Compile Data Set for Download or QSAR

Found 69 hits Enz. Inhib. hit(s) with all data for entry = 50048934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230178 (CHEMBL4087541) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc3OCOc3c2)cc1 Show InChI InChI=1S/C22H17N5O2S/c23-21-24-11-15-2-1-14(9-18(15)27-21)13-3-5-16(6-4-13)25-22(30)26-17-7-8-19-20(10-17)29-12-28-19/h1-11H,12H2,(H2,23,24,27)(H2,25,26,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230179 (CHEMBL4103584) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1 Show InChI InChI=1S/C23H15F6N5S/c24-22(25,26)15-8-16(23(27,28)29)10-18(9-15)33-21(35)32-17-5-3-12(4-6-17)13-1-2-14-11-31-20(30)34-19(14)7-13/h1-11H,(H2,30,31,34)(H2,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230182 (CHEMBL4069517) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5S/c23-16-8-15(22(24,25)26)9-18(10-16)30-21(32)29-17-5-3-12(4-6-17)13-1-2-14-11-28-20(27)31-19(14)7-13/h1-11H,(H2,27,28,31)(H2,29,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230180 (CHEMBL4060841) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(OC(F)(F)F)cc2Br)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-17-10-16(32-22(24,25)26)7-8-18(17)31-21(33)29-15-5-3-12(4-6-15)13-1-2-14-11-28-20(27)30-19(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair				3D Structure (crystal)
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230189 (CHEMBL4066813) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)ccc2OC(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-15-5-8-19(32-22(24,25)26)18(10-15)31-21(33)29-16-6-3-12(4-7-16)13-1-2-14-11-28-20(27)30-17(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230188 (CHEMBL4085653) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C21H15Cl2N5S/c22-17-8-7-16(10-18(17)23)27-21(29)26-15-5-3-12(4-6-15)13-1-2-14-11-25-20(24)28-19(14)9-13/h1-11H,(H2,24,25,28)(H2,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230182 (CHEMBL4069517) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5S/c23-16-8-15(22(24,25)26)9-18(10-16)30-21(32)29-17-5-3-12(4-6-17)13-1-2-14-11-28-20(27)31-19(14)7-13/h1-11H,(H2,27,28,31)(H2,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230173 (CHEMBL4101918) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc5OCOc5c4)cc3)c12 Show InChI InChI=1S/C25H21N5O4/c26-22-21-17(2-1-3-18(21)29-30-22)14-4-6-15(7-5-14)27-23(31)25(10-11-25)24(32)28-16-8-9-19-20(12-16)34-13-33-19/h1-9,12H,10-11,13H2,(H,27,31)(H,28,32)(H3,26,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230172 (CHEMBL4075266) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(cc(c4)C(F)(F)F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C26H19F6N5O2/c27-25(28,29)14-10-15(26(30,31)32)12-17(11-14)35-23(39)24(8-9-24)22(38)34-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(33)37-36-19/h1-7,10-12H,8-9H2,(H,34,38)(H,35,39)(H3,33,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230192 (CHEMBL4089043) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(Br)cc2OC(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-15-5-8-17(19(10-15)32-22(24,25)26)31-21(33)29-16-6-3-12(4-7-16)13-1-2-14-11-28-20(27)30-18(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230174 (CHEMBL4085495) Show SMILES Nc1n[nH]c2cccc(-c3cccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)cc(c4)C(F)(F)F)c3)c12 Show InChI InChI=1S/C25H19BrF3N5O2/c26-15-10-14(25(27,28)29)11-17(12-15)32-23(36)24(7-8-24)22(35)31-16-4-1-3-13(9-16)18-5-2-6-19-20(18)21(30)34-33-19/h1-6,9-12H,7-8H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230182 (CHEMBL4069517) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)cc(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5S/c23-16-8-15(22(24,25)26)9-18(10-16)30-21(32)29-17-5-3-12(4-6-17)13-1-2-14-11-28-20(27)31-19(14)7-13/h1-11H,(H2,27,28,31)(H2,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230171 (CHEMBL4083001) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c12 Show InChI InChI=1S/C24H19Cl2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230177 (CHEMBL4071731) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(OC(F)(F)F)cc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-12-15(37-25(27,28)29)8-9-18(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(30)34-33-19/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230185 (CHEMBL4104599) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Br)cc4OC(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-6-9-17(19(12-14)37-25(27,28)29)32-23(36)24(10-11-24)22(35)31-15-7-4-13(5-8-15)16-2-1-3-18-20(16)21(30)34-33-18/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230185 (CHEMBL4104599) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Br)cc4OC(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-6-9-17(19(12-14)37-25(27,28)29)32-23(36)24(10-11-24)22(35)31-15-7-4-13(5-8-15)16-2-1-3-18-20(16)21(30)34-33-18/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230184 (CHEMBL4092519) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)ccc4OC(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-6-9-19(37-25(27,28)29)18(12-14)32-23(36)24(10-11-24)22(35)31-15-7-4-13(5-8-15)16-2-1-3-17-20(16)21(30)34-33-17/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230175 (CHEMBL4063920) Show SMILES Nc1n[nH]c2cccc(-c3cccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)ccc4OC(F)(F)F)c3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-7-8-19(37-25(27,28)29)18(12-14)32-23(36)24(9-10-24)22(35)31-15-4-1-3-13(11-15)16-5-2-6-17-20(16)21(30)34-33-17/h1-8,11-12H,9-10H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230173 (CHEMBL4101918) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc5OCOc5c4)cc3)c12 Show InChI InChI=1S/C25H21N5O4/c26-22-21-17(2-1-3-18(21)29-30-22)14-4-6-15(7-5-14)27-23(31)25(10-11-25)24(32)28-16-8-9-19-20(12-16)34-13-33-19/h1-9,12H,10-11,13H2,(H,27,31)(H,28,32)(H3,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230169 (CHEMBL4072514) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)cc4Cl)cc3)c12 Show InChI InChI=1S/C24H19Cl2N5O2/c25-14-6-9-18(17(26)12-14)29-23(33)24(10-11-24)22(32)28-15-7-4-13(5-8-15)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230181 (CHEMBL4086694) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)cc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O2/c26-15-10-14(25(27,28)29)11-17(12-15)32-23(36)24(8-9-24)22(35)31-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(30)34-33-19/h1-7,10-12H,8-9H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230180 (CHEMBL4060841) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(OC(F)(F)F)cc2Br)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-17-10-16(32-22(24,25)26)7-8-18(17)31-21(33)29-15-5-3-12(4-6-15)13-1-2-14-11-28-20(27)30-19(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230189 (CHEMBL4066813) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)ccc2OC(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-15-5-8-19(32-22(24,25)26)18(10-15)31-21(33)29-16-6-3-12(4-7-16)13-1-2-14-11-28-20(27)30-17(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230181 (CHEMBL4086694) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)cc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O2/c26-15-10-14(25(27,28)29)11-17(12-15)32-23(36)24(8-9-24)22(35)31-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(30)34-33-19/h1-7,10-12H,8-9H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230192 (CHEMBL4089043) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(Br)cc2OC(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-15-5-8-17(19(10-15)32-22(24,25)26)31-21(33)29-16-6-3-12(4-7-16)13-1-2-14-11-28-20(27)30-18(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230170 (CHEMBL4100979) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12 Show InChI InChI=1S/C24H19F2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230175 (CHEMBL4063920) Show SMILES Nc1n[nH]c2cccc(-c3cccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)ccc4OC(F)(F)F)c3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-7-8-19(37-25(27,28)29)18(12-14)32-23(36)24(9-10-24)22(35)31-15-4-1-3-13(11-15)16-5-2-6-17-20(16)21(30)34-33-17/h1-8,11-12H,9-10H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230187 (CHEMBL4088100) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(OC(F)(F)F)ccc2Br)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-17-8-7-16(32-22(24,25)26)10-19(17)31-21(33)29-15-5-3-12(4-6-15)13-1-2-14-11-28-20(27)30-18(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230181 (CHEMBL4086694) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)cc(c4)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O2/c26-15-10-14(25(27,28)29)11-17(12-15)32-23(36)24(8-9-24)22(35)31-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(30)34-33-19/h1-7,10-12H,8-9H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230184 (CHEMBL4092519) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)ccc4OC(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-6-9-19(37-25(27,28)29)18(12-14)32-23(36)24(10-11-24)22(35)31-15-7-4-13(5-8-15)16-2-1-3-17-20(16)21(30)34-33-17/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230172 (CHEMBL4075266) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(cc(c4)C(F)(F)F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C26H19F6N5O2/c27-25(28,29)14-10-15(26(30,31)32)12-17(11-14)35-23(39)24(8-9-24)22(38)34-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(33)37-36-19/h1-7,10-12H,8-9H2,(H,34,38)(H,35,39)(H3,33,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230180 (CHEMBL4060841) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(OC(F)(F)F)cc2Br)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-17-10-16(32-22(24,25)26)7-8-18(17)31-21(33)29-15-5-3-12(4-6-15)13-1-2-14-11-28-20(27)30-19(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230172 (CHEMBL4075266) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(cc(c4)C(F)(F)F)C(F)(F)F)cc3)c12 Show InChI InChI=1S/C26H19F6N5O2/c27-25(28,29)14-10-15(26(30,31)32)12-17(11-14)35-23(39)24(8-9-24)22(38)34-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(33)37-36-19/h1-7,10-12H,8-9H2,(H,34,38)(H,35,39)(H3,33,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230190 (CHEMBL4080224) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(F)c(F)c2)cc1 Show InChI InChI=1S/C21H15F2N5S/c22-17-8-7-16(10-18(17)23)27-21(29)26-15-5-3-12(4-6-15)13-1-2-14-11-25-20(24)28-19(14)9-13/h1-11H,(H2,24,25,28)(H2,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230187 (CHEMBL4088100) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(OC(F)(F)F)ccc2Br)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-17-8-7-16(32-22(24,25)26)10-19(17)31-21(33)29-15-5-3-12(4-6-15)13-1-2-14-11-28-20(27)30-18(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230189 (CHEMBL4066813) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2cc(Br)ccc2OC(F)(F)F)cc1 Show InChI InChI=1S/C22H15BrF3N5OS/c23-15-5-8-19(32-22(24,25)26)18(10-15)31-21(33)29-16-6-3-12(4-7-16)13-1-2-14-11-28-20(27)30-17(14)9-13/h1-11H,(H2,27,28,30)(H2,29,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230185 (CHEMBL4104599) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Br)cc4OC(F)(F)F)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-14-6-9-17(19(12-14)37-25(27,28)29)32-23(36)24(10-11-24)22(35)31-15-7-4-13(5-8-15)16-2-1-3-18-20(16)21(30)34-33-18/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230186 (CHEMBL4104466) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C21H15Cl2N5S/c22-15-5-8-18(17(23)10-15)28-21(29)26-16-6-3-12(4-7-16)13-1-2-14-11-25-20(24)27-19(14)9-13/h1-11H,(H2,24,25,27)(H2,26,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	164	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230171 (CHEMBL4083001) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c12 Show InChI InChI=1S/C24H19Cl2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230188 (CHEMBL4085653) Show SMILES Nc1ncc2ccc(cc2n1)-c1ccc(NC(=S)Nc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C21H15Cl2N5S/c22-17-8-7-16(10-18(17)23)27-21(29)26-15-5-3-12(4-6-15)13-1-2-14-11-25-20(24)28-19(14)9-13/h1-11H,(H2,24,25,28)(H2,26,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230169 (CHEMBL4072514) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)cc4Cl)cc3)c12 Show InChI InChI=1S/C24H19Cl2N5O2/c25-14-6-9-18(17(26)12-14)29-23(33)24(10-11-24)22(32)28-15-7-4-13(5-8-15)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	384	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230174 (CHEMBL4085495) Show SMILES Nc1n[nH]c2cccc(-c3cccc(NC(=O)C4(CC4)C(=O)Nc4cc(Br)cc(c4)C(F)(F)F)c3)c12 Show InChI InChI=1S/C25H19BrF3N5O2/c26-15-10-14(25(27,28)29)11-17(12-15)32-23(36)24(7-8-24)22(35)31-16-4-1-3-13(9-16)18-5-2-6-19-20(18)21(30)34-33-19/h1-6,9-12H,7-8H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	613	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50230171 (CHEMBL4083001) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c12 Show InChI InChI=1S/C24H19Cl2N5O2/c25-17-9-8-15(12-18(17)26)29-23(33)24(10-11-24)22(32)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	701	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Ephrin type-B receptor 4 (Homo sapiens (Human))	BDBM50230176 (CHEMBL4093247) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(OC(F)(F)F)ccc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-9-8-15(37-25(27,28)29)12-19(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-18-20(16)21(30)34-33-18/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	788	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EphB4 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50230176 (CHEMBL4093247) Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cc(OC(F)(F)F)ccc4Br)cc3)c12 Show InChI InChI=1S/C25H19BrF3N5O3/c26-17-9-8-15(37-25(27,28)29)12-19(17)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-18-20(16)21(30)34-33-18/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	905	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay				Eur J Med Chem 127: 275-285 (2017) Article DOI: 10.1016/j.ejmech.2016.12.059 BindingDB Entry DOI: 10.7270/Q2XW4N27
					More data for this Ligand-Target Pair

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