The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28089347 |
6 |
Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database. |
Xiamen University |
27994765 |
95 |
Discovery of Highly Potent Liver X Receptorß Agonists. |
Bristol-Myers Squibb |
27326332 |
66 |
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist. |
Bristol-Myers Squibb |
27450787 |
2 |
Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site. |
Xiamen University |
27261179 |
11 |
Identification of potent and selective retinoic acid receptor gamma (RAR¿) antagonists for the treatment of osteoarthritis pain using structure based drug design. |
Eli Lilly |
26990539 |
79 |
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist. |
Vitae Pharmaceuticals |
26820900 |
11 |
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. |
University of Gothenburg |
26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
26331194 |
20 |
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. |
University of Alabama At Birmingham |
25815156 |
5 |
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists. |
Okayama University Graduate School of Medicine |
24959987 |
2 |
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene. |
Aichi Gakuin University |
24831826 |
59 |
Small molecule inhibitors targeting activator protein 1 (AP-1). |
University of Texas Medical Branch |
25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
24801499 |
31 |
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. |
University of Alabama At Birmingham |
23434637 |
10 |
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation. |
Xiamen University |
23391145 |
7 |
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency. |
Okayama University Graduate School of Medicine |
23472886 |
21 |
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. |
Purdue University |
22712432 |
5 |
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. |
The University of Illinois At Chicago |
24900488 |
1 |
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists. |
TBA |
21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research and Development |
18690216 |
5 |
Cytosporone B is an agonist for nuclear orphan receptor Nur77. |
Xiamen University |
24900241 |
15 |
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers. |
TBA |
20667726 |
3 |
Fluorescent retinoid X receptor ligands for fluorescence polarization assay. |
Okayama University |
20656484 |
3 |
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation. |
Okayama University |
20695472 |
1 |
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. |
Aichi Gakuin University |
20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
19791803 |
8 |
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). |
Arizona State University |
| 61 |
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands |
TBA |
| 99 |
Synthesis and structure-activity relationships of potent retinoid X receptor ligands |
TBA |
| 83 |
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere |
TBA |
| 31 |
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs |
TBA |
| 54 |
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids |
TBA |
| 35 |
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs |
TBA |
19095448 |
24 |
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. |
Okayama University Graduate School of Medicine |
17651969 |
96 |
Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure. |
Tsukuba Research Institute |
17651968 |
60 |
Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. |
Tsukuba Research Institute |
17490875 |
24 |
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia. |
Johnson and Johnson Pharmaceutical Research and Development |
17485209 |
14 |
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia. |
Johnson and Johnson Pharmaceutical Research and Development |
16364638 |
99 |
Aza-retinoids as novel retinoid X receptor-specific agonists. |
Ligand Pharmaceuticals |
16190748 |
10 |
Ligand recognition by RAR and RXR receptors: binding and selectivity. |
Universidad De Santiago De Compostela |
15317450 |
7 |
Determinants of retinoid X receptor transcriptional antagonism. |
Institute |
15125928 |
44 |
Design and synthesis of benzofused heterocyclic RXR modulators. |
Eli Lilly |
15056000 |
82 |
Structure-based design of potent retinoid X receptor alpha agonists. |
Glaxosmithkline |
15006411 |
126 |
Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
Ligand Pharmaceuticals |
14592510 |
150 |
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
Ligand Pharmaceuticals |
12951091 |
36 |
Design and synthesis of fluorinated RXR modulators. |
Eli Lilly |
12801232 |
71 |
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
Ligand Pharmaceuticals |
12482435 |
75 |
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid. |
Ligand Pharmaceuticals |
12182871 |
3 |
Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure. |
Universidade De Vigo |
12161154 |
11 |
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide. |
The Ohio State University |
11906293 |
7 |
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. |
Takeda Chemical Industries |
32356658 |
32 |
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?. |
Goethe-University Frankfurt |
11428923 |
39 |
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
Allergan |
32391701 |
2 |
Structure-Activity Relationship Study Enables the Discovery of a Novel |
Xiamen University |
30776227 |
38 |
Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold. |
Kyoto Prefectural University of Medicine |
27503683 |
12 |
Non-canonical modulators of nuclear receptors. |
Vitae Pharmaceuticals |
31160175 |
5 |
3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity. |
Okayama University Graduate School of Medicine |
27592633 |
13 |
Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN). |
Arizona State University |
30634084 |
4 |
Design, synthesis and biological evaluation of tetrazole-containing RXR? ligands as anticancer agents. |
Xiamen University |
31483660 |
20 |
Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening. |
Okayama University Graduate School of Medicine |
30702885 |
256 |
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. |
Goethe University Frankfurt |
10585206 |
45 |
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid. |
Università |
31940200 |
62 |
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. |
Genomics Institute of The Novartis Research Foundation (Gnf) |
10098670 |
24 |
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands. |
Allergan |
10052980 |
138 |
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells. |
Ligand Pharmaceuticals |
9733501 |
33 |
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. |
University of Oklahoma Health Sciences Center |
30783504 |
87 |
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype. |
Goethe-University Frankfurt |
9435893 |
46 |
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. |
University of Tokyo |
30594433 |
90 |
Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies. |
Inception Sciences |
31729873 |
43 |
Structure-Based and Property-Driven Optimization of |
Global Discovery Chemistry |
31038949 |
2 |
Cytotoxic Components from Hypericum elodeoides Targeting RXR? and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. |
Xiamen University |
8809153 |
60 |
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. |
University of Alabama At Birmingham |
8784454 |
76 |
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. |
Allergan |
31531208 |
46 |
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. |
Goethe-University Frankfurt |
8765503 |
39 |
Identification of the first retinoid X, receptor homodimer antagonist. |
Ligand Pharmaceuticals |
8709094 |
41 |
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. |
Ligand Pharmaceuticals |
26355531 |
7 |
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo. |
Ume£ |
25057340 |
2 |
Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site. |
Xiamen University |
8410972 |
52 |
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. |
Sri International |
8308867 |
72 |
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. |
Ligand Pharmaceuticals |
8071941 |
240 |
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. |
Ligand Pharmaceuticals |
23707260 |
4 |
Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay. |
Shenyang Pharmaceutical University |
23217961 |
2 |
Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids. |
Tohoku Pharmaceutical University |
7650690 |
64 |
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
Sri International |
7636877 |
96 |
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. |
Ligand Pharmaceuticals |
7636843 |
40 |
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
Allergan |
7608895 |
61 |
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity. |
University of Alabama At Birmingham |
7490725 |
9 |
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. |
Allergan |
30193216 |
12 |
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity. |
China Pharmaceutical University |
29288071 |
16 |
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist. |
King'S College |
29901398 |
29 |
Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. |
Swiss Federal Institute of Technology (Eth) |
28735214 |
54 |
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents. |
Janssen Research and Development |
28850227 |
85 |
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry. |
St. John'S University |
15016836 |
90 |
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. |
Georgetown University |
9479476 |
10 |
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. |
University of Texas Southwestern Medical Center |
19361210 |
44 |
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. |
Bristol-Myers Squibb |
11020282 |
512 |
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. |
Universita Degli Studi |