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USPatent US10189845

Compile Data Set for Download or QSAR

Found 867 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325456
PNG
(US10189845, Example 118 | US10730880, Example 121 ...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CC[C@H](O)CC1 |r,wD:27.31,(.79,4.45,;-.3,3.36,;-1.78,3.76,;-2.18,5.25,;-1.09,6.34,;-2.87,2.67,;-2.4,1.21,;-3.64,.3,;-4.89,1.21,;-4.41,2.67,;-3.64,-1.24,;-2.31,-2.01,;-2.31,-3.55,;-3.64,-4.32,;-4.98,-3.55,;-6.44,-4.03,;-7.35,-2.78,;-6.44,-1.53,;-4.98,-2.01,;-.97,-4.32,;-.97,-5.86,;.49,-6.34,;1.4,-5.09,;.49,-3.84,;2.88,-4.69,;3.28,-3.2,;4.77,-2.81,;5.86,-3.89,;7.35,-3.5,;5.46,-5.38,;3.97,-5.78,)|
Show InChI InChI=1S/C23H29N7O/c1-3-18(4-2)28-14-17(12-26-28)23-22-9-10-24-30(22)15-21(27-23)16-11-25-29(13-16)19-5-7-20(31)8-6-19/h9-15,18-20,31H,3-8H2,1-2H3/t19?,20-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325499
PNG
(US10189845, Example 161 | US10730880, Example 161 ...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)|
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325543
PNG
(US10189845, Example 205A | US10189845, Example 206...)
Show SMILES CCC(CC1CC1)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1 |r|
Show InChI InChI=1S/C22H27N7O2/c1-2-18(7-15-3-4-15)28-11-17(9-25-28)22-21-5-6-23-29(21)13-20(26-22)16-8-24-27(10-16)12-19(31)14-30/h5-6,8-11,13,15,18-19,30-31H,2-4,7,12,14H2,1H3/t18?,19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325385
PNG
(3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...)
Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325422
PNG
((S)-2-(4-(4-(1-(sec- butyl)-1H-pyrazol-4- yl)pyraz...)
Show SMILES CC[C@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO |r|
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)24-9-15(7-21-24)19-18-4-5-20-26(18)10-17(23-19)14-6-22-25(8-14)16(11-27)12-28/h4-10,13,16,27-28H,3,11-12H2,1-2H3/t13-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325513
PNG
((R)-2-hydroxy-1-(3-(4-(4-(1-(pentan-3-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)[C@@H](C)O |r|
Show InChI InChI=1S/C23H28N8O2/c1-4-18(5-2)29-11-17(9-26-29)22-21-6-7-24-31(21)14-20(27-22)16-8-25-30(10-16)19-12-28(13-19)23(33)15(3)32/h6-11,14-15,18-19,32H,4-5,12-13H2,1-3H3/t15-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325423
PNG
((R)-2-(4-(4-(1-(sec- butyl)-1H-pyrazol-4- yl)pyraz...)
Show SMILES CC[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO |r|
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)24-9-15(7-21-24)19-18-4-5-20-26(18)10-17(23-19)14-6-22-25(8-14)16(11-27)12-28/h4-10,13,16,27-28H,3,11-12H2,1-2H3/t13-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325514
PNG
(2-hydroxy-2-methyl-1-(3- (4-(4-(1-(pentan-3-yl)- 1...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C(C)(C)O
Show InChI InChI=1S/C24H30N8O2/c1-5-18(6-2)30-12-17(10-27-30)22-21-7-8-25-32(21)15-20(28-22)16-9-26-31(11-16)19-13-29(14-19)23(33)24(3,4)34/h7-12,15,18-19,34H,5-6,13-14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325369
PNG
(1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H30N8O/c1-4-20(5-2)30-15-19(13-27-30)24-23-6-9-25-32(23)16-22(28-24)18-12-26-31(14-18)21-7-10-29(11-8-21)17(3)33/h6,9,12-16,20-21H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325351
PNG
(3-(4-(4-(1-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CS(=O)(=O)C1
Show InChI InChI=1S/C20H23N7O2S/c1-3-16(4-2)25-10-15(8-23-25)20-19-5-6-21-27(19)11-18(24-20)14-7-22-26(9-14)17-12-30(28,29)13-17/h5-11,16-17H,3-4,12-13H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325500
PNG
((1s,3s)-1-methyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@](C)(O)C1 |r,wU:26.31,wD:26.30,(.46,9.04,;-.31,7.71,;.46,6.38,;2,6.38,;2.77,7.71,;-.31,5.04,;.17,3.58,;-1.08,2.67,;-2.33,3.58,;-1.85,5.04,;-1.08,1.13,;.25,.36,;.25,-1.18,;-1.08,-1.95,;-2.41,-1.18,;-3.88,-1.65,;-4.78,-.41,;-3.88,.84,;-2.41,.36,;1.59,-1.95,;3.05,-1.47,;3.96,-2.72,;3.05,-3.96,;1.59,-3.49,;3.45,-5.45,;4.78,-6.22,;4.01,-7.56,;3.24,-8.89,;4.41,-9.04,;2.68,-6.79,)|
Show InChI InChI=1S/C22H27N7O/c1-4-17(5-2)27-13-16(11-25-27)21-20-6-7-23-29(20)14-19(26-21)15-10-24-28(12-15)18-8-22(3,30)9-18/h6-7,10-14,17-18,30H,4-5,8-9H2,1-3H3/t18?,22-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325372
PNG
(N-methyl-4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol- 4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)NC
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)31-15-18(13-28-31)23-22-6-9-26-33(22)16-21(29-23)17-12-27-32(14-17)20-7-10-30(11-8-20)24(34)25-3/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3,(H,25,34)
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325385
PNG
(3-(4-(6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- ...)
Show SMILES CCC(CCO)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C18H21N7O/c1-3-15(5-7-26)24-11-14(9-21-24)18-17-4-6-19-25(17)12-16(22-18)13-8-20-23(2)10-13/h4,6,8-12,15,26H,3,5,7H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325455
PNG
(2-methyl-1-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)O)c1
Show InChI InChI=1S/C21H27N7O/c1-5-17(6-2)27-12-16(10-24-27)20-19-7-8-22-28(19)13-18(25-20)15-9-23-26(11-15)14-21(3,4)29/h7-13,17,29H,5-6,14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325470
PNG
(US10189845, Example 132A | US10189845, Example 133...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H]1C[C@H](O)[C@H](O)C1 |r|
Show InChI InChI=1S/C22H27N7O2/c1-3-16(4-2)27-12-15(10-25-27)22-19-5-6-23-29(19)13-18(26-22)14-9-24-28(11-14)17-7-20(30)21(31)8-17/h5-6,9-13,16-17,20-21,30-31H,3-4,7-8H2,1-2H3/t17-,20+,21-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325375
PNG
(6-(1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N8O2S/c1-4-17(5-2)27-11-16(9-24-27)21-20-6-7-22-29(20)14-19(25-21)15-8-23-28(10-15)18-12-26(13-18)32(3,30)31/h6-11,14,17-18H,4-5,12-13H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325466
PNG
((R)-2-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CNCCO2)c1 |r|
Show InChI InChI=1S/C22H28N8O/c1-3-18(4-2)29-13-17(10-26-29)22-21-5-6-24-30(21)15-20(27-22)16-9-25-28(12-16)14-19-11-23-7-8-31-19/h5-6,9-10,12-13,15,18-19,23H,3-4,7-8,11,14H2,1-2H3/t19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325466
PNG
((R)-2-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CNCCO2)c1 |r|
Show InChI InChI=1S/C22H28N8O/c1-3-18(4-2)29-13-17(10-26-29)22-21-5-6-24-30(21)15-20(27-22)16-9-25-28(12-16)14-19-11-23-7-8-31-19/h5-6,9-10,12-13,15,18-19,23H,3-4,7-8,11,14H2,1-2H3/t19-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325478
PNG
((R)-1-(2-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CC[C@@H](O)C2)c1 |r|
Show InChI InChI=1S/C23H30N8O/c1-3-19(4-2)30-14-18(12-26-30)23-22-5-7-24-31(22)16-21(27-23)17-11-25-29(13-17)10-9-28-8-6-20(32)15-28/h5,7,11-14,16,19-20,32H,3-4,6,8-10,15H2,1-2H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325478
PNG
((R)-1-(2-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CC[C@@H](O)C2)c1 |r|
Show InChI InChI=1S/C23H30N8O/c1-3-19(4-2)30-14-18(12-26-30)23-22-5-7-24-31(22)16-21(27-23)17-11-25-29(13-17)10-9-28-8-6-20(32)15-28/h5,7,11-14,16,19-20,32H,3-4,6,8-10,15H2,1-2H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325480
PNG
((S)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@H]2CCN(C)C2=O)c1 |r|
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325481
PNG
((R)-1-methyl-3-((2-(4-(4-(1- (pentan-3-yl)-1H-pyra...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN[C@@H]2CCN(C)C2=O)c1 |r|
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)32-15-18(13-28-32)23-22-6-8-26-33(22)16-21(29-23)17-12-27-31(14-17)11-9-25-20-7-10-30(3)24(20)34/h6,8,12-16,19-20,25H,4-5,7,9-11H2,1-3H3/t20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325492
PNG
(US10189845, Example 154B | US10730880, Example 154...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1CCC[C@@H]1O |r|
Show InChI InChI=1S/C22H27N7O/c1-3-17(4-2)27-13-16(11-24-27)22-20-8-9-23-29(20)14-18(26-22)15-10-25-28(12-15)19-6-5-7-21(19)30/h8-14,17,19,21,30H,3-7H2,1-2H3/t19-,21-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325493
PNG
(US10189845, Example 155A | US10730880, Example 155...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@H](C)O |r|
Show InChI InChI=1S/C21H27N7O/c1-5-18(6-2)27-12-17(10-24-27)21-20-7-8-22-28(20)13-19(25-21)16-9-23-26(11-16)14(3)15(4)29/h7-15,18,29H,5-6H2,1-4H3/t14-,15-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325497
PNG
(US10189845, Example 159A | US11028093, Example 159)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H]1COC[C@H]1O |r|
Show InChI InChI=1S/C21H25N7O2/c1-3-16(4-2)26-10-15(8-23-26)21-18-5-6-22-28(18)11-17(25-21)14-7-24-27(9-14)19-12-30-13-20(19)29/h5-11,16,19-20,29H,3-4,12-13H2,1-2H3/t19-,20-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325499
PNG
(US10189845, Example 161 | US10730880, Example 161 ...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)|
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325509
PNG
((1r,3r)-N-(2-hydroxyethyl)-3-(4-(4-(1-(pentan-3-yl...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@@H](C1)C(=O)NCCO |r,wU:26.32,wD:24.27,(-4.07,7.21,;-4.84,5.88,;-4.07,4.55,;-2.53,4.55,;-1.76,5.88,;-4.84,3.21,;-4.36,1.75,;-5.61,.84,;-6.85,1.75,;-6.38,3.21,;-5.61,-.7,;-4.27,-1.47,;-4.27,-3.01,;-5.61,-3.78,;-6.94,-3.01,;-8.4,-3.48,;-9.31,-2.24,;-8.4,-.99,;-6.94,-1.47,;-2.94,-3.78,;-2.94,-5.32,;-1.47,-5.79,;-.57,-4.55,;-1.47,-3.3,;.97,-4.55,;2.06,-5.64,;3.15,-4.55,;2.06,-3.46,;4.69,-4.55,;5.46,-3.21,;5.46,-5.88,;7,-5.88,;7.77,-7.21,;9.31,-7.21,)|
Show InChI InChI=1S/C24H30N8O2/c1-3-19(4-2)30-14-18(12-28-30)23-22-5-6-26-32(22)15-21(29-23)17-11-27-31(13-17)20-9-16(10-20)24(34)25-7-8-33/h5-6,11-16,19-20,33H,3-4,7-10H2,1-2H3,(H,25,34)/t16-,20-
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325520
PNG
(N,N-dimethyl-2-oxo-2-(3-(4-(4-(1-(pentan-3-yl)-1H-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C(=O)N(C)C
Show InChI InChI=1S/C24H29N9O2/c1-5-18(6-2)31-12-17(10-27-31)22-21-7-8-25-33(21)15-20(28-22)16-9-26-32(11-16)19-13-30(14-19)24(35)23(34)29(3)4/h7-12,15,18-19H,5-6,13-14H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325524
PNG
(2-amino-1-(3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)CN
Show InChI InChI=1S/C22H27N9O/c1-3-17(4-2)29-11-16(9-26-29)22-20-5-6-24-31(20)14-19(27-22)15-8-25-30(10-15)18-12-28(13-18)21(32)7-23/h5-6,8-11,14,17-18H,3-4,7,12-13,23H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325525
PNG
(2-(methylamino)-1-(3-(4-(4-(1-(pentan-3-yl)-1H-pyr...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)CNC
Show InChI InChI=1S/C23H29N9O/c1-4-18(5-2)30-12-17(9-27-30)23-21-6-7-25-32(21)15-20(28-23)16-8-26-31(11-16)19-13-29(14-19)22(33)10-24-3/h6-9,11-12,15,18-19,24H,4-5,10,13-14H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325529
PNG
(2,2-dimethyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(C)(C)CO)c1
Show InChI InChI=1S/C22H29N7O/c1-5-18(6-2)28-12-17(10-25-28)21-20-7-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(3,4)15-30/h7-13,18,30H,5-6,14-15H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325538
PNG
(US10189845, Example 200A | US10730880, Example 200...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CCO)c1 |r|
Show InChI InChI=1S/C21H27N7O2/c1-3-17(4-2)27-12-16(10-24-27)21-20-5-7-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(30)6-8-29/h5,7,9-12,14,17-18,29-30H,3-4,6,8,13H2,1-2H3/t18-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325546
PNG
(US10189845, Example 208B | US10730880, Example 208...)
Show SMILES CC[C@H]1CCC[C@H]1n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1 |r|
Show InChI InChI=1S/C22H27N7O2/c1-2-15-4-3-5-20(15)28-11-17(9-25-28)22-21-6-7-23-29(21)13-19(26-22)16-8-24-27(10-16)12-18(31)14-30/h6-11,13,15,18,20,30-31H,2-5,12,14H2,1H3/t15-,18+,20+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325550
PNG
(US10189845, Example 212B)
Show SMILES CC[C@@H](CC(F)(F)F)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO |r|
Show InChI InChI=1S/C20H22F3N7O2/c1-2-15(5-20(21,22)23)28-9-14(7-26-28)19-18-3-4-24-30(18)10-17(27-19)13-6-25-29(8-13)16(11-31)12-32/h3-4,6-10,15-16,31-32H,2,5,11-12H2,1H3/t15-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325345
PNG
(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCCS(C)(=O)=O)c1
Show InChI InChI=1S/C21H27N7O2S/c1-4-18(5-2)27-14-17(12-24-27)21-20-7-8-22-28(20)15-19(25-21)16-11-23-26(13-16)9-6-10-31(3,29)30/h7-8,11-15,18H,4-6,9-10H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325347
PNG
(N-methyl-N-(2-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-4...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN(C)S(C)(=O)=O)c1
Show InChI InChI=1S/C21H28N8O2S/c1-5-18(6-2)28-14-17(12-24-28)21-20-7-8-22-29(20)15-19(25-21)16-11-23-27(13-16)10-9-26(3)32(4,30)31/h7-8,11-15,18H,5-6,9-10H2,1-4H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325349
PNG
(4-((4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC2CCS(=O)(=O)CC2)c1
Show InChI InChI=1S/C23H29N7O2S/c1-3-20(4-2)29-15-19(12-26-29)23-22-5-8-24-30(22)16-21(27-23)18-11-25-28(14-18)13-17-6-9-33(31,32)10-7-17/h5,8,11-12,14-17,20H,3-4,6-7,9-10,13H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM325353
PNG
((S)-2-methyl-3-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](C)CO)c1 |r|
Show InChI InChI=1S/C21H27N7O/c1-4-18(5-2)27-12-17(9-24-27)21-20-6-7-22-28(20)13-19(25-21)16-8-23-26(11-16)10-15(3)14-29/h6-9,11-13,15,18,29H,4-5,10,14H2,1-3H3/t15-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM325358
PNG
(2-(4-(4-(l-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C19H23N7O/c1-3-16(4-2)25-12-15(10-22-25)19-18-5-6-20-26(18)13-17(23-19)14-9-21-24(11-14)7-8-27/h5-6,9-13,16,27H,3-4,7-8H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325358
PNG
(2-(4-(4-(l-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C19H23N7O/c1-3-16(4-2)25-12-15(10-22-25)19-18-5-6-20-26(18)13-17(23-19)14-9-21-24(11-14)7-8-27/h5-6,9-13,16,27H,3-4,7-8H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325363
PNG
(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)-6-(1-(piperidi...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H28N8/c1-3-18(4-2)28-14-17(12-26-28)22-21-7-10-24-30(21)15-20(27-22)16-11-25-29(13-16)19-5-8-23-9-6-19/h7,10-15,18-19,23H,3-6,8-9H2,1-2H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325365
PNG
((R)-4-(1-(pentan-3-yl)- 1H-pyrazol-4-yl)-6-(1- (py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CCCN2)c1 |r|
Show InChI InChI=1S/C22H28N8/c1-3-19(4-2)29-13-17(11-26-29)22-21-7-9-24-30(21)15-20(27-22)16-10-25-28(12-16)14-18-6-5-8-23-18/h7,9-13,15,18-19,23H,3-6,8,14H2,1-2H3/t18-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM325375
PNG
(6-(1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N8O2S/c1-4-17(5-2)27-11-16(9-24-27)21-20-6-7-22-29(20)14-19(25-21)15-8-23-28(10-15)18-12-26(13-18)32(3,30)31/h6-11,14,17-18H,4-5,12-13H2,1-3H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM325389
PNG
((2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]...)
Show SMILES Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)C1CCCC1CO
Show InChI InChI=1S/C19H21N7O/c1-24-9-14(7-21-24)16-11-26-18(5-6-20-26)19(23-16)15-8-22-25(10-15)17-4-2-3-13(17)12-27/h5-11,13,17,27H,2-4,12H2,1H3
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Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...

US Patent US10189845 (2019)


BindingDB Entry DOI: 10.7270/Q2Z03B7Q
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 867 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%