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Compile Data Set for Download or QSAR

Found 55 hits of ec50 for UniProtKB: P08909   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50014945
PNG
(3-(2-aminopropyl)-1H-indol-5-ol | CHEMBL275854 | a...)
Show SMILES CC(N)Cc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
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n/an/an/an/a 1.80n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 2.80n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50014219
PNG
(2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine | ...)
Show SMILES COc1ccc2[nH]cc(CC(C)N)c2c1
Show InChI InChI=1S/C12H16N2O/c1-8(13)5-9-7-14-12-4-3-10(15-2)6-11(9)12/h3-4,6-8,14H,5,13H2,1-2H3
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n/an/an/an/a 3.10n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180251
PNG
(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Show SMILES C[C@H](N)Cn1ncc2ccc(O)cc12
Show InChI InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,14H,6,11H2,1H3/t7-/m0/s1
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n/an/an/an/a 3.70n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210083
PNG
(CHEMBL232995 | [8-((R)-2-amino-propyl)-2,3,6,7-tet...)
Show SMILES C[C@@H](N)Cc1c2CCOc2c(COCC(=O)Oc2ccccc2)c2CCOc12
Show InChI InChI=1S/C22H25NO5/c1-14(23)11-18-16-7-9-27-22(16)19(17-8-10-26-21(17)18)12-25-13-20(24)28-15-5-3-2-4-6-15/h2-6,14H,7-13,23H2,1H3/t14-/m1/s1
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n/an/an/an/a 4.5n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180257
PNG
(1-(2-aminoethyl)-1H-indazol-6-ol | CHEMBL199385)
Show SMILES NCCn1ncc2ccc(O)cc12
Show InChI InChI=1S/C9H11N3O/c10-3-4-12-9-5-8(13)2-1-7(9)6-11-12/h1-2,5-6,13H,3-4,10H2
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n/an/an/an/a 4.5n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180255
PNG
(1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol | C...)
Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(Cl)c12
Show InChI InChI=1S/C10H12ClN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1
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n/an/an/an/a 4.90n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180258
PNG
(1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol | C...)
Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(F)c12
Show InChI InChI=1S/C10H12FN3O/c1-6(12)5-14-10-7(4-13-14)2-3-8(15)9(10)11/h2-4,6,15H,5,12H2,1H3/t6-/m0/s1
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n/an/an/an/a 5.5n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180252
PNG
((2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine |...)
Show SMILES COc1ccc2cnn(C[C@H](C)N)c2c1
Show InChI InChI=1S/C11H15N3O/c1-8(12)7-14-11-5-10(15-2)4-3-9(11)6-13-14/h3-6,8H,7,12H2,1-2H3/t8-/m0/s1
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n/an/an/an/a 6.70n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180253
PNG
(1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol | C...)
Show SMILES C[C@H](N)Cn1ncc2ccc(O)c(C)c12
Show InChI InChI=1S/C11H15N3O/c1-7(12)6-14-11-8(2)10(15)4-3-9(11)5-13-14/h3-5,7,15H,6,12H2,1-2H3/t7-/m0/s1
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n/an/an/an/a 7.30n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210079
PNG
((R)-2-[8-(2-methoxy-ethoxymethyl)-2,3,6,7-tetrahyd...)
Show SMILES COCCOCc1c2CCOc2c(C[C@@H](C)N)c2CCOc12
Show InChI InChI=1S/C17H25NO4/c1-11(18)9-14-12-3-5-22-17(12)15(10-20-8-7-19-2)13-4-6-21-16(13)14/h11H,3-10,18H2,1-2H3/t11-/m1/s1
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n/an/an/an/a 8.60n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210078
PNG
((R)-2-(8-methoxymethyl-2,3,6,7-tetrahydro-benzo[1,...)
Show SMILES COCc1c2CCOc2c(C[C@@H](C)N)c2CCOc12
Show InChI InChI=1S/C15H21NO3/c1-9(16)7-12-10-3-5-19-15(10)13(8-17-2)11-4-6-18-14(11)12/h9H,3-8,16H2,1-2H3/t9-/m1/s1
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n/an/an/an/a 12.6n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50133231
PNG
((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I
Show InChI InChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3/t7-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50133231
PNG
((R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine |...)
Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1I
Show InChI InChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3/t7-/m1/s1
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n/an/an/an/a 30.2n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210081
PNG
((1R,2R)-2-amino-1-(8-bromo-2,3,6,7-tetrahydro-benz...)
Show SMILES C[C@@H](N)[C@H](O)c1c2CCOc2c(Br)c2CCOc12
Show InChI InChI=1S/C13H16BrNO3/c1-6(15)11(16)9-7-2-4-18-13(7)10(14)8-3-5-17-12(8)9/h6,11,16H,2-5,15H2,1H3/t6-,11+/m1/s1
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n/an/an/an/a 39n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50309343
PNG
(8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7...)
Show SMILES Cc1cccc2N3CCNCCC3NC(=O)c12
Show InChI InChI=1S/C13H17N3O/c1-9-3-2-4-10-12(9)13(17)15-11-5-6-14-7-8-16(10)11/h2-4,11,14H,5-8H2,1H3,(H,15,17)
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n/an/an/an/a 61n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor in rat fundus

Bioorg Med Chem Lett 20: 1128-33 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.014
BindingDB Entry DOI: 10.7270/Q2K074DK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM30707
PNG
(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
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n/an/an/an/a 78n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210084
PNG
((R)-1-methyl-2-[8-(3-methyl-[1,2,4]oxadiazol-5-ylm...)
Show SMILES C[C@@H](N)Cc1c2ccoc2c(Cc2nc(C)no2)c2ccoc12
Show InChI InChI=1S/C17H17N3O3/c1-9(18)7-13-11-3-5-22-17(11)14(12-4-6-21-16(12)13)8-15-19-10(2)20-23-15/h3-6,9H,7-8,18H2,1-2H3/t9-/m1/s1
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n/an/an/an/a 82n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50180256
PNG
(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Show SMILES C[C@@H](N)Cn1ncc2ccc(O)cc12
Show InChI InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,14H,6,11H2,1H3/t7-/m1/s1
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n/an/an/an/a 87n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells

J Med Chem 49: 318-28 (2006)


Article DOI: 10.1021/jm050663x
BindingDB Entry DOI: 10.7270/Q23B5ZQW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471324
PNG
(CHEMBL318639)
Show SMILES COc1ccc2c(c1)-c1c(ccn1CC(C)N)C2(C)C
Show InChI InChI=1S/C17H22N2O/c1-11(18)10-19-8-7-15-16(19)13-9-12(20-4)5-6-14(13)17(15,2)3/h5-9,11H,10,18H2,1-4H3
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n/an/an/an/a 100n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471319
PNG
(CHEMBL2115252)
Show SMILES C[C@@H](N)Cn1ccc2cc(F)c(F)cc12 |r|
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m1/s1
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n/an/an/an/a 126n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50025197
PNG
(CHEMBL96816)
Show SMILES CC(N)Cc1c[nH]c2ccc(F)cc12
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F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM28582
PNG
(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Show SMILES COc1cc(CC(C)N)c(OC)cc1I
Show InChI InChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3
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n/an/an/an/a 178n/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Agonist activity at rat 5-HT2C receptor expressed in African clawed frog oocytes assessed as increase in current amplitude

J Med Chem 60: 6273-6288 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00584
BindingDB Entry DOI: 10.7270/Q2MK6G5C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471322
PNG
(CHEMBL94272)
Show SMILES CC(N)Cn1ccc2c1-c1cc(F)ccc1C2(C)C
Show InChI InChI=1S/C16H19FN2/c1-10(18)9-19-7-6-14-15(19)12-8-11(17)4-5-13(12)16(14,2)3/h4-8,10H,9,18H2,1-3H3
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n/an/an/an/a 200n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50144841
PNG
((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(Cl)cc12
Show InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM85863
PNG
(CAS_170493-63-7 | NSC_3045228 | Ro 600332)
Show SMILES CC(N)Cn1ccc2c1-c1cc(C)ccc1C2(C)C
Show InChI InChI=1S/C17H22N2/c1-11-5-6-14-13(9-11)16-15(17(14,3)4)7-8-19(16)10-12(2)18/h5-9,12H,10,18H2,1-4H3
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n/an/an/an/a 200n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50108306
PNG
((S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine |...)
Show SMILES C[C@H](N)Cn1ccc2cc(F)c(F)cc12
Show InChI InChI=1S/C11H12F2N2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471326
PNG
(CHEMBL2114265)
Show SMILES COc1ccc2Cc3ccn(C[C@H](C)N)c3-c2c1 |r|
Show InChI InChI=1S/C15H18N2O/c1-10(16)9-17-6-5-12-7-11-3-4-13(18-2)8-14(11)15(12)17/h3-6,8,10H,7,9,16H2,1-2H3/t10-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471318
PNG
(CHEMBL2114266)
Show SMILES C[C@H](N)Cn1ccc2c(Cl)c(F)ccc12 |r|
Show InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-5-4-8-10(15)3-2-9(13)11(8)12/h2-5,7H,6,14H2,1H3/t7-/m0/s1
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n/an/an/an/a 316n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471314
PNG
(CHEMBL414163)
Show SMILES COc1ccc2Cc3ccn(CC(C)N)c3-c2c1
Show InChI InChI=1S/C15H18N2O/c1-10(16)9-17-6-5-12-7-11-3-4-13(18-2)8-14(11)15(12)17/h3-6,8,10H,7,9,16H2,1-2H3
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n/an/an/an/a 398n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471312
PNG
(CHEMBL313856)
Show SMILES CC(N)Cn1ccc2cc(Cl)c(F)cc12
Show InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-9(12)10(13)5-11(8)15/h2-5,7H,6,14H2,1H3
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n/an/an/an/a 398n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471332
PNG
(CHEMBL96312)
Show SMILES CC(N)Cn1ccc2Cc3ccc(C)cc3-c12
Show InChI InChI=1S/C15H18N2/c1-10-3-4-12-8-13-5-6-17(9-11(2)16)15(13)14(12)7-10/h3-7,11H,8-9,16H2,1-2H3
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n/an/an/an/a 501n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471328
PNG
(CHEMBL92656)
Show SMILES CC(N)Cn1ccc2ccc(F)cc12
Show InChI InChI=1S/C11H13FN2/c1-8(13)7-14-5-4-9-2-3-10(12)6-11(9)14/h2-6,8H,7,13H2,1H3
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n/an/an/an/a 631n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471325
PNG
(CHEMBL93154)
Show SMILES CC(N)Cn1ccc2Cc3ccc(F)cc3-c12
Show InChI InChI=1S/C14H15FN2/c1-9(16)8-17-5-4-11-6-10-2-3-12(15)7-13(10)14(11)17/h2-5,7,9H,6,8,16H2,1H3
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n/an/an/an/a 631n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50210085
PNG
((R)-1-methyl-2-[8-(3-methyl-[1,2,4]oxadiazol-5-ylm...)
Show SMILES C[C@@H](N)Cc1c2CCOc2c(Cc2nc(C)no2)c2CCOc12
Show InChI InChI=1S/C17H21N3O3/c1-9(18)7-13-11-3-5-22-17(11)14(12-4-6-21-16(12)13)8-15-19-10(2)20-23-15/h9H,3-8,18H2,1-2H3/t9-/m1/s1
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n/an/an/an/a 689n/an/an/an/a



Alcon Research, Ltd

Curated by ChEMBL


Assay Description
Agonist activity at 5HT2C receptor expressed in rat SR3T3 cells assessed as intracellular calcium mobilization relative to 5HT

Bioorg Med Chem Lett 17: 2998-3002 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.073
BindingDB Entry DOI: 10.7270/Q2KS6R7B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471329
PNG
(CHEMBL2115254)
Show SMILES C[C@@H](N)Cn1ccc2c(Cl)c(F)ccc12 |r|
Show InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-5-4-8-10(15)3-2-9(13)11(8)12/h2-5,7H,6,14H2,1H3/t7-/m1/s1
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n/an/an/an/a 794n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50059890
PNG
(2-(8-Methoxy-2,3,5,6-tetrahydro-benzo[1,2-b;5,4-b'...)
Show SMILES COc1c2OCCc2c(CCN)c2CCOc12
Show InChI InChI=1S/C13H17NO3/c1-15-13-11-9(3-6-16-11)8(2-5-14)10-4-7-17-12(10)13/h2-7,14H2,1H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor

J Med Chem 40: 2997-3008 (1997)


Article DOI: 10.1021/jm970219x
BindingDB Entry DOI: 10.7270/Q2RF5T50
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471313
PNG
(CHEMBL92565)
Show SMILES CC(N)Cn1ccc2c(F)cccc12
Show InChI InChI=1S/C11H13FN2/c1-8(13)7-14-6-5-9-10(12)3-2-4-11(9)14/h2-6,8H,7,13H2,1H3
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n/an/an/an/a 1.26E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50321881
PNG
((R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine | 2...)
Show SMILES CC(N)Cn1ccc2cc(F)ccc12
Show InChI InChI=1S/C11H13FN2/c1-8(13)7-14-5-4-9-6-10(12)2-3-11(9)14/h2-6,8H,7,13H2,1H3
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n/an/an/an/a 1.59E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471320
PNG
(CHEMBL273304)
Show SMILES COc1ccc-2c(Cc3ccn(CC(C)N)c-23)c1
Show InChI InChI=1S/C15H18N2O/c1-10(16)9-17-6-5-11-7-12-8-13(18-2)3-4-14(12)15(11)17/h3-6,8,10H,7,9,16H2,1-2H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50321879
PNG
((R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine | 2-...)
Show SMILES CC(N)Cn1ccc2cc(Br)ccc12
Show InChI InChI=1S/C11H13BrN2/c1-8(13)7-14-5-4-9-6-10(12)2-3-11(9)14/h2-6,8H,7,13H2,1H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50321880
PNG
((R,S)-1-(5-chloro-1H-indol-1-yl)propan-2-amine | 2...)
Show SMILES CC(N)Cn1ccc2cc(Cl)ccc12
Show InChI InChI=1S/C11H13ClN2/c1-8(13)7-14-5-4-9-6-10(12)2-3-11(9)14/h2-6,8H,7,13H2,1H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50059893
PNG
(2-(4-Ethoxy-3,5-dimethoxy-phenyl)-ethylamine | CHE...)
Show SMILES CCOc1c(OC)cc(CCN)cc1OC
Show InChI InChI=1S/C12H19NO3/c1-4-16-12-10(14-2)7-9(5-6-13)8-11(12)15-3/h7-8H,4-6,13H2,1-3H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor

J Med Chem 40: 2997-3008 (1997)


Article DOI: 10.1021/jm970219x
BindingDB Entry DOI: 10.7270/Q2RF5T50
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50059892
PNG
(2-(6,7-Dimethoxy-2,3-dihydro-benzofuran-4-yl)-ethy...)
Show SMILES COc1cc(CCN)c2CCOc2c1OC
Show InChI InChI=1S/C12H17NO3/c1-14-10-7-8(3-5-13)9-4-6-16-11(9)12(10)15-2/h7H,3-6,13H2,1-2H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Effect on phosphoinositide hydrolysis in NIH 3T3 fibroblast 5-hydroxytryptamine 2C receptor

J Med Chem 40: 2997-3008 (1997)


Article DOI: 10.1021/jm970219x
BindingDB Entry DOI: 10.7270/Q2RF5T50
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471316
PNG
(CHEMBL317677)
Show SMILES CC(N)Cn1ccc2c(C)cccc12
Show InChI InChI=1S/C12H16N2/c1-9-4-3-5-12-11(9)6-7-14(12)8-10(2)13/h3-7,10H,8,13H2,1-2H3
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n/an/an/an/a 2.51E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471315
PNG
(CHEMBL320145)
Show SMILES CC(N)Cn1ccc2Cc3ccc(Br)cc3-c12
Show InChI InChI=1S/C14H15BrN2/c1-9(16)8-17-5-4-11-6-10-2-3-12(15)7-13(10)14(11)17/h2-5,7,9H,6,8,16H2,1H3
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n/an/an/an/a 2.51E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50321882
PNG
((R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine | 1...)
Show SMILES CC(N)Cn1ccc2cc(C)ccc12
Show InChI InChI=1S/C12H16N2/c1-9-3-4-12-11(7-9)5-6-14(12)8-10(2)13/h3-7,10H,8,13H2,1-2H3
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n/an/an/an/a 2.51E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471321
PNG
(CHEMBL91855)
Show SMILES CC(N)Cn1ccc2Cc3ccc(Cl)cc3-c12
Show InChI InChI=1S/C14H15ClN2/c1-9(16)8-17-5-4-11-6-10-2-3-12(15)7-13(10)14(11)17/h2-5,7,9H,6,8,16H2,1H3
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n/an/an/an/a 2.51E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50298361
PNG
((R)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)
Show SMILES C[C@@H](N)Cn1ccc2cc(F)c(Cl)cc12 |r|
Show InChI InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m1/s1
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Article
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n/an/an/an/a 3.16E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Rattus norvegicus (Rat))		BDBM50471323
PNG
(CHEMBL96876)
Show SMILES COc1cccc2Cc3ccn(CC(C)N)c3-c12
Show InChI InChI=1S/C15H18N2O/c1-10(16)9-17-7-6-12-8-11-4-3-5-13(18-2)14(11)15(12)17/h3-7,10H,8-9,16H2,1-2H3
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n/an/an/an/a 6.31E+3n/an/an/an/a



F. Hoffmann-La Roche Inc

Curated by ChEMBL


Assay Description
Efficacy (pEC50) was evaluated for 5-HT2C receptor-mediated stimulation of IP3 formation in vitro in choroid plexus of the rat

J Med Chem 40: 2762-9 (1997)


Article DOI: 10.1021/jm970030l
BindingDB Entry DOI: 10.7270/Q270845Q
More data for this
Ligand-Target Pair
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