13-6-4-3-5-7-13/h8-13,21H,3-7H2,1-2H3,(H,19,20)
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660n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224209
PNG
(5-isopropyl-2-(2-methoxyphenylamino)thiazol-4(5H)-...)
Show SMILES COc1ccccc1Nc1nc(O)c(s1)C(C)C
Show InChI InChI=1S/C13H16N2O2S/c1-8(2)11-12(16)15-13(18-11)14-9-6-4-5-7-10(9)17-3/h4-8,16H,1-3H3,(H,14,15)
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1.00E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224214
PNG
(2-(1H-indazol-5-ylamino)-5-isopropylthiazol-4(5H)-...)
Show SMILES CC(C)c1sc(Nc2ccc3n[nH]cc3c2)nc1O
Show InChI InChI=1S/C13H14N4OS/c1-7(2)11-12(18)16-13(19-11)15-9-3-4-10-8(5-9)6-14-17-10/h3-7,18H,1-2H3,(H,14,17)(H,15,16)
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1.00E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224224
PNG
(5-isopropyl-2-(pyridin-4-ylamino)thiazol-4(5H)-one...)
Show SMILES CC(C)c1sc(Nc2ccncc2)nc1O
Show InChI InChI=1S/C11H13N3OS/c1-7(2)9-10(15)14-11(16-9)13-8-3-5-12-6-4-8/h3-7,15H,1-2H3,(H,12,13,14)
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2.50E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224204
PNG
(5-isopropyl-2-(pyridin-2-ylamino)thiazol-4(5H)-one...)
Show SMILES CC(C)c1sc(Nc2ccccn2)nc1O
Show InChI InChI=1S/C11H13N3OS/c1-7(2)9-10(15)14-11(16-9)13-8-5-3-4-6-12-8/h3-7,15H,1-2H3,(H,12,13,14)
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4.90E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224213
PNG
(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Show SMILES CC(C)c1sc(Nc2ccccc2C)nc1O
Show InChI InChI=1S/C13H16N2OS/c1-8(2)11-12(16)15-13(17-11)14-10-7-5-4-6-9(10)3/h4-8,16H,1-3H3,(H,14,15)
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n/an/a 1.30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assay


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224212
PNG
(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Show SMILES CC(C)c1sc(Nc2ccccc2C(F)(F)F)nc1O
Show InChI InChI=1S/C13H13F3N2OS/c1-7(2)10-11(19)18-12(20-10)17-9-6-4-3-5-8(9)13(14,15)16/h3-7,19H,1-2H3,(H,17,18)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assay


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a>10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assay


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224208
PNG
(2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2Cl)nc1O
Show InChI InChI=1S/C12H13ClN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224216
PNG
(2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)...)
Show SMILES Oc1nc(Nc2ccccc2Cl)sc1C1CCCC1
Show InChI InChI=1S/C14H15ClN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17)
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224221
PNG
(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCC1
Show InChI InChI=1S/C14H15FN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17)
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224205
PNG
(2-(2,6-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2c(Cl)cccc2Cl)nc1O
Show InChI InChI=1S/C12H12Cl2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-7(13)4-3-5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224212
PNG
(5-isopropyl-2-(2-(trifluoromethyl)phenylamino)thia...)
Show SMILES CC(C)c1sc(Nc2ccccc2C(F)(F)F)nc1O
Show InChI InChI=1S/C13H13F3N2OS/c1-7(2)10-11(19)18-12(20-10)17-9-6-4-3-5-8(9)13(14,15)16/h3-7,19H,1-2H3,(H,17,18)
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224217
PNG
(2-(2,5-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2cc(F)ccc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-5-7(13)3-4-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224203
PNG
(2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2Cl)sc1C1CCCCC1
Show InChI InChI=1S/C15H17ClN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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n/an/a 33n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224222
PNG
(2-(2,4-dichlorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(Cl)cc2Cl)nc1O
Show InChI InChI=1S/C12H12Cl2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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n/an/a 43n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224200
PNG
(2-(2,4-difluorophenylamino)-5-isopropylthiazol-4(5...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2F)nc1O
Show InChI InChI=1S/C12H12F2N2OS/c1-6(2)10-11(17)16-12(18-10)15-9-4-3-7(13)5-8(9)14/h3-6,17H,1-2H3,(H,15,16)
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 50n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224207
PNG
(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccccc2F)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 97n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224213
PNG
(2-(o-toluidino)-5-isopropylthiazol-4(5H)-one | CHE...)
Show SMILES CC(C)c1sc(Nc2ccccc2C)nc1O
Show InChI InChI=1S/C13H16N2OS/c1-8(2)11-12(16)15-13(17-11)14-10-7-5-4-6-9(10)3/h4-8,16H,1-3H3,(H,14,15)
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224211
PNG
(5-isopropyl-2-(isoquinolin-5-ylamino)thiazol-4(5H)...)
Show SMILES CC(C)c1sc(Nc2cccc3cnccc23)nc1O
Show InChI InChI=1S/C15H15N3OS/c1-9(2)13-14(19)18-15(20-13)17-12-5-3-4-10-8-16-7-6-11(10)12/h3-9,19H,1-2H3,(H,17,18)
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n/an/a 200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224201
PNG
(2-(4-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Show SMILES CC(C)c1sc(Nc2ccc(F)cc2)nc1O
Show InChI InChI=1S/C12H13FN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-5-3-8(13)4-6-9/h3-7,16H,1-2H3,(H,14,15)
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n/an/a 230n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224206
PNG
(5-isopropyl-2-(phenylamino)thiazol-4(5H)-one | CHE...)
Show SMILES CC(C)c1sc(Nc2ccccc2)nc1O
Show InChI InChI=1S/C12H14N2OS/c1-8(2)10-11(15)14-12(16-10)13-9-6-4-3-5-7-9/h3-8,15H,1-2H3,(H,13,14)
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n/an/a 310n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224215
PNG
(2-(1H-indol-4-ylamino)-5-isopropylthiazol-4(5H)-on...)
Show SMILES CC(C)c1sc(Nc2cccc3[nH]ccc23)nc1O
Show InChI InChI=1S/C14H15N3OS/c1-8(2)12-13(18)17-14(19-12)16-11-5-3-4-10-9(11)6-7-15-10/h3-8,15,18H,1-2H3,(H,16,17)
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n/an/a 360n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2


(Homo sapiens (Human))
BDBM50224221
PNG
(5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCC1
Show InChI InChI=1S/C14H15FN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17)
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n/an/a 380n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD2 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2


(Homo sapiens (Human))
BDBM50224202
PNG
(5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-...)
Show SMILES Oc1nc(Nc2ccccc2F)sc1C1CCCCC1
Show InChI InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18)
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n/an/a 530n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD2 by SPA


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50224204
PNG
(5-isopropyl-2-(pyridin-2-ylamino)thiazol-4(5H)-one...)
Show SMILES CC(C)c1sc(Nc2ccccn2)nc1O
Show InChI InChI=1S/C11H13N3OS/c1-7(2)9-10(15)14-11(16-9)13-8-5-3-4-6-12-8/h3-7,15H,1-2H3,(H,12,13,14)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisol


Bioorg Med Chem Lett 17: 6056-61 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.070
BindingDB Entry DOI: 10.7270/Q2X34X6D
More data for this
Ligand-Target Pair
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