Found 27 hits Enz. Inhib. hit(s) with all data for entry = 50009386 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082910
((S)-2-({5-[((S)-1-Cyclohexylmethyl-2-ethanesulfony...)Show SMILES CCS(=O)(=O)C[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C31H44N2O5S2/c1-4-40(37,38)21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-39-3/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 | PDB
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| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082897
((S)-2-({5-[((S)-2-Cyclohexyl-1-hydroxymethyl-ethyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C29H40N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h6-8,11-13,17,21,23,27,30,32H,3-5,9-10,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082918
(2-({5-[(2-Cyclohexyl-ethylamino)-methyl]-2'-methyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CNCCC2CCCCC2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C28H38N2O3S/c1-20-8-6-7-11-23(20)25-18-22(19-29-16-14-21-9-4-3-5-10-21)12-13-24(25)27(31)30-26(28(32)33)15-17-34-2/h6-8,11-13,18,21,26,29H,3-5,9-10,14-17,19H2,1-2H3,(H,30,31)(H,32,33)/p-1/t26-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082909
(2-[(5-{[tert-Butoxycarbonyl-(2-cyclohexyl-ethyl)-a...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)OC(C)(C)C)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C33H46N2O5S/c1-23-11-9-10-14-26(23)28-21-25(15-16-27(28)30(36)34-29(31(37)38)18-20-41-5)22-35(32(39)40-33(2,3)4)19-17-24-12-7-6-8-13-24/h9-11,14-16,21,24,29H,6-8,12-13,17-20,22H2,1-5H3,(H,34,36)(H,37,38)/p-1/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM16180
((2S)-2-{[4-({[(2S)-1-cyclohexyl-3-(ethylsulfanyl)p...)Show SMILES CCSC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C |r| Show InChI InChI=1S/C31H44N2O3S2/c1-4-38-21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-37-3/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082904
((S)-2-({5-[((S)-1-Cyclohexylmethyl-2-phenylsulfany...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSc2ccccc2)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C35H44N2O3S2/c1-25-11-9-10-16-30(25)32-22-27(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)23-36-28(21-26-12-5-3-6-13-26)24-42-29-14-7-4-8-15-29/h4,7-11,14-18,22,26,28,33,36H,3,5-6,12-13,19-21,23-24H2,1-2H3,(H,37,38)(H,39,40)/t28-,33-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082895
(2-({5-[(1-Cyclohexylmethyl-5-methyl-hex-2-enylamin...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CC2CCCCC2)\C=C\CC(C)C)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C34H48N2O3S/c1-24(2)11-10-15-28(21-26-13-6-5-7-14-26)35-23-27-17-18-30(31(22-27)29-16-9-8-12-25(29)3)33(37)36-32(34(38)39)19-20-40-4/h8-10,12,15-18,22,24,26,28,32,35H,5-7,11,13-14,19-21,23H2,1-4H3,(H,36,37)(H,38,39)/p-1/b15-10+/t28-,32+/m1/s1 | PDB
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Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082914
(2-({5-[(2-Cyclohexyl-1-cyclohexylmethyl-ethylamino...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CNC(CC2CCCCC2)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C35H50N2O3S/c1-25-11-9-10-16-30(25)32-23-28(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)24-36-29(21-26-12-5-3-6-13-26)22-27-14-7-4-8-15-27/h9-11,16-18,23,26-27,29,33,36H,3-8,12-15,19-22,24H2,1-2H3,(H,37,38)(H,39,40)/p-1/t33-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082899
(2-({5-[(1-Cyclohexylmethyl-5-methyl-hex-2-enylamin...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CCCC(C)C)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C34H50N2O3S/c1-24(2)11-10-15-28(21-26-13-6-5-7-14-26)35-23-27-17-18-30(31(22-27)29-16-9-8-12-25(29)3)33(37)36-32(34(38)39)19-20-40-4/h8-9,12,16-18,22,24,26,28,32,35H,5-7,10-11,13-15,19-21,23H2,1-4H3,(H,36,37)(H,38,39)/p-1/t28-,32+/m1/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082919
((S)-2-({5-[((S)-1-Cyclohexylmethyl-2-cyclohexylsul...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSC2CCCCC2)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C35H50N2O3S2/c1-25-11-9-10-16-30(25)32-22-27(17-18-31(32)34(38)37-33(35(39)40)19-20-41-2)23-36-28(21-26-12-5-3-6-13-26)24-42-29-14-7-4-8-15-29/h9-11,16-18,22,26,28-29,33,36H,3-8,12-15,19-21,23-24H2,1-2H3,(H,37,38)(H,39,40)/t28-,33-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082915
((S)-2-({5-[((S)-1-Cyclohexylmethyl-2-o-tolylsulfan...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSc2ccccc2C)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C36H46N2O3S2/c1-25-11-7-9-15-30(25)32-22-28(17-18-31(32)35(39)38-33(36(40)41)19-20-42-3)23-37-29(21-27-13-5-4-6-14-27)24-43-34-16-10-8-12-26(34)2/h7-12,15-18,22,27,29,33,37H,4-6,13-14,19-21,23-24H2,1-3H3,(H,38,39)(H,40,41)/t29-,33-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082907
(2-({5-[(1-Cyclohexylmethyl-pentylamino)-methyl]-2'...)Show SMILES CCCC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C32H46N2O3S/c1-4-5-14-26(20-24-12-7-6-8-13-24)33-22-25-16-17-28(29(21-25)27-15-10-9-11-23(27)2)31(35)34-30(32(36)37)18-19-38-3/h9-11,15-17,21,24,26,30,33H,4-8,12-14,18-20,22H2,1-3H3,(H,34,35)(H,36,37)/p-1/t26-,30+/m1/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082905
((S)-2-({5-[((S)-2-tert-Butylsulfanyl-1-cyclohexylm...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CSC(C)(C)C)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H48N2O3S2/c1-23-11-9-10-14-27(23)29-20-25(15-16-28(29)31(36)35-30(32(37)38)17-18-39-5)21-34-26(22-40-33(2,3)4)19-24-12-7-6-8-13-24/h9-11,14-16,20,24,26,30,34H,6-8,12-13,17-19,21-22H2,1-5H3,(H,35,36)(H,37,38)/t26-,30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082911
(2-({5-[(2-Cyclohexyl-1-methoxymethyl-ethylamino)-m...)Show SMILES COC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C30H42N2O4S/c1-21-9-7-8-12-25(21)27-18-23(19-31-24(20-36-2)17-22-10-5-4-6-11-22)13-14-26(27)29(33)32-28(30(34)35)15-16-37-3/h7-9,12-14,18,22,24,28,31H,4-6,10-11,15-17,19-20H2,1-3H3,(H,32,33)(H,34,35)/p-1/t24-,28-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082896
(2-({5-[(1-Cyclohexylmethyl-propylamino)-methyl]-2'...)Show SMILES CC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCSC)C([O-])=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C30H42N2O3S/c1-4-24(18-22-11-6-5-7-12-22)31-20-23-14-15-26(27(19-23)25-13-9-8-10-21(25)2)29(33)32-28(30(34)35)16-17-36-3/h8-10,13-15,19,22,24,28,31H,4-7,11-12,16-18,20H2,1-3H3,(H,32,33)(H,34,35)/p-1/t24-,28+/m1/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082901
(2-({5-[(2-Cyclohexyl-1-methyl-ethylamino)-methyl]-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](C)CC2CCCCC2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C29H40N2O3S/c1-20-9-7-8-12-24(20)26-18-23(19-30-21(2)17-22-10-5-4-6-11-22)13-14-25(26)28(32)31-27(29(33)34)15-16-35-3/h7-9,12-14,18,21-22,27,30H,4-6,10-11,15-17,19H2,1-3H3,(H,31,32)(H,33,34)/p-1/t21-,27+/m1/s1 | PDB
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Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082913
(2-[(5-{[(2-Cyclohexyl-ethyl)-methyl-amino]-methyl}...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(C)CCC2CCCCC2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C29H40N2O3S/c1-21-9-7-8-12-24(21)26-19-23(20-31(2)17-15-22-10-5-4-6-11-22)13-14-25(26)28(32)30-27(29(33)34)16-18-35-3/h7-9,12-14,19,22,27H,4-6,10-11,15-18,20H2,1-3H3,(H,30,32)(H,33,34)/p-1/t27-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082898
((S)-2-({5-[((S)-2-Cyclohexyl-1-ethylsulfanylmethyl...)Show SMILES CCSC[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCS(C)(=O)=O)C(O)=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C31H44N2O5S2/c1-4-39-21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-40(3,37)38/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082903
(2-[(5-{[Benzoyl-(2-cyclohexyl-ethyl)-amino]-methyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)c2ccccc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C35H42N2O4S/c1-25-11-9-10-16-29(25)31-23-27(17-18-30(31)33(38)36-32(35(40)41)20-22-42-2)24-37(21-19-26-12-5-3-6-13-26)34(39)28-14-7-4-8-15-28/h4,7-11,14-18,23,26,32H,3,5-6,12-13,19-22,24H2,1-2H3,(H,36,38)(H,40,41)/p-1/t32-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082894
((S)-2-({5-[((S)-1-Cyclohexylmethyl-2-ethanesulfony...)Show SMILES CCS(=O)(=O)C[C@H](CC1CCCCC1)NCc1ccc(C(=O)N[C@@H](CCS(C)(=O)=O)C(O)=O)c(c1)-c1ccccc1C Show InChI InChI=1S/C31H44N2O7S2/c1-4-42(39,40)21-25(18-23-11-6-5-7-12-23)32-20-24-14-15-27(28(19-24)26-13-9-8-10-22(26)2)30(34)33-29(31(35)36)16-17-41(3,37)38/h8-10,13-15,19,23,25,29,32H,4-7,11-12,16-18,20-21H2,1-3H3,(H,33,34)(H,35,36)/t25-,29-/m0/s1 | PDB
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| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082906
(2-[(5-{[Acetyl-(2-cyclohexyl-ethyl)-amino]-methyl}...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(C)=O)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C30H40N2O4S/c1-21-9-7-8-12-25(21)27-19-24(20-32(22(2)33)17-15-23-10-5-4-6-11-23)13-14-26(27)29(34)31-28(30(35)36)16-18-37-3/h7-9,12-14,19,23,28H,4-6,10-11,15-18,20H2,1-3H3,(H,31,34)(H,35,36)/p-1/t28-/m0/s1 | PDB
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| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082902
(2-[(5-{[Benzyl-(2-cyclohexyl-ethyl)-amino]-methyl}...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)Cc2ccccc2)cc1-c1ccccc1C)C([O-])=O Show InChI InChI=1S/C35H44N2O3S/c1-26-11-9-10-16-30(26)32-23-29(17-18-31(32)34(38)36-33(35(39)40)20-22-41-2)25-37(24-28-14-7-4-8-15-28)21-19-27-12-5-3-6-13-27/h4,7-11,14-18,23,27,33H,3,5-6,12-13,19-22,24-25H2,1-2H3,(H,36,38)(H,39,40)/p-1/t33-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082912
((S)-2-({5-[((S)-1-Cyclohexyl-2-hydroxy-ethylamino)...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)C2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C28H38N2O4S/c1-19-8-6-7-11-22(19)24-16-20(17-29-26(18-31)21-9-4-3-5-10-21)12-13-23(24)27(32)30-25(28(33)34)14-15-35-2/h6-8,11-13,16,21,25-26,29,31H,3-5,9-10,14-15,17-18H2,1-2H3,(H,30,32)(H,33,34)/t25-,26+/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082916
((S)-2-({5-[((S)-1-Hydroxymethyl-2-phenyl-ethylamin...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C29H34N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h3-13,17,23,27,30,32H,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082917
((S)-2-({5-[((S)-2-Cyclohexyl-1-hydroxymethyl-ethyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@H](CO)CC2CCCCC2)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C28H38N2O4S/c1-35-15-14-26(28(33)34)30-27(32)24-13-12-21(17-25(24)22-10-6-3-7-11-22)18-29-23(19-31)16-20-8-4-2-5-9-20/h3,6-7,10-13,17,20,23,26,29,31H,2,4-5,8-9,14-16,18-19H2,1H3,(H,30,32)(H,33,34)/t23-,26-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082908
((S)-2-({5-[((R)-1-Cyclohexyl-2-hydroxy-ethylamino)...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CO)C2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C28H38N2O4S/c1-19-8-6-7-11-22(19)24-16-20(17-29-26(18-31)21-9-4-3-5-10-21)12-13-23(24)27(32)30-25(28(33)34)14-15-35-2/h6-8,11-13,16,21,25-26,29,31H,3-5,9-10,14-15,17-18H2,1-2H3,(H,30,32)(H,33,34)/t25-,26-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50082900
((S)-2-({5-[((R)-2-Cyclohexyl-1-hydroxymethyl-ethyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN[C@@H](CO)CC2CCCCC2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C29H40N2O4S/c1-20-8-6-7-11-24(20)26-17-22(18-30-23(19-32)16-21-9-4-3-5-10-21)12-13-25(26)28(33)31-27(29(34)35)14-15-36-2/h6-8,11-13,17,21,23,27,30,32H,3-5,9-10,14-16,18-19H2,1-2H3,(H,31,33)(H,34,35)/t23-,27+/m1/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase) |
J Med Chem 42: 4844-52 (1999)
BindingDB Entry DOI: 10.7270/Q2WW7GWR |
More data for this
Ligand-Target Pair | |
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