Found 25 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 6313 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122451
(US8729074, 8)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1cccnc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-6-4-18(25)5-7-19)10-17(12-28-23)21-13-27-22-8-3-16(14-30(21)22)15-2-1-9-26-11-15/h1-14,29H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1 | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122459
(US8729074, 19)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C20H16ClF3N6O2S/c1-29(2)33(31,32)28-15-7-14(9-27-19(15)21)16-10-26-18-4-3-13(11-30(16)18)12-5-6-25-17(8-12)20(22,23)24/h3-11,28H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122468
(US8729074, 18)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(10-23-19(16)20)17-11-22-18-4-3-14(12-26(17)18)13-5-7-21-8-6-13/h3-12,24H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122450
(US8729074, 7)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)-c1ccncc1 Show InChI InChI=1S/C23H15ClFN5O2S/c24-23-20(29-33(31,32)19-4-2-18(25)3-5-19)11-17(12-28-23)21-13-27-22-6-1-16(14-30(21)22)15-7-9-26-10-8-15/h1-14,29H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 2 | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122452
(US8729074, 9)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(cn12)N1CCOCC1 Show InChI InChI=1S/C22H19ClFN5O3S/c23-22-19(27-33(30,31)18-4-1-16(24)2-5-18)11-15(12-26-22)20-13-25-21-6-3-17(14-29(20)21)28-7-9-32-10-8-28/h1-6,11-14,27H,7-10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 4 | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122469
(US8729074, 23)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(C)c(cn12)-c1ccncc1 Show InChI InChI=1S/C20H19ClN6O2S/c1-13-8-19-23-11-18(27(19)12-16(13)14-4-6-22-7-5-14)15-9-17(20(21)24-10-15)25-30(28,29)26(2)3/h4-12,25H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122460
(US8729074, 20)Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C18H14ClN5O2S/c1-27(25,26)23-15-7-14(10-22-18(15)19)16-11-21-17-8-12(4-6-24(16)17)13-3-2-5-20-9-13/h2-11,23H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122449
(US8729074, 6)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Br)cn12 Show InChI InChI=1S/C18H11BrClFN4O2S/c19-12-1-6-17-22-9-16(25(17)10-12)11-7-15(18(20)23-8-11)24-28(26,27)14-4-2-13(21)3-5-14/h1-10,24H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 6 | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122461
(US8729074, 21)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1ccncc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-9-15(11-23-19(16)20)17-12-22-18-10-14(5-8-26(17)18)13-3-6-21-7-4-13/h3-12,24H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122465
(US8729074, 4)Show SMILES Cc1ccn2c(cnc2c1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-6-7-25-17(11-22-18(25)8-12)13-9-16(19(20)23-10-13)24-28(26,27)15-4-2-14(21)3-5-15/h2-11,24H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 19 | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122448
(US8729074, 5)Show SMILES Cc1nc2ccc(Br)cn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H13BrClFN4O2S/c1-11-18(26-10-13(20)2-7-17(26)24-11)12-8-16(19(21)23-9-12)25-29(27,28)15-5-3-14(22)4-6-15/h2-10,25H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 20 | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122462
(US8729074, 22)Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2cc(ccn12)-c1cccnc1 Show InChI InChI=1S/C19H17ClN6O2S/c1-25(2)29(27,28)24-16-8-15(11-23-19(16)20)17-12-22-18-9-13(5-7-26(17)18)14-4-3-6-21-10-14/h3-12,24H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122463
(US8729074, 25)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccc(Cl)nn12 Show InChI InChI=1S/C17H10Cl2FN5O2S/c18-15-5-6-16-21-9-14(25(16)23-15)10-7-13(17(19)22-8-10)24-28(26,27)12-3-1-11(20)2-4-12/h1-9,24H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 22 | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122464
(US8729074, 3)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccccn12 Show InChI InChI=1S/C18H12ClFN4O2S/c19-18-15(23-27(25,26)14-6-4-13(20)5-7-14)9-12(10-22-18)16-11-21-17-3-1-2-8-24(16)17/h1-11,23H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 28 | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122446
(US8729074, 1)Show SMILES Cc1nc2ccccn2c1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H14ClFN4O2S/c1-12-18(25-9-3-2-4-17(25)23-12)13-10-16(19(20)22-11-13)24-28(26,27)15-7-5-14(21)6-8-15/h2-11,24H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 126 | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122456
(US8729074, 14)Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 268 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122457
(US8729074, 15)Show SMILES COc1cc(cnc1OC)-c1cnc2ccc(cn12)N1[C@@H](Cc2ccccc2)COC1=O |r| Show InChI InChI=1S/C24H22N4O4/c1-30-21-11-17(12-26-23(21)31-2)20-13-25-22-9-8-18(14-27(20)22)28-19(15-32-24(28)29)10-16-6-4-3-5-7-16/h3-9,11-14,19H,10,15H2,1-2H3/t19-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 286 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122470
(US8729074, 24)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ncccn12 Show InChI InChI=1S/C17H11ClFN5O2S/c18-16-14(23-27(25,26)13-4-2-12(19)3-5-13)8-11(9-21-16)15-10-22-17-20-6-1-7-24(15)17/h1-10,23H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 378 | n/a | 781 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122467
(US8729074, 17)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cnc2ccn(Cc3ccccc3)c(=O)n12 Show InChI InChI=1S/C24H17ClFN5O3S/c25-23-20(29-35(33,34)19-8-6-18(26)7-9-19)12-17(13-28-23)21-14-27-22-10-11-30(24(32)31(21)22)15-16-4-2-1-3-5-16/h1-14,29H,15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 465 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122454
(US8729074, 12)Show InChI InChI=1S/C19H16N4O2/c1-24-17-9-15(10-22-19(17)25-2)16-11-21-18-4-3-14(12-23(16)18)13-5-7-20-8-6-13/h3-12H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 626 | n/a | 861 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122453
(US8729074, 11)Show InChI InChI=1S/C14H12BrN3O2/c1-19-12-5-9(6-17-14(12)20-2)11-7-16-13-4-3-10(15)8-18(11)13/h3-8H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 779 | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122458
(US8729074, 16)Show InChI InChI=1S/C18H20N4O3/c1-23-16-9-13(10-20-18(16)24-2)15-11-19-17-4-3-14(12-22(15)17)21-5-7-25-8-6-21/h3-4,9-12H,5-8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122447
(US8729074, 2)Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cncc(c1)-c1cnc2ccccn12 Show InChI InChI=1S/C18H13FN4O2S/c19-14-4-6-16(7-5-14)26(24,25)22-15-9-13(10-20-11-15)17-12-21-18-3-1-2-8-23(17)18/h1-12,22H | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 1.29E+3 | n/a | 931 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122455
(US8729074, 13)Show InChI InChI=1S/C17H16N4O4/c1-23-14-7-11(8-19-16(14)24-2)13-9-18-15-4-3-12(10-21(13)15)20-5-6-25-17(20)22/h3-4,7-10H,5-6H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| >1.50E+3 | n/a | 4.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM122466
(US8729074, 10)Show InChI InChI=1S/C14H13N3O2/c1-18-12-7-10(8-16-14(12)19-2)11-9-15-13-5-3-4-6-17(11)13/h3-9H,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| >1.50E+3 | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description
The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI3Kβ,... |
US Patent US8729074 (2014)
BindingDB Entry DOI: 10.7270/Q2RJ4H4G |
More data for this
Ligand-Target Pair | |
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