Found 164 hits with Last Name = 'garner' and Initial = 'ap' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420953
(CHEMBL2088260)Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)on4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C22H25N7O3/c1-14-8-17(29-32-14)13-24-22-23-7-6-20(26-22)25-21-11-16(27-28-21)5-4-15-9-18(30-2)12-19(10-15)31-3/h6-12H,4-5,13H2,1-3H3,(H3,23,24,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420961
(CHEMBL2088096)Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)no4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C22H25N7O3/c1-14-8-19(32-29-14)13-24-22-23-7-6-20(26-22)25-21-11-16(27-28-21)5-4-15-9-17(30-2)12-18(10-15)31-3/h6-12H,4-5,13H2,1-3H3,(H3,23,24,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420959
(CHEMBL2088095)Show SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1 Show InChI InChI=1S/C20H20BrN7O/c1-13-9-16(29-28-13)11-22-20-23-12-17(21)19(25-20)24-18-10-15(26-27-18)8-7-14-5-3-2-4-6-14/h2-6,9-10,12H,7-8,11H2,1H3,(H3,22,23,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420968
(CHEMBL2088259)Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C23H25N7O2/c1-31-19-11-16(12-20(14-19)32-2)6-7-17-13-22(30-29-17)27-21-8-10-25-23(28-21)26-15-18-5-3-4-9-24-18/h3-5,8-14H,6-7,15H2,1-2H3,(H3,25,26,27,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420964
(CHEMBL2088100)Show SMILES Cc1cc(CNc2nccc(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1 Show InChI InChI=1S/C20H21N7O/c1-14-11-17(28-27-14)13-22-20-21-10-9-18(24-20)23-19-12-16(25-26-19)8-7-15-5-3-2-4-6-15/h2-6,9-12H,7-8,13H2,1H3,(H3,21,22,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420958
(CHEMBL2088094)Show InChI InChI=1S/C15H18BrN7O/c1-3-4-10-6-13(22-21-10)19-14-12(16)8-18-15(20-14)17-7-11-5-9(2)23-24-11/h5-6,8H,3-4,7H2,1-2H3,(H3,17,18,19,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419102
(CHEMBL1824369)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2C#N)c1 Show InChI InChI=1S/C28H29N3O4/c29-19-21-7-1-2-8-22(21)20-35-27-18-25(34-16-6-15-31-13-3-4-14-31)11-12-26(27)28(33)30-23-9-5-10-24(32)17-23/h1-2,5,7-12,17-18,32H,3-4,6,13-16,20H2,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420959
(CHEMBL2088095)Show SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1 Show InChI InChI=1S/C20H20BrN7O/c1-13-9-16(29-28-13)11-22-20-23-12-17(21)19(25-20)24-18-10-15(26-27-18)8-7-14-5-3-2-4-6-14/h2-6,9-10,12H,7-8,11H2,1H3,(H3,22,23,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420946
(CHEMBL2088108)Show InChI InChI=1S/C15H17N7O/c1-9-6-14(21-20-9)18-13-4-5-16-15(19-13)17-8-11-7-12(22-23-11)10-2-3-10/h4-7,10H,2-3,8H2,1H3,(H3,16,17,18,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420951
(CHEMBL2088257)Show SMILES COCCCc1cc(Nc2ccnc(NCc3cc(no3)C3CC3)n2)[nH]n1 Show InChI InChI=1S/C18H23N7O2/c1-26-8-2-3-13-9-17(24-23-13)21-16-6-7-19-18(22-16)20-11-14-10-15(25-27-14)12-4-5-12/h6-7,9-10,12H,2-5,8,11H2,1H3,(H3,19,20,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420950
(CHEMBL2088113)Show InChI InChI=1S/C16H18BrN7/c1-2-4-12-7-14(24-23-12)21-15-13(17)10-20-16(22-15)19-9-11-5-3-6-18-8-11/h3,5-8,10H,2,4,9H2,1H3,(H3,19,20,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420960
(CHEMBL2088092)Show SMILES Cc1cc(Nc2nc(NCc3cc(no3)C(C)(C)C)ncc2Br)[nH]n1 Show InChI InChI=1S/C16H20BrN7O/c1-9-5-13(23-22-9)20-14-11(17)8-19-15(21-14)18-7-10-6-12(24-25-10)16(2,3)4/h5-6,8H,7H2,1-4H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420963
(CHEMBL2088097)Show InChI InChI=1S/C13H14ClN7O/c1-7-4-11(20-19-7)17-12-10(14)6-16-13(18-12)15-5-9-3-8(2)21-22-9/h3-4,6H,5H2,1-2H3,(H3,15,16,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420948
(CHEMBL2088111)Show InChI InChI=1S/C15H16BrN7/c1-2-10-7-13(23-22-10)20-14-12(16)9-19-15(21-14)18-8-11-5-3-4-6-17-11/h3-7,9H,2,8H2,1H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419101
(CHEMBL1824368)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2F)c1 Show InChI InChI=1S/C27H29FN2O4/c28-25-10-2-1-7-20(25)19-34-26-18-23(33-16-6-15-30-13-3-4-14-30)11-12-24(26)27(32)29-21-8-5-9-22(31)17-21/h1-2,5,7-12,17-18,31H,3-4,6,13-16,19H2,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40.7 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419123
(CHEMBL1824371)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(F)c2)c1 Show InChI InChI=1S/C27H29FN2O4/c28-21-7-3-6-20(16-21)19-34-26-18-24(33-15-5-14-30-12-1-2-13-30)10-11-25(26)27(32)29-22-8-4-9-23(31)17-22/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55.0 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420967
(CHEMBL2088256)Show InChI InChI=1S/C16H18BrN7/c1-10(2)13-6-14(24-23-13)21-15-12(17)9-20-16(22-15)19-8-11-4-3-5-18-7-11/h3-7,9-10H,8H2,1-2H3,(H3,19,20,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420957
(CHEMBL2088093)Show InChI InChI=1S/C16H20BrN7O2/c1-10-6-12(26-24-10)8-18-16-19-9-13(17)15(21-16)20-14-7-11(22-23-14)4-3-5-25-2/h6-7,9H,3-5,8H2,1-2H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420956
(CHEMBL2088091)Show InChI InChI=1S/C13H14BrN7O/c1-7-4-11(20-19-7)17-12-10(14)6-16-13(18-12)15-5-9-3-8(2)21-22-9/h3-4,6H,5H2,1-2H3,(H3,15,16,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420959
(CHEMBL2088095)Show SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1 Show InChI InChI=1S/C20H20BrN7O/c1-13-9-16(29-28-13)11-22-20-23-12-17(21)19(25-20)24-18-10-15(26-27-18)8-7-14-5-3-2-4-6-14/h2-6,9-10,12H,7-8,11H2,1H3,(H3,22,23,24,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblotting |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420952
(CHEMBL2088258)Show SMILES COCCCc1cc(Nc2ccnc(NCc3cc(no3)C(N)=O)n2)[nH]n1 Show InChI InChI=1S/C16H20N8O3/c1-26-6-2-3-10-7-14(23-22-10)20-13-4-5-18-16(21-13)19-9-11-8-12(15(17)25)24-27-11/h4-5,7-8H,2-3,6,9H2,1H3,(H2,17,25)(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419103
(CHEMBL1824370)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2c(F)cccc2F)c1 Show InChI InChI=1S/C27H28F2N2O4/c28-24-8-4-9-25(29)23(24)18-35-26-17-21(34-15-5-14-31-12-1-2-13-31)10-11-22(26)27(33)30-19-6-3-7-20(32)16-19/h3-4,6-11,16-17,32H,1-2,5,12-15,18H2,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69.2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420961
(CHEMBL2088096)Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)no4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C22H25N7O3/c1-14-8-19(32-29-14)13-24-22-23-7-6-20(26-22)25-21-11-16(27-28-21)5-4-15-9-17(30-2)12-18(10-15)31-3/h6-12H,4-5,13H2,1-3H3,(H3,23,24,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420962
(CHEMBL2088098)Show InChI InChI=1S/C13H15N7O/c1-8-6-12(19-18-8)16-11-3-4-14-13(17-11)15-7-10-5-9(2)20-21-10/h3-6H,7H2,1-2H3,(H3,14,15,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420949
(CHEMBL2088112)Show SMILES CCc1cc(Nc2nc(NCc3cc(no3)-c3ccccn3)ncc2Br)[nH]n1 Show InChI InChI=1S/C18H17BrN8O/c1-2-11-7-16(26-25-11)23-17-13(19)10-22-18(24-17)21-9-12-8-15(27-28-12)14-5-3-4-6-20-14/h3-8,10H,2,9H2,1H3,(H3,21,22,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420939
(CHEMBL2088099)Show InChI InChI=1S/C16H21N7O2/c1-11-8-13(25-23-11)10-18-16-17-6-5-14(20-16)19-15-9-12(21-22-15)4-3-7-24-2/h5-6,8-9H,3-4,7,10H2,1-2H3,(H3,17,18,19,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420944
(CHEMBL2088106)Show InChI InChI=1S/C15H16BrN7/c1-9-4-3-5-17-12(9)8-19-15-18-7-11(16)14(21-15)20-13-6-10(2)22-23-13/h3-7H,8H2,1-2H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419105
(CHEMBL1824373)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(c2)C#N)c1 Show InChI InChI=1S/C28H29N3O4/c29-19-21-6-3-7-22(16-21)20-35-27-18-25(34-15-5-14-31-12-1-2-13-31)10-11-26(27)28(33)30-23-8-4-9-24(32)17-23/h3-4,6-11,16-18,32H,1-2,5,12-15,20H2,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419104
(CHEMBL1824372)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(Cl)c2)c1 Show InChI InChI=1S/C27H29ClN2O4/c28-21-7-3-6-20(16-21)19-34-26-18-24(33-15-5-14-30-12-1-2-13-30)10-11-25(26)27(32)29-22-8-4-9-23(31)17-22/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97.7 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420943
(CHEMBL2088104)Show InChI InChI=1S/C14H15BrN8/c1-8-3-12(23-22-8)20-13-11(15)7-19-14(21-13)18-6-10-5-16-9(2)4-17-10/h3-5,7H,6H2,1-2H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420947
(CHEMBL2088109)Show InChI InChI=1S/C13H14N8O2/c1-7-4-11(20-19-7)17-10-2-3-15-13(18-10)16-6-8-5-9(12(14)22)21-23-8/h2-5H,6H2,1H3,(H2,14,22)(H3,15,16,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50420949
(CHEMBL2088112)Show SMILES CCc1cc(Nc2nc(NCc3cc(no3)-c3ccccn3)ncc2Br)[nH]n1 Show InChI InChI=1S/C18H17BrN8O/c1-2-11-7-16(26-25-11)23-17-13(19)10-22-18(24-17)21-9-12-8-15(27-28-12)14-5-3-4-6-20-14/h3-8,10H,2,9H2,1H3,(H3,21,22,23,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420958
(CHEMBL2088094)Show InChI InChI=1S/C15H18BrN7O/c1-3-4-10-6-13(22-21-10)19-14-12(16)8-18-15(20-14)17-7-11-5-9(2)23-24-11/h5-6,8H,3-4,7H2,1-2H3,(H3,17,18,19,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblotting |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419099
(CHEMBL1824364)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccc(F)cc2)c1 Show InChI InChI=1S/C27H29FN2O4/c28-21-9-7-20(8-10-21)19-34-26-18-24(33-16-4-15-30-13-1-2-14-30)11-12-25(26)27(32)29-22-5-3-6-23(31)17-22/h3,5-12,17-18,31H,1-2,4,13-16,19H2,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420953
(CHEMBL2088260)Show SMILES COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)on4)n3)[nH]n2)cc(OC)c1 Show InChI InChI=1S/C22H25N7O3/c1-14-8-17(29-32-14)13-24-22-23-7-6-20(26-22)25-21-11-16(27-28-21)5-4-15-9-18(30-2)12-19(10-15)31-3/h6-12H,4-5,13H2,1-3H3,(H3,23,24,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419117
(CHEMBL1824374)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(c2)[N+]([O-])=O)c1 Show InChI InChI=1S/C27H29N3O6/c31-23-9-4-7-21(17-23)28-27(32)25-11-10-24(35-15-5-14-29-12-1-2-13-29)18-26(25)36-19-20-6-3-8-22(16-20)30(33)34/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419100
(CHEMBL1824367)Show SMILES Cc1ccccc1COc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1cccc(O)c1 Show InChI InChI=1S/C28H32N2O4/c1-21-8-2-3-9-22(21)20-34-27-19-25(33-17-7-16-30-14-4-5-15-30)12-13-26(27)28(32)29-23-10-6-11-24(31)18-23/h2-3,6,8-13,18-19,31H,4-5,7,14-17,20H2,1H3,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420950
(CHEMBL2088113)Show InChI InChI=1S/C16H18BrN7/c1-2-4-12-7-14(24-23-12)21-15-13(17)10-20-16(22-15)19-9-11-5-3-6-18-8-11/h3,5-8,10H,2,4,9H2,1H3,(H3,19,20,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420941
(CHEMBL2088102)Show InChI InChI=1S/C15H19BrN8/c1-9-6-13(24-22-9)20-14-12(16)8-18-15(21-14)17-5-3-4-11-7-19-23-10(11)2/h6-8H,3-5H2,1-2H3,(H,19,23)(H3,17,18,20,21,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420964
(CHEMBL2088100)Show SMILES Cc1cc(CNc2nccc(Nc3cc(CCc4ccccc4)n[nH]3)n2)on1 Show InChI InChI=1S/C20H21N7O/c1-14-11-17(28-27-14)13-22-20-21-10-9-18(24-20)23-19-12-16(25-26-19)8-7-15-5-3-2-4-6-15/h2-6,9-12H,7-8,13H2,1H3,(H3,21,22,23,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419114
(CHEMBL1824363)Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1 Show InChI InChI=1S/C27H30N2O4/c30-23-11-6-10-22(18-23)28-27(31)25-13-12-24(32-17-7-16-29-14-4-5-15-29)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19,30H,4-5,7,14-17,20H2,(H,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420956
(CHEMBL2088091)Show InChI InChI=1S/C13H14BrN7O/c1-7-4-11(20-19-7)17-12-10(14)6-16-13(18-12)15-5-9-3-8(2)21-22-9/h3-4,6H,5H2,1-2H3,(H3,15,16,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblotting |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420958
(CHEMBL2088094)Show InChI InChI=1S/C15H18BrN7O/c1-3-4-10-6-13(22-21-10)19-14-12(16)8-18-15(20-14)17-7-11-5-9(2)23-24-11/h5-6,8H,3-4,7H2,1-2H3,(H3,17,18,19,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420960
(CHEMBL2088092)Show SMILES Cc1cc(Nc2nc(NCc3cc(no3)C(C)(C)C)ncc2Br)[nH]n1 Show InChI InChI=1S/C16H20BrN7O/c1-9-5-13(23-22-9)20-14-11(17)8-19-15(21-14)18-7-10-6-12(24-25-10)16(2,3)4/h5-6,8H,7H2,1-4H3,(H3,18,19,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblotting |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50420942
(CHEMBL2088103)Show InChI InChI=1S/C14H15BrN6O/c1-9-7-12(21-20-9)18-13-11(15)8-17-14(19-13)16-5-4-10-3-2-6-22-10/h2-3,6-8H,4-5H2,1H3,(H3,16,17,18,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420940
(CHEMBL2088101)Show InChI InChI=1S/C14H14BrN7/c1-9-6-12(22-21-9)19-13-11(15)8-18-14(20-13)17-7-10-4-2-3-5-16-10/h2-6,8H,7H2,1H3,(H3,17,18,19,20,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420942
(CHEMBL2088103)Show InChI InChI=1S/C14H15BrN6O/c1-9-7-12(21-20-9)18-13-11(15)8-17-14(19-13)16-5-4-10-3-2-6-22-10/h2-3,6-8H,4-5H2,1H3,(H3,16,17,18,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50419111
(CHEMBL1824382)Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1 Show InChI InChI=1S/C27H30N2O3/c30-27(28-23-12-5-2-6-13-23)25-15-14-24(31-19-9-18-29-16-7-8-17-29)20-26(25)32-21-22-10-3-1-4-11-22/h1-6,10-15,20H,7-9,16-19,21H2,(H,28,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 339 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft... |
Bioorg Med Chem Lett 21: 5224-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50420965
(CHEMBL2088105)Show InChI InChI=1S/C14H16BrN7O/c1-8-6-12(21-20-8)18-13-11(15)7-17-14(19-13)16-4-3-10-5-9(2)22-23-10/h5-7H,3-4H2,1-2H3,(H3,16,17,18,19,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50420958
(CHEMBL2088094)Show InChI InChI=1S/C15H18BrN7O/c1-3-4-10-6-13(22-21-10)19-14-12(16)8-18-15(20-14)17-7-11-5-9(2)23-24-11/h5-6,8H,3-4,7H2,1-2H3,(H3,17,18,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil... |
J Med Chem 55: 5003-12 (2012)
Article DOI: 10.1021/jm3004043
BindingDB Entry DOI: 10.7270/Q25X2B62 |
More data for this
Ligand-Target Pair | |
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