332 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28259626	90	Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.	University of Applied Sciences Darmstadt
15149697	10	Thiol-based SAHA analogues as potent histone deacetylase inhibitors.	Nagoya City University
15109664	4	Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.	The University of Tokyo
15109636	14	Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.	University College London
14643318	23	Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.	Nagoya City University
14592473	35	Heterocyclic ketones as inhibitors of histone deacetylase.	Abbott Laboratories
12270175	13	Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).	Abbott Laboratories
27377864	55	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.	Broad Institute of Mit and Harvard
27186676	186	Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.	West China Hospital of Sichuan University
27142751	22	Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.	China Pharmaceutical University
26996372	10	Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.	Sungkyunkwan University
26890116	30	Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.	University of Milan
26819662	13	Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.	Biofocus
27060764	30	Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.	Sungkyunkwan University
26443078	108	Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.	Sichuan University
26890114	56	Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.	Shanghai Institute of Materia Medica
26814680	71	Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.	Shenyang Pharmaceutical University
26706171	138	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Shenyang Pharmaceutical University
26689485	18	Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.	Orchid Chemicals & Pharmaceuticals
26741358	56	Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.	China Pharmaceutical University
26629860	58	Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.	European Institute of Oncology
26753813	22	Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.	University of Minnesota
26639764	17	Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.	Wroclaw University of Technology
26475519	40	Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.	China Pharmaceutical University
26241876	1	Triazine as a promising scaffold for its versatile biological behavior.	Thapar University
26331334	99	Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.	Guangzhou Institute of Biomedicine and Health
26086931	38	Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.	Shandong University
26264503	46	Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.	University of Minnesota
26287310	87	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.	University College London
25637120	94	Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).	St. Jude Children'S Research Hospital
22344701	30	Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).	Novartis Institutes For Biomedical Research
25147612	25	Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.	University of Florida
26035239	1	Natural Product Primary Sulfonamides and Primary Sulfamates.	Griffith University
25906087	14	Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.	Shandong University
25905694	24	Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.	Istituto Ortopedico Rizzoli (Ior)
25811792	32	Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.	Yonsei University
25800646	40	Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.	Central South University
25113875	14	Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.	Taipei Medical University
25022972	24	Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.	University of Rajshahi
24999749	1	A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.	University of Oklahoma
24997578	41	Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.	University of Rajshahi
24972008	36	1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.	Sapienza University of Rome
24864038	112	Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.	Nippon Pharmaceutical Chemicals
25462271	33	Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.	Shandong University
25455492	22	Aurones as histone deacetylase inhibitors: identification of key features.	University of Geneva
25454270	82	Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.	TBA
25238284	52	Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.	Roche Pharmaceutical Research and Early Development
25233084	247	ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25221651	12	Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.	University of Bologna
25218912	103	Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.	Chinese Academy of Sciences
25176189	7	Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.	Csir-Indian Institute of Integrative Medicine
24900838	30	Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.	Merck Research Laboratories
24588105	56	Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.	Universit£
24565573	35	4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.	Universit£
24742384	90	Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.	Universit£
24694055	35	Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.	Shandong University
17196388	12	Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.	Sapienza University of Rome
24015327	42	Development of a chimeric c-Src kinase and HDAC inhibitor.	University of Michigan
23368884	80	Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.	Broad Institute of Mit and Harvard
23252603	35	Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.	Heinrich Heine Universit£T
23116147	30	Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.	Kyoto Prefectural University of Medicine
23061376	63	Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.	Roche R & D Center China
23009203	39	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.	University of Illinois At Chicago
23021104	32	Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.	Graduate School of Life Science and Systems Engineering
22642300	160	Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.	Kyoto Prefectural University of Medicine
22541394	30	Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.	Guru Ghasidas University
21984958	83	Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR.	TBA
21874153	54	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	Broad Institute of Harvard and Mit
18809328	64	Optimization of a series of potent and selective ketone histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
17956988	14	Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.	Istituto Di Ricerche Di Biologia Molecolare
18397826	18	Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.	Waseda University
18381238	4	Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.	Sapienza University of Rome
18182289	127	Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18247554	134	Histone deacetylase inhibitors: from bench to clinic.	Menarini Ricerche
16987657	45	A series of novel, potent, and selective histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
15454224	15	Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.	Crest Research Project
14613312	106	Histone deacetylase inhibitors.	Aton Pharma
14584932	23	Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.	Sapienza University of Rome
11206439	51	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.	Merck Research Laboratories
11206438	48	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.	Merck Research Laboratories
21417419	5	Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Dac
21548582	57	Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.	University of Illinois At Chicago
21875805	5	Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.	Drexel University
21793558	39	Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.	University of Wisconsin-Milwaukee
21634430	218	Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.	S*Bio
21712146	20	Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.	Taipei Medical University
21696956	243	A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.	Broad Institute of Harvard and Mit
21417297	220	Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.	Universita` Degli Studi Di Siena
21256006	11	Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.	Yonsei University
21073160	143	Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity	TBA
19966789	40	Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.	The Scripps Research Institute
20491440	12	Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.	Universidade De Vigo
20451378	107	Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.	S*Bio
20381359	17	Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.	Universit£
20205394	44	Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).	Novartis Institutes For Biomedical Research
20045316	18	Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.	Graduate School of Life Science and Systems Engineering
20143778	70	Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.	Curis
19906529	22	Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.	Ortho-Biotech Oncology Research & Development
19822426	4	Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.	China Pharmaceutical University
19699639	58	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.	Methylgene
19359173	51	Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.	Sigma-Tau Research and Development
19410459	33	Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.	Irbm/Merck Research Laboratories
19285395	66	N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.	R&D Sigma-Tau
19268585	30	Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).	Merck Research Laboratories
19181524	46	N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.	S*Bio
18951790	109	SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18930398	117	2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.	Irbm-Merck Research Laboratories Rome
18701301	38	Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.	China Pharmaceutical University
18672316	41	Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.	Institute of Organic Synthesis
18060775	67	Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).	Merck Research Laboratories
17900911	21	Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.	Graduate School of Life Science and Systems Engineering
17881232	42	Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.	Graduate School of Life Science and Systems Engineering
17588744	18	Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.	The University of Tokyo
17447750	4	Bispyridinium dienes: histone deacetylase inhibitors with selective activities.	Universidade De Vigo
16884291	12	Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.	Nagoya City University
16137884	6	Design and synthesis of phthalimide-type histone deacetylase inhibitors.	The University of Tokyo Yayoi
14698179	58	Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.	The Scripps Research Institute
14684344	49	(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.	Methylgene
32787077	23	Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.	Sichuan University
32676157	102	Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.	Merck
32631504	29	Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.	Sichuan University
32273215	16	Influence of side-chain changes on histone deacetylase inhibitory and cytotoxicity activities of curcuminoid derivatives.	Khon Kaen University
32247729	23	Environment-sensitive fluorescent inhibitors of histone deacetylase.	Shandong University
32672458	164	Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.	University of Toronto Mississauga
32435414	24	Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.	Sapienza University of Rome
30660827	70	Quinolone hybrids and their anti-cancer activities: An overview.	Qilu University of Technology (Shandong Academy of Sciences)
32435375	22	New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes.	Universidad San Pablo-Ceu
31787463	67	Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.	Heinrich-Heine-Universit£T D£Sseldorf
30594678	22	Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.	Jadavpur University
30879863	50	Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.	Shandong University
27774131	32	Development of a Potent and Selective HDAC8 Inhibitor.	Boston University
27614919	66	Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.	University of Connecticut
27460171	44	Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.	Shenyang Pharmaceutical University
30597327	32	A novel class of anthraquinone-based HDAC6 inhibitors.	Keimyung University
30245394	363	HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.	Indian Csir-Central Drug Research Institute
30629434	64	Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.	TBA
31630054	335	Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.	University of Applied Sciences
32212730	206	Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.	National Center For Advancing Translational Sciences
30735902	69	Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides.	Jadavpur University
31431326	63	Novel ?,?-unsaturated hydroxamic acid derivatives overcome cisplatin resistance.	Heinrich-Heine-University D£Sseldorf
31223439	25	Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.	Umr Cnrs 7285
31103900	36	Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.	Beijing University of Chemical Technology
31400938	15	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.	Qingdao University
31003060	27	Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors.	Beijing University of Chemical Technology
31938464	93	Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.	University of Toronto Mississauga
31655430	56	N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.	Taipei Medical University
31561937	32	Recent advances in class IIa histone deacetylases research.	Heinrich-Heine-Universit£T D£Sseldorf
31177073	22	Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.	Sichuan University and Collaborative Innovation Center of Biotherapy
31855601	73	Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.	Chinese Academy of Sciences
31414801	84	Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.	University of Illinois At Chicago
30901208	96	Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.	Shandong University
32347094	10	Discovery of Novel Fungal Lanosterol 14?-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.	Second Military Medical University
32321249	138	Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.	Ocean University of China
32267687	37	Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.	Shandong University
32153186	118	Discovery of Thieno[2,3-	Sichuan University and Collaborative Innovation Center of Biotherapy
31536895	27	Indole: A privileged scaffold for the design of anti-cancer agents.	Hunan University of Science and Technology
30418766	35	Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.	Qingdao University
31762274	122	Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties.	Heinrich-Heine-Universit£T D£Sseldorf
30448419	74	Highly fluorescent and HDAC6 selective scriptaid analogues.	Deakin University
30366254	49	Identification of novel quinazoline derivatives as potent antiplasmodial agents.	Universit£
31050421	48	Overview of Recent Strategic Advances in Medicinal Chemistry.	Shandong University
31271281	9	Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.	Institute of Biotechnology of The Czech Academy of Sciences
31117517	103	Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.	TBA
30463802	54	Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.	Charles River Discovery (Previously Biofocus)
31413795	57	Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.	Shandong University
26588603	21	Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.	Mashhad University of Medical Sciences
26555243	45	Novel ?-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.	China Pharmaceutical University
24702857	28	Search for novel histone deacetylase inhibitors. Part II: design and synthesis of novel isoferulic acid derivatives.	Xi'An Jiaotong University
23997923	21	Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from	University of Wisconsin-Milwaukee
24405391	2	Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.	Wayne State University
24296013	3	Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors.	Nantong University
24164245	11	Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.	University of Connecticut
24119555	13	Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors.	Central South University
24095016	28	Development of novel ferulic acid derivatives as potent histone deacetylase inhibitors.	Xi'An Jiaotong University
23820574	89	Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).	China Pharmaceutical University
24900734	9	Histone Deacetylase 4 (HDAC4) Inhibitors: A Promising Treatment for Huntington's Disease.	Therachem Research Medilab (India)
23792316	40	Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring.	University of Florence
24900743	86	Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.	University of Connecticut
23768910	12	Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.	Menarini Ricerche
23707260	4	Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.	Shenyang Pharmaceutical University
23639537	9	Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors.	Central South University
23622981	25	Dual-acting histone deacetylase-topoisomerase I inhibitors.	Georgia Institute of Technology
22877635	6	Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.	Menarini Ricerche Pomezia
22435669	16	Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.	Nankai University
22326398	22	Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.	London School of Hygiene and Tropical Medicine
21978679	10	4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.	Menarini Ricerche Pomezia
21621883	18	Structure-based optimization of click-based histone deacetylase inhibitors.	Nankai University
21420859	7	Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.	Menarini Ricerche Pomezia
24900225	26	Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.	Menarini Ricerche
19223622	8	Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.	Georgetown University Medical Center
21067930	8	Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase.	Nanjing University
16921367	19	Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.	The Scripps Research Institute
20576572	15	New aryldithiolethione derivatives as potent histone deacetylase inhibitors.	Sulfidris
20167479	3	SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.	Pennsylvania State Hershey College of Medicine
20036560	5	Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.	Saga University
19914074	13	Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.	Georgia Institute of Technology
20017493	29	Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.	Congenia
19520580	17	Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.	Hacettepe University
19534534	3	Recent advances in the development of polyamine analogues as antitumor agents.	Johns Hopkins University
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14667227	8	Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.	In2Gen
14521422	41	N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).	Novartis Institute For Biomedical Research
11831887	34	Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.	TBA
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29150330	54	The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.	Wayne State University
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29549837	151	Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.	University of Navarra
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29348808	35	Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.	Second Military Medical University
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29776742	55	Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.	Forma Therapeutics
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28453994	118	Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.	Ghent University
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29304284	59	(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.	Taipei Medical University
29499113	77	Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.	Medical University of South Carolina
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27416889	35	Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.	Shandong University
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1554381	19	Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.	National Institutes of Diabetes and Digestive and Kidney Diseases
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17825569	48	The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.	Polish Academy of Sciences
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