Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50073956 (CHEMBL85567 | {5-Aminomethyl-2-[2-((S)-9-chloro-2,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Pharmaceuticals Co., Ltd Curated by ChEMBL | Assay Description Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-... | J Med Chem 46: 691-701 (2003) Article DOI: 10.1021/jm020239l BindingDB Entry DOI: 10.7270/Q2G44PP3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215294 (2-(N-(6-chloro-7-methyl-2,3-dioxo-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038171 (7-Chloro-4-hydroxy-3-[3-(thiophen-3-yloxy)-phenyl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50123792 (3-[(4-Aminomethyl-2-carboxymethyl-phenylcarbamoyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Pharmaceuticals Co., Ltd Curated by ChEMBL | Assay Description Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-... | J Med Chem 46: 691-701 (2003) Article DOI: 10.1021/jm020239l BindingDB Entry DOI: 10.7270/Q2G44PP3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038168 (7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Urbino Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor... | J Med Chem 41: 808-20 (1998) Article DOI: 10.1021/jm970416w BindingDB Entry DOI: 10.7270/Q2QZ293M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038168 (7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace [3H]-L-689,560 from rat cortical membrane | Bioorg Med Chem Lett 5: 2089-2092 (1995) Article DOI: 10.1016/0960-894X(95)00374-3 BindingDB Entry DOI: 10.7270/Q2HX1CMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038168 (7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038168 (7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membrane... | J Med Chem 40: 754-65 (1997) Article DOI: 10.1021/jm9605492 BindingDB Entry DOI: 10.7270/Q2J67G1J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215284 (2-(N-(7-chloro-6-methyl-2,3-dioxo-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215283 (2-(N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroqui...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50041466 (7-Chloro-4-hydroxy-3-[3-(4-methoxymethoxy-benzyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50041468 (7-Chloro-4-hydroxy-3-(3-thiophen-3-ylmethyl-phenyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50123790 (3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Pharmaceuticals Co., Ltd Curated by ChEMBL | Assay Description Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-... | J Med Chem 46: 691-701 (2003) Article DOI: 10.1021/jm020239l BindingDB Entry DOI: 10.7270/Q2G44PP3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50035373 (7-Chloro-2-(4-methoxy-phenyl)-3,5-dihydro-2H-pyraz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]-3 binding to the glycine site on the NMDA receptor in Rat cortical slices | J Med Chem 38: 2239-43 (1995) BindingDB Entry DOI: 10.7270/Q2125RQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215282 (CHEMBL429296 | N-(6-chloro-7-methyl-2,3-dioxo-1,2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005075 ((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50041464 (3-(3-Benzyl-phenyl)-7-chloro-4-hydroxy-1H-quinolin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50041465 (7-Chloro-4-hydroxy-3-[3-(4-methoxy-benzyl)-phenyl]...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes | J Med Chem 37: 1402-5 (1994) BindingDB Entry DOI: 10.7270/Q2DF6Q8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50056605 (7-Chloro-6-methyl-5-nitro-1,4-dihydro-quinoxaline-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys Inc. Curated by ChEMBL | Assay Description Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ... | J Med Chem 40: 730-8 (1997) Article DOI: 10.1021/jm960654b BindingDB Entry DOI: 10.7270/Q2NZ86RJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50073922 (CHEMBL86313 | {(S)-1-[(7-Bromo-2,3-dioxo-1,2,3,4-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University Hospital Zurich Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin... | Bioorg Med Chem Lett 10: 75-8 (2000) BindingDB Entry DOI: 10.7270/Q2M907WV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005072 (5,7-Dichloro-4-(3-p-tolyl-ureido)-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50091637 (5-(3-(4-benzylpiperidin-1-yl)prop-1-ynyl)-1H-benzo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes | J Med Chem 43: 3408-19 (2000) BindingDB Entry DOI: 10.7270/Q2VH5N26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50038161 (6,7-Dichloro-3-hydroxy-5-nitro-3,4-dihydro-1H-quin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys Inc. Curated by ChEMBL | Assay Description Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ... | J Med Chem 40: 730-8 (1997) Article DOI: 10.1021/jm960654b BindingDB Entry DOI: 10.7270/Q2NZ86RJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005044 ((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Urbino Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor... | J Med Chem 41: 808-20 (1998) Article DOI: 10.1021/jm970416w BindingDB Entry DOI: 10.7270/Q2QZ293M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50084064 (CHEMBL167952 | {(S)-1-[(7-Chloro-2,3-dioxo-1,2,3,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University Hospital Zurich Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin... | Bioorg Med Chem Lett 10: 75-8 (2000) BindingDB Entry DOI: 10.7270/Q2M907WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005055 (7-Chloro-5-iodo-4-(3-phenyl-ureido)-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005044 ((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50091635 (5-{3-[4-(3-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes | J Med Chem 43: 3408-19 (2000) BindingDB Entry DOI: 10.7270/Q2VH5N26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069471 (CHEMBL357190 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50052635 (5,6,7-Trichloro-1H-quinoline-2,3,4-trione 3-oxime ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys Inc. Curated by ChEMBL | Assay Description Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | J Med Chem 39: 3248-55 (1996) Article DOI: 10.1021/jm960214k BindingDB Entry DOI: 10.7270/Q2QC02KC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005086 (5,7-Dichloro-4-(3-o-tolyl-ureido)-1,2,3,4-tetrahyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005075 ((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50123796 (3-[(2-Carboxymethyl-phenylcarbamoyl)-methyl]-7-chl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Pharmaceuticals Co., Ltd Curated by ChEMBL | Assay Description Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-... | J Med Chem 46: 691-701 (2003) Article DOI: 10.1021/jm020239l BindingDB Entry DOI: 10.7270/Q2G44PP3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005075 ((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Urbino Curated by ChEMBL | Assay Description Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor... | J Med Chem 41: 808-20 (1998) Article DOI: 10.1021/jm970416w BindingDB Entry DOI: 10.7270/Q2QZ293M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50073930 (CHEMBL82963 | {(S)-1-[(2,3-Dioxo-7-trifluoromethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
University Hospital Zurich Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin... | Bioorg Med Chem Lett 10: 75-8 (2000) BindingDB Entry DOI: 10.7270/Q2M907WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50084062 (CHEMBL354295 | {(S)-1-[(7-Iodo-2,3-dioxo-1,2,3,4-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
University Hospital Zurich Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin... | Bioorg Med Chem Lett 10: 75-8 (2000) BindingDB Entry DOI: 10.7270/Q2M907WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215286 (CHEMBL399275 | N-(6,7-dichloro-2,3-dioxo-1,2,3,4-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50215286 (CHEMBL399275 | N-(6,7-dichloro-2,3-dioxo-1,2,3,4-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human NMDA NR1 receptor | Bioorg Med Chem Lett 17: 4599-603 (2007) Article DOI: 10.1016/j.bmcl.2007.05.083 BindingDB Entry DOI: 10.7270/Q2QR4WTR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50091636 (5-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-prop-1-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description Concentration required for 50% Inhibition of responses at cloned NR1A/2AB NMDA expressed in Xenopus oocytes | J Med Chem 43: 3408-19 (2000) BindingDB Entry DOI: 10.7270/Q2VH5N26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50056596 (7-Bromo-6-methyl-5-nitro-1,4-dihydro-quinoxaline-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys Inc. Curated by ChEMBL | Assay Description Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain ... | J Med Chem 40: 730-8 (1997) Article DOI: 10.1021/jm960654b BindingDB Entry DOI: 10.7270/Q2NZ86RJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50000663 ((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 6.9 | n/a |
Medical University of Lublin Curated by ChEMBL | Assay Description Antagonist activity at NR1/2B receptor (unknown origin) expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method | J Med Chem 51: 3765-76 (2008) Article DOI: 10.1021/jm7011694 BindingDB Entry DOI: 10.7270/Q21Z447W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (Homo sapiens (Human)) | BDBM50084063 (CHEMBL162675 | {(S)-1-[(7-Fluoro-2,3-dioxo-1,2,3,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
University Hospital Zurich Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin... | Bioorg Med Chem Lett 10: 75-8 (2000) BindingDB Entry DOI: 10.7270/Q2M907WV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069458 (CHEMBL147895 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069482 (CHEMBL357916 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069465 (CHEMBL343863 | Thiophene-2-carboxylic acid (7-brom...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005047 (7-Chloro-5-iodo-4-phenylacetylamino-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069483 (CHEMBL356281 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069495 (CHEMBL147894 | N-(7-Chloro-2,3-dioxo-1,2,3,4-tetra...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50069459 (CHEMBL413125 | Thiophene-3-carboxylic acid (7-brom...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG Curated by ChEMBL | Assay Description In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptors | Bioorg Med Chem Lett 8: 493-8 (1999) BindingDB Entry DOI: 10.7270/Q29G5NBG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50005053 ((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes. | J Med Chem 35: 1954-68 (1992) BindingDB Entry DOI: 10.7270/Q2T72GCZ | |||||||||||
More data for this Ligand-Target Pair |
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