The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28131714 |
119 |
Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-a/ß. |
Novartis Institutes For Biomedical Research |
| 1597853 |
2 |
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. |
National Cancer Institute-Frederick |
| 1992155 |
30 |
Design of potent protein kinase inhibitors using the bisubstrate approach. |
Ura Cnrs 1309 |
| 2342075 |
11 |
Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties. |
University of North Carolina |
| 11454465 |
4 |
Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication. |
Glaxosmithkline |
| 26762835 |
342 |
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). |
Icahn School of Medicine At Mount Sinai |
| 25662701 |
23 |
Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3ß inhibitors and neuroprotective agents. |
Zhejiang University |
| 25437619 |
88 |
Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones). |
Seoul National University |
| 25000588 |
72 |
Discovery of selective and orally bioavailable protein kinase C¿ (PKC¿) inhibitors from a fragment hit. |
Abbvie Bioresearch Center |
| 24939756 |
28 |
Strategies for the modulation of phase II metabolism in a series of PKCe inhibitors. |
Vertex Pharmaceuticals |
| 24794745 |
20 |
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. |
National Institute of Industrial Technology |
| 24712764 |
6 |
Thienoquinolines as novel disruptors of the PKCe/RACK2 protein-protein interaction. |
Innsbruck Medical University |
| 23394126 |
170 |
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). |
Exelixis |
| 23398373 |
88 |
Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases. |
Vertex Pharmaceuticals |
| 21251828 |
44 |
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. |
Msd |
| 23039927 |
44 |
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. |
Martin-Luther-University Halle-Wittenberg |
| 21797275 |
139 |
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis. |
Novartis Institutes For Biomedical Research |
| 21413800 |
56 |
A one-pot synthesis and biological activity of ageladine A and analogues. |
Macquarie University |
| 22078216 |
146 |
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes. |
Novartis Institutes For Biomedical Research |
| 22625994 |
28 |
Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity. |
Kyoto University |
| 22695126 |
98 |
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases. |
Abbott Laboratories |
| 22738630 |
76 |
Structure-based optimization of aminopyridines as PKC¿ inhibitors. |
Vertex Pharmaceuticals |
| 24900361 |
27 |
Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets. |
TBA |
| 20471253 |
32 |
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. |
Boehringer Ingelheim Pharmaceuticals |
| 20000469 |
179 |
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. |
Boehringer Ingelheim Pharmaceuticals |
| 20100661 |
21 |
Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. |
University of Houston |
| 19703774 |
56 |
C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II. |
Wyeth Research |
| 18183025 |
12060 |
A quantitative analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
| 9677190 |
49 |
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. |
University of California |
| 18434148 |
43 |
Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles. |
Wyeth Research |
| 18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
| 17977729 |
40 |
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/pi interaction. |
Kyoto University |
| 16876403 |
85 |
Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure. |
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories |
| 15380221 |
58 |
Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. |
Central Pharmaceutical Research Institute |
| 12672248 |
50 |
Kinase inhibitors: not just for kinases anymore. |
Northwestern University |
| 12166950 |
208 |
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family. |
Millennium Pharmaceuticals |
| 10999477 |
40 |
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V. |
Kyoto University |
| 10843211 |
38 |
Structure-activity relationship studies of flavopiridol analogues. |
Mitotix |
| | 80 |
Synthesis and PKC inhibitory activities of balanol analogs with a cyclopentane substructure |
TBA |
| 21975067 |
12 |
Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C. |
University of Houston |
| 22037378 |
31824 |
Comprehensive analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
| 21696964 |
12 |
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP. |
Keio University |
| 20817520 |
40 |
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity. |
Kyoto University |
| 19654408 |
2521 |
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). |
Ambit Biosciences |
| 20462760 |
70 |
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. |
Boehringer Ingelheim Pharmaceuticals |
| 20153643 |
68 |
Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors. |
Wyeth Research |
| 19854645 |
87 |
Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. |
Wyeth Research |
| 19762237 |
58 |
First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. |
Wyeth Research |
| 19682896 |
49 |
C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I. |
Wyeth Research |
| 19481464 |
41 |
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3beta (GSK-3beta) inhibitors. |
Zhejiang University |
| 8176401 |
21 |
Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids |
TBA |
| | 4 |
Benzo[c]quinoliziniums: A new family of inhibitors for protein kinase CK II |
TBA |
| | 42 |
A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation |
TBA |
| | 77 |
Synthesis and protein kinase C inhibitory activities of indane analogs of balanol |
TBA |
| | 70 |
Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety |
TBA |
| | 40 |
Heteroatom effect in the PKC inhibitory activities of perhydroazepine analogs of balanol |
TBA |
| | 88 |
Novel PKC inhibitory analogs of balanol with replacement of the ester functionality |
TBA |
| | 40 |
Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements |
TBA |
| | 2 |
2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C |
TBA |
| | 7 |
Conformationally constrained analogues of diacylglycerol (DAG). 4. Interaction of α-alkylidene-γ-lactones with protein kinase C (PK-C) |
TBA |
| 19447612 |
59 |
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors. |
Wyeth Research |
| 19379015 |
40 |
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths. |
National Cancer Institute-Frederick |
| 19111463 |
46 |
Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCtheta inhibitors. |
Wyeth Research |
| 18606543 |
68 |
2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. |
Wyeth Research |
| 17875639 |
12 |
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. |
University of California San Francisco |
| 18072722 |
42 |
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes. |
Kyoto University |
| 16682193 |
62 |
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 16640328 |
13 |
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. |
Kyoto University |
| 16216497 |
67 |
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. |
Abbott Bioresearch Center |
| 15317463 |
16 |
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 14552791 |
35 |
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. |
Eli Lilly |
| 12954072 |
46 |
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. |
Georgetown University Medical Center |
| 12941331 |
96 |
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. |
Johnson & Johnson Pharmaceutical Research & Development |
| 12941324 |
66 |
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes. |
Kyoto University |
| 12824047 |
99 |
Novel IKK inhibitors: beta-carbolines. |
Millennium Pharmaceuticals |
| 12749884 |
126 |
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. |
Eli Lilly |
| 12672234 |
64 |
Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. |
Boehringer Ingelheim Pharmaceuticals |
| 12270156 |
8 |
Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a. |
Cephalon |
| 12039590 |
51 |
Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of Lck. |
Abbott Bioresearch Center |
| 11909733 |
30 |
Beta-carbolines as specific inhibitors of cyclin-dependent kinases. |
Institute of Molecular and Cell Biology |
| 11327599 |
25 |
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. |
Georgetotwn University |
| 11266178 |
39 |
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities. |
Kyoto University |
| 11266177 |
26 |
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding. |
Kyoto University |
| 11206480 |
6 |
Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C. |
Institute of Organic Chemistry |
| 11012021 |
69 |
Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. |
Basf Bioresearch |
| 10743939 |
63 |
Synthesis and biological activities of NB-506 analogues modified at the glucose group. |
Banyu Tsukuba Research Institute |
| 10612598 |
29 |
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70. |
Celltech Therapeutics |
| 10612590 |
56 |
Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings. |
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories |
| 10397502 |
36 |
Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes. |
Stanford University |
| 9135029 |
29 |
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity. |
Georgetown University Medical Center |
| 9003521 |
249 |
Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety. |
Eli Lilly |
| 8709095 |
87 |
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. |
Eli Lilly |
| 28392275 |
24 |
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKC?, PKC?, and RasGRP. |
National Institute of Industrial Technology |
| 27943581 |
8 |
Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products. |
The University of Sydney |
| 3549712 |
24 |
The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. |
University of Chicago |
| 11121615 |
32 |
Synthesis and in vitro opioid activity profiles of DALDA analogues. |
Clinical Research Institute of Montreal |
| 16236500 |
26 |
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors. |
Johnson & Johnson Pharmaceutical |
| 16279769 |
28 |
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives. |
Sapienza University of Rome |
| 15689148 |
19 |
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. |
Shanghai Institute of Materia Medica |
| 15664516 |
21 |
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. |
University of Dundee |
| 15026054 |
55 |
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
Cnrs |
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