The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27997171 |
48 |
Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. |
The University of Newcastle |
| 2153204 |
6 |
Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules. |
Creighton University |
| 2709383 |
39 |
Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines. |
Anaquest Pharmaceuticals |
| 2536439 |
10 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist. |
University of Innsbruck |
| 3039139 |
3 |
X-ray crystal structure of the opioid ligand naltrexonazine. |
TBA |
| 3012085 |
3 |
Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity. |
TBA |
| 3009813 |
3 |
Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan. |
TBA |
| 3023609 |
14 |
Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. |
TBA |
| 2876106 |
6 |
3,7-Diazabicyclane: a new narcotic analgesic. |
TBA |
| 3020246 |
11 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. |
TBA |
| 2863378 |
7 |
Acylmorphinans. A novel class of potent analgesic agents. |
TBA |
| 2409280 |
35 |
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone. |
TBA |
| 2999399 |
4 |
Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. |
TBA |
| 6094809 |
32 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones. |
TBA |
| 6315939 |
2 |
14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone. |
TBA |
| 6600791 |
32 |
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties. |
TBA |
| 6288945 |
28 |
Potential affinity labels for the opiate receptor based on fentanyl and related compounds. |
TBA |
| 6276546 |
12 |
Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone. |
TBA |
| 6268789 |
22 |
Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
TBA |
| 6268786 |
27 |
Opiate receptor interaction of compounds derived from or structurally related to fentanyl. |
TBA |
| 6273560 |
16 |
Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan. |
TBA |
| 6249930 |
7 |
Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes. |
TBA |
| 6248644 |
4 |
Some spiro analogues of the potent analgesic ketobemidone. |
TBA |
| 26988801 |
55 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. |
Jagiellonian University Medical College |
| 26656913 |
85 |
Multitarget opioid ligands in pain relief: New players in an old game. |
University of Catania |
| 26491810 |
35 |
Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin. |
The University of Kansas |
| 25593096 |
65 |
Potency enhancement of theż-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. |
University of Kansas Specialized Chemistry Center |
| 25513968 |
21 |
Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies. |
Universit£ |
| 25221662 |
24 |
Novel cyclic biphalin analogue with improved antinociceptive properties. |
Universit£ |
| 23360448 |
18 |
Development of¿ opioid receptor antagonists. |
Research Triangle Institute |
| 22677527 |
38 |
Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors. |
University of Maryland |
| 18403056 |
8 |
Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
Universit£T Des Saarlandes |
| 18293909 |
5 |
Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. |
University of Minnesota |
| 16033285 |
24 |
Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency. |
University of Innsbruck |
| 12954070 |
24 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic. |
University of Innsbruck |
| 11300879 |
77 |
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides. |
Research Triangle Institute |
| 11300867 |
32 |
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus. |
University of Minnesota |
| 11405645 |
13 |
Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole. |
University of Minnesota |
| 10753461 |
13 |
Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function. |
University of Minnesota |
| 10841791 |
8 |
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. |
Universit£ |
| 9836606 |
12 |
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors. |
University of Minnesota |
| 9804688 |
51 |
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes. |
University of Minnesota |
| 9719602 |
24 |
3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy. |
University of Bristol |
| 2167979 |
43 |
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. |
Universit£ |
| 2536436 |
24 |
Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5. |
Smith Kline and French Laboratories |
| 2888899 |
34 |
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds. |
Istituto Superiore Di Sanit£ |
| 3007760 |
93 |
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
TBA |
| 10782696 |
67 |
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones. |
F. Hoffmann-La Roche |
| 11078198 |
12 |
N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
University of Maryland |
| 9873480 |
35 |
Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors. |
Institute For Bioorganic Research |
| | 17 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivity |
TBA |
| 20692738 |
34 |
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. |
Sapienza University of Rome |
| 20591666 |
66 |
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. |
Università |
| 20144865 |
18 |
Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. |
Kyorin Pharmaceutical |
| 19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj |
| 19807094 |
45 |
The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. |
University of Kansas |
| 19715279 |
20 |
Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. |
The University of Kansas |
| | 17 |
trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists |
TBA |
| | 35 |
Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic |
TBA |
| 17303418 |
8 |
Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. |
University of Mississippi |
| 15658846 |
13 |
Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. |
The University of Melbourne |
| 15163203 |
45 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime. |
University of Innsbruck |
| 14736254 |
70 |
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. |
Biological Research Center of The Hungarian Academy of Sciences |
| 14711314 |
63 |
Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3. |
University of Maryland |
| 12954053 |
39 |
Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2. |
University of Maryland |
| 12672238 |
3 |
Mechanism of action of the diazabicyclononanone-type kappa-agonists. |
UniversitäT WüRzburg |
| 12372527 |
27 |
Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin. |
Institute For Molecular Studies |
| 12161117 |
2 |
3-Pyrroline containing arylacetamides: a novel series of remarkably selective kappa-agonists. |
Chinese Academy of Sciences |
| 32199689 |
64 |
Design, synthesis, and biological activity of new endomorphin analogs with multi-site modifications. |
Lanzhou University |
| 32787075 |
163 |
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists. |
Astrazeneca |
| 30685525 |
34 |
Benzimidazolone-based selective ? |
University of Florida |
| 10893314 |
24 |
Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. |
University of Minnesota |
| 27624520 |
24 |
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain. |
University of Catania |
| 29939744 |
179 |
Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. |
Shanghaitech University |
| 31498617 |
29 |
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. |
Eisai |
| 9083489 |
30 |
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3. |
Hungarian Academy of Sciences |
| 8411007 |
392 |
Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. |
Mayo Foundation |
| 207868 |
36 |
Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines. |
TBA |
| 209186 |
19 |
Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin. |
TBA |
| 206698 |
2 |
Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone. |
TBA |
| 73588 |
5 |
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics. |
TBA |
| 218015 |
16 |
Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
TBA |
| 218012 |
12 |
Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
TBA |
| 109618 |
9 |
N-(2-Cyanoethyl) derivatives of meperidine, ketobemidone, and a potent 6,7-benzomorphan. |
TBA |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 7908696 |
45 |
Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. |
Searle |
| 6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 29273415 |
15 |
Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl). |
University of Kansas |
| 2153212 |
87 |
Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. |
Merck Sharp & Dohme Research Laboratories |
| 28314512 |
33 |
Modulation of opioid receptor affinity and efficacy via N-substitution of 9?-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study. |
National Institute On Drug Abuse and The National Institute On Alcohol Abuse |
| 1346276 |
25 |
Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. |
G.D. Searle And |
| 1323682 |
61 |
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor. |
Upjohn |
| 27128978 |
8 |
Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening. |
Icahn School of Medicine At Mount Sinai |
| 26032047 |
15 |
Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors. |
Cairo University |
| 7774675 |
35 |
Characterisation of melanocortin receptor subtypes by radioligand binding analysis. |
Uppsala |
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