Compile Data Set for Download or QSAR

Found 122 hits Enz. Inhib. hit(s) with all data for entry = 7382   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192361 (US9187462, I-41) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(OC(F)F)cc1 |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-15-19(14-30-34)23(16-4-6-21(7-5-16)37-25(27)28)33-24(35)17-2-3-18-13-29-26(32-22(18)12-17)31-20-8-10-36-11-9-20/h2-7,12-15,20,23,25H,8-11H2,1H3,(H,33,35)(H,29,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192386 (US9187462, I-66) Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H26ClFN6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)20(27)9-15)33-25(35)16-10-21(28)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192385 (US9187462, I-65) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C26H23ClFN7O2/c1-35-14-18(12-31-35)24(15-2-3-16(11-29)21(27)8-15)34-25(36)17-9-22(28)20-13-30-26(33-23(20)10-17)32-19-4-6-37-7-5-19/h2-3,8-10,12-14,19,24H,4-7H2,1H3,(H,34,36)(H,30,32,33)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192322 (US9187462, I-2) Show SMILES Cn1cc(cn1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192364 (US9187462, I-44) Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27ClN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192368 (US9187462, I-48) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 |r| Show InChI InChI=1S/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192352 (US9187462, I-32) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H27FN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192436 (US9187462, II-46) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cncn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-29-13-22(34)24(15-3-4-23(36-2)20(28)9-15)33-25(35)16-10-19(27)18-12-30-26(32-21(18)11-16)31-17-5-7-37-8-6-17/h3-4,9-14,17,24H,5-8H2,1-2H3,(H,33,35)(H,30,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192388 (BDBM192402 | US9187462, I-68) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192403 (US9187462, II-13) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,9.10,wD:25.26,(9.38,1.49,;8.05,2.26,;6.72,1.49,;5.33,2.24,;4,1.47,;4,-.07,;5.33,-.84,;6.67,-.07,;8,-.84,;2.67,-.84,;1.33,-.07,;1.33,1.47,;2.67,2.24,;,2.24,;,3.78,;-1.33,4.55,;-1.33,6.09,;-2.67,3.78,;-4,4.55,;-5.33,3.78,;-5.33,2.24,;-6.67,1.47,;-6.67,-.07,;-5.33,-.84,;-5.33,-2.38,;-6.67,-3.15,;-6.67,-4.69,;-8,-2.38,;-8,-.84,;-4,1.47,;-2.67,2.24,;-1.33,1.47,;2.67,-2.38,;3.91,-3.29,;3.44,-4.75,;1.87,-4.79,;.97,-6.03,;1.42,-3.29,)| Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192335 (US9187462, I-15) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13?,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192389 (US9187462, I-69) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,wD:9.10,25.26,(11.38,-2.65,;10.05,-3.42,;8.72,-2.65,;7.34,-3.39,;6,-2.62,;6,-1.08,;7.34,-.31,;8.67,-1.08,;10,-.31,;4.67,-.31,;3.33,-1.08,;2,-.31,;2,1.23,;.67,-1.08,;.67,-2.62,;-.67,-3.39,;-.67,-4.93,;-2,-2.62,;-3.33,-3.39,;-4.67,-2.62,;-4.67,-1.08,;-6,-.31,;-7.34,-1.08,;-7.34,-2.62,;-8.67,-3.39,;-10,-2.62,;-11.34,-3.39,;-10,-1.08,;-8.67,-.31,;-3.33,-.31,;-2,-1.08,;-.67,-.31,;4.67,1.23,;3.42,2.13,;3.9,3.6,;5.46,3.63,;6.37,4.88,;5.91,2.13,)| Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192359 (US9187462, I-39) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1 |r| Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192437 (US9187462, II-47) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnco1 |r| Show InChI InChI=1S/C25H23F2N5O4/c1-34-21-3-2-14(8-19(21)27)23(22-12-28-13-36-22)32-24(33)15-9-18(26)17-11-29-25(31-20(17)10-15)30-16-4-6-35-7-5-16/h2-3,8-13,16,23H,4-7H2,1H3,(H,32,33)(H,29,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192388 (BDBM192402 | US9187462, I-68) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192332 (US9187462, I-12) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192438 (US9187462, II-48) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnnn1C |r| Show InChI InChI=1S/C25H25F2N7O3/c1-34-21(13-29-33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192367 (US9187462, I-47) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20+,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192342 (US9187462, I-22) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-7-4-21(33-34)23(14-2-3-18(26)20(28)10-14)32-24(35)15-11-19(27)17-13-29-25(31-22(17)12-15)30-16-5-8-36-9-6-16/h2-4,7,10-13,16,23H,5-6,8-9H2,1H3,(H,32,35)(H,29,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192443 (US9187462, II-53) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(Nc3ccnn3C)nc2c1)c1cncn1C |r| Show InChI InChI=1S/C25H22F2N8O2/c1-34-13-28-12-20(34)23(14-4-5-21(37-3)18(27)8-14)33-24(36)15-9-17(26)16-11-29-25(31-19(16)10-15)32-22-6-7-30-35(22)2/h4-13,23H,1-3H3,(H,33,36)(H,29,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192353 (US9187462, I-33) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)21(28)9-15)33-25(35)16-10-20(27)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192356 (US9187462, I-36) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1 |r| Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192351 (US9187462, I-31) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1C[C@H](F)CN1 |r| Show InChI InChI=1S/C26H29F2N5O3/c1-35-23-5-4-15(10-20(23)28)24(22-12-18(27)14-29-22)33-25(34)16-2-3-17-13-30-26(32-21(17)11-16)31-19-6-8-36-9-7-19/h2-5,10-11,13,18-19,22,24,29H,6-9,12,14H2,1H3,(H,33,34)(H,30,31,32)/t18-,22+,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192327 (US9187462, I-7) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 |r| Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192442 (US9187462, II-52) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1nccn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-8-7-29-24(34)23(15-3-4-22(36-2)20(28)11-15)33-25(35)16-12-19(27)18-14-30-26(32-21(18)13-16)31-17-5-9-37-10-6-17/h3-4,7-8,11-14,17,23H,5-6,9-10H2,1-2H3,(H,33,35)(H,30,31,32)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192381 (US9187462, I-61) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@@H]3CCOC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C25H24F2N6O3/c1-33-12-16(10-29-33)23(14-3-4-22(35-2)20(27)7-14)32-24(34)15-8-19(26)18-11-28-25(31-21(18)9-15)30-17-5-6-36-13-17/h3-4,7-12,17,23H,5-6,13H2,1-2H3,(H,32,34)(H,28,30,31)/t17-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192346 (US9187462, I-26) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H](C)C3CC3)nc2c1)[C@H]1CCCN1 |r| Show InChI InChI=1S/C26H30FN5O2/c1-15(16-5-6-16)30-26-29-14-19-8-7-18(13-22(19)31-26)25(33)32-24(21-4-3-11-28-21)17-9-10-23(34-2)20(27)12-17/h7-10,12-16,21,24,28H,3-6,11H2,1-2H3,(H,32,33)(H,29,30,31)/t15-,21-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192340 (US9187462, I-20) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192355 (US9187462, I-35) Show SMILES C[C@@H]1CC[C@@H](N1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C26H29ClFN5O2/c1-15-2-7-22(30-15)24(16-5-6-20(27)21(28)12-16)33-25(34)17-3-4-18-14-29-26(32-23(18)13-17)31-19-8-10-35-11-9-19/h3-6,12-15,19,22,24,30H,2,7-11H2,1H3,(H,33,34)(H,29,31,32)/t15-,22-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192408 (US9187462, II-18) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H25FN8O2/c1-15-9-23(35(3)33-15)31-26-28-12-18-6-5-17(11-21(18)30-26)25(36)32-24(19-13-29-34(2)14-19)16-7-8-22(37-4)20(27)10-16/h5-14,24H,1-4H3,(H,32,36)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192323 (US9187462, I-3) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCCN1 |r| Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192350 (US9187462, I-30) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCOC[C@H]3F)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192406 (US9187462, II-16) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3ccnn3C)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C25H23FN8O2/c1-33-14-18(13-29-33)23(15-6-7-21(36-3)19(26)10-15)32-24(35)16-4-5-17-12-27-25(30-20(17)11-16)31-22-8-9-28-34(22)2/h4-14,23H,1-3H3,(H,32,35)(H,27,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192419 (US9187462, II-29) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccnn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-22(5-8-30-34)24(15-3-4-23(36-2)20(28)11-15)33-25(35)16-12-19(27)18-14-29-26(32-21(18)13-16)31-17-6-9-37-10-7-17/h3-5,8,11-14,17,24H,6-7,9-10H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192325 (US9187462, I-5) Show SMILES CC(C)Nc1ncc2ccc(cc2n1)C(=O)N[C@H]([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C24H25F4N5O/c1-13(2)31-23-30-12-16-6-5-15(11-20(16)32-23)22(34)33-21(19-4-3-9-29-19)14-7-8-17(18(25)10-14)24(26,27)28/h5-8,10-13,19,21,29H,3-4,9H2,1-2H3,(H,33,34)(H,30,31,32)/t19-,21+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192343 (US9187462, I-23) Show SMILES Fc1cc(ccc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 |r| Show InChI InChI=1S/C25H27ClFN5O2/c26-19-6-5-15(12-20(19)27)23(21-2-1-9-28-21)32-24(33)16-3-4-17-14-29-25(31-22(17)13-16)30-18-7-10-34-11-8-18/h3-6,12-14,18,21,23,28H,1-2,7-11H2,(H,32,33)(H,29,30,31)/t21-,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192411 (US9187462, II-21) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@@H](C)CO)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C24H24F2N6O3/c1-13(12-33)29-24-27-10-17-18(25)7-15(8-20(17)30-24)23(34)31-22(16-9-28-32(2)11-16)14-4-5-21(35-3)19(26)6-14/h4-11,13,22,33H,12H2,1-3H3,(H,31,34)(H,27,29,30)/t13-,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192339 (US9187462, I-19) Show SMILES Fc1cc(ccc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cc[nH]n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192321 (US9187462, I-1) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)NC(c1cnn(C)c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192348 (US9187462, I-28) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@H]3CCOC[C@H]3F)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21+,23+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192372 (US9187462, I-52) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CCOC[C@H]3F)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C26H25F3N6O3/c1-35-12-16(10-31-35)24(14-3-4-23(37-2)19(28)7-14)34-25(36)15-8-18(27)17-11-30-26(33-22(17)9-15)32-21-5-6-38-13-20(21)29/h3-4,7-12,20-21,24H,5-6,13H2,1-2H3,(H,34,36)(H,30,32,33)/t20-,21+,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192375 (US9187462, I-55) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-21(27)20(26)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192337 (US9187462, I-17) Show SMILES CN1CCC[C@@H]1[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C27H29F4N5O2/c1-36-10-2-3-23(36)24(16-6-7-20(21(28)13-16)27(29,30)31)35-25(37)17-4-5-18-15-32-26(34-22(18)14-17)33-19-8-11-38-12-9-19/h4-7,13-15,19,23-24H,2-3,8-12H2,1H3,(H,35,37)(H,32,33,34)/t23-,24+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192371 (US9187462, I-51) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)n1 |r| Show InChI InChI=1S/C25H25F2N7O3/c1-34-29-13-21(33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192428 (US9187462, II-38) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3ccnn3C)nc2c1)c1ccnn1C |r| Show InChI InChI=1S/C25H23FN8O2/c1-33-20(8-10-28-33)23(15-6-7-21(36-3)18(26)12-15)32-24(35)16-4-5-17-14-27-25(30-19(17)13-16)31-22-9-11-29-34(22)2/h4-14,23H,1-3H3,(H,32,35)(H,27,30,31)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192418 (US9187462, II-28) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccnn1C |r| Show InChI InChI=1S/C26H27FN6O3/c1-33-22(7-10-29-33)24(16-5-6-23(35-2)20(27)13-16)32-25(34)17-3-4-18-15-28-26(31-21(18)14-17)30-19-8-11-36-12-9-19/h3-7,10,13-15,19,24H,8-9,11-12H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192415 (US9187462, II-25) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(Nc3ccnn3C)nc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C24H20ClFN8O/c1-33-13-17(12-29-33)22(14-5-6-18(25)19(26)9-14)32-23(35)15-3-4-16-11-27-24(30-20(16)10-15)31-21-7-8-28-34(21)2/h3-13,22H,1-2H3,(H,32,35)(H,27,30,31)/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192376 (US9187462, I-56) Show SMILES COc1ccc(cc1C#N)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C27H27N7O3/c1-34-16-21(15-30-34)25(17-5-6-24(36-2)20(11-17)13-28)33-26(35)18-3-4-19-14-29-27(32-23(19)12-18)31-22-7-9-37-10-8-22/h3-6,11-12,14-16,22,25H,7-10H2,1-2H3,(H,33,35)(H,29,31,32)/t25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192427 (US9187462, II-37) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H]3CCOC[C@@H]3F)nc2c1)c1ccnn1C |r| Show InChI InChI=1S/C26H26F2N6O3/c1-34-22(7-9-30-34)24(15-5-6-23(36-2)18(27)11-15)33-25(35)16-3-4-17-13-29-26(32-21(17)12-16)31-20-8-10-37-14-19(20)28/h3-7,9,11-13,19-20,24H,8,10,14H2,1-2H3,(H,33,35)(H,29,31,32)/t19-,20-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM192354 (US9187462, I-34) Show SMILES Fc1cc(ccc1Cl)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ncno1 Show InChI InChI=1S/C23H20ClFN6O3/c24-17-4-3-13(9-18(17)25)20(22-27-12-28-34-22)31-21(32)14-1-2-15-11-26-23(30-19(15)10-14)29-16-5-7-33-8-6-16/h1-4,9-12,16,20H,5-8H2,(H,31,32)(H,26,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair

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