Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176407 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176411 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176407 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176411 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176403 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29061 (CHEMBL201602 | pyrazolopyrimidinone-based antagoni...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.600 | -53.5 | n/a | n/a | 1 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29061 (CHEMBL201602 | pyrazolopyrimidinone-based antagoni...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.650 | -53.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM27337 (1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 0.700 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29070 (lactam-based compound, 12i) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.700 | -53.1 | n/a | n/a | 0.800 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 0.900 | -52.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176418 (8-(2-chlorophenyl)-9-(4-chlorophenyl)-1-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176416 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-ethyl-6-(2...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29061 (CHEMBL201602 | pyrazolopyrimidinone-based antagoni...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176403 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176402 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176402 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29075 (PF-514273) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | -52.2 | n/a | n/a | 0.820 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176418 (8-(2-chlorophenyl)-9-(4-chlorophenyl)-1-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29073 (ether-based lactam, 19b) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | -51.6 | n/a | n/a | 4.80 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29076 (ether-based lactam, 19e) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 1.40 | -51.4 | n/a | n/a | 0.700 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29069 (lactam-based compound, 12h) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.70 | -50.9 | n/a | n/a | 3.10 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 1.80 | -50.7 | n/a | n/a | 1.60 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176415 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(3,3,3-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29074 (ether-based lactam, 19c) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 1.90 | -50.6 | n/a | n/a | 1.5 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176413 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-propyl-2H-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176413 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-propyl-2H-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM27341 (8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(piperidin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.10 | -50.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM21278 (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM27341 (8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(piperidin...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.30 | -50.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29065 (lactam-based compound, 12d) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.5 | -49.9 | n/a | n/a | 9.80 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29064 (lactam-based compound, 12c) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | -49.9 | n/a | n/a | 5.5 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM27337 (1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | -49.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM27343 (8-(2-chlorophenyl)-9-(4-chlorophenyl)-6-(4-methylp...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.80 | -49.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176410 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2-fluoroe...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176416 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-ethyl-6-(2...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM27338 (9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-N-(piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.60 | -49.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176415 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(3,3,3-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176409 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-ethyl-2H-p...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176412 (6-benzyl-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176404 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176409 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-ethyl-2H-p...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM27340 (9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.20 | -48.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29063 (lactam-based compound, 12b) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.70 | -48.3 | n/a | n/a | 25 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM29066 (lactam-based compound, 12e) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.70 | -48.3 | n/a | n/a | 11 | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 2652-5 (2009) Article DOI: 10.1021/jm900255t BindingDB Entry DOI: 10.7270/Q2F47MGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176410 (2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2-fluoroe...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assay | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50176412 (6-benzyl-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-Groton Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 731-6 (2005) Article DOI: 10.1016/j.bmcl.2005.10.019 BindingDB Entry DOI: 10.7270/Q2TM79PM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM27342 (9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(4-met...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.20 | -48.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM27342 (9-(4-chlorophenyl)-8-(2,4-dichlorophenyl)-6-(4-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.90 | -47.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c... | J Med Chem 52: 234-7 (2009) Article DOI: 10.1021/jm8012932 BindingDB Entry DOI: 10.7270/Q2CN7276 | |||||||||||
More data for this Ligand-Target Pair |
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