Found 486 hits with Last Name = 'carrière' and Initial = 'mc' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193920
(3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)...)Show SMILES O=C(NS(=O)(=O)c1cccs1)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 Show InChI InChI=1S/C31H25NO4S2/c33-30(32-38(34,35)31-11-6-18-37-31)17-15-25-9-4-5-10-26(25)19-24-12-13-28-21-29(16-14-27(28)20-24)36-22-23-7-2-1-3-8-23/h1-18,20-21H,19,22H2,(H,32,33)/b17-15+ | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193922
(CHEMBL218071 | N-(5-bromo-2-methoxyphenylsulfonyl)...)Show SMILES COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1 Show InChI InChI=1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+ | PDB
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193935
(3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)...)Show SMILES COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 Show InChI InChI=1S/C34H28BrNO5S/c1-40-32-17-15-30(35)22-33(32)42(38,39)36-34(37)18-14-26-9-5-6-10-27(26)19-25-11-12-29-21-31(16-13-28(29)20-25)41-23-24-7-3-2-4-8-24/h2-18,20-22H,19,23H2,1H3,(H,36,37)/b18-14+ | PDB
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PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor in presence of HSA |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193935
(3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)...)Show SMILES COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 Show InChI InChI=1S/C34H28BrNO5S/c1-40-32-17-15-30(35)22-33(32)42(38,39)36-34(37)18-14-26-9-5-6-10-27(26)19-25-11-12-29-21-31(16-13-28(29)20-25)41-23-24-7-3-2-4-8-24/h2-18,20-22H,19,23H2,1H3,(H,36,37)/b18-14+ | PDB
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| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193921
(3-(2-(naphthalen-2-ylmethyl)phenyl)-N-(thiophen-2-...)Show SMILES O=C(NS(=O)(=O)c1cccs1)\C=C\c1ccccc1Cc1ccc2ccccc2c1 Show InChI InChI=1S/C24H19NO3S2/c26-23(25-30(27,28)24-10-5-15-29-24)14-13-20-7-2-4-9-22(20)17-18-11-12-19-6-1-3-8-21(19)16-18/h1-16H,17H2,(H,25,26)/b14-13+ | PDB
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| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193918
(3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-...)Show SMILES COc1cc(C\C=C\c2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 Show InChI InChI=1S/C30H27NO5S2/c1-35-28-21-23(16-18-27(28)36-22-24-9-3-2-4-10-24)11-7-14-25-12-5-6-13-26(25)17-19-29(32)31-38(33,34)30-15-8-20-37-30/h2-10,12-21H,11,22H2,1H3,(H,31,32)/b14-7+,19-17+ | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193938
(3-(2-(4-(benzyloxy)-3-methoxycinnamyl)phenyl)-N-(t...)Show SMILES COc1cc(\C=C\Cc2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 Show InChI InChI=1S/C30H27NO5S2/c1-35-28-21-23(16-18-27(28)36-22-24-9-3-2-4-10-24)11-7-14-25-12-5-6-13-26(25)17-19-29(32)31-38(33,34)30-15-8-20-37-30/h2-13,15-21H,14,22H2,1H3,(H,31,32)/b11-7+,19-17+ | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193923
(3-(2-(4-methoxycinnamyl)phenyl)-N-(thiophen-2-ylsu...)Show SMILES COc1ccc(\C=C\Cc2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)cc1 Show InChI InChI=1S/C23H21NO4S2/c1-28-21-14-11-18(12-15-21)6-4-9-19-7-2-3-8-20(19)13-16-22(25)24-30(26,27)23-10-5-17-29-23/h2-8,10-17H,9H2,1H3,(H,24,25)/b6-4+,16-13+ | PDB
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193920
(3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)...)Show SMILES O=C(NS(=O)(=O)c1cccs1)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 Show InChI InChI=1S/C31H25NO4S2/c33-30(32-38(34,35)31-11-6-18-37-31)17-15-25-9-4-5-10-26(25)19-24-12-13-28-21-29(16-14-27(28)20-24)36-22-23-7-2-1-3-8-23/h1-18,20-21H,19,22H2,(H,32,33)/b17-15+ | PDB
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor in presence of HSA |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193937
(3-(2-((E)-3-(4-methoxyphenyl)prop-1-enyl)phenyl)-N...)Show SMILES COc1ccc(C\C=C\c2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)cc1 Show InChI InChI=1S/C23H21NO4S2/c1-28-21-14-11-18(12-15-21)6-4-9-19-7-2-3-8-20(19)13-16-22(25)24-30(26,27)23-10-5-17-29-23/h2-5,7-17H,6H2,1H3,(H,24,25)/b9-4+,16-13+ | PDB
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193926
(3-(2-(2-(2,6-dichlorobenzyloxy)-5-methylcinnamyl)p...)Show SMILES Cc1ccc(OCc2c(Cl)cccc2Cl)c(\C=C\Cc2ccccc2\C=C\C(O)=O)c1 Show InChI InChI=1S/C26H22Cl2O3/c1-18-12-14-25(31-17-22-23(27)10-5-11-24(22)28)21(16-18)9-4-8-19-6-2-3-7-20(19)13-15-26(29)30/h2-7,9-16H,8,17H2,1H3,(H,29,30)/b9-4+,15-13+ | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159778
((E)-3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-meth...)Show SMILES Cc1cccc(\C=C\Cc2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl Show InChI InChI=1S/C26H22Cl2O3/c1-18-7-4-11-21(26(18)31-17-22-23(27)13-6-14-24(22)28)12-5-10-19-8-2-3-9-20(19)15-16-25(29)30/h2-9,11-16H,10,17H2,1H3,(H,29,30)/b12-5+,16-15+ | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160912
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)Show SMILES OC(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F Show InChI InChI=1S/C24H17ClF3NO2S/c25-18-6-7-21(31-14-15-4-2-1-3-5-15)20(11-18)19-8-9-32-22(19)16-10-17(13-29-12-16)23(30)24(26,27)28/h1-13,23,30H,14H2 | KEGG
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50134526
(2-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl...)Show SMILES OC(=O)C1CC1c1ccccc1-c1csc(c1)-c1ccccc1OCc1ccccc1 Show InChI InChI=1S/C27H22O3S/c28-27(29)24-15-23(24)21-11-5-4-10-20(21)19-14-26(31-17-19)22-12-6-7-13-25(22)30-16-18-8-2-1-3-9-18/h1-14,17,23-24H,15-16H2,(H,28,29) | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line. |
Bioorg Med Chem Lett 13: 3813-6 (2003)
BindingDB Entry DOI: 10.7270/Q26T0M1N |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160907
(5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)Show SMILES OC(=O)c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C23H16ClNO3S/c24-18-6-7-21(28-14-15-4-2-1-3-5-15)20(11-18)19-8-9-29-22(19)16-10-17(23(26)27)13-25-12-16/h1-13H,14H2,(H,26,27) | KEGG
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Similars
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193924
(3-(2-((6-(benzyloxy)naphthalen-2-yl)methyl)phenyl)...)Show SMILES OC(=O)\C=C\c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1 Show InChI InChI=1S/C27H22O3/c28-27(29)15-13-22-8-4-5-9-23(22)16-21-10-11-25-18-26(14-12-24(25)17-21)30-19-20-6-2-1-3-7-20/h1-15,17-18H,16,19H2,(H,28,29)/b15-13+ | PDB
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| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160915
(CHEMBL180046 | N-{3-[3-(2-Benzyloxy-5-chloro-pheny...)Show SMILES Clc1ccc(OCc2ccccc2)c(c1)-c1ccsc1-c1cccc(NC(=O)Cc2ccccc2)c1 Show InChI InChI=1S/C31H24ClNO2S/c32-25-14-15-29(35-21-23-10-5-2-6-11-23)28(20-25)27-16-17-36-31(27)24-12-7-13-26(19-24)33-30(34)18-22-8-3-1-4-9-22/h1-17,19-20H,18,21H2,(H,33,34) | KEGG
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PC cid
PC sid
UniChem
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160917
(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)Show SMILES OC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C24H17ClO3S/c25-19-9-10-22(28-15-16-5-2-1-3-6-16)21(14-19)20-11-12-29-23(20)17-7-4-8-18(13-17)24(26)27/h1-14H,15H2,(H,26,27) | KEGG
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| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160909
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)Show SMILES OC(O)(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F Show InChI InChI=1S/C24H17ClF3NO3S/c25-18-6-7-21(32-14-15-4-2-1-3-5-15)20(11-18)19-8-9-33-22(19)16-10-17(13-29-12-16)23(30,31)24(26,27)28/h1-13,30-31H,14H2 | KEGG
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160909
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)Show SMILES OC(O)(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F Show InChI InChI=1S/C24H17ClF3NO3S/c25-18-6-7-21(32-14-15-4-2-1-3-5-15)20(11-18)19-8-9-33-22(19)16-10-17(13-29-12-16)23(30,31)24(26,27)28/h1-13,30-31H,14H2 | KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193925
(3-(2-cinnamylphenyl)-N-(thiophen-2-ylsulfonyl)acry...)Show SMILES O=C(NS(=O)(=O)c1cccs1)\C=C\c1ccccc1C\C=C\c1ccccc1 Show InChI InChI=1S/C22H19NO3S2/c24-21(23-28(25,26)22-14-7-17-27-22)16-15-20-12-5-4-11-19(20)13-6-10-18-8-2-1-3-9-18/h1-12,14-17H,13H2,(H,23,24)/b10-6+,16-15+ | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160915
(CHEMBL180046 | N-{3-[3-(2-Benzyloxy-5-chloro-pheny...)Show SMILES Clc1ccc(OCc2ccccc2)c(c1)-c1ccsc1-c1cccc(NC(=O)Cc2ccccc2)c1 Show InChI InChI=1S/C31H24ClNO2S/c32-25-14-15-29(35-21-23-10-5-2-6-11-23)28(20-25)27-16-17-36-31(27)24-12-7-13-26(19-24)33-30(34)18-22-8-3-1-4-9-22/h1-17,19-20H,18,21H2,(H,33,34) | KEGG
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193930
(3-(2-((E)-3-phenylprop-1-enyl)phenyl)-N-(thiophen-...)Show SMILES O=C(NS(=O)(=O)c1cccs1)\C=C\c1ccccc1\C=C\Cc1ccccc1 Show InChI InChI=1S/C22H19NO3S2/c24-21(23-28(25,26)22-14-7-17-27-22)16-15-20-12-5-4-11-19(20)13-6-10-18-8-2-1-3-9-18/h1-9,11-17H,10H2,(H,23,24)/b13-6+,16-15+ | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160912
(1-{5-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-y...)Show SMILES OC(c1cncc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)C(F)(F)F Show InChI InChI=1S/C24H17ClF3NO2S/c25-18-6-7-21(31-14-15-4-2-1-3-5-15)20(11-18)19-8-9-32-22(19)16-10-17(13-29-12-16)23(30)24(26,27)28/h1-13,23,30H,14H2 | KEGG
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor in presence of 2% human serum albumin |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160913
(6-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)Show SMILES OC(=O)c1cccc(n1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C23H16ClNO3S/c24-16-9-10-21(28-14-15-5-2-1-3-6-15)18(13-16)17-11-12-29-22(17)19-7-4-8-20(25-19)23(26)27/h1-13H,14H2,(H,26,27) | KEGG
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193922
(CHEMBL218071 | N-(5-bromo-2-methoxyphenylsulfonyl)...)Show SMILES COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1 Show InChI InChI=1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+ | PDB
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| 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor in presence of HSA |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50134524
((E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-ally...)Show SMILES Cc1cccc(\C=C\Cc2ccccc2\C=C\C(O)=O)c1OCc1ccccc1 Show InChI InChI=1S/C26H24O3/c1-20-9-7-15-24(26(20)29-19-21-10-3-2-4-11-21)16-8-14-22-12-5-6-13-23(22)17-18-25(27)28/h2-13,15-18H,14,19H2,1H3,(H,27,28)/b16-8+,18-17+ | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line. |
Bioorg Med Chem Lett 13: 3813-6 (2003)
BindingDB Entry DOI: 10.7270/Q26T0M1N |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159762
((E)-3-(2-{(E)-3-[2-(4-Fluoro-benzyloxy)-3-methyl-p...)Show SMILES Cc1cccc(\C=C\Cc2ccccc2\C=C\C(O)=O)c1OCc1ccc(F)cc1 Show InChI InChI=1S/C26H23FO3/c1-19-6-4-10-23(26(19)30-18-20-12-15-24(27)16-13-20)11-5-9-21-7-2-3-8-22(21)14-17-25(28)29/h2-8,10-17H,9,18H2,1H3,(H,28,29)/b11-5+,17-14+ | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50134524
((E)-3-{2-[(E)-3-(2-Benzyloxy-3-methyl-phenyl)-ally...)Show SMILES Cc1cccc(\C=C\Cc2ccccc2\C=C\C(O)=O)c1OCc1ccccc1 Show InChI InChI=1S/C26H24O3/c1-20-9-7-15-24(26(20)29-19-21-10-3-2-4-11-21)16-8-14-22-12-5-6-13-23(22)17-18-25(27)28/h2-13,15-18H,14,19H2,1H3,(H,27,28)/b16-8+,18-17+ | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50410087
(CHEMBL2113029)Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccsc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C23H18ClNO3S2/c24-18-9-10-22(28-15-16-5-2-1-3-6-16)21(14-18)23-20(11-12-29-23)17-7-4-8-19(13-17)30(25,26)27/h1-14H,15H2,(H2,25,26,27) | KEGG
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50159763
((E)-3-{2-[(E)-2-(2-Benzyloxy-phenyl)-vinyl]-phenyl...)Show InChI InChI=1S/C24H20O3/c25-24(26)17-16-21-11-5-4-10-20(21)14-15-22-12-6-7-13-23(22)27-18-19-8-2-1-3-9-19/h1-17H,18H2,(H,25,26)/b15-14+,17-16+ | PDB
Reactome pathway
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP2 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159774
((E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-pro...)Show SMILES COc1cc(C\C=C\c2ccccc2\C=C\C(O)=O)ccc1OCc1ccccc1 Show InChI InChI=1S/C26H24O4/c1-29-25-18-20(14-16-24(25)30-19-21-8-3-2-4-9-21)10-7-13-22-11-5-6-12-23(22)15-17-26(27)28/h2-9,11-18H,10,19H2,1H3,(H,27,28)/b13-7+,17-15+ | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159774
((E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-pro...)Show SMILES COc1cc(C\C=C\c2ccccc2\C=C\C(O)=O)ccc1OCc1ccccc1 Show InChI InChI=1S/C26H24O4/c1-29-25-18-20(14-16-24(25)30-19-21-8-3-2-4-9-21)10-7-13-22-11-5-6-12-23(22)15-17-26(27)28/h2-9,11-18H,10,19H2,1H3,(H,27,28)/b13-7+,17-15+ | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193931
(3-(2-(4-(benzyloxy)-3-methoxycinnamyl)phenyl)acryl...)Show SMILES COc1cc(\C=C\Cc2ccccc2\C=C\C(O)=O)ccc1OCc1ccccc1 Show InChI InChI=1S/C26H24O4/c1-29-25-18-20(14-16-24(25)30-19-21-8-3-2-4-9-21)10-7-13-22-11-5-6-12-23(22)15-17-26(27)28/h2-12,14-18H,13,19H2,1H3,(H,27,28)/b10-7+,17-15+ | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193928
(3-(2-((E)-3-(2-(benzyloxy)-5-methylphenyl)prop-1-e...)Show SMILES Cc1ccc(OCc2ccccc2)c(C\C=C\c2ccccc2\C=C\C(O)=O)c1 Show InChI InChI=1S/C26H24O3/c1-20-14-16-25(29-19-21-8-3-2-4-9-21)24(18-20)13-7-12-22-10-5-6-11-23(22)15-17-26(27)28/h2-12,14-18H,13,19H2,1H3,(H,27,28)/b12-7+,17-15+ | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193929
(3-(2-(2-(benzyloxy)-5-methylcinnamyl)phenyl)acryli...)Show SMILES Cc1ccc(OCc2ccccc2)c(\C=C\Cc2ccccc2\C=C\C(O)=O)c1 Show InChI InChI=1S/C26H24O3/c1-20-14-16-25(29-19-21-8-3-2-4-9-21)24(18-20)13-7-12-22-10-5-6-11-23(22)15-17-26(27)28/h2-11,13-18H,12,19H2,1H3,(H,27,28)/b13-7+,17-15+ | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160914
(3-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)Show SMILES CC(NC(=O)c1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1)c1cccnc1 Show InChI InChI=1S/C31H25ClN2O2S/c1-21(25-11-6-15-33-19-25)34-31(35)24-10-5-9-23(17-24)30-27(14-16-37-30)28-18-26(32)12-13-29(28)36-20-22-7-3-2-4-8-22/h2-19,21H,20H2,1H3,(H,34,35) | KEGG
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PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50370467
(CHEMBL1237295)Show SMILES Cc1cccc(C\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1ccccc1 Show InChI InChI=1S/C26H24O3/c1-20-9-7-15-24(26(20)29-19-21-10-3-2-4-11-21)16-8-14-22-12-5-6-13-23(22)17-18-25(27)28/h2-15,17-18H,16,19H2,1H3,(H,27,28)/b14-8+,18-17+ | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50370467
(CHEMBL1237295)Show SMILES Cc1cccc(C\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1ccccc1 Show InChI InChI=1S/C26H24O3/c1-20-9-7-15-24(26(20)29-19-21-10-3-2-4-11-21)16-8-14-22-12-5-6-13-23(22)17-18-25(27)28/h2-15,17-18H,16,19H2,1H3,(H,27,28)/b14-8+,18-17+ | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159758
(3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-methyl-p...)Show SMILES Cc1cccc(C(O)\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl Show InChI InChI=1S/C26H22Cl2O4/c1-17-6-4-9-20(26(17)32-16-21-22(27)10-5-11-23(21)28)24(29)14-12-18-7-2-3-8-19(18)13-15-25(30)31/h2-15,24,29H,16H2,1H3,(H,30,31)/b14-12+,15-13+ | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159771
((E)-3-{2-[(E)-3-(2-Hydroxy-3-methyl-phenyl)-allyl]...)Show InChI InChI=1S/C19H18O3/c1-14-6-4-10-17(19(14)22)11-5-9-15-7-2-3-8-16(15)12-13-18(20)21/h2-8,10-13,22H,9H2,1H3,(H,20,21)/b11-5+,13-12+ | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193927
(3-(2-((E)-3-(2-(benzyloxy)-5-methylphenyl)prop-1-e...)Show SMILES Cc1ccc(OCc2ccccc2)c(C\C=C\c2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)c1 Show InChI InChI=1S/C30H27NO4S2/c1-23-16-18-28(35-22-24-9-3-2-4-10-24)27(21-23)14-7-13-25-11-5-6-12-26(25)17-19-29(32)31-37(33,34)30-15-8-20-36-30/h2-13,15-21H,14,22H2,1H3,(H,31,32)/b13-7+,19-17+ | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159773
(3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-methyl-p...)Show SMILES Cc1cccc(\C=C\C(O)c2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl Show InChI InChI=1S/C26H22Cl2O4/c1-17-6-4-8-19(26(17)32-16-21-22(27)10-5-11-23(21)28)12-14-24(29)20-9-3-2-7-18(20)13-15-25(30)31/h2-15,24,29H,16H2,1H3,(H,30,31)/b14-12+,15-13+ | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50193933
(3-(2-(2-(benzyloxy)-5-methylcinnamyl)phenyl)-N-(th...)Show SMILES Cc1ccc(OCc2ccccc2)c(\C=C\Cc2ccccc2\C=C\C(=O)NS(=O)(=O)c2cccs2)c1 Show InChI InChI=1S/C30H27NO4S2/c1-23-16-18-28(35-22-24-9-3-2-4-10-24)27(21-23)14-7-13-25-11-5-6-12-26(25)17-19-29(32)31-37(33,34)30-15-8-20-36-30/h2-12,14-21H,13,22H2,1H3,(H,31,32)/b14-7+,19-17+ | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 16: 5639-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.025
BindingDB Entry DOI: 10.7270/Q2NS0VQ6 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50370468
(CHEMBL1237296)Show SMILES OC(=O)\C=C\c1ccccc1C\C=C/c1cccc(O)c1OCc1ccccc1 Show InChI InChI=1S/C25H22O4/c26-23-15-7-14-22(25(23)29-18-19-8-2-1-3-9-19)13-6-12-20-10-4-5-11-21(20)16-17-24(27)28/h1-11,13-17,26H,12,18H2,(H,27,28)/b13-6-,17-16+ | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Rattus norvegicus (Rat)) | BDBM50160913
(6-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)Show SMILES OC(=O)c1cccc(n1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C23H16ClNO3S/c24-16-9-10-21(28-14-15-5-2-1-3-6-15)18(13-16)17-11-12-29-22(17)19-7-4-8-20(25-19)23(26)27/h1-13H,14H2,(H,26,27) | Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity towards Prostaglandin E receptor was determined in rat |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50159761
((E)-3-{2-[3-(2-Benzyloxy-3-methyl-phenyl)-propyl]-...)Show SMILES Cc1cccc(CCCc2ccccc2\C=C\C(O)=O)c1OCc1ccccc1 Show InChI InChI=1S/C26H26O3/c1-20-9-7-15-24(26(20)29-19-21-10-3-2-4-11-21)16-8-14-22-12-5-6-13-23(22)17-18-25(27)28/h2-7,9-13,15,17-18H,8,14,16,19H2,1H3,(H,27,28)/b18-17+ | PDB
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50370472
(CHEMBL1237305)Show SMILES OCc1cccc(C\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl Show InChI InChI=1S/C26H22Cl2O4/c27-23-12-5-13-24(28)22(23)17-32-26-20(10-4-11-21(26)16-29)9-3-8-18-6-1-2-7-19(18)14-15-25(30)31/h1-8,10-15,29H,9,16-17H2,(H,30,31)/b8-3+,15-14+ | PDB
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity for human prostanoid EP3 receptor |
Bioorg Med Chem Lett 15: 527-30 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.051
BindingDB Entry DOI: 10.7270/Q26H4J51 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50160910
(CHEMBL184779 | {3-[3-(2-Benzyloxy-5-chloro-phenyl)...)Show SMILES OC(=O)Cc1cccc(c1)-c1sccc1-c1cc(Cl)ccc1OCc1ccccc1 Show InChI InChI=1S/C25H19ClO3S/c26-20-9-10-23(29-16-17-5-2-1-3-6-17)22(15-20)21-11-12-30-25(21)19-8-4-7-18(13-19)14-24(27)28/h1-13,15H,14,16H2,(H,27,28) | KEGG
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Binding affinity against Prostaglandin E receptor was determined in human |
Bioorg Med Chem Lett 15: 1155-60 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.005
BindingDB Entry DOI: 10.7270/Q2SF2VNV |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50134516
(CHEMBL434637 | Thiophene-2-sulfonic acid [3-(2''-b...)Show SMILES O=C(CCc1ccccc1-c1cccc(c1)-c1ccccc1OCc1ccccc1)NS(=O)(=O)c1cccs1 Show InChI InChI=1S/C32H27NO4S2/c34-31(33-39(35,36)32-18-9-21-38-32)20-19-25-12-4-5-15-28(25)26-13-8-14-27(22-26)29-16-6-7-17-30(29)37-23-24-10-2-1-3-11-24/h1-18,21-22H,19-20,23H2,(H,33,34) | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description
Affinity at human Prostanoid EP3 receptor in the human embryonic kidney (HEK) 293 cell line. |
Bioorg Med Chem Lett 13: 3813-6 (2003)
BindingDB Entry DOI: 10.7270/Q26T0M1N |
More data for this
Ligand-Target Pair | |
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