Found 437 hits with Last Name = 'willard' and Initial = 'dh' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167296
![PNG](/data/jpeg/tenK5016/BindingDB_50167296.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-ethylhyd...)Show InChI InChI=1S/C13H23N3O2/c1-3-16(10-14)15-13(17)18-11(2)9-12-7-5-4-6-8-12/h11-12H,3-9H2,1-2H3,(H,15,17)/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167302
![PNG](/data/jpeg/tenK5016/BindingDB_50167302.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isobutyl...)Show InChI InChI=1S/C15H27N3O2/c1-12(2)10-18(11-16)17-15(19)20-13(3)9-14-7-5-4-6-8-14/h12-14H,4-10H2,1-3H3,(H,17,19)/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167295
![PNG](/data/jpeg/tenK5016/BindingDB_50167295.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-propylhy...)Show InChI InChI=1S/C14H25N3O2/c1-3-9-17(11-15)16-14(18)19-12(2)10-13-7-5-4-6-8-13/h12-13H,3-10H2,1-2H3,(H,16,18)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167298
![PNG](/data/jpeg/tenK5016/BindingDB_50167298.png) ((1S)-2-cyclohexyl-1-methylethyl 2-benzyl-2-cyanohy...)Show InChI InChI=1S/C18H25N3O2/c1-15(12-16-8-4-2-5-9-16)23-18(22)20-21(14-19)13-17-10-6-3-7-11-17/h3,6-7,10-11,15-16H,2,4-5,8-9,12-13H2,1H3,(H,20,22)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167303
![PNG](/data/jpeg/tenK5016/BindingDB_50167303.png) ((1S)-2-cyclohexyl-1-methylethyl 2-butyl-2-cyanohyd...)Show InChI InChI=1S/C15H27N3O2/c1-3-4-10-18(12-16)17-15(19)20-13(2)11-14-8-6-5-7-9-14/h13-14H,3-11H2,1-2H3,(H,17,19)/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.00700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167289
![PNG](/data/jpeg/tenK5016/BindingDB_50167289.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)Show InChI InChI=1S/C12H21N3O2/c1-10(8-11-6-4-3-5-7-11)17-12(16)14-15(2)9-13/h10-11H,3-8H2,1-2H3,(H,14,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.00900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167290
![PNG](/data/jpeg/tenK5016/BindingDB_50167290.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)Show InChI InChI=1S/C14H25N3O2/c1-11(2)17(10-15)16-14(18)19-12(3)9-13-7-5-4-6-8-13/h11-13H,4-9H2,1-3H3,(H,16,18)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50167289
![PNG](/data/jpeg/tenK5016/BindingDB_50167289.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)Show InChI InChI=1S/C12H21N3O2/c1-10(8-11-6-4-3-5-7-11)17-12(16)14-15(2)9-13/h10-11H,3-8H2,1-2H3,(H,14,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167288
![PNG](/data/jpeg/tenK5016/BindingDB_50167288.png) ((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)Show InChI InChI=1S/C13H17N3O2/c1-3-12(9-11-7-5-4-6-8-11)18-13(17)15-16(2)10-14/h4-8,12H,3,9H2,1-2H3,(H,15,17)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50167288
![PNG](/data/jpeg/tenK5016/BindingDB_50167288.png) ((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)Show InChI InChI=1S/C13H17N3O2/c1-3-12(9-11-7-5-4-6-8-11)18-13(17)15-16(2)10-14/h4-8,12H,3,9H2,1-2H3,(H,15,17)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.0360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Rattus norvegicus) | BDBM50167288
![PNG](/data/jpeg/tenK5016/BindingDB_50167288.png) ((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)Show InChI InChI=1S/C13H17N3O2/c1-3-12(9-11-7-5-4-6-8-11)18-13(17)15-16(2)10-14/h4-8,12H,3,9H2,1-2H3,(H,15,17)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.0720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against rat cathepsin K |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50167289
![PNG](/data/jpeg/tenK5016/BindingDB_50167289.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)Show InChI InChI=1S/C12H21N3O2/c1-10(8-11-6-4-3-5-7-11)17-12(16)14-15(2)9-13/h10-11H,3-8H2,1-2H3,(H,14,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50167288
![PNG](/data/jpeg/tenK5016/BindingDB_50167288.png) ((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)Show InChI InChI=1S/C13H17N3O2/c1-3-12(9-11-7-5-4-6-8-11)18-13(17)15-16(2)10-14/h4-8,12H,3,9H2,1-2H3,(H,15,17)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Pro-cathepsin H
(Homo sapiens (Human)) | BDBM50167290
![PNG](/data/jpeg/tenK5016/BindingDB_50167290.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)Show InChI InChI=1S/C14H25N3O2/c1-11(2)17(10-15)16-14(18)19-12(3)9-13-7-5-4-6-8-13/h11-13H,4-9H2,1-3H3,(H,16,18)/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin H using L-Arg-b-naphthalamide |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50167290
![PNG](/data/jpeg/tenK5016/BindingDB_50167290.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)Show InChI InChI=1S/C14H25N3O2/c1-11(2)17(10-15)16-14(18)19-12(3)9-13-7-5-4-6-8-13/h11-13H,4-9H2,1-3H3,(H,16,18)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.790 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50167290
![PNG](/data/jpeg/tenK5016/BindingDB_50167290.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)Show InChI InChI=1S/C14H25N3O2/c1-11(2)17(10-15)16-14(18)19-12(3)9-13-7-5-4-6-8-13/h11-13H,4-9H2,1-3H3,(H,16,18)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Pro-cathepsin H
(Homo sapiens (Human)) | BDBM50167289
![PNG](/data/jpeg/tenK5016/BindingDB_50167289.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)Show InChI InChI=1S/C12H21N3O2/c1-10(8-11-6-4-3-5-7-11)17-12(16)14-15(2)9-13/h10-11H,3-8H2,1-2H3,(H,14,16)/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin H using L-Arg-b-naphthalamide |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50163832
![PNG](/data/jpeg/tenK5016/BindingDB_50163832.png) ((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)Show InChI InChI=1S/C15H24N2O2/c1-12(10-13-6-3-2-4-7-13)19-15(18)14-8-5-9-17(14)11-16/h12-14H,2-10H2,1H3/t12-,14?/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167297
![PNG](/data/jpeg/tenK5016/BindingDB_50167297.png) ((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)Show InChI InChI=1S/C13H22N2O2/c1-11(8-12-6-4-3-5-7-12)17-13(16)9-15(2)10-14/h11-12H,3-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167291
![PNG](/data/jpeg/tenK5016/BindingDB_50167291.png) (CHEMBL363610 | tert-butyl (2S)-1-cyanopyrrolidine-...)Show InChI InChI=1S/C10H16N2O2/c1-10(2,3)14-9(13)8-5-4-6-12(8)7-11/h8H,4-6H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167305
![PNG](/data/jpeg/tenK5016/BindingDB_50167305.png) ((1S)-2-cyclohexyl-1-methylethyl 2-cyano-1,2-dimeth...)Show InChI InChI=1S/C13H23N3O2/c1-11(9-12-7-5-4-6-8-12)18-13(17)16(3)15(2)10-14/h11-12H,4-9H2,1-3H3/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167292
![PNG](/data/jpeg/tenK5016/BindingDB_50167292.png) (2-(Cyano-methyl-amino)-N-((S)-2-cyclohexyl-1-methy...)Show InChI InChI=1S/C13H23N3O/c1-11(8-12-6-4-3-5-7-12)15-13(17)9-16(2)10-14/h11-12H,3-9H2,1-2H3,(H,15,17)/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167304
![PNG](/data/jpeg/tenK5016/BindingDB_50167304.png) ((1S)-2-cyclohexyl-1-methylethyl 2-tert-butyl-2-cya...)Show InChI InChI=1S/C15H27N3O2/c1-12(10-13-8-6-5-7-9-13)20-14(19)17-18(11-16)15(2,3)4/h12-13H,5-10H2,1-4H3,(H,17,19)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Procathepsin L
(Homo sapiens (Human)) | BDBM50167297
![PNG](/data/jpeg/tenK5016/BindingDB_50167297.png) ((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)Show InChI InChI=1S/C13H22N2O2/c1-11(8-12-6-4-3-5-7-12)17-13(16)9-15(2)10-14/h11-12H,3-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin L using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50095495
![PNG](/data/jpeg/tenK5009/BindingDB_50095495.png) (CHEMBL262697 | Pyrrolidine-1-carbonitrile)Show InChI InChI=1S/C5H8N2/c6-5-7-3-1-2-4-7/h1-4H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167294
![PNG](/data/jpeg/tenK5016/BindingDB_50167294.png) ((S)-2-(Cyano-methyl-amino)-propionic acid (S)-2-cy...)Show InChI InChI=1S/C14H24N2O2/c1-11(9-13-7-5-4-6-8-13)18-14(17)12(2)16(3)10-15/h11-13H,4-9H2,1-3H3/t11-,12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50167297
![PNG](/data/jpeg/tenK5016/BindingDB_50167297.png) ((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)Show InChI InChI=1S/C13H22N2O2/c1-11(8-12-6-4-3-5-7-12)17-13(16)9-15(2)10-14/h11-12H,3-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167299
![PNG](/data/jpeg/tenK5016/BindingDB_50167299.png) (CHEMBL191367 | Cyanomethyl-carbamic acid (S)-2-cyc...)Show InChI InChI=1S/C12H20N2O2/c1-10(16-12(15)14-8-7-13)9-11-5-3-2-4-6-11/h10-11H,2-6,8-9H2,1H3,(H,14,15)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167293
![PNG](/data/jpeg/tenK5016/BindingDB_50167293.png) ((R)-2-(Cyano-methyl-amino)-propionic acid (S)-2-cy...)Show InChI InChI=1S/C14H24N2O2/c1-11(9-13-7-5-4-6-8-13)18-14(17)12(2)16(3)10-15/h11-13H,4-9H2,1-3H3/t11-,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167301
![PNG](/data/jpeg/tenK5016/BindingDB_50167301.png) (((S)-Cyano-methyl-methyl)-carbamic acid (S)-2-cycl...)Show InChI InChI=1S/C13H22N2O2/c1-10(9-14)15-13(16)17-11(2)8-12-6-4-3-5-7-12/h10-12H,3-8H2,1-2H3,(H,15,16)/t10-,11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50167300
![PNG](/data/jpeg/tenK5016/BindingDB_50167300.png) (((R)-Cyano-methyl-methyl)-carbamic acid (S)-2-cycl...)Show InChI InChI=1S/C13H22N2O2/c1-10(9-14)15-13(16)17-11(2)8-12-6-4-3-5-7-12/h10-12H,3-8H2,1-2H3,(H,15,16)/t10-,11+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin K in fluorescence assay using Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Pro-cathepsin H
(Homo sapiens (Human)) | BDBM50167297
![PNG](/data/jpeg/tenK5016/BindingDB_50167297.png) ((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)Show InChI InChI=1S/C13H22N2O2/c1-11(8-12-6-4-3-5-7-12)17-13(16)9-15(2)10-14/h11-12H,3-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition constant against human cathepsin H using L-Arg-b-naphthalamide |
Bioorg Med Chem Lett 15: 3039-43 (2005)
Article DOI: 10.1016/j.bmcl.2005.04.032 BindingDB Entry DOI: 10.7270/Q2MS3S8C |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50163831
![PNG](/data/jpeg/tenK5016/BindingDB_50163831.png) ((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)Show InChI InChI=1S/C14H22N2O2/c1-11(9-12-5-3-2-4-6-12)18-14(17)13-7-8-16(13)10-15/h11-13H,2-9H2,1H3/t11-,13?/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0480 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 1815-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.033 BindingDB Entry DOI: 10.7270/Q2DR2V1G |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50084655
![PNG](/data/jpeg/tenK5008/BindingDB_50084655.png) (CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |r| Show InChI InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibiory activity against recombinant human cathepsin K |
Bioorg Med Chem Lett 14: 275-8 (2003)
BindingDB Entry DOI: 10.7270/Q2GM86PN |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148310
![PNG](/data/jpeg/tenK5014/BindingDB_50148310.png) (((S)-1-Formyl-pentyl)-carbamic acid (S)-1-benzyl-p...)Show InChI InChI=1S/C17H25NO3/c1-3-5-11-15(13-19)18-17(20)21-16(4-2)12-14-9-7-6-8-10-14/h6-10,13,15-16H,3-5,11-12H2,1-2H3,(H,18,20)/t15-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMC |
Bioorg Med Chem Lett 15: 1815-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.033 BindingDB Entry DOI: 10.7270/Q2DR2V1G |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148310
![PNG](/data/jpeg/tenK5014/BindingDB_50148310.png) (((S)-1-Formyl-pentyl)-carbamic acid (S)-1-benzyl-p...)Show InChI InChI=1S/C17H25NO3/c1-3-5-11-15(13-19)18-17(20)21-16(4-2)12-14-9-7-6-8-10-14/h6-10,13,15-16H,3-5,11-12H2,1-2H3,(H,18,20)/t15-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 microM Cbz-Phe-Arg-AMC as substrate |
Bioorg Med Chem Lett 14: 3425-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.084 BindingDB Entry DOI: 10.7270/Q2SF2VMD |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (docked) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138858
![PNG](/data/jpeg/tenK5013/BindingDB_50138858.png) (CHEMBL154579 | [(S)-1-(4-Phenyl-1H-pyrazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1-c1ccccc1 Show InChI InChI=1S/C24H34N4O4/c1-6-7-13-19(26-24(31)32-21(15(2)3)16(4)5)20(29)23(30)27-22-18(14-25-28-22)17-11-9-8-10-12-17/h8-12,14-16,19,21H,6-7,13H2,1-5H3,(H,26,31)(H2,25,27,28,30)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138853
![PNG](/data/jpeg/tenK5013/BindingDB_50138853.png) (CHEMBL157072 | [(S)-1-(4-Bromo-1H-pyrazol-3-ylamin...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1Br Show InChI InChI=1S/C18H29BrN4O4/c1-6-7-8-13(21-18(26)27-15(10(2)3)11(4)5)14(24)17(25)22-16-12(19)9-20-23-16/h9-11,13,15H,6-8H2,1-5H3,(H,21,26)(H2,20,22,23,25)/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138876
![PNG](/data/jpeg/tenK5013/BindingDB_50138876.png) (CHEMBL345569 | [(S)-1-(4-Fluoro-1H-indazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]nc2cccc(F)c12 Show InChI InChI=1S/C22H31FN4O4/c1-6-7-10-16(24-22(30)31-19(12(2)3)13(4)5)18(28)21(29)25-20-17-14(23)9-8-11-15(17)26-27-20/h8-9,11-13,16,19H,6-7,10H2,1-5H3,(H,24,30)(H2,25,26,27,29)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50177501
![PNG](/data/jpeg/tenK5017/BindingDB_50177501.png) (CHEMBL203663 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)Show SMILES CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=NNC(=O)N1CCOCC1 |w:21.22| Show InChI InChI=1S/C23H36N4O4/c1-4-5-11-20(17-24-26-22(28)27-12-14-30-15-13-27)25-23(29)31-21(18(2)3)16-19-9-7-6-8-10-19/h6-10,17-18,20-21H,4-5,11-16H2,1-3H3,(H,25,29)(H,26,28)/t20-,21+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human cathepsin K in a fluorescence assay |
Bioorg Med Chem Lett 16: 978-83 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.108 BindingDB Entry DOI: 10.7270/Q2X929VS |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148292
![PNG](/data/jpeg/tenK5014/BindingDB_50148292.png) (((S)-1-Formyl-pentyl)-carbamic acid 1-benzyl-cyclo...)Show InChI InChI=1S/C19H27NO3/c1-2-3-11-17(15-21)20-18(22)23-19(12-7-8-13-19)14-16-9-5-4-6-10-16/h4-6,9-10,15,17H,2-3,7-8,11-14H2,1H3,(H,20,22)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 microM Cbz-Phe-Arg-AMC as substrate |
Bioorg Med Chem Lett 14: 3425-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.084 BindingDB Entry DOI: 10.7270/Q2SF2VMD |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148292
![PNG](/data/jpeg/tenK5014/BindingDB_50148292.png) (((S)-1-Formyl-pentyl)-carbamic acid 1-benzyl-cyclo...)Show InChI InChI=1S/C19H27NO3/c1-2-3-11-17(15-21)20-18(22)23-19(12-7-8-13-19)14-16-9-5-4-6-10-16/h4-6,9-10,15,17H,2-3,7-8,11-14H2,1H3,(H,20,22)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human cathepsin K in a fluorescence assay |
Bioorg Med Chem Lett 16: 978-83 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.108 BindingDB Entry DOI: 10.7270/Q2X929VS |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138866
![PNG](/data/jpeg/tenK5013/BindingDB_50138866.png) (CHEMBL156764 | [(S)-1-(1-Methyl-1H-pyrazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1ccn(C)n1 Show InChI InChI=1S/C19H32N4O4/c1-7-8-9-14(20-19(26)27-17(12(2)3)13(4)5)16(24)18(25)21-15-10-11-23(6)22-15/h10-14,17H,7-9H2,1-6H3,(H,20,26)(H,21,22,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50179446
![PNG](/data/jpeg/tenK5017/BindingDB_50179446.png) ((S)-4,4-dimethyl-2-oxo-1-((4-(trifluoromethyl)phen...)Show SMILES CCCC[C@H](NC(=O)O[C@@H]1C(=O)N(CC1(C)C)C(=O)Nc1ccc(cc1)C(F)(F)F)C(=O)C(=O)Nc1ccn[nH]1 Show InChI InChI=1S/C25H29F3N6O6/c1-4-5-6-16(18(35)20(36)32-17-11-12-29-33-17)31-23(39)40-19-21(37)34(13-24(19,2)3)22(38)30-15-9-7-14(8-10-15)25(26,27)28/h7-12,16,19H,4-6,13H2,1-3H3,(H,30,38)(H,31,39)(H2,29,32,33,36)/t16-,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human cathepsin K by fluorescence assay |
Bioorg Med Chem Lett 16: 1735-9 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.101 BindingDB Entry DOI: 10.7270/Q23J3CJX |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138869
![PNG](/data/jpeg/tenK5013/BindingDB_50138869.png) (CHEMBL154959 | [(S)-1-(4-Methyl-1H-pyrazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1[nH]ncc1C Show InChI InChI=1S/C19H32N4O4/c1-7-8-9-14(21-19(26)27-16(11(2)3)12(4)5)15(24)18(25)22-17-13(6)10-20-23-17/h10-12,14,16H,7-9H2,1-6H3,(H,21,26)(H2,20,22,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148298
![PNG](/data/jpeg/tenK5014/BindingDB_50148298.png) (((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)Show InChI InChI=1S/C18H27NO3/c1-4-5-11-16(13-20)19-18(21)22-17(14(2)3)12-15-9-7-6-8-10-15/h6-10,13-14,16-17H,4-5,11-12H2,1-3H3,(H,19,21)/t16-,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of recombinant human cathepsin K in a fluorescence assay |
Bioorg Med Chem Lett 16: 978-83 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.108 BindingDB Entry DOI: 10.7270/Q2X929VS |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148298
![PNG](/data/jpeg/tenK5014/BindingDB_50148298.png) (((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)Show InChI InChI=1S/C18H27NO3/c1-4-5-11-16(13-20)19-18(21)22-17(14(2)3)12-15-9-7-6-8-10-15/h6-10,13-14,16-17H,4-5,11-12H2,1-3H3,(H,19,21)/t16-,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 microM Cbz-Phe-Arg-AMC as substrate |
Bioorg Med Chem Lett 14: 3425-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.084 BindingDB Entry DOI: 10.7270/Q2SF2VMD |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Cathepsin K
(Homo sapiens (Human)) | BDBM50148307
![PNG](/data/jpeg/tenK5014/BindingDB_50148307.png) (((S)-1-Formyl-pentyl)-carbamic acid 1-isopropyl-2-...)Show InChI InChI=1S/C14H27NO3/c1-6-7-8-12(9-16)15-14(17)18-13(10(2)3)11(4)5/h9-13H,6-8H2,1-5H3,(H,15,17)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant human cathepsin K determined in a fluorescence assay using 10 microM Cbz-Phe-Arg-AMC as substrate |
Bioorg Med Chem Lett 14: 3425-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.084 BindingDB Entry DOI: 10.7270/Q2SF2VMD |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138879
![PNG](/data/jpeg/tenK5013/BindingDB_50138879.png) (CHEMBL345982 | [(S)-1-(5-Phenyl-1H-pyrazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc(n[nH]1)-c1ccccc1 Show InChI InChI=1S/C24H34N4O4/c1-6-7-13-18(25-24(31)32-22(15(2)3)16(4)5)21(29)23(30)26-20-14-19(27-28-20)17-11-9-8-10-12-17/h8-12,14-16,18,22H,6-7,13H2,1-5H3,(H,25,31)(H2,26,27,28,30)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50138871
![PNG](/data/jpeg/tenK5013/BindingDB_50138871.png) (CHEMBL154818 | [(S)-1-(5-Methyl-1H-pyrazol-3-ylami...)Show SMILES CCCC[C@H](NC(=O)OC(C(C)C)C(C)C)C(=O)C(=O)Nc1cc(C)n[nH]1 Show InChI InChI=1S/C19H32N4O4/c1-7-8-9-14(20-19(26)27-17(11(2)3)12(4)5)16(24)18(25)21-15-10-13(6)22-23-15/h10-12,14,17H,7-9H2,1-6H3,(H,20,26)(H2,21,22,23,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Concentration required to inhibit 50% of cysteine protease cathepsin K of human |
J Med Chem 47: 588-99 (2004)
Article DOI: 10.1021/jm030373l BindingDB Entry DOI: 10.7270/Q29S1QF7 |
More data for this Ligand-Target Pair | |