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PubMed code 19097784

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28200
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(O)=O)c2cc1OC
Show InChI InChI=1S/C22H17F3N2O5S/c1-30-16-7-14-15(8-17(16)31-2)27(11-26-14)19-9-18(20(33-19)21(28)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H,28,29)
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n/an/a 2n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28194
PNG
(3-[(3-chlorothiophen-2-yl)methoxy]-5-(5,6-dimethox...)
Show SMILES COc1cc2ncn(-c3cc(OCc4sccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H16ClN3O4S2/c1-25-13-5-11-12(6-14(13)26-2)23(9-22-11)17-7-15(18(29-17)19(21)24)27-8-16-10(20)3-4-28-16/h3-7,9H,8H2,1-2H3,(H2,21,24)
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n/an/a 2n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28175
PNG
(5-(6-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifl...)
Show SMILES COc1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM25120
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28177
PNG
(3-[(2-bromophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4Br)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H18BrN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28178
PNG
(3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H18ClN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26)
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n/an/a 2n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28169
PNG
(5-(6-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylp...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccc(Cl)cc12
Show InChI InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-7-6-14(21)8-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25)
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n/an/a 4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28182
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4OC(F)(F)F)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18F3N3O5S/c1-30-16-7-13-14(8-17(16)31-2)28(11-27-13)19-9-18(20(34-19)21(26)29)32-10-12-5-3-4-6-15(12)33-22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
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n/an/a 5n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28202
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=S)c2cc1OC
Show InChI InChI=1S/C22H18F3N3O3S2/c1-29-16-7-14-15(8-17(16)30-2)28(11-27-14)19-9-18(20(33-19)21(26)32)31-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,32)
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n/an/a 6n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28179
PNG
(3-[(2-cyanophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C#N)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18N4O4S/c1-28-17-7-15-16(8-18(17)29-2)26(12-25-15)20-9-19(21(31-20)22(24)27)30-11-14-6-4-3-5-13(14)10-23/h3-9,12H,11H2,1-2H3,(H2,24,27)
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n/an/a 6n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28174
PNG
(5-(5-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifl...)
Show SMILES COc1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O
Show InChI InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 8n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28183
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)
Show SMILES COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C22H21N3O5S/c1-27-16-7-5-4-6-13(16)11-30-19-10-20(31-21(19)22(23)26)25-12-24-14-8-17(28-2)18(29-3)9-15(14)25/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 8n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM25120
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
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n/an/a 9n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28171
PNG
(3-[(2-bromophenyl)methoxy]-5-[6-(trifluoromethyl)-...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-6-5-12(7-15(14)27)20(22,23)24/h1-8,10H,9H2,(H2,25,28)
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n/an/a 9n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28166
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-bromophenyl)meth...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14BrN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 11n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28192
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(thiop...)
Show SMILES COc1cc2ncn(-c3cc(OCc4cccs4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H17N3O4S2/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)26-9-11-4-3-5-27-11/h3-8,10H,9H2,1-2H3,(H2,20,23)
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n/an/a 11n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28158
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methylphenyl)met...)
Show SMILES Cc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O2S/c1-13-5-4-6-14(9-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28173
PNG
(5-(6-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[...)
Show SMILES CS(=O)(=O)c1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1
Show InChI InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28159
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methoxyphenyl)me...)
Show SMILES COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O3S/c1-25-16-9-5-2-6-13(16)11-26-17-10-18(27-19(17)20(21)24)23-12-22-14-7-3-4-8-15(14)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28157
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)met...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-2-3-7-14(13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-8-4-5-9-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28176
PNG
(3-(benzyloxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H19N3O4S/c1-26-16-8-14-15(9-17(16)27-2)24(12-23-14)19-10-18(20(29-19)21(22)25)28-11-13-6-4-3-5-7-13/h3-10,12H,11H2,1-2H3,(H2,22,25)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28162
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Cl)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28187
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C22H21N3O5S/c1-27-14-6-4-13(5-7-14)11-30-19-10-20(31-21(19)22(23)26)25-12-24-15-8-17(28-2)18(29-3)9-16(15)25/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 13n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28198
PNG
(3-[(2-bromopyridin-4-yl)methoxy]-5-(5,6-dimethoxy-...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccnc(Br)c4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C20H17BrN4O4S/c1-27-14-6-12-13(7-15(14)28-2)25(10-24-12)18-8-16(19(30-18)20(22)26)29-9-11-3-4-23-17(21)5-11/h3-8,10H,9H2,1-2H3,(H2,22,26)
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n/an/a 14n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28167
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-fluorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1F)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14FN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 14n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28165
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2ccccc12
Show InChI InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)10-28-16-9-17(29-18(16)19(24)27)26-11-25-14-7-3-4-8-15(14)26/h1-9,11H,10H2,(H2,24,27)
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n/an/a 15n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28181
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-ac...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(C)=O)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C23H21N3O5S/c1-13(27)15-7-5-4-6-14(15)11-31-20-10-21(32-22(20)23(24)28)26-12-25-16-8-18(29-2)19(30-3)9-17(16)26/h4-10,12H,11H2,1-3H3,(H2,24,28)
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n/an/a 17n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28193
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(thiop...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccsc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H17N3O4S2/c1-24-14-5-12-13(6-15(14)25-2)22(10-21-12)17-7-16(18(28-17)19(20)23)26-8-11-3-4-27-9-11/h3-7,9-10H,8H2,1-2H3,(H2,20,23)
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n/an/a 17n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28191
PNG
(3-(cyclohexylmethoxy)-5-(5,6-dimethoxy-1H-1,3-benz...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCCC4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H25N3O4S/c1-26-16-8-14-15(9-17(16)27-2)24(12-23-14)19-10-18(20(29-19)21(22)25)28-11-13-6-4-3-5-7-13/h8-10,12-13H,3-7,11H2,1-2H3,(H2,22,25)
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n/an/a 17n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28168
PNG
(5-(5-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylp...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2cc(Cl)ccc12
Show InChI InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-8-14(21)6-7-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25)
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n/an/a 21n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28185
PNG
(3-[(3-aminophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4cccc(N)c4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C21H20N4O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-4-3-5-13(22)6-12/h3-9,11H,10,22H2,1-2H3,(H2,23,26)
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n/an/a 21n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28163
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1cccc(Cl)c1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-5-3-4-12(8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-6-1-2-7-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 22n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28195
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(furan...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccco4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H17N3O5S/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)27-9-11-4-3-5-26-11/h3-8,10H,9H2,1-2H3,(H2,20,23)
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n/an/a 27n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28160
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methoxyphenyl)me...)
Show SMILES COc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-6-4-5-13(9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 28n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28184
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[3-(d...)
Show SMILES COc1cc2ncn(-c3cc(OCc4cccc(c4)N(C)C)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C23H24N4O4S/c1-26(2)15-7-5-6-14(8-15)12-31-20-11-21(32-22(20)23(24)28)27-13-25-16-9-18(29-3)19(30-4)10-17(16)27/h5-11,13H,12H2,1-4H3,(H2,24,28)
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n/an/a 31n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28180
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H21N3O6S2/c1-29-16-8-14-15(9-17(16)30-2)25(12-24-14)20-10-18(21(32-20)22(23)26)31-11-13-6-4-5-7-19(13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 31n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28190
PNG
(3-(cyclopentylmethoxy)-5-(5,6-dimethoxy-1H-1,3-ben...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCC4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C20H23N3O4S/c1-25-15-7-13-14(8-16(15)26-2)23(11-22-13)18-9-17(19(28-18)20(21)24)27-10-12-5-3-4-6-12/h7-9,11-12H,3-6,10H2,1-2H3,(H2,21,24)
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n/an/a 34n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28161
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methoxyphenyl)me...)
Show SMILES COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-8-6-13(7-9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 35n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28189
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(3-phe...)
Show SMILES COc1cc2ncn(-c3cc(OCCCc4ccccc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C23H23N3O4S/c1-28-18-11-16-17(12-19(18)29-2)26(14-25-16)21-13-20(22(31-21)23(24)27)30-10-6-9-15-7-4-3-5-8-15/h3-5,7-8,11-14H,6,9-10H2,1-2H3,(H2,24,27)
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n/an/a 61n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28156
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-(benzyloxy)thiophene...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c20-19(23)18-16(24-11-13-6-2-1-3-7-13)10-17(25-18)22-12-21-14-8-4-5-9-15(14)22/h1-10,12H,11H2,(H2,20,23)
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n/an/a 61n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM27443
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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n/an/a 70n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28201
PNG
(5,6-dimethoxy-1-[5-(1H-1,2,3,4-tetrazol-5-yl)-4-{[...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)-c3nnn[nH]3)c2cc1OC
Show InChI InChI=1S/C22H17F3N6O3S/c1-32-16-7-14-15(8-17(16)33-2)31(11-26-14)19-9-18(20(35-19)21-27-29-30-28-21)34-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H,27,28,29,30)
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n/an/a 73n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM27444
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 75n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28203
PNG
(1-[5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(C)=O)c2cc1OC
Show InChI InChI=1S/C23H19F3N2O4S/c1-13(29)22-20(32-11-14-6-4-5-7-15(14)23(24,25)26)10-21(33-22)28-12-27-16-8-18(30-2)19(31-3)9-17(16)28/h4-10,12H,11H2,1-3H3
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n/an/a 85n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28186
PNG
(3-[(3-cyanophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3...)
Show SMILES COc1cc2ncn(-c3cc(OCc4cccc(c4)C#N)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H18N4O4S/c1-28-17-7-15-16(8-18(17)29-2)26(12-25-15)20-9-19(21(31-20)22(24)27)30-11-14-5-3-4-13(6-14)10-23/h3-9,12H,11H2,1-2H3,(H2,24,27)
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n/an/a 99n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28164
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccc(Cl)cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-7-5-12(6-8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-3-1-2-4-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 100n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28188
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(2-phe...)
Show SMILES COc1cc2ncn(-c3cc(OCCc4ccccc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H21N3O4S/c1-27-17-10-15-16(11-18(17)28-2)25(13-24-15)20-12-19(21(30-20)22(23)26)29-9-8-14-6-4-3-5-7-14/h3-7,10-13H,8-9H2,1-2H3,(H2,23,26)
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n/an/a 130n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28197
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(pyrid...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccncc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C20H18N4O4S/c1-26-15-7-13-14(8-16(15)27-2)24(11-23-13)18-9-17(19(29-18)20(21)25)28-10-12-3-5-22-6-4-12/h3-9,11H,10H2,1-2H3,(H2,21,25)
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n/an/a 130n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28196
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(furan...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccoc4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H17N3O5S/c1-24-14-5-12-13(6-15(14)25-2)22(10-21-12)17-7-16(18(28-17)19(20)23)27-9-11-3-4-26-8-11/h3-8,10H,9H2,1-2H3,(H2,20,23)
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n/an/a 190n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28172
PNG
(5-(5-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[...)
Show SMILES CS(=O)(=O)c1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O
Show InChI InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28)
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n/an/a 250n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28170
PNG
(3-[(2-bromophenyl)methoxy]-5-[5-(trifluoromethyl)-...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-7-12(20(22,23)24)5-6-15(14)27/h1-8,10H,9H2,(H2,25,28)
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n/an/a 300n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM27448
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(t...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C22H16F3N3O3S/c1-29-17-7-15-16(8-18(17)30-2)28(12-27-15)21-9-19(20(10-26)32-21)31-11-13-5-3-4-6-14(13)22(23,24)25/h3-9,12H,11H2,1-2H3
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n/an/a 700n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28205
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-N,N-dime...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(=O)N(C)C)c2cc1OC
Show InChI InChI=1S/C24H22F3N3O4S/c1-29(2)23(31)22-20(34-12-14-7-5-6-8-15(14)24(25,26)27)11-21(35-22)30-13-28-16-9-18(32-3)19(33-4)10-17(16)30/h5-11,13H,12H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28199
PNG
(benzimidazole thiophene analogue, 51 | methyl 5-(5...)
Show SMILES COC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H19F3N2O5S/c1-30-17-8-15-16(9-18(17)31-2)28(12-27-15)20-10-19(21(34-20)22(29)32-3)33-11-13-6-4-5-7-14(13)23(24,25)26/h4-10,12H,11H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM28204
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-N-methyl...)
Show SMILES CNC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H20F3N3O4S/c1-27-22(30)21-19(33-11-13-6-4-5-7-14(13)23(24,25)26)10-20(34-21)29-12-28-15-8-17(31-2)18(32-3)9-16(15)29/h4-10,12H,11H2,1-3H3,(H,27,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...

Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%