Affinity Data by PubMed id=11459668

PubMed code 11459668

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102217 (3-[5-(4-Fluoro-phenylcarbamoyl)-1-oxy-pyridine-2-s...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102229 (6-Benzenesulfonyl-N-(4-fluoro-phenyl)-1-oxy-nicoti...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102225 (CHEMBL39740 \| N'-(3-[2,2']Bithiophenyl-5-yl-6,7-di...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Compound binding was evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human C-X-C chem...				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102216 (6-Ethanesulfonyl-N-(4-fluoro-phenyl)-1-oxy-nicotin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102219 (CHEMBL61835 \| N-(4-Fluoro-phenyl)-6-methanesulfony...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102226 (CHEMBL58619 \| N-(4-Fluoro-phenyl)-1-oxy-6-phenylme...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102218 (CHEMBL61655 \| N-(4-Fluoro-phenyl)-1-oxy-6-(propane...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102230 (6-Cyclopentanesulfonyl-N-(4-fluoro-phenyl)-1-oxy-n...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102221 (6-Chloro-N-(4-fluoro-phenyl)-1-oxy-nicotinamide \| ...) Show SMILES [O-][n+]1cc(ccc1Cl)C(=O)Nc1ccc(F)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102223 (6-Chloro-N-(4-methoxy-phenyl)-1-oxy-nicotinamide \|...) Show SMILES COc1ccc(NC(=O)c2ccc(Cl)[n+]([O-])c2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102215 (6-Chloro-N-(2-hydroxy-phenyl)-1-oxy-nicotinamide \|...) Show SMILES Oc1ccccc1NC(=O)c1ccc(Cl)[n+]([O-])c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102214 (6-Chloro-N-(4-fluoro-benzyl)-1-oxy-nicotinamide \| ...) Show SMILES [O-][n+]1cc(ccc1Cl)C(=O)NCc1ccc(F)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102224 (6-Chloro-N-(4-iodo-phenyl)-1-oxy-nicotinamide \| CH...) Show SMILES [O-][n+]1cc(ccc1Cl)C(=O)Nc1ccc(I)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102220 (CHEMBL293139 \| N-(4-tert-Butyl-phenyl)-6-chloro-1-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102227 (6-Chloro-N-cyclohexyl-1-oxy-nicotinamide \| CHEMBL6...) Show SMILES [O-][n+]1cc(ccc1Cl)C(=O)NC1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50102228 (CHEMBL60578 \| N-Benzhydryl-6-chloro-1-oxy-nicotina...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Evaluated using an SPA assay with recombinant human [125I]-IL-8 and membranes preparedfrom Sf9 cells expressing human CXCR2				Bioorg Med Chem Lett 11: 1951-4 (2001) BindingDB Entry DOI: 10.7270/Q2TX3DN0
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%