Compile Data Set for Download or QSAR

Found 1800 hits with Last Name = 'leopoldo' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50122050 (CHEMBL156599 | N-{2-[4-(2,3-Dichloro-phenyl)-piper...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C20H23Cl2N3O2/c1-27-16-5-2-4-15(14-16)20(26)23-8-9-24-10-12-25(13-11-24)18-7-3-6-17(21)19(18)22/h2-7,14H,8-13H2,1H3,(H,23,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50122028 (3-Methoxy-N-[2-(4-p-tolyl-piperazin-1-yl)-ethyl]-b...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1ccc(C)cc1 Show InChI InChI=1S/C21H27N3O2/c1-17-6-8-19(9-7-17)24-14-12-23(13-15-24)11-10-22-21(25)18-4-3-5-20(16-18)26-2/h3-9,16H,10-15H2,1-2H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50274835 (CHEMBL511857 | trans-1-(4-(3-methoxyphenyl)cyclohe...) Show SMILES COc1cccc(c1)[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1ccccn1 |r,wU:8.8,wD:11.15,(1.87,-39.15,;3.2,-38.38,;3.2,-36.84,;1.87,-36.07,;1.87,-34.53,;3.2,-33.76,;4.53,-34.52,;4.54,-36.07,;5.86,-33.74,;5.85,-32.21,;7.19,-31.43,;8.53,-32.2,;8.52,-33.74,;7.2,-34.51,;9.85,-31.43,;11.19,-32.21,;12.52,-31.44,;12.52,-29.9,;11.19,-29.13,;9.85,-29.9,;13.86,-29.14,;13.86,-27.61,;15.19,-26.84,;16.53,-27.61,;16.52,-29.15,;15.19,-29.92,)| Show InChI InChI=1S/C22H29N3O/c1-26-21-6-4-5-19(17-21)18-8-10-20(11-9-18)24-13-15-25(16-14-24)22-7-2-3-12-23-22/h2-7,12,17-18,20H,8-11,13-16H2,1H3/t18-,20-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL					Assay Description Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...				Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50373901 (CHEMBL271987) Show SMILES COc1ccccc1N1CCN(CCCCCNc2ccc3ccccc3n2)CC1 Show InChI InChI=1S/C25H32N4O/c1-30-24-12-6-5-11-23(24)29-19-17-28(18-20-29)16-8-2-7-15-26-25-14-13-21-9-3-4-10-22(21)27-25/h3-6,9-14H,2,7-8,15-20H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 120 mins				J Med Chem 51: 1492-5 (2008) Article DOI: 10.1021/jm7013919 BindingDB Entry DOI: 10.7270/Q2NG4RHP
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50122026 (CHEMBL157322 | N-{2-[4-(2-Chloro-phenyl)-piperazin...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1ccccc1Cl Show InChI InChI=1S/C20H24ClN3O2/c1-26-17-6-4-5-16(15-17)20(25)22-9-10-23-11-13-24(14-12-23)19-8-3-2-7-18(19)21/h2-8,15H,9-14H2,1H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50068366 (CHEMBL93403 | N-{2-[4-(4-Chloro-phenyl)-piperazin-...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-4-2-3-16(15-19)20(25)22-9-10-23-11-13-24(14-12-23)18-7-5-17(21)6-8-18/h2-8,15H,9-14H2,1H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50068366 (CHEMBL93403 | N-{2-[4-(4-Chloro-phenyl)-piperazin-...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-4-2-3-16(15-19)20(25)22-9-10-23-11-13-24(14-12-23)18-7-5-17(21)6-8-18/h2-8,15H,9-14H2,1H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universitá di Bari Curated by ChEMBL					Assay Description In vitro binding affinity at human Dopamine receptor D4.4 by [3H]-YM-09151-2 displacement.				J Med Chem 43: 270-7 (2000) BindingDB Entry DOI: 10.7270/Q2610ZH4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50068362 (3-Methoxy-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-y...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C21H27N3O3/c1-26-18-7-5-6-17(16-18)21(25)22-10-11-23-12-14-24(15-13-23)19-8-3-4-9-20(19)27-2/h3-9,16H,10-15H2,1-2H3,(H,22,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampal membranes				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50033852 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12 Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding affinity of the compound was determined on human cloned 5-hydroxytryptamine 1A receptor transfected in human cell lines (He La)				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50275197 (6-(4-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)...) Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc(cc2)C2CN3C=CSC3=N2)CC1 |c:28,32| Show InChI InChI=1S/C26H32N4O2S/c1-31-25-7-3-2-6-24(25)29-15-13-28(14-16-29)12-4-5-18-32-22-10-8-21(9-11-22)23-20-30-17-19-33-26(30)27-23/h2-3,6-11,17,19,23H,4-5,12-16,18,20H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor by liquid scintillation counting				Bioorg Med Chem 17: 758-66 (2009) Article DOI: 10.1016/j.bmc.2008.11.044 BindingDB Entry DOI: 10.7270/Q2WH2PV3
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D2 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM21383 (6-[4-(2-phenylphenyl)piperazin-1-yl]-N-(1,2,3,4-te...) Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NC1CCCc2ccccc12 Show InChI InChI=1S/C32H39N3O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	0.130	-58.7	n/a	n/a	n/a	n/a	n/a	7.4	37
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50176070 (7-Methoxy-benzofuran-2-carboxylic acid {4-[4-(2,3-...) Show SMILES COc1cccc2cc(oc12)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H27Cl2N3O3/c1-31-20-9-4-6-17-16-21(32-23(17)20)24(30)27-10-2-3-11-28-12-14-29(15-13-28)19-8-5-7-18(25)22(19)26/h4-9,16H,2-3,10-15H2,1H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor by liquid scintillation counting				Bioorg Med Chem 17: 758-66 (2009) Article DOI: 10.1016/j.bmc.2008.11.044 BindingDB Entry DOI: 10.7270/Q2WH2PV3
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50176070 (7-Methoxy-benzofuran-2-carboxylic acid {4-[4-(2,3-...) Show SMILES COc1cccc2cc(oc12)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H27Cl2N3O3/c1-31-20-9-4-6-17-16-21(32-23(17)20)24(30)27-10-2-3-11-28-12-14-29(15-13-28)19-8-5-7-18(25)22(19)26/h4-9,16H,2-3,10-15H2,1H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 expressed in CHO cells				J Med Chem 49: 358-65 (2006) Article DOI: 10.1021/jm050734s BindingDB Entry DOI: 10.7270/Q2TX3F0W
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50176070 (7-Methoxy-benzofuran-2-carboxylic acid {4-[4-(2,3-...) Show SMILES COc1cccc2cc(oc12)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C24H27Cl2N3O3/c1-31-20-9-4-6-17-16-21(32-23(17)20)24(30)27-10-2-3-11-28-12-14-29(15-13-28)19-8-5-7-18(25)22(19)26/h4-9,16H,2-3,10-15H2,1H3,(H,27,30)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Milano/Bicocca Curated by ChEMBL					Assay Description Binding affinity for rat dopamine D3 receptor using [11C] radiotracer				J Med Chem 48: 7018-23 (2005) Article DOI: 10.1021/jm050171k BindingDB Entry DOI: 10.7270/Q2H994SR
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50305263 (2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)				J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50107249 (1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...) Show SMILES COc1ccc2CCC(CCN3CCN(CC3)c3ccccn3)Cc2c1 Show InChI InChI=1S/C22H29N3O/c1-26-21-8-7-19-6-5-18(16-20(19)17-21)9-11-24-12-14-25(15-13-24)22-4-2-3-10-23-22/h2-4,7-8,10,17-18H,5-6,9,11-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL					Assay Description Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...				Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50107249 (1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...) Show SMILES COc1ccc2CCC(CCN3CCN(CC3)c3ccccn3)Cc2c1 Show InChI InChI=1S/C22H29N3O/c1-26-21-8-7-19-6-5-18(16-20(19)17-21)9-11-24-12-14-25(15-13-24)22-4-2-3-10-23-22/h2-4,7-8,10,17-18H,5-6,9,11-16H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50122029 (CHEMBL433741 | N-{4-[4-(2,3-Dimethyl-phenyl)-piper...) Show SMILES COc1cccc(c1)C(=O)NCCCCN1CCN(CC1)c1cccc(C)c1C Show InChI InChI=1S/C24H33N3O2/c1-19-8-6-11-23(20(19)2)27-16-14-26(15-17-27)13-5-4-12-25-24(28)21-9-7-10-22(18-21)29-3/h6-11,18H,4-5,12-17H2,1-3H3,(H,25,28)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D3 of rat using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50122057 (1H-Indazole-3-carboxylic acid {4-[4-(2,3-dichloro-...) Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)c3[nH]nc4ccccc34)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N5O/c23-17-7-5-9-19(20(17)24)29-14-12-28(13-15-29)11-4-3-10-25-22(30)21-16-6-1-2-8-18(16)26-27-21/h1-2,5-9H,3-4,10-15H2,(H,25,30)(H,26,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D3 of rat using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50107235 (CHEMBL138109 | [3-(5-Methoxy-naphthalen-1-yl)-prop...) Show SMILES COc1cccc2c(CCCNCCOc3ccccn3)cccc12 Show InChI InChI=1S/C21H24N2O2/c1-24-20-11-5-9-18-17(7-4-10-19(18)20)8-6-13-22-15-16-25-21-12-2-3-14-23-21/h2-5,7,9-12,14,22H,6,8,13,15-16H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50373895 (CHEMBL259686) Show SMILES COc1ccc2ccc(NCCCN3CCN(CC3)c3ccccc3OC)nc2c1 Show InChI InChI=1S/C24H30N4O2/c1-29-20-10-8-19-9-11-24(26-21(19)18-20)25-12-5-13-27-14-16-28(17-15-27)22-6-3-4-7-23(22)30-2/h3-4,6-11,18H,5,12-17H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 120 mins				J Med Chem 51: 1492-5 (2008) Article DOI: 10.1021/jm7013919 BindingDB Entry DOI: 10.7270/Q2NG4RHP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50329675 (6-methoxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)...) Show SMILES COc1ccc2nc(NCCCCN3CCN(CC3)c3ccccc3OC)ccc2c1 Show InChI InChI=1S/C25H32N4O2/c1-30-21-10-11-22-20(19-21)9-12-25(27-22)26-13-5-6-14-28-15-17-29(18-16-28)23-7-3-4-8-24(23)31-2/h3-4,7-12,19H,5-6,13-18H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari A. Moro Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in HEK293 cells				Bioorg Med Chem Lett 20: 6628-32 (2010) Article DOI: 10.1016/j.bmcl.2010.09.027 BindingDB Entry DOI: 10.7270/Q26M372M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50329675 (6-methoxy-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)...) Show SMILES COc1ccc2nc(NCCCCN3CCN(CC3)c3ccccc3OC)ccc2c1 Show InChI InChI=1S/C25H32N4O2/c1-30-21-10-11-22-20(19-21)9-12-25(27-22)26-13-5-6-14-28-15-17-29(18-16-28)23-7-3-4-8-24(23)31-2/h3-4,7-12,19H,5-6,13-18H2,1-2H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 120 mins				J Med Chem 51: 1492-5 (2008) Article DOI: 10.1021/jm7013919 BindingDB Entry DOI: 10.7270/Q2NG4RHP
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50122032 (3-Methoxy-N-[2-(4-naphthalen-1-yl-piperazin-1-yl)-...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1cccc2ccccc12 Show InChI InChI=1S/C24H27N3O2/c1-29-21-9-4-8-20(18-21)24(28)25-12-13-26-14-16-27(17-15-26)23-11-5-7-19-6-2-3-10-22(19)23/h2-11,18H,12-17H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM21367 (6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...) Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay				J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM21367 (6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...) Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells				J Med Chem 47: 6616-24 (2004) Article DOI: 10.1021/jm049702f BindingDB Entry DOI: 10.7270/Q2RX9BKX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Rattus norvegicus (rat))	BDBM21367 (6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...) Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.220	-57.3	n/a	n/a	n/a	n/a	n/a	7.4	37
Universita degli Studi di Bari					Assay Description IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...				J Med Chem 50: 4214-21 (2007) Article DOI: 10.1021/jm070487n BindingDB Entry DOI: 10.7270/Q20000CJ
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50119386 (Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...) Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1 Show InChI InChI=1S/C24H29N3O2S/c1-29-21-10-4-3-9-20(21)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-5-11-22(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor by liquid scintillation counting				Bioorg Med Chem 17: 758-66 (2009) Article DOI: 10.1016/j.bmc.2008.11.044 BindingDB Entry DOI: 10.7270/Q2WH2PV3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50107240 (CHEMBL344432 | [3-(5-Methoxy-1,2,3,4-tetrahydro-na...) Show SMILES COc1cccc2C(CCCNCCOc3ccccn3)CCCc12 Show InChI InChI=1S/C21H28N2O2/c1-24-20-11-5-9-18-17(7-4-10-19(18)20)8-6-13-22-15-16-25-21-12-2-3-14-23-21/h2-3,5,9,11-12,14,17,22H,4,6-8,10,13,15-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding affinity of the compound was determined on human cloned 5-hydroxytryptamine 1A receptor transfected in human cell lines(He La)				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50122047 (CHEMBL157388 | N-{2-[4-(3-Chloro-phenyl)-piperazin...) Show SMILES COc1cccc(c1)C(=O)NCCN1CCN(CC1)c1cccc(Cl)c1 Show InChI InChI=1S/C20H24ClN3O2/c1-26-19-7-2-4-16(14-19)20(25)22-8-9-23-10-12-24(13-11-23)18-6-3-5-17(21)15-18/h2-7,14-15H,8-13H2,1H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50122039 (CHEMBL152391 | N-{4-[4-(2,3-Dichloro-phenyl)-piper...) Show SMILES COc1cccc(c1)C(=O)NCCCCN1CCN(CC1)c1cccc(Cl)c1Cl Show InChI InChI=1S/C22H27Cl2N3O2/c1-29-18-7-4-6-17(16-18)22(28)25-10-2-3-11-26-12-14-27(15-13-26)20-9-5-8-19(23)21(20)24/h4-9,16H,2-3,10-15H2,1H3,(H,25,28)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D3 of rat using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50132080 (Biphenyl-4-carboxylic acid {4-[4-(2-methoxy-phenyl...) Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)-c2ccccc2)CC1 Show InChI InChI=1S/C28H33N3O2/c1-33-27-12-6-5-11-26(27)31-21-19-30(20-22-31)18-8-7-17-29-28(32)25-15-13-24(14-16-25)23-9-3-2-4-10-23/h2-6,9-16H,7-8,17-22H2,1H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 in CHO cell membrane				J Med Chem 48: 7919-22 (2005) Article DOI: 10.1021/jm050729o BindingDB Entry DOI: 10.7270/Q24M943G
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM21392 (3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...) Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari A. Moro Curated by ChEMBL					Assay Description Displacement of [3H]-5-CT from human cloned 5HT7 receptor				J Med Chem 55: 6375-80 (2012) Article DOI: 10.1021/jm3003679 BindingDB Entry DOI: 10.7270/Q2N87BWQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50033843 (1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...) Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL					Assay Description Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...				Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50033843 (1-[3-(5-Methoxy-3,4-dihydro-2H-naphthalen-1-yliden...) Show SMILES COc1cccc2\C(CCCc12)=C\CCN1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C23H29N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,8-9,11-13H,4,6-7,10,14-18H2,1H3/b19-8+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50033852 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12 Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding affinity was determined on human cloned alpha1a adrenoceptor				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
D(4) dopamine receptor (RAT)	BDBM50329410 (CHEMBL1270323 | N-(2-(4-(benzo[d]isoxazol-3-yl)pip...) Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)c1noc2ccccc12 Show InChI InChI=1S/C20H21FN4O2/c21-16-7-5-15(6-8-16)20(26)22-9-10-24-11-13-25(14-12-24)19-17-3-1-2-4-18(17)27-23-19/h1-8H,9-14H2,(H,22,26)	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` degli Studi di Bari A Moro Curated by ChEMBL					Assay Description Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation counting				J Med Chem 53: 7344-55 (2010) Article DOI: 10.1021/jm100925m BindingDB Entry DOI: 10.7270/Q28G8KX3
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM21392 (3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...) Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand bind...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112395 BindingDB Entry DOI: 10.7270/Q2MW2MW1
					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50373891 (CHEMBL410515) Show SMILES COc1ccccc1N1CCN(CCCCNc2ccc3cc(N)ccc3n2)CC1 Show InChI InChI=1S/C24H31N5O/c1-30-23-7-3-2-6-22(23)29-16-14-28(15-17-29)13-5-4-12-26-24-11-8-19-18-20(25)9-10-21(19)27-24/h2-3,6-11,18H,4-5,12-17,25H2,1H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 120 mins				J Med Chem 51: 1492-5 (2008) Article DOI: 10.1021/jm7013919 BindingDB Entry DOI: 10.7270/Q2NG4RHP
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50107234 (1-[3-(5-Methoxy-naphthalen-1-yl)-propyl]-4-pyridin...) Show SMILES COc1cccc2c(CCCN3CCN(CC3)c3ccccn3)cccc12 Show InChI InChI=1S/C23H27N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-5,7,9-13H,6,8,14-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL					Assay Description Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...				Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50107234 (1-[3-(5-Methoxy-naphthalen-1-yl)-propyl]-4-pyridin...) Show SMILES COc1cccc2c(CCCN3CCN(CC3)c3ccccn3)cccc12 Show InChI InChI=1S/C23H27N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-5,7,9-13H,6,8,14-18H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Rattus norvegicus (Rat))	BDBM50084494 (CHEMBL315879 | N-{4-[4-(4-Chloro-phenyl)-piperazin...) Show SMILES COc1cccc(c1)C(=O)NCCCCN1CCN(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H28ClN3O2/c1-28-21-6-4-5-18(17-21)22(27)24-11-2-3-12-25-13-15-26(16-14-25)20-9-7-19(23)8-10-20/h4-10,17H,2-3,11-16H2,1H3,(H,24,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards Dopamine receptor D3 of rat using [3H]spiroperidol as radioligand				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM84637 (CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...) Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12 |r| Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]spiroperidol from cloned human dopamine receptor D3 in CHO cell membrane				J Med Chem 48: 7919-22 (2005) Article DOI: 10.1021/jm050729o BindingDB Entry DOI: 10.7270/Q24M943G
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM85093 (CAS_3853 | CHEMBL267014 | CHEMBL555670 | L 745,870...) Show SMILES Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ncccc23)CC1 Show InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universitá di Bari Curated by ChEMBL					Assay Description In vitro binding affinity was measured at the cloned human Dopamine receptor D4.2 using [3H]-YM-09151-2 as radioligand.				J Med Chem 41: 4903-9 (1998) Article DOI: 10.1021/jm981041x BindingDB Entry DOI: 10.7270/Q2S46R3V
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50122046 (3-Methoxy-N-[4-(4-naphthalen-1-yl-piperazin-1-yl)-...) Show SMILES COc1cccc(c1)C(=O)NCCCCN1CCN(CC1)c1cccc2ccccc12 Show InChI InChI=1S/C26H31N3O2/c1-31-23-11-6-10-22(20-23)26(30)27-14-4-5-15-28-16-18-29(19-17-28)25-13-7-9-21-8-2-3-12-24(21)25/h2-3,6-13,20H,4-5,14-19H2,1H3,(H,27,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Bari Curated by ChEMBL					Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampal membranes				J Med Chem 45: 5727-35 (2002) BindingDB Entry DOI: 10.7270/Q2TT4RQC
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458532 (CHEMBL4216782) Show SMILES CN(C)CCc1cc(ccc1O)-c1c(C)nn(C)c1C Show InChI InChI=1S/C16H23N3O/c1-11-16(12(2)19(5)17-11)14-6-7-15(20)13(10-14)8-9-18(3)4/h6-7,10,20H,8-9H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Binding affinity to 5-HT7 receptor (unknown origin)				J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50300487 (5-(Dimethylamino)-2-[3-[4-(2-methoxyphenyl)-1-pipe...) Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)c3ccc(cc3C2=O)N(C)C)CC1 Show InChI InChI=1S/C24H30N4O3/c1-25(2)18-9-10-19-20(17-18)24(30)28(23(19)29)12-6-11-26-13-15-27(16-14-26)21-7-4-5-8-22(21)31-3/h4-5,7-10,17H,6,11-16H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bari Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells after 120 mins				J Med Chem 52: 7892-6 (2009) Article DOI: 10.1021/jm900706d BindingDB Entry DOI: 10.7270/Q2251K3Q
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50033852 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12 Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institute and Karolinska University Hospital Curated by ChEMBL					Assay Description Agonist activity at human 5-HT1A receptor expressed in human HeLa cell membranes assessed as stimulation of [35S]GTPgammaS binding after 20 mins by l...				Bioorg Med Chem 23: 4824-30 (2015) Article DOI: 10.1016/j.bmc.2015.05.042 BindingDB Entry DOI: 10.7270/Q21R6S8W
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50033852 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12 Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università Bari Curated by ChEMBL					Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes				J Med Chem 44: 4431-42 (2001) BindingDB Entry DOI: 10.7270/Q2NC60GV
					More data for this Ligand-Target Pair

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