Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with all data for entry = 994   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301997 (US9598405, 1.5 | US9598405, 1.6) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0710	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302002 (US9598405, 2.1) Show SMILES Cc1cc(Nc2cc(ccn2)-c2c[nH]nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C23H23N7O3S/c1-13-8-16(18-12-25-22(34-18)23(33)5-2-14(3-6-23)21(31)32)27-20(9-13)28-19-10-15(4-7-24-19)17-11-26-30-29-17/h4,7-12,14,33H,2-3,5-6H2,1H3,(H,31,32)(H,24,27,28)(H,26,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0720	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302016 (US9598405, 3.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@]1(O)CC[C@@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0730	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302034 (BDBM302035 | US9598405, 4.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2(CCCCC2)C1C(O)=O Show InChI InChI=1S/C25H25F3N4O3S/c1-14-9-16(31-19(10-14)32-18-11-15(5-8-29-18)25(26,27)28)17-12-30-22(36-17)24(35)13-23(20(24)21(33)34)6-3-2-4-7-23/h5,8-12,20,35H,2-4,6-7,13H2,1H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0860	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302018 (US9598405, 3.3 | US9598405, 3.7) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H23F3N4O3S/c1-21(2)12-22(33,8-6-14(21)19(31)32)20-28-11-16(34-20)15-4-3-5-17(29-15)30-18-10-13(7-9-27-18)23(24,25)26/h3-5,7,9-11,14,33H,6,8,12H2,1-2H3,(H,31,32)(H,27,29,30)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0920	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302028 (US9598405, 3.13) Show SMILES Cc1cc(Nc2cc(C)c(Cl)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H27ClN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301993 (BDBM301994 | US9598405, 1.1) Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C26H30N4O3S/c1-15-10-19(29-22(11-15)30-21-12-17(7-9-27-21)16-4-5-16)20-13-28-24(34-20)26(33)8-6-18(23(31)32)25(2,3)14-26/h7,9-13,16,18,33H,4-6,8,14H2,1-3H3,(H,31,32)(H,27,29,30)/t18-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.103	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302029 (US9598405, 3.14) Show SMILES COc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C24H28N4O4S/c1-14-9-17(27-20(10-14)28-19-11-15(32-4)6-8-25-19)18-12-26-22(33-18)24(31)7-5-16(21(29)30)23(2,3)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.104	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302032 (US9598405, 3.17) Show SMILES Cc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C24H28N4O3S/c1-14-6-8-25-19(10-14)28-20-11-15(2)9-17(27-20)18-12-26-22(32-18)24(31)7-5-16(21(29)30)23(3,4)13-24/h6,8-12,16,31H,5,7,13H2,1-4H3,(H,29,30)(H,25,27,28)/t16-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.113	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302000 (US9598405, 1.8) Show SMILES CC1(C)CC(O)(CCC1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.119	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302030 (US9598405, 3.15) Show SMILES Cc1cc(Nc2cc(C)c(F)cn2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H27FN4O3S/c1-13-7-17(28-20(8-13)29-19-9-14(2)16(25)10-26-19)18-11-27-22(33-18)24(32)6-5-15(21(30)31)23(3,4)12-24/h7-11,15,32H,5-6,12H2,1-4H3,(H,30,31)(H,26,28,29)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.127	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302013 (US9598405, 2.12) Show SMILES Cc1cc(Nc2cc(OC3CCNCC3)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(10.66,-14.61,;11.29,-13.2,;12.82,-13.04,;13.45,-11.63,;14.98,-11.47,;15.61,-10.06,;17.14,-9.9,;17.76,-8.5,;19.3,-8.33,;20.2,-9.58,;21.73,-9.42,;22.64,-10.66,;22.01,-12.07,;20.48,-12.23,;19.57,-10.99,;16.86,-7.25,;15.33,-7.41,;14.7,-8.82,;12.54,-10.38,;11.01,-10.55,;10.38,-11.95,;10.11,-9.3,;8.57,-9.3,;8.09,-7.84,;9.34,-6.93,;10.58,-7.84,;9.34,-5.39,;10.85,-5.66,;7.82,-5.66,;6.83,-4.48,;7.36,-3.03,;8.87,-2.76,;9.86,-3.94,;6.37,-1.85,;4.85,-2.12,;6.89,-.4,)| Show InChI InChI=1S/C26H31N5O4S/c1-16-12-20(21-15-29-25(36-21)26(34)7-2-17(3-8-26)24(32)33)30-23(13-16)31-22-14-19(6-11-28-22)35-18-4-9-27-10-5-18/h6,11-15,17-18,27,34H,2-5,7-10H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.152	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302017 (US9598405, 3.2 | US9598405, 3.6) Show SMILES CC(C)(C)c1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C26H32N4O3S/c1-24(2,3)16-10-12-27-21(13-16)30-20-8-6-7-18(29-20)19-14-28-23(34-19)26(33)11-9-17(22(31)32)25(4,5)15-26/h6-8,10,12-14,17,33H,9,11,15H2,1-5H3,(H,31,32)(H,27,29,30)/t17-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302033 (US9598405, 3.18) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)/t15-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302042 (US9598405, 5.1) Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 Show InChI InChI=1S/C23H25FN4O3S/c1-12-6-17(27-20(7-12)28-19-8-13(2)16(24)10-25-19)18-11-26-22(32-18)23(31)5-4-15(21(29)30)14(3)9-23/h6-8,10-11,14-15,31H,4-5,9H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,15+,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.161	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301996 (US9598405, 1.4) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C24H25F3N4O3S/c1-13-8-16(30-19(9-13)31-18-10-14(5-7-28-18)24(25,26)27)17-11-29-21(35-17)23(34)6-4-15(20(32)33)22(2,3)12-23/h5,7-11,15,34H,4,6,12H2,1-3H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.164	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302026 (US9598405, 3.11) Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1Cl Show InChI InChI=1S/C23H25ClN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.208	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302036 (BDBM302037 | US9598405, 4.3) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2CCC(C1)C2C(O)=O |TLB:24:23:27.28:31,(13.28,-2.32,;11.96,-1.53,;11.98,.01,;10.66,.8,;10.68,2.34,;9.36,3.13,;9.38,4.67,;8.06,5.46,;6.71,4.71,;6.69,3.17,;8.01,2.38,;8.08,7,;8.1,8.54,;9.62,6.98,;6.54,7.02,;9.31,.05,;9.29,-1.49,;10.61,-2.28,;7.95,-2.24,;7.76,-3.77,;6.25,-4.07,;5.5,-2.72,;6.55,-1.59,;3.97,-2.54,;3.36,-3.95,;3.71,-1.01,;1.98,-1.04,;1.38,-2.36,;.22,-3.07,;1.19,-1.74,;3.01,-1.74,;.93,-.22,;.14,1.1,;.9,2.45,;-1.4,1.08,)| Show InChI InChI=1S/C24H23F3N4O3S/c1-12-6-16(30-19(7-12)31-18-8-15(4-5-28-18)24(25,26)27)17-11-29-22(35-17)23(34)9-13-2-3-14(10-23)20(13)21(32)33/h4-8,11,13-14,20,34H,2-3,9-10H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.228	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302006 (US9598405, 2.5) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2cn(C)nn2)n1 Show InChI InChI=1S/C26H29N7O3S/c1-4-36-24(34)17-5-8-26(35,9-6-17)25-28-14-21(37-25)19-11-16(2)12-23(29-19)30-22-13-18(7-10-27-22)20-15-33(3)32-31-20/h7,10-15,17,35H,4-6,8-9H2,1-3H3,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.316	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302014 (US9598405, 2.13) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2c[nH]nn2)n1 Show InChI InChI=1S/C25H27N7O3S/c1-3-35-23(33)16-4-7-25(34,8-5-16)24-27-14-20(36-24)18-10-15(2)11-22(29-18)30-21-12-17(6-9-26-21)19-13-28-32-31-19/h6,9-14,16,34H,3-5,7-8H2,1-2H3,(H,26,29,30)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.333	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302039 (US9598405, 4.6) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C22H21F3N4O3S/c1-12-8-15(28-18(9-12)29-17-10-14(4-7-26-17)22(23,24)25)16-11-27-20(33-16)21(32)5-2-13(3-6-21)19(30)31/h4,7-11,13,32H,2-3,5-6H2,1H3,(H,30,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.392	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302034 (BDBM302035 | US9598405, 4.1) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2(CCCCC2)C1C(O)=O Show InChI InChI=1S/C25H25F3N4O3S/c1-14-9-16(31-19(10-14)32-18-11-15(5-8-29-18)25(26,27)28)17-12-30-22(36-17)24(35)13-23(20(24)21(33)34)6-3-2-4-7-23/h5,8-12,20,35H,2-4,6-7,13H2,1H3,(H,33,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.508	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301997 (US9598405, 1.5 | US9598405, 1.6) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H24F3N5O3S/c1-21(2)11-22(34,5-3-14(21)19(32)33)20-29-10-16(35-20)15-8-13(27)9-18(30-15)31-17-7-12(4-6-28-17)23(24,25)26/h4,6-10,14,34H,3,5,11H2,1-2H3,(H,32,33)(H3,27,28,30,31)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.516	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302018 (US9598405, 3.3 | US9598405, 3.7) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C23H23F3N4O3S/c1-21(2)12-22(33,8-6-14(21)19(31)32)20-28-11-16(34-20)15-4-3-5-17(29-15)30-18-10-13(7-9-27-18)23(24,25)26/h3-5,7,9-11,14,33H,6,8,12H2,1-2H3,(H,31,32)(H,27,29,30)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.574	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302043 (US9598405, 5.2) Show SMILES C[C@H]1C[C@@](O)(CC[C@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(C)c(F)cn2)n1 Show InChI InChI=1S/C23H25FN4O3S/c1-12-6-17(27-20(7-12)28-19-8-13(2)16(24)10-25-19)18-11-26-22(32-18)23(31)5-4-15(21(29)30)14(3)9-23/h6-8,10-11,14-15,31H,4-5,9H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,15+,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301993 (BDBM301994 | US9598405, 1.1) Show SMILES Cc1cc(Nc2cc(ccn2)C2CC2)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C26H30N4O3S/c1-15-10-19(29-22(11-15)30-21-12-17(7-9-27-21)16-4-5-16)20-13-28-24(34-20)26(33)8-6-18(23(31)32)25(2,3)14-26/h7,9-13,16,18,33H,4-6,8,14H2,1-3H3,(H,31,32)(H,27,29,30)/t18-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.581	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302027 (US9598405, 3.12) Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C23H26N4O3S/c1-14-8-10-24-19(11-14)27-18-6-4-5-16(26-18)17-12-25-21(31-17)23(30)9-7-15(20(28)29)22(2,3)13-23/h4-6,8,10-12,15,30H,7,9,13H2,1-3H3,(H,28,29)(H,24,26,27)/t15-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302020 (US9598405, 3.5 | US9598405, 3.9) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(Cl)ccn2)n1 Show InChI InChI=1S/C22H23ClN4O3S/c1-21(2)12-22(30,8-6-14(21)19(28)29)20-25-11-16(31-20)15-4-3-5-17(26-15)27-18-10-13(23)7-9-24-18/h3-5,7,9-11,14,30H,6,8,12H2,1-2H3,(H,28,29)(H,24,26,27)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.733	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302019 (BDBM302023 | US9598405, 3.4) Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1F Show InChI InChI=1S/C23H25FN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.784	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302005 (US9598405, 2.4) Show SMILES Cc1cc(Nc2cc(ccn2)-c2cn(C)nn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O Show InChI InChI=1S/C24H25N7O3S/c1-14-9-17(19-12-26-23(35-19)24(34)6-3-15(4-7-24)22(32)33)27-21(10-14)28-20-11-16(5-8-25-20)18-13-31(2)30-29-18/h5,8-13,15,34H,3-4,6-7H2,1-2H3,(H,32,33)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.808	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302038 (US9598405, 4.5) Show SMILES CC(C)Oc1ccnc(Nc2cc(C)cc(n2)-c2cnc(s2)C2(O)CCC(CC2)C(O)=O)c1 Show InChI InChI=1S/C24H28N4O4S/c1-14(2)32-17-6-9-25-20(12-17)28-21-11-15(3)10-18(27-21)19-13-26-23(33-19)24(31)7-4-16(5-8-24)22(29)30/h6,9-14,16,31H,4-5,7-8H2,1-3H3,(H,29,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.862	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302036 (BDBM302037 | US9598405, 4.3) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CC2CCC(C1)C2C(O)=O |TLB:24:23:27.28:31,(13.28,-2.32,;11.96,-1.53,;11.98,.01,;10.66,.8,;10.68,2.34,;9.36,3.13,;9.38,4.67,;8.06,5.46,;6.71,4.71,;6.69,3.17,;8.01,2.38,;8.08,7,;8.1,8.54,;9.62,6.98,;6.54,7.02,;9.31,.05,;9.29,-1.49,;10.61,-2.28,;7.95,-2.24,;7.76,-3.77,;6.25,-4.07,;5.5,-2.72,;6.55,-1.59,;3.97,-2.54,;3.36,-3.95,;3.71,-1.01,;1.98,-1.04,;1.38,-2.36,;.22,-3.07,;1.19,-1.74,;3.01,-1.74,;.93,-.22,;.14,1.1,;.9,2.45,;-1.4,1.08,)| Show InChI InChI=1S/C24H23F3N4O3S/c1-12-6-16(30-19(7-12)31-18-8-15(4-5-28-18)24(25,26)27)17-11-29-22(35-17)23(34)9-13-2-3-14(10-23)20(13)21(32)33/h4-8,11,13-14,20,34H,2-3,9-10H2,1H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.898	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302012 (US9598405, 2.11) Show SMILES Cc1cc(Nc2cc(OCCCN)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(5.83,2.98,;4.5,2.21,;3.17,2.98,;1.83,2.21,;.5,2.98,;.5,4.52,;1.83,5.29,;1.83,6.83,;3.17,7.6,;3.17,9.14,;4.5,9.91,;4.5,11.45,;5.83,12.22,;.5,7.6,;-.84,6.83,;-.84,5.29,;1.83,.67,;3.17,-.1,;4.5,.67,;3.17,-1.64,;4.41,-2.55,;3.94,-4.01,;2.4,-4.01,;1.92,-2.55,;1.49,-5.26,;2.87,-5.93,;1.07,-6.74,;-.43,-7.11,;-1.5,-6,;-1.07,-4.52,;.42,-4.15,;-2.99,-6.38,;-4.06,-5.27,;-3.42,-7.86,)| Show InChI InChI=1S/C24H29N5O4S/c1-15-11-18(19-14-27-23(34-19)24(32)6-3-16(4-7-24)22(30)31)28-21(12-15)29-20-13-17(5-9-26-20)33-10-2-8-25/h5,9,11-14,16,32H,2-4,6-8,10,25H2,1H3,(H,30,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.911	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302008 (US9598405, 2.7) Show SMILES Cc1cc(Nc2cc(CC(O)=O)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(5.83,2.98,;4.5,2.21,;3.17,2.98,;1.83,2.21,;.5,2.98,;.5,4.52,;1.83,5.29,;1.83,6.83,;3.17,7.6,;3.17,9.14,;1.83,9.91,;4.5,9.91,;.5,7.6,;-.84,6.83,;-.84,5.29,;1.83,.67,;3.17,-.1,;4.5,.67,;3.17,-1.64,;4.41,-2.55,;3.94,-4.01,;2.4,-4.01,;1.92,-2.55,;1.49,-5.26,;2.87,-5.93,;1.07,-6.74,;-.43,-7.11,;-1.5,-6,;-1.07,-4.52,;.42,-4.15,;-2.99,-6.38,;-4.06,-5.27,;-3.42,-7.86,)| Show InChI InChI=1S/C23H24N4O5S/c1-13-8-16(26-19(9-13)27-18-10-14(4-7-24-18)11-20(28)29)17-12-25-22(33-17)23(32)5-2-15(3-6-23)21(30)31/h4,7-10,12,15,32H,2-3,5-6,11H2,1H3,(H,28,29)(H,30,31)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.01	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302003 (US9598405, 2.2) Show SMILES COc1ccc(Cn2cc(nn2)-c2ccnc(Nc3cc(C)cc(n3)-c3cnc(s3)C3(O)CCC(CC3)C(O)=O)c2)cc1 |(30.13,-12,;28.79,-11.23,;28.79,-9.69,;30.13,-8.92,;30.13,-7.38,;28.79,-6.61,;28.79,-5.07,;27.46,-4.3,;26.05,-4.93,;25.02,-3.79,;25.79,-2.45,;27.3,-2.77,;23.49,-3.95,;22.59,-2.7,;21.06,-2.86,;20.43,-4.27,;21.33,-5.51,;20.71,-6.92,;19.18,-7.08,;18.55,-8.49,;17.02,-8.65,;16.39,-10.06,;16.11,-7.4,;16.74,-6,;18.27,-5.84,;15.83,-4.75,;14.29,-4.75,;13.82,-3.29,;15.06,-2.38,;16.31,-3.29,;15.06,-.84,;16.58,-1.11,;13.55,-1.11,;12.56,.07,;13.08,1.52,;14.6,1.78,;15.59,.61,;12.09,2.7,;10.58,2.43,;12.62,4.14,;22.87,-5.35,;27.46,-7.38,;27.46,-8.92,)| Show InChI InChI=1S/C31H31N7O4S/c1-19-13-24(26-16-33-30(43-26)31(41)10-7-21(8-11-31)29(39)40)34-28(14-19)35-27-15-22(9-12-32-27)25-18-38(37-36-25)17-20-3-5-23(42-2)6-4-20/h3-6,9,12-16,18,21,41H,7-8,10-11,17H2,1-2H3,(H,39,40)(H,32,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301995 (US9598405, 1.3) Show SMILES COC(=O)[C@H]1CC[C@@](O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C2CC2)n1 Show InChI InChI=1S/C27H32N4O3S/c1-16-11-20(30-23(12-16)31-22-13-18(8-10-28-22)17-5-6-17)21-14-29-25(35-21)27(33)9-7-19(24(32)34-4)26(2,3)15-27/h8,10-14,17,19,33H,5-7,9,15H2,1-4H3,(H,28,30,31)/t19-,27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302031 (US9598405, 3.16) Show SMILES Cc1cc(Nc2cc(ccn2)C(C)(C)C)nc(c1)-c1cnc(s1)[C@@]1(O)CC[C@H](C(O)=O)C(C)(C)C1 Show InChI InChI=1S/C27H34N4O3S/c1-16-11-19(30-22(12-16)31-21-13-17(8-10-28-21)25(2,3)4)20-14-29-24(35-20)27(34)9-7-18(23(32)33)26(5,6)15-27/h8,10-14,18,34H,7,9,15H2,1-6H3,(H,32,33)(H,28,30,31)/t18-,27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302007 (US9598405, 2.6) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2cnn(C)n2)n1 Show InChI InChI=1S/C26H29N7O3S/c1-4-36-24(34)17-5-8-26(35,9-6-17)25-28-15-21(37-25)19-11-16(2)12-23(30-19)31-22-13-18(7-10-27-22)20-14-29-33(3)32-20/h7,10-15,17,35H,4-6,8-9H2,1-3H3,(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.47	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302017 (US9598405, 3.2 | US9598405, 3.6) Show SMILES CC(C)(C)c1ccnc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)c1 Show InChI InChI=1S/C26H32N4O3S/c1-24(2,3)16-10-12-27-21(13-16)30-20-8-6-7-18(29-20)19-14-28-23(34-19)26(33)11-9-17(22(31)32)25(4,5)15-26/h6-8,10,12-14,17,33H,9,11,15H2,1-5H3,(H,31,32)(H,27,29,30)/t17-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.72	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302011 (US9598405, 2.10) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C(=O)OC)n1 |(-7.3,.16,;-5.76,.1,;-5.04,-1.26,;-3.5,-1.31,;-2.69,-0,;-2.78,-2.67,;-1.24,-2.72,;-.52,-4.08,;-1.33,-5.39,;-.06,-6.25,;-2.87,-5.34,;-3.6,-3.98,;-1.33,-6.93,;-2.58,-7.84,;-2.1,-9.3,;-.56,-9.3,;-.09,-7.84,;.34,-10.55,;1.87,-10.38,;2.78,-11.63,;4.31,-11.47,;2.15,-13.04,;.62,-13.2,;-.01,-14.61,;.9,-15.85,;.27,-17.26,;1.18,-18.5,;2.71,-18.34,;3.34,-16.94,;2.43,-15.69,;.55,-19.91,;-.98,-20.07,;1.46,-21.16,;2.99,-21,;-.28,-11.95,)| Show InChI InChI=1S/C25H28N4O5S/c1-4-34-23(31)16-5-8-25(32,9-6-16)24-27-14-19(35-24)18-11-15(2)12-21(28-18)29-20-13-17(7-10-26-20)22(30)33-3/h7,10-14,16,32H,4-6,8-9H2,1-3H3,(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.84	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302020 (US9598405, 3.5 | US9598405, 3.9) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2cc(Cl)ccn2)n1 Show InChI InChI=1S/C22H23ClN4O3S/c1-21(2)12-22(30,8-6-14(21)19(28)29)20-25-11-16(31-20)15-4-3-5-17(26-15)27-18-10-13(23)7-9-24-18/h3-5,7,9-11,14,30H,6,8,12H2,1-2H3,(H,28,29)(H,24,26,27)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.17	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302010 (US9598405, 2.9) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(CC(=O)OC)ccn2)n1 Show InChI InChI=1S/C26H30N4O5S/c1-4-35-24(32)18-5-8-26(33,9-6-18)25-28-15-20(36-25)19-11-16(2)12-22(29-19)30-21-13-17(7-10-27-21)14-23(31)34-3/h7,10-13,15,18,33H,4-6,8-9,14H2,1-3H3,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.18	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302019 (BDBM302023 | US9598405, 3.4) Show SMILES Cc1cc(Nc2cccc(n2)-c2cnc(s2)[C@@]2(O)CC[C@H](C(O)=O)C(C)(C)C2)ncc1F Show InChI InChI=1S/C23H25FN4O3S/c1-13-9-19(25-10-15(13)24)28-18-6-4-5-16(27-18)17-11-26-21(32-17)23(31)8-7-14(20(29)30)22(2,3)12-23/h4-6,9-11,14,31H,7-8,12H2,1-3H3,(H,29,30)(H,25,27,28)/t14-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302001 (US9598405, 1.9) Show SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C24H26F3N5O3S/c1-22(2)12-23(34,6-4-15(22)20(33)35-3)21-30-11-17(36-21)16-9-14(28)10-19(31-16)32-18-8-13(5-7-29-18)24(25,26)27/h5,7-11,15,34H,4,6,12H2,1-3H3,(H3,28,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302025 (US9598405, 3.10) Show SMILES CC1(C)C[C@](O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cccc(Nc2ccc(F)cn2)n1 Show InChI InChI=1S/C22H23FN4O3S/c1-21(2)12-22(30,9-8-14(21)19(28)29)20-25-11-16(31-20)15-4-3-5-18(26-15)27-17-7-6-13(23)10-24-17/h3-7,10-11,14,30H,8-9,12H2,1-2H3,(H,28,29)(H,24,26,27)/t14-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301999 (US9598405, 1.7) Show SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(NC(C)=O)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C26H28F3N5O4S/c1-14(35)32-16-10-18(33-21(11-16)34-20-9-15(6-8-30-20)26(27,28)29)19-12-31-23(39-19)25(37)7-5-17(22(36)38-4)24(2,3)13-25/h6,8-12,17,37H,5,7,13H2,1-4H3,(H2,30,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302004 (US9598405, 2.3) Show SMILES Cc1cc(Nc2cc(OCCCNC(=O)OC(C)(C)C)ccn2)nc(c1)-c1cnc(s1)C1(O)CCC(CC1)C(O)=O |(25.24,-4.59,;26.58,-5.36,;26.58,-6.9,;27.91,-7.67,;27.91,-9.21,;26.58,-9.98,;25.24,-9.21,;23.91,-9.98,;22.57,-9.21,;21.24,-9.98,;19.91,-9.21,;18.57,-9.98,;17.24,-9.21,;15.91,-9.98,;15.91,-11.52,;14.57,-9.21,;13.24,-9.98,;11.91,-10.75,;14.01,-11.31,;12.47,-8.65,;23.91,-11.52,;25.24,-12.29,;26.58,-11.52,;29.24,-6.9,;29.24,-5.36,;27.91,-4.59,;30.58,-4.59,;30.74,-3.06,;32.24,-2.74,;33.01,-4.07,;31.98,-5.22,;34.55,-4.23,;34.44,-2.7,;36.04,-3.86,;37.11,-4.97,;36.68,-6.45,;35.19,-6.82,;34.12,-5.71,;37.75,-7.56,;37.33,-9.04,;39.25,-7.18,)| Show InChI InChI=1S/C29H37N5O6S/c1-18-14-21(22-17-32-26(41-22)29(38)9-6-19(7-10-29)25(35)36)33-24(15-18)34-23-16-20(8-12-30-23)39-13-5-11-31-27(37)40-28(2,3)4/h8,12,14-17,19,38H,5-7,9-11,13H2,1-4H3,(H,31,37)(H,35,36)(H,30,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23.9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302040 (US9598405, 4.7) Show SMILES COCc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C1(O)CCC(C(C)C1)C(O)=O Show InChI InChI=1S/C24H25F3N4O4S/c1-13-10-23(34,5-3-16(13)21(32)33)22-29-11-18(36-22)17-7-14(12-35-2)8-20(30-17)31-19-9-15(4-6-28-19)24(25,26)27/h4,6-9,11,13,16,34H,3,5,10,12H2,1-2H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71.2	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302015 (US9598405, 2.14) Show SMILES CCOC(=O)C1CCC(O)(CC1)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)-c2cn(Cc3ccc(OC)cc3)nn2)n1 |(12.16,6.77,;11.63,5.32,;12.62,4.14,;12.09,2.7,;10.58,2.43,;13.08,1.52,;12.56,.07,;13.55,-1.11,;15.06,-.84,;16.58,-1.11,;15.59,.61,;14.6,1.78,;15.06,-2.38,;13.82,-3.29,;14.29,-4.75,;15.83,-4.75,;16.31,-3.29,;16.74,-6,;16.11,-7.4,;17.02,-8.65,;16.39,-10.06,;18.55,-8.49,;19.18,-7.08,;20.71,-6.92,;21.33,-5.51,;22.87,-5.35,;23.49,-3.95,;22.59,-2.7,;21.06,-2.86,;20.43,-4.27,;25.02,-3.79,;26.05,-4.93,;27.46,-4.3,;28.79,-5.07,;28.79,-6.61,;30.13,-7.38,;30.13,-8.92,;28.79,-9.69,;28.79,-11.23,;30.13,-12,;27.46,-8.92,;27.46,-7.38,;27.3,-2.77,;25.79,-2.45,;18.27,-5.84,)| Show InChI InChI=1S/C33H35N7O4S/c1-4-44-31(41)23-9-12-33(42,13-10-23)32-35-18-28(45-32)26-15-21(2)16-30(36-26)37-29-17-24(11-14-34-29)27-20-40(39-38-27)19-22-5-7-25(43-3)8-6-22/h5-8,11,14-18,20,23,42H,4,9-10,12-13,19H2,1-3H3,(H,34,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM302044 (US9598405, 6.1) Show SMILES C[C@@H]1CC(O)(CC[C@@H]1C(O)=O)c1ncc(s1)-c1cc(C)cc(Nc2cc(O)ccn2)n1 Show InChI InChI=1S/C22H24N4O4S/c1-12-7-16(25-19(8-12)26-18-9-14(27)4-6-23-18)17-11-24-21(31-17)22(30)5-3-15(20(28)29)13(2)10-22/h4,6-9,11,13,15,30H,3,5,10H2,1-2H3,(H,28,29)(H2,23,25,26,27)/t13-,15+,22?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
					More data for this Ligand-Target Pair

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