Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220612 (3-amino-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220606 (CHEMBL249093 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220611 (6-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220592 (CHEMBL248875 | N-(3-phenethoxybenzyl)-4-hydroxyben...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220608 (2-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220602 (CHEMBL249307 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220603 (4-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220595 (3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(2-phenoxyeth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220591 (CHEMBL249909 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220598 (6-oxo-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)met...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220599 (3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(phenoxymethy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220610 (CHEMBL250108 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220601 (CHEMBL400917 | N-benzyl-3-{[(4-hydroxybenzoyl)amin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220597 (CHEMBL398356 | N-(((1s,4s)-4-(2-phenoxyethyl)cyclo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220607 (2-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220590 (4-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220600 (CHEMBL398357 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220609 (3,5-dimethyl-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220596 (3-amino-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220594 (3,5-dimethyl-N-(((1s,4s)-4-(phenoxymethyl)cyclohex...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220604 (CHEMBL249297 | N-(((1s,4s)-4-(phenoxymethyl)cycloh...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220605 (6-oxo-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)meth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat)) | BDBM50220593 (6-hydroxy-N-(((1s,4s)-4-(phenoxymethyl)cyclohexyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development Curated by ChEMBL | Assay Description Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane | Bioorg Med Chem Lett 17: 5537-42 (2007) Article DOI: 10.1016/j.bmcl.2007.08.033 BindingDB Entry DOI: 10.7270/Q2M908D0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Multidrug and toxin extrusion protein 1 (Mus musculus) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies Curated by ChEMBL | Assay Description Inhibition of mouse Mate1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analy... | Bioorg Med Chem 21: 7584-90 (2013) Article DOI: 10.1016/j.bmc.2013.10.041 BindingDB Entry DOI: 10.7270/Q2CN75C7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 1 (Mus musculus) | BDBM18512 (5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RIKEN Center for Life Science Technologies Curated by ChEMBL | Assay Description Inhibition of mouse Oct1 transfected in HEK293 cells assessed as uptake of [14C]-TEA preincubated for 15 mins by liquid scintillation counting analys... | Bioorg Med Chem 21: 7584-90 (2013) Article DOI: 10.1016/j.bmc.2013.10.041 BindingDB Entry DOI: 10.7270/Q2CN75C7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 (Homo sapiens (Human)) | BDBM17909 (4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as... | J Med Chem 52: 7974-92 (2009) Article DOI: 10.1021/jm901154c BindingDB Entry DOI: 10.7270/Q20G3MFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17909 (4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4 (Homo sapiens (Human)) | BDBM17909 (4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cells | Bioorg Med Chem 16: 9991-10000 (2008) Article DOI: 10.1016/j.bmc.2008.10.020 BindingDB Entry DOI: 10.7270/Q26H4H7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 (Homo sapiens (Human)) | BDBM50423675 (CHEMBL567396) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as... | J Med Chem 52: 7974-92 (2009) Article DOI: 10.1021/jm901154c BindingDB Entry DOI: 10.7270/Q20G3MFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17910 (4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-methylphenyl)carb...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17900 (4-{[(2S,4S)-1-[2-(4-{[(2-chlorophenyl)carbamoyl]am...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17922 (2-(1-{[(2S,4R)-4-(benzyloxy)-1-[2-(3-methoxy-4-{[(...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17930 (2-(4-{[(2S,3S)-3-hydroxy-1-[2-(3-methoxy-4-{[(2-me...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17937 (2-(4-{[(2S)-1-[2-(3-methoxy-4-{[(2-methylphenyl)ca...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17931 (2-(4-{[(2S,4S)-4-fluoro-1-[2-(3-methoxy-4-{[(2-met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17934 (2-(4-{[(2S,4S)-4-chloro-1-[2-(3-methoxy-4-{[(2-met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17920 (2-(1-{[(2S,4R)-4-methoxy-1-[2-(3-methoxy-4-{[(2-me...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17924 (2-(1-{[(2S,4R)-4-hydroxy-1-[2-(3-methoxy-4-{[(2-me...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 (Homo sapiens (Human)) | BDBM50428682 (CHEMBL2332705) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assay | Bioorg Med Chem 21: 42-61 (2012) Article DOI: 10.1016/j.bmc.2012.11.003 BindingDB Entry DOI: 10.7270/Q2DV1M7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 (Homo sapiens (Human)) | BDBM50428687 (CHEMBL2332700) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assay | Bioorg Med Chem 21: 42-61 (2012) Article DOI: 10.1016/j.bmc.2012.11.003 BindingDB Entry DOI: 10.7270/Q2DV1M7X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17927 (2-(4-{[(2S,4S)-1-[2-(3-methoxy-4-{[(2-methylphenyl...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17899 (4-{[(2S,4S)-4-fluoro-1-[2-(3-methoxy-4-{[(2-methyl...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17913 (4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-chlorophenyl)carb...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17929 (2-(4-{[(2S,3S)-3-(benzyloxy)-1-[2-(3-methoxy-4-{[(...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17912 (4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-chlorophenyl)car...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17926 (2-(4-{[(2S,3R,4S)-3,4-dihydroxy-1-[2-(3-methoxy-4-...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17928 (2-(4-{[(2S,4S)-1-[2-(3-methoxy-4-{[(2-methylphenyl...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17916 (4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-bromophenyl)carba...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 15: 1679-93 (2007) Article DOI: 10.1016/j.bmc.2006.12.006 BindingDB Entry DOI: 10.7270/Q23N21NS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 (Homo sapiens (Human)) | BDBM50157050 (CHEMBL361914 | [4-(1-{2-[3-Methoxy-4-(3-o-tolyl-ur...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Pharmaceutical Co. Ltd Curated by ChEMBL | Assay Description Inhibition of VLA-4 receptor expressed in CHO cells | Bioorg Med Chem Lett 15: 41-5 (2004) Article DOI: 10.1016/j.bmcl.2004.10.041 BindingDB Entry DOI: 10.7270/Q23J3F7Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-4/beta-1 [T112H] (Homo sapiens (Human)) | BDBM17933 (2-(4-{[(2S)-4,4-difluoro-1-[2-(3-methoxy-4-{[(2-me...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Daiichi Pharmaceutical | Assay Description The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera... | Bioorg Med Chem 14: 2725-46 (2006) Article DOI: 10.1016/j.bmc.2005.11.058 BindingDB Entry DOI: 10.7270/Q2ZW1J5H | |||||||||||
More data for this Ligand-Target Pair |
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