Found 96 hits Enz. Inhib. hit(s) with all data for entry = 50017118 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50045767
((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)Show SMILES C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C21H27NO/c1-17-16-22(13-11-18-7-4-3-5-8-18)14-12-21(17,2)19-9-6-10-20(23)15-19/h3-10,15,17,23H,11-14,16H2,1-2H3/t17-,21+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177695
(3-(1-heptyl-trans-4,5-dimethyl-2-alpha-propylpiper...)Show SMILES CCCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C23H39NO/c1-5-7-8-9-10-15-24-18-19(3)23(4,17-21(24)12-6-2)20-13-11-14-22(25)16-20/h11,13-14,16,19,21,25H,5-10,12,15,17-18H2,1-4H3/t19-,21+,23+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177696
(3-(2(alpha),4,5(trans)-trimethyl-1-phenethylpiperi...)Show SMILES C[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C22H29NO/c1-17-16-23(13-12-19-8-5-4-6-9-19)18(2)15-22(17,3)20-10-7-11-21(24)14-20/h4-11,14,17-18,24H,12-13,15-16H2,1-3H3/t17-,18+,22+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50045767
((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)Show SMILES C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C21H27NO/c1-17-16-22(13-11-18-7-4-3-5-8-18)14-12-21(17,2)19-9-6-10-20(23)15-19/h3-10,15,17,23H,11-14,16H2,1-2H3/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177702
(3-(trans-4,5-dimethyl-1-(3-phenylpropyl)-2-alpha-p...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-10-23-18-25(3,22-14-8-15-24(27)17-22)20(2)19-26(23)16-9-13-21-11-6-5-7-12-21/h5-8,11-12,14-15,17,20,23,27H,4,9-10,13,16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177701
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-propylpi...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C24H33NO/c1-4-9-22-17-24(3,21-12-8-13-23(26)16-21)19(2)18-25(22)15-14-20-10-6-5-7-11-20/h5-8,10-13,16,19,22,26H,4,9,14-15,17-18H2,1-3H3/t19-,22+,24+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50045767
((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)Show SMILES C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C21H27NO/c1-17-16-22(13-11-18-7-4-3-5-8-18)14-12-21(17,2)19-9-6-10-20(23)15-19/h3-10,15,17,23H,11-14,16H2,1-2H3/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177692
(3-(1-hexyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C22H37NO/c1-5-7-8-9-14-23-17-18(3)22(4,16-20(23)11-6-2)19-12-10-13-21(24)15-19/h10,12-13,15,18,20,24H,5-9,11,14,16-17H2,1-4H3/t18-,20+,22+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177695
(3-(1-heptyl-trans-4,5-dimethyl-2-alpha-propylpiper...)Show SMILES CCCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C23H39NO/c1-5-7-8-9-10-15-24-18-19(3)23(4,17-21(24)12-6-2)20-13-11-14-22(25)16-20/h11,13-14,16,19,21,25H,5-10,12,15,17-18H2,1-4H3/t19-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177685
(CHEMBL201845 | N-(2-(4-(3-hydroxyphenyl)-trans-4,5...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCNC(=O)c2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C30H36N2O2/c1-23-22-32(19-17-24-10-5-3-6-11-24)27(16-18-31-29(34)25-12-7-4-8-13-25)21-30(23,2)26-14-9-15-28(33)20-26/h3-15,20,23,27,33H,16-19,21-22H2,1-2H3,(H,31,34)/t23-,27+,30+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177696
(3-(2(alpha),4,5(trans)-trimethyl-1-phenethylpiperi...)Show SMILES C[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C22H29NO/c1-17-16-23(13-12-19-8-5-4-6-9-19)18(2)15-22(17,3)20-10-7-11-21(24)14-20/h4-11,14,17-18,24H,12-13,15-16H2,1-3H3/t17-,18+,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177702
(3-(trans-4,5-dimethyl-1-(3-phenylpropyl)-2-alpha-p...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-10-23-18-25(3,22-14-8-15-24(27)17-22)20(2)19-26(23)16-9-13-21-11-6-5-7-12-21/h5-8,11-12,14-15,17,20,23,27H,4,9-10,13,16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177698
(3-(2-alpha-ethyl-trans-4,5-dimethyl-1-phenethylpip...)Show SMILES CC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C23H31NO/c1-4-21-16-23(3,20-11-8-12-22(25)15-20)18(2)17-24(21)14-13-19-9-6-5-7-10-19/h5-12,15,18,21,25H,4,13-14,16-17H2,1-3H3/t18-,21+,23+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177695
(3-(1-heptyl-trans-4,5-dimethyl-2-alpha-propylpiper...)Show SMILES CCCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C23H39NO/c1-5-7-8-9-10-15-24-18-19(3)23(4,17-21(24)12-6-2)20-13-11-14-22(25)16-20/h11,13-14,16,19,21,25H,5-10,12,15,17-18H2,1-4H3/t19-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177696
(3-(2(alpha),4,5(trans)-trimethyl-1-phenethylpiperi...)Show SMILES C[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C22H29NO/c1-17-16-23(13-12-19-8-5-4-6-9-19)18(2)15-22(17,3)20-10-7-11-21(24)14-20/h4-11,14,17-18,24H,12-13,15-16H2,1-3H3/t17-,18+,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177683
(3-(2-alpha-butyl-trans-4,5-dimethyl-1-phenethylpip...)Show SMILES CCCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-5-13-23-18-25(3,22-12-9-14-24(27)17-22)20(2)19-26(23)16-15-21-10-7-6-8-11-21/h6-12,14,17,20,23,27H,4-5,13,15-16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177701
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-propylpi...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C24H33NO/c1-4-9-22-17-24(3,21-12-8-13-23(26)16-21)19(2)18-25(22)15-14-20-10-6-5-7-11-20/h5-8,10-13,16,19,22,26H,4,9,14-15,17-18H2,1-3H3/t19-,22+,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177701
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-propylpi...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C24H33NO/c1-4-9-22-17-24(3,21-12-8-13-23(26)16-21)19(2)18-25(22)15-14-20-10-6-5-7-11-20/h5-8,10-13,16,19,22,26H,4,9,14-15,17-18H2,1-3H3/t19-,22+,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177692
(3-(1-hexyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C22H37NO/c1-5-7-8-9-14-23-17-18(3)22(4,16-20(23)11-6-2)19-12-10-13-21(24)15-19/h10,12-13,15,18,20,24H,5-9,11,14,16-17H2,1-4H3/t18-,20+,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177691
(3-(trans-4,5-dimethyl-1,2(alpha)-diphenethylpiperi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C29H35NO/c1-23-22-30(19-18-25-12-7-4-8-13-25)27(17-16-24-10-5-3-6-11-24)21-29(23,2)26-14-9-15-28(31)20-26/h3-15,20,23,27,31H,16-19,21-22H2,1-2H3/t23-,27+,29+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177702
(3-(trans-4,5-dimethyl-1-(3-phenylpropyl)-2-alpha-p...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-10-23-18-25(3,22-14-8-15-24(27)17-22)20(2)19-26(23)16-9-13-21-11-6-5-7-12-21/h5-8,11-12,14-15,17,20,23,27H,4,9-10,13,16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177681
(CHEMBL383491 | N-(2-(4-(3-hydroxyphenyl)-trans-4,5...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCNC(C)=O)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C25H34N2O2/c1-19-18-27(15-13-21-8-5-4-6-9-21)23(12-14-26-20(2)28)17-25(19,3)22-10-7-11-24(29)16-22/h4-11,16,19,23,29H,12-15,17-18H2,1-3H3,(H,26,28)/t19-,23+,25+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177685
(CHEMBL201845 | N-(2-(4-(3-hydroxyphenyl)-trans-4,5...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCNC(=O)c2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C30H36N2O2/c1-23-22-32(19-17-24-10-5-3-6-11-24)27(16-18-31-29(34)25-12-7-4-8-13-25)21-30(23,2)26-14-9-15-28(33)20-26/h3-15,20,23,27,33H,16-19,21-22H2,1-2H3,(H,31,34)/t23-,27+,30+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177683
(3-(2-alpha-butyl-trans-4,5-dimethyl-1-phenethylpip...)Show SMILES CCCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-5-13-23-18-25(3,22-12-9-14-24(27)17-22)20(2)19-26(23)16-15-21-10-7-6-8-11-21/h6-12,14,17,20,23,27H,4-5,13,15-16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177686
(3-(1-methyl-4,5-trans-dimethyl-2-alpha-propylpiper...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1C)c1cccc(O)c1 Show InChI InChI=1S/C17H27NO/c1-5-7-15-11-17(3,13(2)12-18(15)4)14-8-6-9-16(19)10-14/h6,8-10,13,15,19H,5,7,11-12H2,1-4H3/t13-,15+,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177682
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-(3-pheny...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCCc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C30H37NO/c1-24-23-31(20-19-26-13-7-4-8-14-26)28(17-9-15-25-11-5-3-6-12-25)22-30(24,2)27-16-10-18-29(32)21-27/h3-8,10-14,16,18,21,24,28,32H,9,15,17,19-20,22-23H2,1-2H3/t24-,28+,30+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177689
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-phenylpi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@@H](C[C@@]1(C)c1cccc(O)c1)c1ccccc1 Show InChI InChI=1S/C27H31NO/c1-21-20-28(17-16-22-10-5-3-6-11-22)26(23-12-7-4-8-13-23)19-27(21,2)24-14-9-15-25(29)18-24/h3-15,18,21,26,29H,16-17,19-20H2,1-2H3/t21-,26-,27+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177682
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-(3-pheny...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCCc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C30H37NO/c1-24-23-31(20-19-26-13-7-4-8-14-26)28(17-9-15-25-11-5-3-6-12-25)22-30(24,2)27-16-10-18-29(32)21-27/h3-8,10-14,16,18,21,24,28,32H,9,15,17,19-20,22-23H2,1-2H3/t24-,28+,30+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177688
(3-(1-ethyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CC)c1cccc(O)c1 Show InChI InChI=1S/C18H29NO/c1-5-8-16-12-18(4,14(3)13-19(16)6-2)15-9-7-10-17(20)11-15/h7,9-11,14,16,20H,5-6,8,12-13H2,1-4H3/t14-,16+,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177700
(3-(2-alpha-isopropyl-trans-4,5-dimethyl-1-phenethy...)Show SMILES CC(C)[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C24H33NO/c1-18(2)23-16-24(4,21-11-8-12-22(26)15-21)19(3)17-25(23)14-13-20-9-6-5-7-10-20/h5-12,15,18-19,23,26H,13-14,16-17H2,1-4H3/t19-,23-,24+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177689
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-phenylpi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@@H](C[C@@]1(C)c1cccc(O)c1)c1ccccc1 Show InChI InChI=1S/C27H31NO/c1-21-20-28(17-16-22-10-5-3-6-11-22)26(23-12-7-4-8-13-23)19-27(21,2)24-14-9-15-25(29)18-24/h3-15,18,21,26,29H,16-17,19-20H2,1-2H3/t21-,26-,27+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177684
(3-(2-alpha-benzyl-trans-4,5-dimethyl-1-phenethylpi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](Cc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C28H33NO/c1-22-21-29(17-16-23-10-5-3-6-11-23)26(18-24-12-7-4-8-13-24)20-28(22,2)25-14-9-15-27(30)19-25/h3-15,19,22,26,30H,16-18,20-21H2,1-2H3/t22-,26+,28+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177689
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-phenylpi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@@H](C[C@@]1(C)c1cccc(O)c1)c1ccccc1 Show InChI InChI=1S/C27H31NO/c1-21-20-28(17-16-22-10-5-3-6-11-22)26(23-12-7-4-8-13-23)19-27(21,2)24-14-9-15-25(29)18-24/h3-15,18,21,26,29H,16-17,19-20H2,1-2H3/t21-,26-,27+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177682
(3-(trans-4,5-dimethyl-1-phenethyl-2-alpha-(3-pheny...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCCc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C30H37NO/c1-24-23-31(20-19-26-13-7-4-8-14-26)28(17-9-15-25-11-5-3-6-12-25)22-30(24,2)27-16-10-18-29(32)21-27/h3-8,10-14,16,18,21,24,28,32H,9,15,17,19-20,22-23H2,1-2H3/t24-,28+,30+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177692
(3-(1-hexyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C22H37NO/c1-5-7-8-9-14-23-17-18(3)22(4,16-20(23)11-6-2)19-12-10-13-21(24)15-19/h10,12-13,15,18,20,24H,5-9,11,14,16-17H2,1-4H3/t18-,20+,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177693
(3-(trans-4,5-dimethyl-1,2(alpha)-dipropylpiperidin...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCC)c1cccc(O)c1 Show InChI InChI=1S/C19H31NO/c1-5-8-17-13-19(4,15(3)14-20(17)11-6-2)16-9-7-10-18(21)12-16/h7,9-10,12,15,17,21H,5-6,8,11,13-14H2,1-4H3/t15-,17+,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177687
(3-(1-benzyl-4,5-trans-dimethyl-2-alpha-propylpiper...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1Cc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C23H31NO/c1-4-9-21-15-23(3,20-12-8-13-22(25)14-20)18(2)16-24(21)17-19-10-6-5-7-11-19/h5-8,10-14,18,21,25H,4,9,15-17H2,1-3H3/t18-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177690
(3-(trans-4,5-dimethyl-1-pentyl-2-alpha-propylpiper...)Show SMILES CCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C21H35NO/c1-5-7-8-13-22-16-17(3)21(4,15-19(22)10-6-2)18-11-9-12-20(23)14-18/h9,11-12,14,17,19,23H,5-8,10,13,15-16H2,1-4H3/t17-,19+,21+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177688
(3-(1-ethyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CC)c1cccc(O)c1 Show InChI InChI=1S/C18H29NO/c1-5-8-16-12-18(4,14(3)13-19(16)6-2)15-9-7-10-17(20)11-15/h7,9-11,14,16,20H,5-6,8,12-13H2,1-4H3/t14-,16+,18+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177693
(3-(trans-4,5-dimethyl-1,2(alpha)-dipropylpiperidin...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1CCC)c1cccc(O)c1 Show InChI InChI=1S/C19H31NO/c1-5-8-17-13-19(4,15(3)14-20(17)11-6-2)16-9-7-10-18(21)12-16/h7,9-10,12,15,17,21H,5-6,8,11,13-14H2,1-4H3/t15-,17+,19+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177697
(3-(2-alpha-(2-aminoethyl)-trans-4,5-dimethyl-1-phe...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCN)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C23H32N2O/c1-18-17-25(14-12-19-7-4-3-5-8-19)21(11-13-24)16-23(18,2)20-9-6-10-22(26)15-20/h3-10,15,18,21,26H,11-14,16-17,24H2,1-2H3/t18-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177686
(3-(1-methyl-4,5-trans-dimethyl-2-alpha-propylpiper...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1C)c1cccc(O)c1 Show InChI InChI=1S/C17H27NO/c1-5-7-15-11-17(3,13(2)12-18(15)4)14-8-6-9-16(19)10-14/h6,8-10,13,15,19H,5,7,11-12H2,1-4H3/t13-,15+,17+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177694
(3-(1-butyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C20H33NO/c1-5-7-12-21-15-16(3)20(4,14-18(21)9-6-2)17-10-8-11-19(22)13-17/h8,10-11,13,16,18,22H,5-7,9,12,14-15H2,1-4H3/t16-,18+,20+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Mu-type opioid receptor
(Homo sapiens (Human)) | BDBM50177699
(3-(trans-4,5-dimethyl-2-alpha-propylpiperidin-4-yl...)Show SMILES CCC[C@@H]1C[C@](C)([C@@H](C)CN1)c1cccc(O)c1 Show InChI InChI=1S/C16H25NO/c1-4-6-14-10-16(3,12(2)11-17-14)13-7-5-8-15(18)9-13/h5,7-9,12,14,17-18H,4,6,10-11H2,1-3H3/t12-,14+,16+/m0/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Inhibition of loperamide-stimulated [35S]GTP-gamma-S binding to membranes containing mu opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177690
(3-(trans-4,5-dimethyl-1-pentyl-2-alpha-propylpiper...)Show SMILES CCCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C21H35NO/c1-5-7-8-13-22-16-17(3)21(4,15-19(22)10-6-2)18-11-9-12-20(23)14-18/h9,11-12,14,17,19,23H,5-8,10,13,15-16H2,1-4H3/t17-,19+,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177683
(3-(2-alpha-butyl-trans-4,5-dimethyl-1-phenethylpip...)Show SMILES CCCC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C25H35NO/c1-4-5-13-23-18-25(3,22-12-9-14-24(27)17-22)20(2)19-26(23)16-15-21-10-7-6-8-11-21/h6-12,14,17,20,23,27H,4-5,13,15-16,18-19H2,1-3H3/t20-,23+,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177691
(3-(trans-4,5-dimethyl-1,2(alpha)-diphenethylpiperi...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCc2ccccc2)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C29H35NO/c1-23-22-30(19-18-25-12-7-4-8-13-25)27(17-16-24-10-5-3-6-11-24)21-29(23,2)26-14-9-15-28(31)20-26/h3-15,20,23,27,31H,16-19,21-22H2,1-2H3/t23-,27+,29+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177694
(3-(1-butyl-trans-4,5-dimethyl-2-alpha-propylpiperi...)Show SMILES CCCCN1C[C@H](C)[C@@](C)(C[C@H]1CCC)c1cccc(O)c1 Show InChI InChI=1S/C20H33NO/c1-5-7-12-21-15-16(3)20(4,14-18(21)9-6-2)17-10-8-11-19(22)13-17/h8,10-11,13,16,18,22H,5-7,9,12,14-15H2,1-4H3/t16-,18+,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Kappa-type opioid receptor
(Homo sapiens (Human)) | BDBM50177681
(CHEMBL383491 | N-(2-(4-(3-hydroxyphenyl)-trans-4,5...)Show SMILES C[C@H]1CN(CCc2ccccc2)[C@H](CCNC(C)=O)C[C@@]1(C)c1cccc(O)c1 Show InChI InChI=1S/C25H34N2O2/c1-19-18-27(15-13-21-8-5-4-6-9-21)23(12-14-26-20(2)28)17-25(19,3)22-10-7-11-24(29)16-22/h4-11,16,19,23,29H,12-15,17-18H2,1-3H3,(H,26,28)/t19-,23+,25+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned kappa opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
Delta-type opioid receptor
(Homo sapiens (Human)) | BDBM50177698
(3-(2-alpha-ethyl-trans-4,5-dimethyl-1-phenethylpip...)Show SMILES CC[C@@H]1C[C@](C)([C@@H](C)CN1CCc1ccccc1)c1cccc(O)c1 Show InChI InChI=1S/C23H31NO/c1-4-21-16-23(3,20-11-8-12-22(25)15-20)18(2)17-24(21)14-13-19-9-6-5-7-10-19/h5-12,15,18,21,25H,4,13-14,16-17H2,1-3H3/t18-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation
Curated by ChEMBL
| Assay Description
Displacement of [3H]diprenorphine from human cloned delta opioid receptor |
Bioorg Med Chem Lett 16: 864-8 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.010
BindingDB Entry DOI: 10.7270/Q2RJ4J1J |
More data for this
Ligand-Target Pair | |
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