BindingDB PrimarySearch

Found 39 hits of ph data with Target = 'MAP kinase-activated protein kinase 2'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM27344 (2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...) Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccncc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	171	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM236557 (US9365572, 5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	28
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...				US Patent US9365572 (2016) BindingDB Entry DOI: 10.7270/Q20C4TNC
Xuanzhu Pharma Co., Ltd. US Patent					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30178 (Pyrrolopyridine, 9) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30179 (Pyrrolopyridine, 10) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30180 (Pyrrolopyridine, 11) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30181 (Pyrrolopyridine, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30182 (Pyrrolopyridine, 13) Show SMILES O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1ccsc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30183 (Pyrrolopyridine, 14) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30184 (Pyrrolopyridine, 15) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30185 (CHEMBL226403 \| Pyrrolopyridine, 16) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (crystal)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30186 (Pyrrolopyridine, 17) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30187 (Pyrrolopyridine, 18) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30188 (Pyrrolopyridine, 19) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30189 (Pyrrolopyridine, 20) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	606	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30190 (Pyrrolopyridine, 21) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30191 (Pyrrolopyridine, 22) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30192 (Pyrrolopyridine, 23) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (crystal)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30193 (Pyrrolopyridine, 24) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30194 (Pyrrolopyridine, 25) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30195 (Pyrrolopyridine, 26) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30309 (Pyrrolo-pyrimidone, 2) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30310 (Pyrrolo-pyrimidone, 3) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30311 (Pyrrolo-pyrimidone, 4) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30312 (Pyrrolo-pyrimidone, 5) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30313 (Pyrrolo-pyrimidone, 6) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30314 (Pyrrolo-pyrimidone, 7) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30315 (Pyrrolo-pyrimidone, 8) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30316 (Pyrrolo-pyrimidone, 9) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30317 (Pyrrolo-pyrimidone, 10) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30318 (Pyrrolo-pyrimidone, 11) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30319 (Pyrrolo-pyrimidone, 12) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30320 (Pyrrolo-pyrimidone, 13) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30321 (Pyrrolo-pyrimidone, 14) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30322 (Pyrrolo-pyrimidone, 15) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30323 (Pyrrolo-pyrimidone, 16) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30324 (Pyrrolo-pyrimidone, 17) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM30325 (Pyrrolo-pyrimidone, 18) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	22
Novartis					Assay Description For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...				Bioorg Med Chem Lett 18: 6142-6 (2008) Article DOI: 10.1016/j.bmcl.2008.10.039 BindingDB Entry DOI: 10.7270/Q2V40SKW
Novartis					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM175242 (US11844801, Compound (M)-I \| US9115089, 49) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	n/a
CONFLUENCE LIFE SCIENCES, INC. US Patent					Assay Description The ability of compounds to inhibit activated phospho-p38alpha is evaluated using a p38alpha /MK2 and a p38alpha /PRAK cascade assay format. The kina...				US Patent US9115089 (2015) BindingDB Entry DOI: 10.7270/Q25M64H1
CONFLUENCE LIFE SCIENCES, INC. US Patent					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM27388 (2-(2-chloropyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...) Show SMILES Clc1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	608	n/a	n/a	n/a	n/a	7.5	30
Pfizer					Assay Description The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...				J Med Chem 50: 2647-54 (2007) Article DOI: 10.1021/jm0611004 BindingDB Entry DOI: 10.7270/Q2794313
Pfizer					More data for this Ligand-Target Pair