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Compile Data Set for Download or QSAR

Found 357 hits with Last Name = 'lo' and Initial = 'hy'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM130670
PNG
(US8829200, 3)
Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1ccccc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C27H25N7O/c1-27(2,3)34-23-9-8-17(18-15-30-26(28)31-16-18)14-22(23)33-24(34)20-6-4-5-7-21(20)25(35)32-19-10-12-29-13-11-19/h4-16H,1-3H3,(H2,28,30,31)(H,29,32,35)
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US Patent
n/an/a 0.910n/an/an/an/an/a7.5



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8829200 (2014)


BindingDB Entry DOI: 10.7270/Q2G73CDF
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))		BDBM50330100
PNG
(CHEMBL1271550 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)
Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)cc1)-c1cccnc1
Show InChI InChI=1S/C22H15F3N4O/c23-22(24,25)20-13-19(16-7-4-12-26-14-16)28-29(20)18-10-8-17(9-11-18)27-21(30)15-5-2-1-3-6-15/h1-14H,(H,27,30)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay

Bioorg Med Chem Lett 20: 6379-83 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.095
BindingDB Entry DOI: 10.7270/Q2V69JT7
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078118
PNG
(CHEMBL3417524)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1ccc(N)nc1 |r|
Show InChI InChI=1S/C25H27N7O2/c1-25(20-9-10-20,19-7-4-16(5-8-19)17-6-11-21(26)27-12-17)24-29-23(34-30-24)18-13-28-32(14-18)15-22(33)31(2)3/h4-8,11-14,20H,9-10,15H2,1-3H3,(H2,26,27)/t25-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078123
PNG
(CHEMBL3417526)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)cn1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-24(18-8-9-18,17-6-4-15(5-7-17)19-11-27-20(25)12-26-19)23-29-22(34-30-23)16-10-28-32(13-16)14-21(33)31(2)3/h4-7,10-13,18H,8-9,14H2,1-3H3,(H2,25,27)/t24-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078080
PNG
(CHEMBL3417520)
Show SMILES Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C21H21N7O/c1-21(17-7-8-17,19-26-18(29-27-19)15-11-25-28(2)12-15)16-5-3-13(4-6-16)14-9-23-20(22)24-10-14/h3-6,9-12,17H,7-8H2,1-2H3,(H2,22,23,24)/t21-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078053
PNG
(CHEMBL3417414)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C22H19N5O/c23-21-24-13-17(14-25-21)15-7-9-18(10-8-15)22(11-4-12-22)20-26-19(28-27-20)16-5-2-1-3-6-16/h1-3,5-10,13-14H,4,11-12H2,(H2,23,24,25)
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n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM130685
PNG
(US8829200, 22)
Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1ccccc1C(=O)Nc1cccnc1
Show InChI InChI=1S/C27H25N7O/c1-27(2,3)34-23-11-10-17(18-14-30-26(28)31-15-18)13-22(23)33-24(34)20-8-4-5-9-21(20)25(35)32-19-7-6-12-29-16-19/h4-16H,1-3H3,(H,32,35)(H2,28,30,31)
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n/an/a 1.5n/an/an/an/an/a7.5



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8829200 (2014)


BindingDB Entry DOI: 10.7270/Q2G73CDF
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078078
PNG
(CHEMBL3417518)
Show SMILES CC(C)[C@@](C)(c1noc(n1)-c1cnn(C)c1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C21H23N7O/c1-13(2)21(3,19-26-18(29-27-19)16-11-25-28(4)12-16)17-7-5-14(6-8-17)15-9-23-20(22)24-10-15/h5-13H,1-4H3,(H2,22,23,24)/t21-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078119
PNG
(CHEMBL3417525)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C24H26N8O2/c1-24(19-8-9-19,18-6-4-15(5-7-18)16-10-26-23(25)27-11-16)22-29-21(34-30-22)17-12-28-32(13-17)14-20(33)31(2)3/h4-7,10-13,19H,8-9,14H2,1-3H3,(H2,25,26,27)/t24-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078035
PNG
(CHEMBL3417429)
Show SMILES Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C20H19N7O/c1-27-12-15(11-24-27)17-25-18(26-28-17)20(7-2-8-20)16-5-3-13(4-6-16)14-9-22-19(21)23-10-14/h3-6,9-12H,2,7-8H2,1H3,(H2,21,22,23)
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n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078077
PNG
(CHEMBL3417517)
Show SMILES CC(C)C(C)(c1noc(n1)-c1cnn(C)c1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H23N7O/c1-13(2)21(3,19-26-18(29-27-19)16-11-25-28(4)12-16)17-7-5-14(6-8-17)15-9-23-20(22)24-10-15/h5-13H,1-4H3,(H2,22,23,24)
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50349174
PNG
(CHEMBL1807526)
Show SMILES Cc1cccc2scc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C20H18N2O3S/c1-13-5-4-8-17-19(13)14(12-26-17)11-22-16-7-3-2-6-15(16)21(20(22)25)10-9-18(23)24/h2-8,12H,9-11H2,1H3,(H,23,24)
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay

Bioorg Med Chem Lett 21: 4533-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.126
BindingDB Entry DOI: 10.7270/Q23B60H0
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078146
PNG
(CHEMBL3417531)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C24H27N7O2/c1-23(2,32)14-31-13-17(12-28-31)20-29-21(30-33-20)24(3,19-8-9-19)18-6-4-15(5-7-18)16-10-26-22(25)27-11-16/h4-7,10-13,19,32H,8-9,14H2,1-3H3,(H2,25,26,27)/t24-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM130700
PNG
(US8829200, 20)
Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1ccccc1C(=O)Nc1ccccn1
Show InChI InChI=1S/C27H25N7O/c1-27(2,3)34-22-12-11-17(18-15-30-26(28)31-16-18)14-21(22)32-24(34)19-8-4-5-9-20(19)25(35)33-23-10-6-7-13-29-23/h4-16H,1-3H3,(H2,28,30,31)(H,29,33,35)
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n/an/a 2.20n/an/an/an/an/a7.5



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8829200 (2014)


BindingDB Entry DOI: 10.7270/Q2G73CDF
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078052
PNG
(CHEMBL3417415)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cccnc1
Show InChI InChI=1S/C21H18N6O/c22-20-24-12-16(13-25-20)14-4-6-17(7-5-14)21(8-2-9-21)19-26-18(28-27-19)15-3-1-10-23-11-15/h1,3-7,10-13H,2,8-9H2,(H2,22,24,25)
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n/an/a 2.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078036
PNG
(CHEMBL3417428)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N7O/c20-18-21-8-13(9-22-18)12-2-4-15(5-3-12)19(6-1-7-19)17-25-16(27-26-17)14-10-23-24-11-14/h2-5,8-11H,1,6-7H2,(H,23,24)(H2,20,21,22)
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n/an/a 2.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078040
PNG
(CHEMBL3417425)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cscn1
Show InChI InChI=1S/C19H16N6OS/c20-18-21-8-13(9-22-18)12-2-4-14(5-3-12)19(6-1-7-19)17-24-16(26-25-17)15-10-27-11-23-15/h2-5,8-11H,1,6-7H2,(H2,20,21,22)
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n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078038
PNG
(CHEMBL3417427)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cc[nH]n1
Show InChI InChI=1S/C19H17N7O/c20-18-21-10-13(11-22-18)12-2-4-14(5-3-12)19(7-1-8-19)17-24-16(27-26-17)15-6-9-23-25-15/h2-6,9-11H,1,7-8H2,(H,23,25)(H2,20,21,22)
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n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078033
PNG
(CHEMBL3417431)
Show SMILES COCCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C22H23N7O2/c1-30-10-9-29-14-17(13-26-29)19-27-20(28-31-19)22(7-2-8-22)18-5-3-15(4-6-18)16-11-24-21(23)25-12-16/h3-6,11-14H,2,7-10H2,1H3,(H2,23,24,25)
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n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078043
PNG
(CHEMBL3417422)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1c[nH]cn1
Show InChI InChI=1S/C19H17N7O/c20-18-22-8-13(9-23-18)12-2-4-14(5-3-12)19(6-1-7-19)17-25-16(27-26-17)15-10-21-11-24-15/h2-5,8-11H,1,6-7H2,(H,21,24)(H2,20,22,23)
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n/an/a 2.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078031
PNG
(CHEMBL3417508)
Show SMILES NCCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C21H22N8O/c22-8-9-29-13-16(12-26-29)18-27-19(28-30-18)21(6-1-7-21)17-4-2-14(3-5-17)15-10-24-20(23)25-11-15/h2-5,10-13H,1,6-9,22H2,(H2,23,24,25)
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n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078115
PNG
(CHEMBL3417522)
Show SMILES Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CCC1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C22H23N7O/c1-22(17-4-3-5-17,20-27-19(30-28-20)16-12-26-29(2)13-16)18-8-6-14(7-9-18)15-10-24-21(23)25-11-15/h6-13,17H,3-5H2,1-2H3,(H2,23,24,25)/t22-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078045
PNG
(CHEMBL3417421)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1ccc[nH]c1=O
Show InChI InChI=1S/C21H18N6O2/c22-20-24-11-14(12-25-20)13-4-6-15(7-5-13)21(8-2-9-21)19-26-18(29-27-19)16-3-1-10-23-17(16)28/h1,3-7,10-12H,2,8-9H2,(H,23,28)(H2,22,24,25)
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n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078141
PNG
(CHEMBL3417527)
Show SMILES CNc1ncc(cn1)-c1ccc(cc1)[C@@](C)(C1CC1)c1noc(n1)-c1cnn(CC(=O)N(C)C)c1 |r|
Show InChI InChI=1S/C25H28N8O2/c1-25(20-9-10-20,19-7-5-16(6-8-19)17-11-27-24(26-2)28-12-17)23-30-22(35-31-23)18-13-29-33(14-18)15-21(34)32(3)4/h5-8,11-14,20H,9-10,15H2,1-4H3,(H,26,27,28)/t25-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274045
PNG
(3-[2-[2-(4-Cyano-phenyl)-2-oxo-ethyl]-5-(2-cyclohe...)
Show SMILES CC(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(CC(=O)c3ccc(cc3)C#N)nc2c1
Show InChI InChI=1S/C28H30N4O3/c1-18(28(35)21-5-3-2-4-6-21)22-11-12-24-23(15-22)31-27(32(24)14-13-26(30)34)16-25(33)20-9-7-19(17-29)8-10-20/h7-12,15,18,21H,2-6,13-14,16H2,1H3,(H2,30,34)
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n/an/a 3n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274339
PNG
(CHEMBL485607 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(Br)cc3)nc2c1
Show InChI InChI=1S/C25H28BrN5O3/c1-30(24(34)17-5-3-2-4-6-17)19-11-12-21-20(15-19)28-25(31(21)14-13-22(27)32)29-23(33)16-7-9-18(26)10-8-16/h7-12,15,17H,2-6,13-14H2,1H3,(H2,27,32)(H,28,29,33)
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n/an/a 3n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078145
PNG
(CHEMBL3417530)
Show SMILES CN(C)CCn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1 |r|
Show InChI InChI=1S/C24H28N8O/c1-24(20-8-9-20,19-6-4-16(5-7-19)17-12-26-23(25)27-13-17)22-29-21(33-30-22)18-14-28-32(15-18)11-10-31(2)3/h4-7,12-15,20H,8-11H2,1-3H3,(H2,25,26,27)/t24-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM125960
PNG
(US8772304, 22)
Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1cc(Cl)cnc1-n1cncn1
Show InChI InChI=1S/C22H20ClN9/c1-22(2,3)32-18-5-4-13(14-8-27-21(24)28-9-14)6-17(18)30-20(32)16-7-15(23)10-26-19(16)31-12-25-11-29-31/h4-12H,1-3H3,(H2,24,27,28)
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n/an/a 3.20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8772304 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M4M
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078060
PNG
(CHEMBL3417511)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H25N7O2/c1-22(2,31)14-30-13-17(12-27-30)19-28-20(29-32-19)23(8-3-9-23)18-6-4-15(5-7-18)16-10-25-21(24)26-11-16/h4-7,10-13,31H,3,8-9,14H2,1-2H3,(H2,24,25,26)
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n/an/a 3.5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078059
PNG
(CHEMBL3417510)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H24N8O2/c1-30(2)19(32)14-31-13-17(12-27-31)20-28-21(29-33-20)23(8-3-9-23)18-6-4-15(5-7-18)16-10-25-22(24)26-11-16/h4-7,10-13H,3,8-9,14H2,1-2H3,(H2,24,25,26)
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n/an/a 3.60n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078058
PNG
(CHEMBL3417509)
Show SMILES CN(C)CCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1S/C23H26N8O/c1-30(2)10-11-31-15-18(14-27-31)20-28-21(29-32-20)23(8-3-9-23)19-6-4-16(5-7-19)17-12-25-22(24)26-13-17/h4-7,12-15H,3,8-11H2,1-2H3,(H2,24,25,26)
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n/an/a 3.60n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274471
PNG
(CHEMBL485556 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(cc3)C#N)nc2c1
Show InChI InChI=1S/C26H28N6O3/c1-31(25(35)19-5-3-2-4-6-19)20-11-12-22-21(15-20)29-26(32(22)14-13-23(28)33)30-24(34)18-9-7-17(16-27)8-10-18/h7-12,15,19H,2-6,13-14H2,1H3,(H2,28,33)(H,29,30,34)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274470
PNG
(CHEMBL485555 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(NC(=O)c3cccc(c3)C#N)nc2c1
Show InChI InChI=1S/C26H28N6O3/c1-31(25(35)18-7-3-2-4-8-18)20-10-11-22-21(15-20)29-26(32(22)13-12-23(28)33)30-24(34)19-9-5-6-17(14-19)16-27/h5-6,9-11,14-15,18H,2-4,7-8,12-13H2,1H3,(H2,28,33)(H,29,30,34)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274669
PNG
(CHEMBL485031 | N-(1-(3-(1H-imidazol-1-yl)propyl)-5...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCCn3ccnc3)c(NC(=O)c3ccc(cc3)C#N)nc2c1
Show InChI InChI=1S/C29H31N7O2/c1-34(28(38)23-6-3-2-4-7-23)24-12-13-26-25(18-24)32-29(36(26)16-5-15-35-17-14-31-20-35)33-27(37)22-10-8-21(19-30)9-11-22/h8-14,17-18,20,23H,2-7,15-16H2,1H3,(H,32,33,37)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274340
PNG
(CHEMBL483403 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(Cl)cc3)nc2c1
Show InChI InChI=1S/C25H28ClN5O3/c1-30(24(34)17-5-3-2-4-6-17)19-11-12-21-20(15-19)28-25(31(21)14-13-22(27)32)29-23(33)16-7-9-18(26)10-8-16/h7-12,15,17H,2-6,13-14H2,1H3,(H2,27,32)(H,28,29,33)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM125961
PNG
(US8772304, 23)
Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1cc(Br)cnc1-n1cncn1
Show InChI InChI=1S/C22H20BrN9/c1-22(2,3)32-18-5-4-13(14-8-27-21(24)28-9-14)6-17(18)30-20(32)16-7-15(23)10-26-19(16)31-12-25-11-29-31/h4-12H,1-3H3,(H2,24,27,28)
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n/an/a 4n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8772304 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M4M
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM125940
PNG
(US8772304, 2)
Show SMILES Cc1ncn(n1)-c1ccc(nc1-c1nc2cc(ccc2n1C(C)(C)C)-c1cnc(N)nc1)C#N
Show InChI InChI=1S/C24H22N10/c1-14-29-13-33(32-14)20-8-6-17(10-25)30-21(20)22-31-18-9-15(16-11-27-23(26)28-12-16)5-7-19(18)34(22)24(2,3)4/h5-9,11-13H,1-4H3,(H2,26,27,28)
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n/an/a 4.20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8772304 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M4M
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078042
PNG
(CHEMBL3417423)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1c[nH]nn1
Show InChI InChI=1S/C18H16N8O/c19-17-20-8-12(9-21-17)11-2-4-13(5-3-11)18(6-1-7-18)16-23-15(27-25-16)14-10-22-26-24-14/h2-5,8-10H,1,6-7H2,(H2,19,20,21)(H,22,24,26)
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))		BDBM50330103
PNG
(CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)
Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nc1)-c1cccnc1
Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)16-8-9-19(26-13-16)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,26,27,30)
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay

Bioorg Med Chem Lett 20: 6379-83 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.095
BindingDB Entry DOI: 10.7270/Q2V69JT7
More data for this
Ligand-Target Pair
Cathepsin G


(Homo sapiens (Human))		BDBM50349176
PNG
(CHEMBL1807531)
Show SMILES Cc1cccc2n(C)cc(Cn3c4ccccc4n(CCC(O)=O)c3=O)c12
Show InChI InChI=1S/C21H21N3O3/c1-14-6-5-9-18-20(14)15(12-22(18)2)13-24-17-8-4-3-7-16(17)23(21(24)27)11-10-19(25)26/h3-9,12H,10-11,13H2,1-2H3,(H,25,26)
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin G after 1 hr by fluorometric assay

Bioorg Med Chem Lett 21: 4533-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.126
BindingDB Entry DOI: 10.7270/Q23B60H0
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274671
PNG
(4-cyano-N-(5-(N-methylcyclohexanecarboxamido)-1-(3...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCCN3CCN(C)CC3)c(NC(=O)c3ccc(cc3)C#N)nc2c1
Show InChI InChI=1S/C31H39N7O2/c1-35-17-19-37(20-18-35)15-6-16-38-28-14-13-26(36(2)30(40)25-7-4-3-5-8-25)21-27(28)33-31(38)34-29(39)24-11-9-23(22-32)10-12-24/h9-14,21,25H,3-8,15-20H2,1-2H3,(H,33,34,39)
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n/an/a 5n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274705
PNG
(4-cyano-N-(5-(N-methylcyclohexanecarboxamido)-1-(3...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(=O)N3CCNCC3)c(NC(=O)c3ccc(cc3)C#N)nc2c1
Show InChI InChI=1S/C30H35N7O3/c1-35(29(40)23-5-3-2-4-6-23)24-11-12-26-25(19-24)33-30(34-28(39)22-9-7-21(20-31)8-10-22)37(26)16-13-27(38)36-17-14-32-15-18-36/h7-12,19,23,32H,2-6,13-18H2,1H3,(H,33,34,39)
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n/an/a 5n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Bifunctional epoxide hydrolase 2


(Homo sapiens (Human))		BDBM50330103
PNG
(CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)
Show SMILES FC(F)(F)c1cc(nn1-c1ccc(NC(=O)c2ccccc2)nc1)-c1cccnc1
Show InChI InChI=1S/C21H14F3N5O/c22-21(23,24)18-11-17(15-7-4-10-25-12-15)28-29(18)16-8-9-19(26-13-16)27-20(30)14-5-2-1-3-6-14/h1-13H,(H,26,27,30)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay

Bioorg Med Chem Lett 20: 6379-83 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.095
BindingDB Entry DOI: 10.7270/Q2V69JT7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM50274246
PNG
(CHEMBL485232 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Show SMILES CN(C(=O)C1CCCCC1)c1ccc2n(CCC(N)=O)c(NC(=O)c3cccnc3)nc2c1
Show InChI InChI=1S/C24H28N6O3/c1-29(23(33)16-6-3-2-4-7-16)18-9-10-20-19(14-18)27-24(30(20)13-11-21(25)31)28-22(32)17-8-5-12-26-15-17/h5,8-10,12,14-16H,2-4,6-7,11,13H2,1H3,(H2,25,31)(H,27,28,32)
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n/an/a 5n/an/an/an/an/an/a



Johnson & Johnson

Curated by ChEMBL


Assay Description
Inhibition of ITK by DELFIA assay

Bioorg Med Chem Lett 18: 5545-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.015
BindingDB Entry DOI: 10.7270/Q2M32VMD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM26881
PNG
(2-aminobenzimidazole with trans-stilbene, 8x | 5-[...)
Show SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(C=Cc4ncc(N)cn4)s3)nc2c1 |w:28.28|
Show InChI InChI=1S/C29H26N8O3S/c1-36(28(40)18-5-3-2-4-6-18)20-7-10-23-22(15-20)34-29(37(23)14-13-25(31)38)35-27(39)24-11-8-21(41-24)9-12-26-32-16-19(30)17-33-26/h2-12,15-17H,13-14,30H2,1H3,(H2,31,38)(H,34,35,39)
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n/an/a 5n/an/an/an/a7.022



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...

Bioorg Med Chem Lett 18: 6218-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.098
BindingDB Entry DOI: 10.7270/Q23B5XFW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM26864
PNG
(2-aminobenzimidazole with trans-stilbene, 8a | N-[...)
Show SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(C=Cc4cccnc4)s3)nc2c1 |w:28.28|
Show InChI InChI=1S/C30H26N6O3S/c1-35(29(39)21-7-3-2-4-8-21)22-10-13-25-24(18-22)33-30(36(25)17-15-27(31)37)34-28(38)26-14-12-23(40-26)11-9-20-6-5-16-32-19-20/h2-14,16,18-19H,15,17H2,1H3,(H2,31,37)(H,33,34,38)
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n/an/a 5n/an/an/an/a7.022



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...

Bioorg Med Chem Lett 18: 6218-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.098
BindingDB Entry DOI: 10.7270/Q23B5XFW
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))		BDBM26860
PNG
(2-aminobenzimidazole with trans-stilbene, 8c | N-[...)
Show SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(C=CC#N)s3)nc2c1 |w:28.28|
Show InChI InChI=1S/C26H22N6O3S/c1-31(25(35)17-6-3-2-4-7-17)18-9-11-21-20(16-18)29-26(32(21)15-13-23(28)33)30-24(34)22-12-10-19(36-22)8-5-14-27/h2-12,16H,13,15H2,1H3,(H2,28,33)(H,29,30,34)
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n/an/a 5n/an/an/an/a7.022



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...

Bioorg Med Chem Lett 18: 6218-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.098
BindingDB Entry DOI: 10.7270/Q23B5XFW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM130672
PNG
(US8829200, 6)
Show SMILES CNC(=O)c1ccc(F)cc1-c1nc2cc(ccc2n1C(C)(C)C)-c1cnc(N)nc1
Show InChI InChI=1S/C23H23FN6O/c1-23(2,3)30-19-8-5-13(14-11-27-22(25)28-12-14)9-18(19)29-20(30)17-10-15(24)6-7-16(17)21(31)26-4/h5-12H,1-4H3,(H,26,31)(H2,25,27,28)
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US Patent
n/an/a 5.07n/an/an/an/an/a7.5



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8829200 (2014)


BindingDB Entry DOI: 10.7270/Q2G73CDF
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM50078050
PNG
(CHEMBL3417417)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cnccn1
Show InChI InChI=1S/C20H17N7O/c21-19-24-10-14(11-25-19)13-2-4-15(5-3-13)20(6-1-7-20)18-26-17(28-27-18)16-12-22-8-9-23-16/h2-5,8-12H,1,6-7H2,(H2,21,24,25)
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n/an/a 5.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis

J Med Chem 58: 1669-90 (2015)


Article DOI: 10.1021/jm501185j
BindingDB Entry DOI: 10.7270/Q2SB47GW
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Homo sapiens (Human))		BDBM125941
PNG
(US8772304, 3)
Show SMILES Cc1ncnn1-c1ccc(nc1-c1nc2cc(ccc2n1C(C)(C)C)-c1cnc(N)nc1)C#N
Show InChI InChI=1S/C24H22N10/c1-14-29-13-30-34(14)20-8-6-17(10-25)31-21(20)22-32-18-9-15(16-11-27-23(26)28-12-16)5-7-19(18)33(22)24(2,3)4/h5-9,11-13H,1-4H3,(H2,26,27,28)
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n/an/a 5.90n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...

US Patent US8772304 (2014)


BindingDB Entry DOI: 10.7270/Q22F7M4M
More data for this
Ligand-Target Pair
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