Compile Data Set for Download or QSAR

Found 50 hits Enz. Inhib. hit(s) with all data for entry = 50031429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313121 (3-(3-chlorophenylsulfonyl)-1-(1-methylpyrrolidin-3...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H19ClN2O2S/c1-21-10-9-15(12-21)22-13-19(17-7-2-3-8-18(17)22)25(23,24)16-6-4-5-14(20)11-16/h2-8,11,13,15H,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313125 (8-(1-(pyrrolidin-3-yl)-1H-indol-3-ylsulfonyl)quino...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1cccc2cccnc12 Show InChI InChI=1S/C21H19N3O2S/c25-27(26,19-9-3-5-15-6-4-11-23-21(15)19)20-14-24(16-10-12-22-13-16)18-8-2-1-7-17(18)20/h1-9,11,14,16,22H,10,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313126 (8-(1-(1-methylpyrrolidin-3-yl)-1H-indol-3-ylsulfon...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2cccnc12 Show InChI InChI=1S/C22H21N3O2S/c1-24-13-11-17(14-24)25-15-21(18-8-2-3-9-19(18)25)28(26,27)20-10-4-6-16-7-5-12-23-22(16)20/h2-10,12,15,17H,11,13-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313147 (3-(3-chlorophenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-...) Show SMILES Clc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccccc12 Show InChI InChI=1S/C18H17ClN2O2S/c19-13-4-3-5-15(10-13)24(22,23)18-12-21(14-8-9-20-11-14)17-7-2-1-6-16(17)18/h1-7,10,12,14,20H,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313141 (3-(3-fluorophenylsulfonyl)-1-(1-methylpyrrolidin-3...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C19H19FN2O2S/c1-21-10-9-15(12-21)22-13-19(17-7-2-3-8-18(17)22)25(23,24)16-6-4-5-14(20)11-16/h2-8,11,13,15H,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313118 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(piperidin-3...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCCNC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H18F2N2O2S/c20-13-3-1-5-16(9-13)26(24,25)19-12-23(15-4-2-8-22-11-15)18-7-6-14(21)10-17(18)19/h1,3,5-7,9-10,12,15,22H,2,4,8,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313122 (3-(3-chlorophenylsulfonyl)-6-methoxy-1-(pyrrolidin...) Show SMILES COc1ccc2c(cn(C3CCNC3)c2c1)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H19ClN2O3S/c1-25-15-5-6-17-18(10-15)22(14-7-8-21-11-14)12-19(17)26(23,24)16-4-2-3-13(20)9-16/h2-6,9-10,12,14,21H,7-8,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313140 (3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccccc12 Show InChI InChI=1S/C18H17FN2O2S/c19-13-4-3-5-15(10-13)24(22,23)18-12-21(14-8-9-20-11-14)17-7-2-1-6-16(17)18/h1-7,10,12,14,20H,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313120 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(1-methylpyr...) Show SMILES CN1CCC(C1)n1cc(c2cc(F)ccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C19H18F2N2O2S/c1-22-8-7-15(11-22)23-12-19(17-10-14(21)5-6-18(17)23)26(24,25)16-4-2-3-13(20)9-16/h2-6,9-10,12,15H,7-8,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313139 (3-(phenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-indole |...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C18H18N2O2S/c21-23(22,15-6-2-1-3-7-15)18-13-20(14-10-11-19-12-14)17-9-5-4-8-16(17)18/h1-9,13-14,19H,10-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313137 (8-(1-(piperidin-3-yl)-1H-indol-3-ylsulfonyl)quinol...) Show SMILES O=S(=O)(c1cn(C2CCCNC2)c2ccccc12)c1cccc2cccnc12 Show InChI InChI=1S/C22H21N3O2S/c26-28(27,20-11-3-6-16-7-4-13-24-22(16)20)21-15-25(17-8-5-12-23-14-17)19-10-2-1-9-18(19)21/h1-4,6-7,9-11,13,15,17,23H,5,8,12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313132 (3-(3-fluorophenylsulfonyl)-1-(piperidin-3-yl)-1H-i...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCCNC2)c2ccccc12 Show InChI InChI=1S/C19H19FN2O2S/c20-14-5-3-7-16(11-14)25(23,24)19-13-22(15-6-4-10-21-12-15)18-9-2-1-8-17(18)19/h1-3,5,7-9,11,13,15,21H,4,6,10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313124 (1-(1-methylpyrrolidin-3-yl)-3-(naphthalen-1-ylsulf...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C23H22N2O2S/c1-24-14-13-18(15-24)25-16-23(20-10-4-5-11-21(20)25)28(26,27)22-12-6-8-17-7-2-3-9-19(17)22/h2-12,16,18H,13-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313119 (1-(1-methylpiperidin-3-yl)-3-(naphthalen-1-ylsulfo...) Show SMILES CN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C24H24N2O2S/c1-25-15-7-10-19(16-25)26-17-24(21-12-4-5-13-22(21)26)29(27,28)23-14-6-9-18-8-2-3-11-20(18)23/h2-6,8-9,11-14,17,19H,7,10,15-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313131 (1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-in...) Show SMILES CCN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H24N2O2S/c1-2-22-14-8-9-17(15-22)23-16-21(19-12-6-7-13-20(19)23)26(24,25)18-10-4-3-5-11-18/h3-7,10-13,16-17H,2,8-9,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313143 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H16F2N2O2S/c19-12-2-1-3-15(8-12)25(23,24)18-11-22(14-6-7-21-10-14)17-5-4-13(20)9-16(17)18/h1-5,8-9,11,14,21H,6-7,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313133 (3-(3-fluorophenylsulfonyl)-5-methoxy-1-(piperidin-...) Show SMILES COc1ccc2n(cc(c2c1)S(=O)(=O)c1cccc(F)c1)C1CCCNC1 Show InChI InChI=1S/C20H21FN2O3S/c1-26-16-7-8-19-18(11-16)20(13-23(19)15-5-3-9-22-12-15)27(24,25)17-6-2-4-14(21)10-17/h2,4,6-8,10-11,13,15,22H,3,5,9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313130 (3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole | ...) Show SMILES O=S(=O)(c1cn(C2CCCNC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C19H20N2O2S/c22-24(23,16-8-2-1-3-9-16)19-14-21(15-7-6-12-20-13-15)18-11-5-4-10-17(18)19/h1-5,8-11,14-15,20H,6-7,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313145 (5-chloro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccc(Cl)cc12 Show InChI InChI=1S/C18H16ClFN2O2S/c19-12-4-5-17-16(8-12)18(11-22(17)14-6-7-21-10-14)25(23,24)15-3-1-2-13(20)9-15/h1-5,8-9,11,14,21H,6-7,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313135 (1-(1-ethylpiperidin-3-yl)-3-(3-fluorophenylsulfony...) Show SMILES CCN1CCCC(C1)n1cc(c2cc(OC)ccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C22H25FN2O3S/c1-3-24-11-5-7-17(14-24)25-15-22(20-13-18(28-2)9-10-21(20)25)29(26,27)19-8-4-6-16(23)12-19/h4,6,8-10,12-13,15,17H,3,5,7,11,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313142 (4-fluoro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2cccc(F)c12 Show InChI InChI=1S/C18H16F2N2O2S/c19-12-3-1-4-14(9-12)25(23,24)17-11-22(13-7-8-21-10-13)16-6-2-5-15(20)18(16)17/h1-6,9,11,13,21H,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313144 (6-fluoro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2cc(F)ccc12 Show InChI InChI=1S/C18H16F2N2O2S/c19-12-2-1-3-15(8-12)25(23,24)18-11-22(14-6-7-21-10-14)17-9-13(20)4-5-16(17)18/h1-5,8-9,11,14,21H,6-7,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313136 (3-(naphthalen-1-ylsulfonyl)-1-(piperidin-3-yl)-1H-...) Show SMILES O=S(=O)(c1cn(C2CCCNC2)c2ccccc12)c1cccc2ccccc12 Show InChI InChI=1S/C23H22N2O2S/c26-28(27,22-13-5-8-17-7-1-2-10-19(17)22)23-16-25(18-9-6-14-24-15-18)21-12-4-3-11-20(21)23/h1-5,7-8,10-13,16,18,24H,6,9,14-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313123 (3-(naphthalen-1-ylsulfonyl)-1-(pyrrolidin-3-yl)-1H...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1cccc2ccccc12 Show InChI InChI=1S/C22H20N2O2S/c25-27(26,21-11-5-7-16-6-1-2-8-18(16)21)22-15-24(17-12-13-23-14-17)20-10-4-3-9-19(20)22/h1-11,15,17,23H,12-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	23.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313127 (1-(1-benzylpiperidin-4-yl)-3-(phenylsulfonyl)-1H-i...) Show SMILES O=S(=O)(c1cn(C2CCN(Cc3ccccc3)CC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C26H26N2O2S/c29-31(30,23-11-5-2-6-12-23)26-20-28(25-14-8-7-13-24(25)26)22-15-17-27(18-16-22)19-21-9-3-1-4-10-21/h1-14,20,22H,15-19H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313134 (3-(3-fluorophenylsulfonyl)-5-methoxy-1-(1-methylpi...) Show SMILES COc1ccc2n(cc(c2c1)S(=O)(=O)c1cccc(F)c1)C1CCCN(C)C1 Show InChI InChI=1S/C21H23FN2O3S/c1-23-10-4-6-16(13-23)24-14-21(19-12-17(27-2)8-9-20(19)24)28(25,26)18-7-3-5-15(22)11-18/h3,5,7-9,11-12,14,16H,4,6,10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313146 (6-chloro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2cc(Cl)ccc12 Show InChI InChI=1S/C18H16ClFN2O2S/c19-12-4-5-16-17(8-12)22(14-6-7-21-10-14)11-18(16)25(23,24)15-3-1-2-13(20)9-15/h1-5,8-9,11,14,21H,6-7,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313128 (3-(phenylsulfonyl)-1-(piperidin-4-yl)-1H-indole | ...) Show SMILES O=S(=O)(c1cn(C2CCNCC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C19H20N2O2S/c22-24(23,16-6-2-1-3-7-16)19-14-21(15-10-12-20-13-11-15)18-9-5-4-8-17(18)19/h1-9,14-15,20H,10-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313138 (1-(1-benzylpyrrolidin-3-yl)-3-(phenylsulfonyl)-1H-...) Show SMILES O=S(=O)(c1cn(C2CCN(Cc3ccccc3)C2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C25H24N2O2S/c28-30(29,22-11-5-2-6-12-22)25-19-27(24-14-8-7-13-23(24)25)21-15-16-26(18-21)17-20-9-3-1-4-10-20/h1-14,19,21H,15-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	113	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313129 (1-(1-benzylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-i...) Show SMILES O=S(=O)(c1cn(C2CCCN(Cc3ccccc3)C2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C26H26N2O2S/c29-31(30,23-13-5-2-6-14-23)26-20-28(25-16-8-7-15-24(25)26)22-12-9-17-27(19-22)18-21-10-3-1-4-11-21/h1-8,10-11,13-16,20,22H,9,12,17-19H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	122	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 2 hrs				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313121 (3-(3-chlorophenylsulfonyl)-1-(1-methylpyrrolidin-3...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H19ClN2O2S/c1-21-10-9-15(12-21)22-13-19(17-7-2-3-8-18(17)22)25(23,24)16-6-4-5-14(20)11-16/h2-8,11,13,15H,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313118 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(piperidin-3...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCCNC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H18F2N2O2S/c20-13-3-1-5-16(9-13)26(24,25)19-12-23(15-4-2-8-22-11-15)18-7-6-14(21)10-17(18)19/h1,3,5-7,9-10,12,15,22H,2,4,8,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313124 (1-(1-methylpyrrolidin-3-yl)-3-(naphthalen-1-ylsulf...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C23H22N2O2S/c1-24-14-13-18(15-24)25-16-23(20-10-4-5-11-21(20)25)28(26,27)22-12-6-8-17-7-2-3-9-19(17)22/h2-12,16,18H,13-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313126 (8-(1-(1-methylpyrrolidin-3-yl)-1H-indol-3-ylsulfon...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2cccnc12 Show InChI InChI=1S/C22H21N3O2S/c1-24-13-11-17(14-24)25-15-21(18-8-2-3-9-19(18)25)28(26,27)20-10-4-6-16-7-5-12-23-22(16)20/h2-10,12,15,17H,11,13-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313122 (3-(3-chlorophenylsulfonyl)-6-methoxy-1-(pyrrolidin...) Show SMILES COc1ccc2c(cn(C3CCNC3)c2c1)S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C19H19ClN2O3S/c1-25-15-5-6-17-18(10-15)22(14-7-8-21-11-14)12-19(17)26(23,24)16-4-2-3-13(20)9-16/h2-6,9-10,12,14,21H,7-8,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313125 (8-(1-(pyrrolidin-3-yl)-1H-indol-3-ylsulfonyl)quino...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1cccc2cccnc12 Show InChI InChI=1S/C21H19N3O2S/c25-27(26,19-9-3-5-15-6-4-11-23-21(15)19)20-14-24(16-10-12-22-13-16)18-8-2-1-7-17(18)20/h1-9,11,14,16,22H,10,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313120 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(1-methylpyr...) Show SMILES CN1CCC(C1)n1cc(c2cc(F)ccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C19H18F2N2O2S/c1-22-8-7-15(11-22)23-12-19(17-10-14(21)5-6-18(17)23)26(24,25)16-4-2-3-13(20)9-16/h2-6,9-10,12,15H,7-8,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313123 (3-(naphthalen-1-ylsulfonyl)-1-(pyrrolidin-3-yl)-1H...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1cccc2ccccc12 Show InChI InChI=1S/C22H20N2O2S/c25-27(26,21-11-5-7-16-6-1-2-8-18(16)21)22-15-24(17-12-13-23-14-17)20-10-4-3-9-19(20)22/h1-11,15,17,23H,12-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313119 (1-(1-methylpiperidin-3-yl)-3-(naphthalen-1-ylsulfo...) Show SMILES CN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc2ccccc12 Show InChI InChI=1S/C24H24N2O2S/c1-25-15-7-10-19(16-25)26-17-24(21-12-4-5-13-22(21)26)29(27,28)23-14-6-9-18-8-2-3-11-20(18)23/h2-6,8-9,11-14,17,19H,7,10,15-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced intracellular cAMP level after 10 min...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313130 (3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole | ...) Show SMILES O=S(=O)(c1cn(C2CCCNC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C19H20N2O2S/c22-24(23,16-8-2-1-3-9-16)19-14-21(15-7-6-12-20-13-15)18-11-5-4-10-17(18)19/h1-5,8-11,14-15,20H,6-7,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	82	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313131 (1-(1-ethylpiperidin-3-yl)-3-(phenylsulfonyl)-1H-in...) Show SMILES CCN1CCCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H24N2O2S/c1-2-22-14-8-9-17(15-22)23-16-21(19-12-6-7-13-20(19)23)26(24,25)18-10-4-3-5-11-18/h3-7,10-13,16-17H,2,8-9,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313132 (3-(3-fluorophenylsulfonyl)-1-(piperidin-3-yl)-1H-i...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCCNC2)c2ccccc12 Show InChI InChI=1S/C19H19FN2O2S/c20-14-5-3-7-16(11-14)25(23,24)19-13-22(15-6-4-10-21-12-15)18-9-2-1-8-17(18)19/h1-3,5,7-9,11,13,15,21H,4,6,10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313133 (3-(3-fluorophenylsulfonyl)-5-methoxy-1-(piperidin-...) Show SMILES COc1ccc2n(cc(c2c1)S(=O)(=O)c1cccc(F)c1)C1CCCNC1 Show InChI InChI=1S/C20H21FN2O3S/c1-26-16-7-8-19-18(11-16)20(13-23(19)15-5-3-9-22-12-15)27(24,25)17-6-2-4-14(21)10-17/h2,4,6-8,10-11,13,15,22H,3,5,9,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313135 (1-(1-ethylpiperidin-3-yl)-3-(3-fluorophenylsulfony...) Show SMILES CCN1CCCC(C1)n1cc(c2cc(OC)ccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C22H25FN2O3S/c1-3-24-11-5-7-17(14-24)25-15-22(20-13-18(28-2)9-10-21(20)25)29(26,27)19-8-4-6-16(23)12-19/h4,6,8-10,12-13,15,17H,3,5,7,11,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	203	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313147 (3-(3-chlorophenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-...) Show SMILES Clc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccccc12 Show InChI InChI=1S/C18H17ClN2O2S/c19-13-4-3-5-15(10-13)24(22,23)18-12-21(14-8-9-20-11-14)17-7-2-1-6-16(17)18/h1-7,10,12,14,20H,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	125	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313139 (3-(phenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-indole |...) Show SMILES O=S(=O)(c1cn(C2CCNC2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C18H18N2O2S/c21-23(22,15-6-2-1-3-7-15)18-13-20(14-10-11-19-12-14)17-9-5-4-8-16(17)18/h1-9,13-14,19H,10-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313140 (3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccccc12 Show InChI InChI=1S/C18H17FN2O2S/c19-13-4-3-5-15(10-13)24(22,23)18-12-21(14-8-9-20-11-14)17-7-2-1-6-16(17)18/h1-7,10,12,14,20H,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	68	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313141 (3-(3-fluorophenylsulfonyl)-1-(1-methylpyrrolidin-3...) Show SMILES CN1CCC(C1)n1cc(c2ccccc12)S(=O)(=O)c1cccc(F)c1 Show InChI InChI=1S/C19H19FN2O2S/c1-21-10-9-15(12-21)22-13-19(17-7-2-3-8-18(17)22)25(23,24)16-6-4-5-14(20)11-16/h2-8,11,13,15H,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	398	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313143 (5-fluoro-3-(3-fluorophenylsulfonyl)-1-(pyrrolidin-...) Show SMILES Fc1cccc(c1)S(=O)(=O)c1cn(C2CCNC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H16F2N2O2S/c19-12-2-1-3-15(8-12)25(23,24)18-11-22(14-6-7-21-10-14)17-5-4-13(20)9-16(17)18/h1-5,8-9,11,14,21H,6-7,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50313137 (8-(1-(piperidin-3-yl)-1H-indol-3-ylsulfonyl)quinol...) Show SMILES O=S(=O)(c1cn(C2CCCNC2)c2ccccc12)c1cccc2cccnc12 Show InChI InChI=1S/C22H21N3O2S/c26-28(27,20-11-3-6-16-7-4-13-24-22(16)20)21-15-25(17-8-5-12-23-14-17)19-10-2-1-9-18(19)21/h1-4,6-7,9-11,13,15,17,23H,5,8,12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	592	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as effect on 5HT-induced intracellular cAMP level after 10 mins by ra...				Bioorg Med Chem Lett 20: 1657-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.073 BindingDB Entry DOI: 10.7270/Q2ZC830C
					More data for this Ligand-Target Pair