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PubMed code 29499108

Compile data set for download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255879
PNG
(CHEMBL4071474)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C=C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C31H35ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h4-10,17-18,24H,1,11-16,19-20H2,2-3H3,(H,33,34,35)/t24-/m0/s1
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KEGG

UniProtKB/SwissProt

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n/an/a 0.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255964
PNG
(CHEMBL4096822)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-23-6-9-27(21(2)16-23)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255927
PNG
(CHEMBL4084726)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-23-6-9-27(21(2)16-23)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 2.10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255893
PNG
(CHEMBL4072688)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H41FN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255926
PNG
(CHEMBL4063067)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1Cl |r|
Show InChI InChI=1S/C32H39ClN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255815
PNG
(CHEMBL4105503)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-12-11-26(21-38)40-30-23(20-39(32(40)42)25-7-6-8-27(18-25)43-4)19-33-31(35-30)34-24-9-10-28(22(2)17-24)37-15-13-36(3)14-16-37/h6-10,17-19,26H,5,11-16,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255921
PNG
(CHEMBL4078801)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 4.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255880
PNG
(CHEMBL4076405)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC(CC4)N(C)C)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-6-31(44)41-16-13-26(21-41)43-32-23(20-42(34(43)45)30-18-27(46-5)8-9-28(30)35)19-36-33(38-32)37-24-7-10-29(22(2)17-24)40-14-11-25(12-15-40)39(3)4/h7-10,17-19,25-26H,6,11-16,20-21H2,1-5H3,(H,36,37,38)/t26-/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255946
PNG
(CHEMBL4083224)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-5-30(43)40-14-11-25(21-40)42-31-23(20-41(33(42)44)29-18-26(45-4)8-9-27(29)34)19-35-32(37-31)36-24-7-10-28(22(2)17-24)39-13-6-12-38(3)15-16-39/h7-10,17-19,25H,5-6,11-16,20-21H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255878
PNG
(CHEMBL4098507)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255829
PNG
(CHEMBL4070640)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1OC |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-13-12-25(21-38)40-30-23(20-39(32(40)42)27-8-6-7-9-28(27)43-4)19-33-31(35-30)34-24-10-11-26(22(2)18-24)37-16-14-36(3)15-17-37/h6-11,18-19,25H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t25-/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255835
PNG
(CHEMBL4060198)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1F |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255862
PNG
(CHEMBL4074601)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(C)=O)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C30H35ClN8O2/c1-20-16-23(8-9-26(20)36-14-12-35(3)13-15-36)33-29-32-17-22-18-38(27-7-5-4-6-25(27)31)30(41)39(28(22)34-29)24-10-11-37(19-24)21(2)40/h4-9,16-17,24H,10-15,18-19H2,1-3H3,(H,32,33,34)/t24-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255834
PNG
(CHEMBL4089951)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1C |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-13-12-26(21-38)40-30-24(20-39(32(40)42)28-9-7-6-8-22(28)2)19-33-31(35-30)34-25-10-11-27(23(3)18-25)37-16-14-36(4)15-17-37/h6-11,18-19,26H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 5.60n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255936
PNG
(CHEMBL4065984)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(OC)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O4/c1-5-29(42)39-11-10-23(20-39)41-30-21(19-40(32(41)43)27-17-24(44-3)7-8-25(27)33)18-34-31(36-30)35-22-6-9-26(28(16-22)45-4)38-14-12-37(2)13-15-38/h6-9,16-18,23H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t23-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255986
PNG
(CHEMBL4081252)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-13-12-26(21-38)40-30-23(20-39(32(40)42)25-7-9-27(43-4)10-8-25)19-33-31(35-30)34-24-6-11-28(22(2)18-24)37-16-14-36(3)15-17-37/h6-11,18-19,26H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255882
PNG
(CHEMBL4104717)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC5(CCN(C)CC5)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C37H47FN8O3/c1-5-33(47)44-15-10-28(24-44)46-34-26(23-45(36(46)48)32-21-29(49-4)7-8-30(32)38)22-39-35(41-34)40-27-6-9-31(25(2)20-27)43-18-13-37(14-19-43)11-16-42(3)17-12-37/h6-9,20-22,28H,5,10-19,23-24H2,1-4H3,(H,39,40,41)/t28-/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255947
PNG
(CHEMBL4078973)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CC5(C4)CCN(C)CC5)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-21-35(22-42)11-14-40(3)15-12-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255903
PNG
(CHEMBL4095063)
Show SMILES CC(C)C(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O2/c1-21(2)30(42)39-12-11-25(20-39)41-29-23(19-40(32(41)43)28-8-6-5-7-26(28)33)18-34-31(36-29)35-24-9-10-27(22(3)17-24)38-15-13-37(4)14-16-38/h5-10,17-18,21,25H,11-16,19-20H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255881
PNG
(CHEMBL4086821)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC5(CCN(C)C5)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-15-12-35(22-42)11-14-40(3)21-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-,35?/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255883
PNG
(CHEMBL4096988)
Show SMILES [H][C@@]12CN(C)C[C@]1([H])CN(C2)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)CC)c3n2)c2cc(OC)ccc2F)cc1C |r|
Show InChI InChI=1S/C34H41FN8O3/c1-5-31(44)40-11-10-26(20-40)43-32-22(19-42(34(43)45)30-13-27(46-4)7-8-28(30)35)14-36-33(38-32)37-25-6-9-29(21(2)12-25)41-17-23-15-39(3)16-24(23)18-41/h6-9,12-14,23-24,26H,5,10-11,15-20H2,1-4H3,(H,36,37,38)/t23-,24+,26-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255905
PNG
(CHEMBL4062178)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)CO)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C30H35ClN8O3/c1-20-15-22(7-8-25(20)36-13-11-35(2)12-14-36)33-29-32-16-21-17-38(26-6-4-3-5-24(26)31)30(42)39(28(21)34-29)23-9-10-37(18-23)27(41)19-40/h3-8,15-16,23,40H,9-14,17-19H2,1-2H3,(H,32,33,34)/t23-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255966
PNG
(CHEMBL4093535)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)C(C)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-6-30(43)40-12-11-25(20-40)42-31-23(19-41(33(42)44)29-16-26(45-5)8-9-27(29)34)17-35-32(37-31)36-24-7-10-28(21(2)15-24)39-14-13-38(4)22(3)18-39/h7-10,15-17,22,25H,6,11-14,18-20H2,1-5H3,(H,35,36,37)/t22?,25-/m0/s1
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n/an/a 7.20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255834
PNG
(CHEMBL4089951)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1C |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-13-12-26(21-38)40-30-24(20-39(32(40)42)28-9-7-6-8-22(28)2)19-33-31(35-30)34-25-10-11-27(23(3)18-25)37-16-14-36(4)15-17-37/h6-11,18-19,26H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 7.60n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255885
PNG
(CHEMBL4103893)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4C[C@H](C)N(C)[C@H](C)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-7-31(44)40-13-12-26(20-40)43-32-24(19-42(34(43)45)30-15-27(46-6)9-10-28(30)35)16-36-33(38-32)37-25-8-11-29(21(2)14-25)41-17-22(3)39(5)23(4)18-41/h8-11,14-16,22-23,26H,7,12-13,17-20H2,1-6H3,(H,36,37,38)/t22-,23+,26-/m0/s1
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n/an/a 7.80n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255903
PNG
(CHEMBL4095063)
Show SMILES CC(C)C(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O2/c1-21(2)30(42)39-12-11-25(20-39)41-29-23(19-40(32(41)43)28-8-6-5-7-26(28)33)18-34-31(36-29)35-24-9-10-27(22(3)17-24)38-15-13-37(4)14-16-38/h5-10,17-18,21,25H,11-16,19-20H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255939
PNG
(CHEMBL4096014)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(CC)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-5-22-17-24(7-10-28(22)39-15-13-38(3)14-16-39)36-32-35-19-23-20-41(29-18-26(45-4)8-9-27(29)34)33(44)42(31(23)37-32)25-11-12-40(21-25)30(43)6-2/h7-10,17-19,25H,5-6,11-16,20-21H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255884
PNG
(CHEMBL4076515)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N(C)CCN(C)C)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H41FN8O3/c1-7-29(42)39-13-12-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-6)9-10-26(28)33)18-34-31(36-30)35-23-8-11-27(21(2)16-23)38(5)15-14-37(3)4/h8-11,16-18,24H,7,12-15,19-20H2,1-6H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of cytoplasmic recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255861
PNG
(CHEMBL4065970)
Show SMILES CCCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O2/c1-4-7-29(42)39-13-12-25(21-39)41-30-23(20-40(32(41)43)28-9-6-5-8-26(28)33)19-34-31(36-30)35-24-10-11-27(22(2)18-24)38-16-14-37(3)15-17-38/h5-6,8-11,18-19,25H,4,7,12-17,20-21H2,1-3H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255860
PNG
(CHEMBL4087375)
Show SMILES CC(C)CC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C33H41ClN8O2/c1-22(2)17-30(43)40-12-11-26(21-40)42-31-24(20-41(33(42)44)29-8-6-5-7-27(29)34)19-35-32(37-31)36-25-9-10-28(23(3)18-25)39-15-13-38(4)14-16-39/h5-10,18-19,22,26H,11-17,20-21H2,1-4H3,(H,35,36,37)/t26-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50177716
PNG
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255862
PNG
(CHEMBL4074601)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(C)=O)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C30H35ClN8O2/c1-20-16-23(8-9-26(20)36-14-12-35(3)13-15-36)33-29-32-17-22-18-38(27-7-5-4-6-25(27)31)30(41)39(28(22)34-29)24-10-11-37(19-24)21(2)40/h4-9,16-17,24H,10-15,18-19H2,1-3H3,(H,32,33,34)/t24-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255832
PNG
(CHEMBL4079649)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-11-10-26(20-38)40-29-22(19-39(31(40)42)25-7-5-6-23(32)17-25)18-33-30(35-29)34-24-8-9-27(21(2)16-24)37-14-12-36(3)13-15-37/h5-9,16-18,26H,4,10-15,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255934
PNG
(CHEMBL4095071)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H37FN8O3/c1-4-28(41)38-12-11-24(20-38)40-29-21(19-39(31(40)42)27-17-25(43-3)9-10-26(27)32)18-33-30(35-29)34-22-5-7-23(8-6-22)37-15-13-36(2)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255918
PNG
(CHEMBL4070404)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(F)c1 |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-11-10-26(20-38)40-29-22(19-39(31(40)42)25-7-5-6-23(32)17-25)18-33-30(35-29)34-24-8-9-27(21(2)16-24)37-14-12-36(3)13-15-37/h5-9,16-18,26H,4,10-15,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255937
PNG
(CHEMBL4103761)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36ClFN8O3/c1-4-28(42)39-10-9-22(19-39)41-29-20(18-40(31(41)43)27-16-23(44-3)6-7-25(27)33)17-34-30(36-29)35-21-5-8-26(24(32)15-21)38-13-11-37(2)12-14-38/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,34,35,36)/t22-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255831
PNG
(CHEMBL4105392)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-26(20-38)40-29-22(19-39(31(40)42)25-8-5-23(32)6-9-25)18-33-30(35-29)34-24-7-10-27(21(2)17-24)37-15-13-36(3)14-16-37/h5-10,17-18,26H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255878
PNG
(CHEMBL4098507)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255965
PNG
(CHEMBL4087525)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(C)c1 |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-12-11-27(21-38)40-30-24(20-39(32(40)42)26-8-6-7-22(2)17-26)19-33-31(35-30)34-25-9-10-28(23(3)18-25)37-15-13-36(4)14-16-37/h6-10,17-19,27H,5,11-16,20-21H2,1-4H3,(H,33,34,35)/t27-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255962
PNG
(CHEMBL4079506)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36F2N8O3/c1-4-28(42)39-10-9-22(19-39)41-29-20(18-40(31(41)43)27-16-23(44-3)6-7-24(27)32)17-34-30(36-29)35-21-5-8-26(25(33)15-21)38-13-11-37(2)12-14-38/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,34,35,36)/t22-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255835
PNG
(CHEMBL4060198)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1F |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255833
PNG
(CHEMBL4097682)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-12-11-26(20-38)40-29-22(19-39(31(40)42)25-8-5-23(32)6-9-25)18-33-30(35-29)34-24-7-10-27(21(2)17-24)37-15-13-36(3)14-16-37/h5-10,17-18,26H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255963
PNG
(CHEMBL4074615)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3C)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-27-9-6-23(16-21(27)2)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255905
PNG
(CHEMBL4062178)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)CO)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C30H35ClN8O3/c1-20-15-22(7-8-25(20)36-13-11-35(2)12-14-36)33-29-32-16-21-17-38(26-6-4-3-5-24(26)31)30(42)39(28(21)34-29)23-9-10-37(18-23)27(41)19-40/h3-8,15-16,23,40H,9-14,17-19H2,1-2H3,(H,32,33,34)/t23-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255904
PNG
(CHEMBL4092632)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C(C)(C)C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C33H41ClN8O2/c1-22-18-24(10-11-27(22)39-16-14-38(5)15-17-39)36-31-35-19-23-20-41(28-9-7-6-8-26(28)34)32(44)42(29(23)37-31)25-12-13-40(21-25)30(43)33(2,3)4/h6-11,18-19,25H,12-17,20-21H2,1-5H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255830
PNG
(CHEMBL4097770)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(C)cc1 |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-13-12-27(21-38)40-30-24(20-39(32(40)42)26-9-6-22(2)7-10-26)19-33-31(35-30)34-25-8-11-28(23(3)18-25)37-16-14-36(4)15-17-37/h6-11,18-19,27H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t27-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255859
PNG
(CHEMBL4064937)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C32H37ClN8O2/c1-21-17-24(9-10-27(21)38-15-13-37(2)14-16-38)35-31-34-18-23-19-40(28-6-4-3-5-26(28)33)32(43)41(29(23)36-31)25-11-12-39(20-25)30(42)22-7-8-22/h3-6,9-10,17-18,22,25H,7-8,11-16,19-20H2,1-2H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255836
PNG
(CHEMBL4098591)
Show SMILES CCC(=O)N1CC[C@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255860
PNG
(CHEMBL4087375)
Show SMILES CC(C)CC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C33H41ClN8O2/c1-22(2)17-30(43)40-12-11-26(21-40)42-31-24(20-41(33(42)44)29-8-6-5-7-27(29)34)19-35-32(37-31)36-25-9-10-28(23(3)18-25)39-15-13-38(4)14-16-39/h5-10,18-19,22,26H,11-17,20-21H2,1-4H3,(H,35,36,37)/t26-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255838
PNG
(CHEMBL4083904)
Show SMILES CN(C)CC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H40ClN9O2/c1-22-17-24(9-10-27(22)39-15-13-38(4)14-16-39)35-31-34-18-23-19-41(28-8-6-5-7-26(28)33)32(44)42(30(23)36-31)25-11-12-40(20-25)29(43)21-37(2)3/h5-10,17-18,25H,11-16,19-21H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255836
PNG
(CHEMBL4098591)
Show SMILES CCC(=O)N1CC[C@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255847
PNG
(CHEMBL4102822)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCCC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C35H43ClN8O2/c1-24-20-27(12-13-30(24)41-18-16-40(2)17-19-41)38-34-37-21-26-22-43(31-11-7-6-10-29(31)36)35(46)44(32(26)39-34)28-14-15-42(23-28)33(45)25-8-4-3-5-9-25/h6-7,10-13,20-21,25,28H,3-5,8-9,14-19,22-23H2,1-2H3,(H,37,38,39)/t28-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255945
PNG
(CHEMBL4102288)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCOCC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36FN7O4/c1-4-28(40)37-10-9-23(19-37)39-29-21(18-38(31(39)41)27-16-24(42-3)6-7-25(27)32)17-33-30(35-29)34-22-5-8-26(20(2)15-22)36-11-13-43-14-12-36/h5-8,15-17,23H,4,9-14,18-19H2,1-3H3,(H,33,34,35)/t23-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255948
PNG
(CHEMBL4078026)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C(C)=O)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H39FN8O4/c1-5-30(44)40-11-10-25(20-40)42-31-23(19-41(33(42)45)29-17-26(46-4)7-8-27(29)34)18-35-32(37-31)36-24-6-9-28(21(2)16-24)39-14-12-38(13-15-39)22(3)43/h6-9,16-18,25H,5,10-15,19-20H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255858
PNG
(CHEMBL4084868)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C34H41ClN8O2/c1-23-19-26(11-12-29(23)40-17-15-39(2)16-18-40)37-33-36-20-25-21-42(30-10-6-5-9-28(30)35)34(45)43(31(25)38-33)27-13-14-41(22-27)32(44)24-7-3-4-8-24/h5-6,9-12,19-20,24,27H,3-4,7-8,13-18,21-22H2,1-2H3,(H,36,37,38)/t27-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255961
PNG
(CHEMBL4083916)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(c3)C(C)C)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-6-31(44)41-12-11-25(21-41)43-32-23(20-42(34(43)45)30-18-26(46-5)8-9-28(30)35)19-36-33(38-32)37-24-7-10-29(27(17-24)22(2)3)40-15-13-39(4)14-16-40/h7-10,17-19,22,25H,6,11-16,20-21H2,1-5H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of cytoplasmic recombinant human His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255829
PNG
(CHEMBL4070640)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1OC |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-13-12-25(21-38)40-30-23(20-39(32(40)42)27-8-6-7-9-28(27)43-4)19-33-31(35-30)34-24-10-11-26(22(2)18-24)37-16-14-36(3)15-17-37/h6-11,18-19,25H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t25-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255838
PNG
(CHEMBL4083904)
Show SMILES CN(C)CC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H40ClN9O2/c1-22-17-24(9-10-27(22)39-15-13-38(4)14-16-39)35-31-34-18-23-19-41(28-8-6-5-7-26(28)33)32(44)42(30(23)36-31)25-11-12-40(20-25)29(43)21-37(2)3/h5-10,17-18,25H,11-16,19-21H2,1-4H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255858
PNG
(CHEMBL4084868)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C34H41ClN8O2/c1-23-19-26(11-12-29(23)40-17-15-39(2)16-18-40)37-33-36-20-25-21-42(30-10-6-5-9-28(30)35)34(45)43(31(25)38-33)27-13-14-41(22-27)32(44)24-7-3-4-8-24/h5-6,9-12,19-20,24,27H,3-4,7-8,13-18,21-22H2,1-2H3,(H,36,37,38)/t27-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255919
PNG
(CHEMBL4067916)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C32H38F2N8O3/c1-4-28(43)40-11-10-25(20-40)42-29-22(19-41(32(42)44)24-6-5-7-26(17-24)45-30(33)34)18-35-31(37-29)36-23-8-9-27(21(2)16-23)39-14-12-38(3)13-15-39/h5-9,16-18,25,30H,4,10-15,19-20H2,1-3H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255859
PNG
(CHEMBL4064937)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C32H37ClN8O2/c1-21-17-24(9-10-27(21)38-15-13-37(2)14-16-38)35-31-34-18-23-19-40(28-6-4-3-5-26(28)33)32(43)41(29(23)36-31)25-11-12-39(20-25)30(42)22-7-8-22/h3-6,9-10,17-18,22,25H,7-8,11-16,19-20H2,1-2H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255861
PNG
(CHEMBL4065970)
Show SMILES CCCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O2/c1-4-7-29(42)39-13-12-25(21-39)41-30-23(20-40(32(41)43)28-9-6-5-8-26(28)33)19-34-31(36-30)35-24-10-11-27(22(2)18-24)38-16-14-37(3)15-17-38/h5-6,8-11,18-19,25H,4,7,12-17,20-21H2,1-3H3,(H,34,35,36)/t25-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255904
PNG
(CHEMBL4092632)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C(C)(C)C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C33H41ClN8O2/c1-22-18-24(10-11-27(22)39-16-14-38(5)15-17-39)36-31-35-19-23-20-41(28-9-7-6-8-26(28)34)32(44)42(29(23)37-31)25-12-13-40(21-25)30(43)33(2,3)4/h6-11,18-19,25H,12-17,20-21H2,1-5H3,(H,35,36,37)/t25-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255935
PNG
(CHEMBL4087383)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O4/c1-5-29(42)39-11-10-23(20-39)41-30-21(19-40(32(41)43)27-17-24(44-3)7-8-25(27)33)18-34-31(36-30)35-26-9-6-22(16-28(26)45-4)38-14-12-37(2)13-15-38/h6-9,16-18,23H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t23-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant cytoplasmic human His-tagged KIT expressed in baculovirus using Ser/Thr 6 peptide as substrate after 1 hr by FRET-based Z'-...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255879
PNG
(CHEMBL4071474)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C=C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C31H35ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h4-10,17-18,24H,1,11-16,19-20H2,2-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255847
PNG
(CHEMBL4102822)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C4CCCCC4)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C35H43ClN8O2/c1-24-20-27(12-13-30(24)41-18-16-40(2)17-19-41)38-34-37-21-26-22-43(31-11-7-6-10-29(31)36)35(46)44(32(26)39-34)28-14-15-42(23-28)33(45)25-8-4-3-5-9-25/h6-7,10-13,20-21,25,28H,3-5,8-9,14-19,22-23H2,1-2H3,(H,37,38,39)/t28-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255938
PNG
(CHEMBL4068695)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(c3)C(F)(F)F)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H36F4N8O3/c1-4-28(45)42-10-9-22(19-42)44-29-20(18-43(31(44)46)27-16-23(47-3)6-7-25(27)33)17-37-30(39-29)38-21-5-8-26(24(15-21)32(34,35)36)41-13-11-40(2)12-14-41/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,37,38,39)/t22-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255918
PNG
(CHEMBL4070404)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(F)c1 |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-11-10-26(20-38)40-29-22(19-39(31(40)42)25-7-5-6-23(32)17-25)18-33-30(35-29)34-24-8-9-27(21(2)16-24)37-14-12-36(3)13-15-37/h5-9,16-18,26H,4,10-15,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged FLT3 (564 to 958 residues) expressed in baculovirus using poly (Glu,Tyr) as substrate after 2 hrs by PK-Li...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of cytoplasmic recombinant human His-tagged FGFR3 (399 to 806 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 h...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255940
PNG
(CHEMBL4062192)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCCCC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H38FN7O3/c1-4-29(41)38-15-12-24(20-38)40-30-22(19-39(32(40)42)28-17-25(43-3)9-10-26(28)33)18-34-31(36-30)35-23-8-11-27(21(2)16-23)37-13-6-5-7-14-37/h8-11,16-18,24H,4-7,12-15,19-20H2,1-3H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255837
PNG
(CHEMBL4062830)
Show SMILES CCCN1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H39ClN8O/c1-4-12-37-13-11-25(21-37)40-29-23(20-39(31(40)41)28-8-6-5-7-26(28)32)19-33-30(35-29)34-24-9-10-27(22(2)18-24)38-16-14-36(3)15-17-38/h5-10,18-19,25H,4,11-17,20-21H2,1-3H3,(H,33,34,35)/t25-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255833
PNG
(CHEMBL4097682)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C31H37FN8O2/c1-4-28(41)38-12-11-26(20-38)40-29-22(19-39(31(40)42)25-8-5-23(32)6-9-25)18-33-30(35-29)34-24-7-10-27(21(2)17-24)37-15-13-36(3)14-16-37/h5-10,17-18,26H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 72n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 74n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant cytoplasmic human GST-tagged PDGFRalpha expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr ...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDGFRbeta expressed in baculovirus using poly (4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-Glo assay

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255832
PNG
(CHEMBL4079649)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-11-10-26(20-38)40-29-22(19-39(31(40)42)25-7-5-6-23(32)17-25)18-33-30(35-29)34-24-8-9-27(21(2)16-24)37-14-12-36(3)13-15-37/h5-9,16-18,26H,4,10-15,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 144n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255948
PNG
(CHEMBL4078026)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C(C)=O)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H39FN8O4/c1-5-30(44)40-11-10-25(20-40)42-31-23(19-41(33(42)45)29-17-26(46-4)7-8-27(29)34)18-35-32(37-31)36-24-6-9-28(21(2)16-24)39-14-12-38(13-15-39)22(3)43/h6-9,16-18,25H,5,10-15,19-20H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 148n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255920
PNG
(CHEMBL4089120)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C32H37F3N8O3/c1-4-28(44)41-11-10-25(20-41)43-29-22(19-42(31(43)45)24-6-5-7-26(17-24)46-32(33,34)35)18-36-30(38-29)37-23-8-9-27(21(2)16-23)40-14-12-39(3)13-15-40/h5-9,16-18,25H,4,10-15,19-20H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 151n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255986
PNG
(CHEMBL4081252)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(OC)cc1 |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-13-12-26(21-38)40-30-23(20-39(32(40)42)25-7-9-27(43-4)10-8-25)19-33-31(35-30)34-24-6-11-28(22(2)18-24)37-16-14-36(3)15-17-37/h6-11,18-19,26H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 153n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 167n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of cytoplasmic recombinant human His-tagged FGFR4 (781 to 1338 residues) expressed in baculovirus using tyr4 peptide as substrate after 1 ...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255837
PNG
(CHEMBL4062830)
Show SMILES CCCN1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C31H39ClN8O/c1-4-12-37-13-11-25(21-37)40-29-23(20-39(31(40)41)28-8-6-5-7-26(28)32)19-33-30(35-29)34-24-9-10-27(22(2)18-24)38-16-14-36(3)15-17-38/h5-10,18-19,25H,4,11-17,20-21H2,1-3H3,(H,33,34,35)/t25-/m0/s1
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n/an/a 181n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255946
PNG
(CHEMBL4083224)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-5-30(43)40-14-11-25(21-40)42-31-23(20-41(33(42)44)29-18-26(45-4)8-9-27(29)34)19-35-32(37-31)36-24-7-10-28(22(2)17-24)39-13-6-12-38(3)15-16-39/h7-10,17-19,25H,5-6,11-16,20-21H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 209n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255883
PNG
(CHEMBL4096988)
Show SMILES [H][C@@]12CN(C)C[C@]1([H])CN(C2)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)CC)c3n2)c2cc(OC)ccc2F)cc1C |r|
Show InChI InChI=1S/C34H41FN8O3/c1-5-31(44)40-11-10-26(20-40)43-32-22(19-42(34(43)45)30-13-27(46-4)7-8-28(30)35)14-36-33(38-32)37-25-6-9-29(21(2)12-25)41-17-23-15-39(3)16-24(23)18-41/h6-9,12-14,23-24,26H,5,10-11,15-20H2,1-4H3,(H,36,37,38)/t23-,24+,26-/m0/s1
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n/an/a 216n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255947
PNG
(CHEMBL4078973)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CC5(C4)CCN(C)CC5)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-21-35(22-42)11-14-40(3)15-12-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-/m0/s1
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n/an/a 218n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255882
PNG
(CHEMBL4104717)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC5(CCN(C)CC5)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C37H47FN8O3/c1-5-33(47)44-15-10-28(24-44)46-34-26(23-45(36(46)48)32-21-29(49-4)7-8-30(32)38)22-39-35(41-34)40-27-6-9-31(25(2)20-27)43-18-13-37(14-19-43)11-16-42(3)17-12-37/h6-9,20-22,28H,5,10-19,23-24H2,1-4H3,(H,39,40,41)/t28-/m0/s1
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n/an/a 225n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255919
PNG
(CHEMBL4067916)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC(F)F)c1 |r|
Show InChI InChI=1S/C32H38F2N8O3/c1-4-28(43)40-11-10-25(20-40)42-29-22(19-41(32(42)44)24-6-5-7-26(17-24)45-30(33)34)18-35-31(37-29)36-23-8-9-27(21(2)16-23)39-14-12-38(3)13-15-39/h5-9,16-18,25,30H,4,10-15,19-20H2,1-3H3,(H,35,36,37)/t25-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255880
PNG
(CHEMBL4076405)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC(CC4)N(C)C)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-6-31(44)41-16-13-26(21-41)43-32-23(20-42(34(43)45)30-18-27(46-5)8-9-28(30)35)19-36-33(38-32)37-24-7-10-29(22(2)17-24)40-14-11-25(12-15-40)39(3)4/h7-10,17-19,25-26H,6,11-16,20-21H2,1-5H3,(H,36,37,38)/t26-/m0/s1
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n/an/a 286n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255881
PNG
(CHEMBL4086821)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCC5(CCN(C)C5)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C35H43FN8O3/c1-5-31(45)41-13-10-26(20-41)44-32-24(19-43(34(44)46)30-17-27(47-4)7-8-28(30)36)18-37-33(39-32)38-25-6-9-29(23(2)16-25)42-15-12-35(22-42)11-14-40(3)21-35/h6-9,16-18,26H,5,10-15,19-22H2,1-4H3,(H,37,38,39)/t26-,35?/m0/s1
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n/an/a 296n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255893
PNG
(CHEMBL4072688)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H41FN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 302n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 360n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255964
PNG
(CHEMBL4096822)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-23-6-9-27(21(2)16-23)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 362n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255961
PNG
(CHEMBL4083916)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(c3)C(C)C)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-6-31(44)41-12-11-25(21-41)43-32-23(20-42(34(43)45)30-18-26(46-5)8-9-28(30)35)19-36-33(38-32)37-24-7-10-29(27(17-24)22(2)3)40-15-13-39(4)14-16-40/h7-10,17-19,22,25H,6,11-16,20-21H2,1-5H3,(H,36,37,38)/t25-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255965
PNG
(CHEMBL4087525)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(C)c1 |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-12-11-27(21-38)40-30-24(20-39(32(40)42)26-8-6-7-22(2)17-26)19-33-31(35-30)34-25-9-10-28(23(3)18-25)37-15-13-36(4)14-16-37/h6-10,17-19,27H,5,11-16,20-21H2,1-4H3,(H,33,34,35)/t27-/m0/s1
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n/an/a 365n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255927
PNG
(CHEMBL4084726)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C32H39ClN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-23-6-9-27(21(2)16-23)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 373n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255830
PNG
(CHEMBL4097770)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(C)cc1 |r|
Show InChI InChI=1S/C32H40N8O2/c1-5-29(41)38-13-12-27(21-38)40-30-24(20-39(32(40)42)26-9-6-22(2)7-10-26)19-33-31(35-30)34-25-8-11-28(23(3)18-25)37-16-14-36(4)15-17-37/h6-11,18-19,27H,5,12-17,20-21H2,1-4H3,(H,33,34,35)/t27-/m0/s1
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n/an/a 377n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255831
PNG
(CHEMBL4105392)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C31H37ClN8O2/c1-4-28(41)38-12-11-26(20-38)40-29-22(19-39(31(40)42)25-8-5-23(32)6-9-25)18-33-30(35-29)34-24-7-10-27(21(2)17-24)37-15-13-36(3)14-16-37/h5-10,17-18,26H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 383n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255926
PNG
(CHEMBL4063067)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1Cl |r|
Show InChI InChI=1S/C32H39ClN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 413n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255815
PNG
(CHEMBL4105503)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C32H40N8O3/c1-5-29(41)38-12-11-26(21-38)40-30-23(20-39(32(40)42)25-7-6-8-27(18-25)43-4)19-33-31(35-30)34-24-9-10-28(22(2)17-24)37-15-13-36(3)14-16-37/h6-10,17-19,26H,5,11-16,20-21H2,1-4H3,(H,33,34,35)/t26-/m0/s1
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n/an/a 417n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255921
PNG
(CHEMBL4078801)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC)c1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-28(42)39-12-11-24(20-39)41-30-22(19-40(32(41)43)26-7-6-8-27(44-4)29(26)33)18-34-31(36-30)35-23-9-10-25(21(2)17-23)38-15-13-37(3)14-16-38/h6-10,17-18,24H,5,11-16,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255940
PNG
(CHEMBL4062192)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCCCC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H38FN7O3/c1-4-29(41)38-15-12-24(20-38)40-30-22(19-39(32(40)42)28-17-25(43-3)9-10-26(28)33)18-34-31(36-30)35-23-8-11-27(21(2)16-23)37-13-6-5-7-14-37/h8-11,16-18,24H,4-7,12-15,19-20H2,1-3H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 467n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255939
PNG
(CHEMBL4096014)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(CC)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-5-22-17-24(7-10-28(22)39-15-13-38(3)14-16-39)36-32-35-19-23-20-41(29-18-26(45-4)8-9-27(29)34)33(44)42(31(23)37-32)25-11-12-40(21-25)30(43)6-2/h7-10,17-19,25H,5-6,11-16,20-21H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255936
PNG
(CHEMBL4065984)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(OC)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O4/c1-5-29(42)39-11-10-23(20-39)41-30-21(19-40(32(41)43)27-17-24(44-3)7-8-25(27)33)18-34-31(36-30)35-22-6-9-26(28(16-22)45-4)38-14-12-37(2)13-15-38/h6-9,16-18,23H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t23-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255945
PNG
(CHEMBL4102288)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCOCC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36FN7O4/c1-4-28(40)37-10-9-23(19-37)39-29-21(18-38(31(39)41)27-16-24(42-3)6-7-25(27)32)17-33-30(35-29)34-22-5-8-26(20(2)15-22)36-11-13-43-14-12-36/h5-8,15-17,23H,4,9-14,18-19H2,1-3H3,(H,33,34,35)/t23-/m0/s1
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n/an/a 626n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255966
PNG
(CHEMBL4093535)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)C(C)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-6-30(43)40-12-11-25(20-40)42-31-23(19-41(33(42)44)29-16-26(45-5)8-9-27(29)34)17-35-32(37-31)36-24-7-10-28(21(2)15-24)39-14-13-38(4)22(3)18-39/h7-10,15-17,22,25H,6,11-14,18-20H2,1-5H3,(H,35,36,37)/t22?,25-/m0/s1
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n/an/a 715n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255885
PNG
(CHEMBL4103893)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4C[C@H](C)N(C)[C@H](C)C4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C34H43FN8O3/c1-7-31(44)40-13-12-26(20-40)43-32-24(19-42(34(43)45)30-15-27(46-6)9-10-28(30)35)16-36-33(38-32)37-25-8-11-29(21(2)14-25)41-17-22(3)39(5)23(4)18-41/h8-11,14-16,22-23,26H,7,12-13,17-20H2,1-6H3,(H,36,37,38)/t22-,23+,26-/m0/s1
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n/an/a 888n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255920
PNG
(CHEMBL4089120)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1cccc(OC(F)(F)F)c1 |r|
Show InChI InChI=1S/C32H37F3N8O3/c1-4-28(44)41-11-10-25(20-41)43-29-22(19-42(31(43)45)24-6-5-7-26(17-24)46-32(33,34)35)18-36-30(38-29)37-23-8-9-27(21(2)16-23)40-14-12-39(3)13-15-40/h5-9,16-18,25H,4,10-15,19-20H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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n/an/a 889n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255934
PNG
(CHEMBL4095071)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H37FN8O3/c1-4-28(41)38-12-11-24(20-38)40-29-21(19-39(31(40)42)27-17-25(43-3)9-10-26(27)32)18-33-30(35-29)34-22-5-7-23(8-6-22)37-15-13-36(2)14-16-37/h5-10,17-18,24H,4,11-16,19-20H2,1-3H3,(H,33,34,35)/t24-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255937
PNG
(CHEMBL4103761)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(Cl)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36ClFN8O3/c1-4-28(42)39-10-9-22(19-39)41-29-20(18-40(31(41)43)27-16-23(44-3)6-7-25(27)33)17-34-30(36-29)35-21-5-8-26(24(32)15-21)38-13-11-37(2)12-14-38/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,34,35,36)/t22-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255962
PNG
(CHEMBL4079506)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C31H36F2N8O3/c1-4-28(42)39-10-9-22(19-39)41-29-20(18-40(31(41)43)27-16-23(44-3)6-7-24(27)32)17-34-30(36-29)35-21-5-8-26(25(33)15-21)38-13-11-37(2)12-14-38/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,34,35,36)/t22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255884
PNG
(CHEMBL4076515)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N(C)CCN(C)C)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H41FN8O3/c1-7-29(42)39-13-12-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-6)9-10-26(28)33)18-34-31(36-30)35-23-8-11-27(21(2)16-23)38(5)15-14-37(3)4/h8-11,16-18,24H,7,12-15,19-20H2,1-6H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255935
PNG
(CHEMBL4087383)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O4/c1-5-29(42)39-11-10-23(20-39)41-30-21(19-40(32(41)43)27-17-24(44-3)7-8-25(27)33)18-34-31(36-30)35-26-9-6-22(16-28(26)45-4)38-14-12-37(2)13-15-38/h6-9,16-18,23H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t23-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255963
PNG
(CHEMBL4074615)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3C)N3CCN(C)CC3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H39FN8O3/c1-5-29(42)39-11-10-24(20-39)41-30-22(19-40(32(41)43)28-17-25(44-4)7-8-26(28)33)18-34-31(36-30)35-27-9-6-23(16-21(27)2)38-14-12-37(3)13-15-38/h6-9,16-18,24H,5,10-15,19-20H2,1-4H3,(H,34,35,36)/t24-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50255938
PNG
(CHEMBL4068695)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(c3)C(F)(F)F)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C32H36F4N8O3/c1-4-28(45)42-10-9-22(19-42)44-29-20(18-43(31(44)46)27-16-23(47-3)6-7-25(27)33)17-37-30(39-29)38-21-5-8-26(24(15-21)32(34,35)36)41-13-11-40(2)12-14-41/h5-8,15-17,22H,4,9-14,18-19H2,1-3H3,(H,37,38,39)/t22-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50177716
PNG
(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Show SMILES FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1
Show InChI InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human wild type GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus using tyr4 peptide as su...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%