BindingDB logo
myBDB logout

USPatent US8940736

Compile data set for download or QSAR
Found 142 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142829
PNG
(US8940736, 391)
Show SMILES Cc1nc(Nc2nc(Nc3ccc4n(C)nc(C#N)c4c3)nn3c(cnc23)[N+]#[C-])nn1C
Show InChI InChI=1S/C19H15N13/c1-10-23-18(28-30(10)3)25-16-17-22-9-15(21-2)32(17)29-19(26-16)24-11-5-6-14-12(7-11)13(8-20)27-31(14)4/h5-7,9H,1,3-4H3,(H2,24,25,26,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.0300n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142775
PNG
(US8940736, 7)
Show SMILES OC1CCN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C20H18ClN9O/c21-17-15(5-11(7-22)6-16(17)29-4-3-14(31)10-29)26-20-27-18(25-12-1-2-12)19-24-9-13(8-23)30(19)28-20/h5-6,9,12,14,31H,1-4,10H2,(H2,25,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.0700n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142774
PNG
(US8940736, 6)
Show SMILES Cn1nc(C#N)c2cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)ccc12
Show InChI InChI=1S/C18H14N10/c1-27-15-5-4-11(6-13(15)14(8-20)25-27)23-18-24-16(22-10-2-3-10)17-21-9-12(7-19)28(17)26-18/h4-6,9-10H,2-3H2,1H3,(H2,22,23,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0900n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142816
PNG
(US8940736, 281)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@H]1OP(O)(O)=O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H24ClN10O6P/c1-39-23(35)30-15-4-5-33(11-18(15)40-41(36,37)38)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18H,2-5,11H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32)/t15-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.0900n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142792
PNG
(US8940736, 160)
Show SMILES CS(=O)(=O)C1CCN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H25ClN10O2S/c1-38(36,37)18-4-5-33(13-18)17-11-34(12-17)20-7-14(8-26)6-19(21(20)25)30-24-31-22(29-15-2-3-15)23-28-10-16(9-27)35(23)32-24/h6-7,10,15,17-18H,2-5,11-13H2,1H3,(H2,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.110n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142777
PNG
(US8940736, 49)
Show SMILES Clc1c(NN2CCOCC2)cc(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C20H19ClN10O/c21-17-15(7-12(9-22)8-16(17)28-30-3-5-32-6-4-30)26-20-27-18(25-13-1-2-13)19-24-11-14(10-23)31(19)29-20/h7-8,11,13,28H,1-6H2,(H2,25,26,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142835
PNG
(US8940736, 402)
Show SMILES OCc1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C17H13ClN8O/c18-14-10(8-27)3-9(5-19)4-13(14)23-17-24-15(22-11-1-2-11)16-21-7-12(6-20)26(16)25-17/h3-4,7,11,27H,1-2,8H2,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.110n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142829
PNG
(US8940736, 391)
Show SMILES Cc1nc(Nc2nc(Nc3ccc4n(C)nc(C#N)c4c3)nn3c(cnc23)[N+]#[C-])nn1C
Show InChI InChI=1S/C19H15N13/c1-10-23-18(28-30(10)3)25-16-17-22-9-15(21-2)32(17)29-19(26-16)24-11-5-6-14-12(7-11)13(8-20)27-31(14)4/h5-7,9H,1,3-4H3,(H2,24,25,26,28,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.130n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142822
PNG
(US8940736, 328)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@H](NC(=O)OC)[C@@H](O)C3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23ClN10O3/c1-4-26-19-20-27-10-17(25-2)33(20)31-21(30-19)28-14-7-12(9-24)8-15(18(14)23)32-6-5-13(16(34)11-32)29-22(35)36-3/h7-8,10,13,16,34H,4-6,11H2,1,3H3,(H,29,35)(H2,26,28,30,31)/t13-,16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.130n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142817
PNG
(US8940736, 285)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@@H]1F)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H22ClFN10O2/c1-37-23(36)31-16-4-5-34(11-15(16)25)18-7-12(8-26)6-17(19(18)24)30-22-32-20(29-13-2-3-13)21-28-10-14(9-27)35(21)33-22/h6-7,10,13,15-16H,2-5,11H2,1H3,(H,31,36)(H2,29,30,32,33)/t15-,16+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.140n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142784
PNG
(US8940736, 117)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)NC1CCS(=O)(=O)C1)C#N
Show InChI InChI=1S/C25H27ClN10O2S/c26-22-20(32-25-33-23(31-16-1-2-16)24-29-13-19(12-28)36(24)34-25)9-15(11-27)10-21(22)35-6-3-17(4-7-35)30-18-5-8-39(37,38)14-18/h9-10,13,16-18,30H,1-8,14H2,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.150n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142774
PNG
(US8940736, 6)
Show SMILES Cn1nc(C#N)c2cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)ccc12
Show InChI InChI=1S/C18H14N10/c1-27-15-5-4-11(6-13(15)14(8-20)25-27)23-18-24-16(22-10-2-3-10)17-21-9-12(7-19)28(17)26-18/h4-6,9-10H,2-3H2,1H3,(H2,22,23,24,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142834
PNG
(US8940736, 399)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1C=C)C#N
Show InChI InChI=1S/C18H13ClN8/c1-2-11-5-10(7-20)6-14(15(11)19)24-18-25-16(23-12-3-4-12)17-22-9-13(8-21)27(17)26-18/h2,5-6,9,12H,1,3-4H2,(H2,23,24,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.160n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142835
PNG
(US8940736, 402)
Show SMILES OCc1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C17H13ClN8O/c18-14-10(8-27)3-9(5-19)4-13(14)23-17-24-15(22-11-1-2-11)16-21-7-12(6-20)26(16)25-17/h3-4,7,11,27H,1-2,8H2,(H2,22,23,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.160n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142806
PNG
(US8940736, 229)
Show SMILES CC(=O)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H22ClN9O/c1-13(34)32-6-4-15(5-7-32)18-8-14(10-25)9-19(20(18)24)29-23-30-21(28-16-2-3-16)22-27-12-17(11-26)33(22)31-23/h8-9,12,15-16H,2-7H2,1H3,(H2,28,29,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.160n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142775
PNG
(US8940736, 7)
Show SMILES OC1CCN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C20H18ClN9O/c21-17-15(5-11(7-22)6-16(17)29-4-3-14(31)10-29)26-20-27-18(25-12-1-2-12)19-24-9-13(8-23)30(19)28-20/h5-6,9,12,14,31H,1-4,10H2,(H2,25,26,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.170n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142778
PNG
(US8940736, 55)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCN(CC1)C1CCOC1)C#N
Show InChI InChI=1S/C24H25ClN10O/c25-21-19(30-24-31-22(29-16-1-2-16)23-28-13-18(12-27)35(23)32-24)9-15(11-26)10-20(21)34-6-4-33(5-7-34)17-3-8-36-14-17/h9-10,13,16-17H,1-8,14H2,(H2,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.200n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142832
PNG
(US8940736, 395)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(C[C@@H](C)O)CC2)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C24H27N11O/c1-3-27-22-23-28-13-18(11-25)35(23)32-24(30-22)29-16-4-5-21-19(10-16)20(12-26)31-34(21)17-6-8-33(9-7-17)14-15(2)36/h4-5,10,13,15,17,36H,3,6-9,14H2,1-2H3,(H2,27,29,30,32)/t15-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.210n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142806
PNG
(US8940736, 229)
Show SMILES CC(=O)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H22ClN9O/c1-13(34)32-6-4-15(5-7-32)18-8-14(10-25)9-19(20(18)24)29-23-30-21(28-16-2-3-16)22-27-12-17(11-26)33(22)31-23/h8-9,12,15-16H,2-7H2,1H3,(H2,28,29,30,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.210n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142793
PNG
(US8940736, 161)
Show SMILES COC1CCN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H25ClN10O/c1-36-18-4-5-33(13-18)17-11-34(12-17)20-7-14(8-26)6-19(21(20)25)30-24-31-22(29-15-2-3-15)23-28-10-16(9-27)35(23)32-24/h6-7,10,15,17-18H,2-5,11-13H2,1H3,(H2,29,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.210n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142818
PNG
(US8940736, 313)
Show SMILES FC1CN(CCN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1Cl)C#N)C1COC1
Show InChI InChI=1S/C24H24ClFN10O/c1-28-20-9-29-23-22(30-16-2-3-16)32-24(33-36(20)23)31-18-6-14(8-27)7-19(21(18)25)35-5-4-34(10-15(26)11-35)17-12-37-13-17/h6-7,9,15-17H,2-5,10-13H2,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.210n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142832
PNG
(US8940736, 395)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(C[C@@H](C)O)CC2)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C24H27N11O/c1-3-27-22-23-28-13-18(11-25)35(23)32-24(30-22)29-16-4-5-21-19(10-16)20(12-26)31-34(21)17-6-8-33(9-7-17)14-15(2)36/h4-5,10,13,15,17,36H,3,6-9,14H2,1-2H3,(H2,27,29,30,32)/t15-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.220n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142784
PNG
(US8940736, 117)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)NC1CCS(=O)(=O)C1)C#N
Show InChI InChI=1S/C25H27ClN10O2S/c26-22-20(32-25-33-23(31-16-1-2-16)24-29-13-19(12-28)36(24)34-25)9-15(11-27)10-21(22)35-6-3-17(4-7-35)30-18-5-8-39(37,38)14-18/h9-10,13,16-18,30H,1-8,14H2,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.220n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142777
PNG
(US8940736, 49)
Show SMILES Clc1c(NN2CCOCC2)cc(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C20H19ClN10O/c21-17-15(7-12(9-22)8-16(17)28-30-3-5-32-6-4-30)26-20-27-18(25-13-1-2-13)19-24-11-14(10-23)31(19)29-20/h7-8,11,13,28H,1-6H2,(H2,25,26,27,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.230n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142836
PNG
(US8940736, 408)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC3)C3COC3)c2Cl)C#N)nn2c(cnc12)C#N
Show InChI InChI=1S/C22H23ClN10O/c1-2-26-20-21-27-11-15(10-25)33(21)30-22(29-20)28-17-7-14(9-24)8-18(19(17)23)32-5-3-31(4-6-32)16-12-34-13-16/h7-8,11,16H,2-6,12-13H2,1H3,(H2,26,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.230n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142834
PNG
(US8940736, 399)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1C=C)C#N
Show InChI InChI=1S/C18H13ClN8/c1-2-11-5-10(7-20)6-14(15(11)19)24-18-25-16(23-12-3-4-12)17-22-9-13(8-21)27(17)26-18/h2,5-6,9,12H,1,3-4H2,(H2,23,24,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.230n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142802
PNG
(US8940736, 207)
Show SMILES CN1CCC(=CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |c:4|
Show InChI InChI=1S/C22H20ClN9/c1-31-6-4-14(5-7-31)17-8-13(10-24)9-18(19(17)23)28-22-29-20(27-15-2-3-15)21-26-12-16(11-25)32(21)30-22/h4,8-9,12,15H,2-3,5-7H2,1H3,(H2,27,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.230n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142792
PNG
(US8940736, 160)
Show SMILES CS(=O)(=O)C1CCN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H25ClN10O2S/c1-38(36,37)18-4-5-33(13-18)17-11-34(12-17)20-7-14(8-26)6-19(21(20)25)30-24-31-22(29-15-2-3-15)23-28-10-16(9-27)35(23)32-24/h6-7,10,15,17-18H,2-5,11-13H2,1H3,(H2,29,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.240n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142820
PNG
(US8940736, 319)
Show SMILES CC(=O)N1CC(C1)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C26H27ClN10O/c1-15(38)36-13-20(14-36)35-6-4-17(5-7-35)21-8-16(10-28)9-22(23(21)27)32-26-33-24(31-18-2-3-18)25-30-12-19(11-29)37(25)34-26/h8-9,12,17-18,20H,2-7,13-14H2,1H3,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.25n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142799
PNG
(US8940736, 179)
Show SMILES O[C@@H]1CN(CC[C@H]1NC(=O)OC1COC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C25H25ClN10O4/c26-21-18(31-24-33-22(30-14-1-2-14)23-29-9-15(8-28)36(23)34-24)5-13(7-27)6-19(21)35-4-3-17(20(37)10-35)32-25(38)40-16-11-39-12-16/h5-6,9,14,16-17,20,37H,1-4,10-12H2,(H,32,38)(H2,30,31,33,34)/t17-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.260n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142794
PNG
(US8940736, 163)
Show SMILES COC(=O)N[C@@H]1CN(C[C@H]1C)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C26H28ClN11O2/c1-14-10-36(13-20(14)33-26(39)40-2)18-11-37(12-18)21-6-15(7-28)5-19(22(21)27)32-25-34-23(31-16-3-4-16)24-30-9-17(8-29)38(24)35-25/h5-6,9,14,16,18,20H,3-4,10-13H2,1-2H3,(H,33,39)(H2,31,32,34,35)/t14-,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142816
PNG
(US8940736, 281)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@H]1OP(O)(O)=O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H24ClN10O6P/c1-39-23(35)30-15-4-5-33(11-18(15)40-41(36,37)38)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18H,2-5,11H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32)/t15-,18-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142831
PNG
(US8940736, 394)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(C[C@H](C)O)CC2)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C24H27N11O/c1-3-27-22-23-28-13-18(11-25)35(23)32-24(30-22)29-16-4-5-21-19(10-16)20(12-26)31-34(21)17-6-8-33(9-7-17)14-15(2)36/h4-5,10,13,15,17,36H,3,6-9,14H2,1-2H3,(H2,27,29,30,32)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142796
PNG
(US8940736, 173)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H23ClN10O3/c1-37-23(36)30-15-4-5-33(11-18(15)35)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18,35H,2-5,11H2,1H3,(H,30,36)(H2,28,29,31,32)/t15-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142795
PNG
(US8940736, 167)
Show SMILES OC1CN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C22H21ClN10O/c23-19-17(3-12(5-24)4-18(19)32-8-15(9-32)31-10-16(34)11-31)28-22-29-20(27-13-1-2-13)21-26-7-14(6-25)33(21)30-22/h3-4,7,13,15-16,34H,1-2,8-11H2,(H2,27,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142831
PNG
(US8940736, 394)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(C[C@H](C)O)CC2)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C24H27N11O/c1-3-27-22-23-28-13-18(11-25)35(23)32-24(30-22)29-16-4-5-21-19(10-16)20(12-26)31-34(21)17-6-8-33(9-7-17)14-15(2)36/h4-5,10,13,15,17,36H,3,6-9,14H2,1-2H3,(H2,27,29,30,32)/t15-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142807
PNG
(US8940736, 238)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1C1CCN(CC1)C(=O)OC1COC1)C#N
Show InChI InChI=1S/C25H24ClN9O3/c26-21-19(15-3-5-34(6-4-15)25(36)38-18-12-37-13-18)7-14(9-27)8-20(21)31-24-32-22(30-16-1-2-16)23-29-11-17(10-28)35(23)33-24/h7-8,11,15-16,18H,1-6,12-13H2,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.270n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142779
PNG
(US8940736, 57)
Show SMILES C[C@@H](O)CN1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H25ClN10O/c1-14(35)13-32-4-6-33(7-5-32)19-9-15(10-25)8-18(20(19)24)29-23-30-21(28-16-2-3-16)22-27-12-17(11-26)34(22)31-23/h8-9,12,14,16,35H,2-7,13H2,1H3,(H2,28,29,30,31)/t14-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.280n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142820
PNG
(US8940736, 319)
Show SMILES CC(=O)N1CC(C1)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C26H27ClN10O/c1-15(38)36-13-20(14-36)35-6-4-17(5-7-35)21-8-16(10-28)9-22(23(21)27)32-26-33-24(31-18-2-3-18)25-30-12-19(11-29)37(25)34-26/h8-9,12,17-18,20H,2-7,13-14H2,1H3,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.280n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142778
PNG
(US8940736, 55)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCN(CC1)C1CCOC1)C#N
Show InChI InChI=1S/C24H25ClN10O/c25-21-19(30-24-31-22(29-16-1-2-16)23-28-13-18(12-27)35(23)32-24)9-15(11-26)10-20(21)34-6-4-33(5-7-34)17-3-8-36-14-17/h9-10,13,16-17H,1-8,14H2,(H2,29,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.290n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142818
PNG
(US8940736, 313)
Show SMILES FC1CN(CCN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1Cl)C#N)C1COC1
Show InChI InChI=1S/C24H24ClFN10O/c1-28-20-9-29-23-22(30-16-2-3-16)32-24(33-36(20)23)31-18-6-14(8-27)7-19(21(18)25)35-5-4-34(10-15(26)11-35)17-12-37-13-17/h6-7,9,15-17H,2-5,10-13H2,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.290n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142795
PNG
(US8940736, 167)
Show SMILES OC1CN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C22H21ClN10O/c23-19-17(3-12(5-24)4-18(19)32-8-15(9-32)31-10-16(34)11-31)28-22-29-20(27-13-1-2-13)21-26-7-14(6-25)33(21)30-22/h3-4,7,13,15-16,34H,1-2,8-11H2,(H2,27,28,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.300n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142790
PNG
(US8940736, 133)
Show SMILES O[C@H]1C[C@H](C1)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r,wU:3.5,1.0,(10.45,-1.86,;9.11,-2.63,;8.72,-4.11,;7.23,-3.72,;7.63,-2.23,;5.89,-4.49,;4.56,-3.72,;3.23,-4.49,;1.89,-3.72,;1.89,-2.18,;3.23,-1.41,;4.56,-2.18,;.56,-1.41,;.56,.13,;-.77,.9,;-2.11,.13,;-2.11,-1.41,;-3.44,-2.18,;-4.78,-1.41,;-4.78,.13,;-6.11,.9,;-6.11,2.44,;-7.44,3.21,;-8.21,4.55,;-8.98,3.21,;-7.44,.13,;-8.91,.61,;-9.81,-.64,;-8.91,-1.88,;-9.68,-3.21,;-10.45,-4.55,;-7.44,-1.41,;-6.11,-2.18,;-.77,-2.18,;-.77,-3.72,;-.77,2.44,;-.77,3.98,)|
Show InChI InChI=1S/C25H27ClN10O/c26-22-20(32-25-33-23(31-15-1-2-15)24-29-13-18(12-28)36(24)34-25)7-14(11-27)8-21(22)35-5-3-16(4-6-35)30-17-9-19(37)10-17/h7-8,13,15-17,19,30,37H,1-6,9-10H2,(H2,31,32,33,34)/t17-,19+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.300n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142779
PNG
(US8940736, 57)
Show SMILES C[C@@H](O)CN1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H25ClN10O/c1-14(35)13-32-4-6-33(7-5-32)19-9-15(10-25)8-18(20(19)24)29-23-30-21(28-16-2-3-16)22-27-12-17(11-26)34(22)31-23/h8-9,12,14,16,35H,2-7,13H2,1H3,(H2,28,29,30,31)/t14-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.300n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142793
PNG
(US8940736, 161)
Show SMILES COC1CCN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H25ClN10O/c1-36-18-4-5-33(13-18)17-11-34(12-17)20-7-14(8-26)6-19(21(20)25)30-24-31-22(29-15-2-3-15)23-28-10-16(9-27)35(23)32-24/h6-7,10,15,17-18H,2-5,11-13H2,1H3,(H2,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.310n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142802
PNG
(US8940736, 207)
Show SMILES CN1CCC(=CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |c:4|
Show InChI InChI=1S/C22H20ClN9/c1-31-6-4-14(5-7-31)17-8-13(10-24)9-18(19(17)23)28-22-29-20(27-15-2-3-15)21-26-12-16(11-25)32(21)30-22/h4,8-9,12,15H,2-3,5-7H2,1H3,(H2,27,28,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.310n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142797
PNG
(US8940736, 174)
Show SMILES COC(=O)N[C@H]1CCN(C[C@@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H23ClN10O3/c1-37-23(36)30-15-4-5-33(11-18(15)35)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18,35H,2-5,11H2,1H3,(H,30,36)(H2,28,29,31,32)/t15-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.350n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142827
PNG
(US8940736, 382)
Show SMILES CN1CCN(CC1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1F)C#N
Show InChI InChI=1S/C24H26FN11/c1-27-20-12-28-23-22(29-16-3-4-16)31-24(32-36(20)23)30-18-9-15(11-26)10-19(21(18)25)35-13-17(14-35)34-7-5-33(2)6-8-34/h9-10,12,16-17H,3-8,13-14H2,2H3,(H2,29,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142796
PNG
(US8940736, 173)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H23ClN10O3/c1-37-23(36)30-15-4-5-33(11-18(15)35)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18,35H,2-5,11H2,1H3,(H,30,36)(H2,28,29,31,32)/t15-,18-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.410n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142817
PNG
(US8940736, 285)
Show SMILES COC(=O)N[C@@H]1CCN(C[C@@H]1F)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H22ClFN10O2/c1-37-23(36)31-16-4-5-34(11-15(16)25)18-7-12(8-26)6-17(19(18)24)30-22-32-20(29-13-2-3-13)21-28-10-14(9-27)35(21)33-22/h6-7,10,13,15-16H,2-5,11H2,1H3,(H,31,36)(H2,29,30,32,33)/t15-,16+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.450n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142809
PNG
(US8940736, 253)
Show SMILES CN1CC(C1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C24H27ClF2N10/c1-34-12-17(13-34)35-4-6-36(7-5-35)19-9-14(21(26)27)8-18(20(19)25)31-24-32-22(30-15-2-3-15)23-29-11-16(10-28)37(23)33-24/h8-9,11,15,17,21H,2-7,12-13H2,1H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.470n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142794
PNG
(US8940736, 163)
Show SMILES COC(=O)N[C@@H]1CN(C[C@H]1C)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C26H28ClN11O2/c1-14-10-36(13-20(14)33-26(39)40-2)18-11-37(12-18)21-6-15(7-28)5-19(22(21)27)32-25-34-23(31-16-3-4-16)24-30-9-17(8-29)38(24)35-25/h5-6,9,14,16,18,20H,3-4,10-13H2,1-2H3,(H,33,39)(H2,31,32,34,35)/t14-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.490n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142798
PNG
(US8940736, 176)
Show SMILES COCCOC(=O)N[C@@H]1CCN(C[C@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C25H27ClN10O4/c1-39-6-7-40-25(38)32-17-4-5-35(13-20(17)37)19-9-14(10-27)8-18(21(19)26)31-24-33-22(30-15-2-3-15)23-29-12-16(11-28)36(23)34-24/h8-9,12,15,17,20,37H,2-7,13H2,1H3,(H,32,38)(H2,30,31,33,34)/t17-,20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.490n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142826
PNG
(US8940736, 374)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@@H]4[C@@H](C3)OCCN4C3COC3)c2Cl)C#N)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C25H27ClN10O2/c1-2-29-23-24-30-11-16(10-28)36(24)33-25(32-23)31-18-7-15(9-27)8-20(22(18)26)34-4-3-19-21(12-34)38-6-5-35(19)17-13-37-14-17/h7-8,11,17,19,21H,2-6,12-14H2,1H3,(H2,29,31,32,33)/t19-,21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.520n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142822
PNG
(US8940736, 328)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@H](NC(=O)OC)[C@@H](O)C3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23ClN10O3/c1-4-26-19-20-27-10-17(25-2)33(20)31-21(30-19)28-14-7-12(9-24)8-15(18(14)23)32-6-5-13(16(34)11-32)29-22(35)36-3/h7-8,10,13,16,34H,4-6,11H2,1,3H3,(H,29,35)(H2,26,28,30,31)/t13-,16-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.520n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142790
PNG
(US8940736, 133)
Show SMILES O[C@H]1C[C@H](C1)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r,wU:3.5,1.0,(10.45,-1.86,;9.11,-2.63,;8.72,-4.11,;7.23,-3.72,;7.63,-2.23,;5.89,-4.49,;4.56,-3.72,;3.23,-4.49,;1.89,-3.72,;1.89,-2.18,;3.23,-1.41,;4.56,-2.18,;.56,-1.41,;.56,.13,;-.77,.9,;-2.11,.13,;-2.11,-1.41,;-3.44,-2.18,;-4.78,-1.41,;-4.78,.13,;-6.11,.9,;-6.11,2.44,;-7.44,3.21,;-8.21,4.55,;-8.98,3.21,;-7.44,.13,;-8.91,.61,;-9.81,-.64,;-8.91,-1.88,;-9.68,-3.21,;-10.45,-4.55,;-7.44,-1.41,;-6.11,-2.18,;-.77,-2.18,;-.77,-3.72,;-.77,2.44,;-.77,3.98,)|
Show InChI InChI=1S/C25H27ClN10O/c26-22-20(32-25-33-23(31-15-1-2-15)24-29-13-18(12-28)36(24)34-25)7-14(11-27)8-21(22)35-5-3-16(4-6-35)30-17-9-19(37)10-17/h7-8,13,15-17,19,30,37H,1-6,9-10H2,(H2,31,32,33,34)/t17-,19+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.540n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142825
PNG
(US8940736, 364)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCC(CC3)NC[C@@H](C)O)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C23H27ClN10O/c1-4-27-21-22-29-13-19(26-3)34(22)32-23(31-21)30-17-9-15(11-25)10-18(20(17)24)33-7-5-16(6-8-33)28-12-14(2)35/h9-10,13-14,16,28,35H,4-8,12H2,1-2H3,(H2,27,30,31,32)/t14-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.610n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142827
PNG
(US8940736, 382)
Show SMILES CN1CCN(CC1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1F)C#N
Show InChI InChI=1S/C24H26FN11/c1-27-20-12-28-23-22(29-16-3-4-16)31-24(32-36(20)23)30-18-9-15(11-26)10-19(21(18)25)35-13-17(14-35)34-7-5-33(2)6-8-34/h9-10,12,16-17H,3-8,13-14H2,2H3,(H2,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.610n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142800
PNG
(US8940736, 184)
Show SMILES CN1CCN(CC(=O)N[C@@H]2CCN(C[C@H]2O)c2cc(cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C#N)CC1 |r|
Show InChI InChI=1S/C28H33ClN12O2/c1-38-6-8-39(9-7-38)16-24(43)34-20-4-5-40(15-23(20)42)22-11-17(12-30)10-21(25(22)29)35-28-36-26(33-18-2-3-18)27-32-14-19(13-31)41(27)37-28/h10-11,14,18,20,23,42H,2-9,15-16H2,1H3,(H,34,43)(H2,33,35,36,37)/t20-,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.640n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142782
PNG
(US8940736, 108)
Show SMILES FC1(F)CC(C1)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1Cl)C#N
Show InChI InChI=1S/C25H25ClF2N10/c1-30-20-13-31-23-22(33-15-2-3-15)35-24(36-38(20)23)34-18-8-14(12-29)9-19(21(18)26)37-6-4-16(5-7-37)32-17-10-25(27,28)11-17/h8-9,13,15-17,32H,2-7,10-11H2,(H2,33,34,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.700n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142797
PNG
(US8940736, 174)
Show SMILES COC(=O)N[C@H]1CCN(C[C@@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C23H23ClN10O3/c1-37-23(36)30-15-4-5-33(11-18(15)35)17-7-12(8-25)6-16(19(17)24)29-22-31-20(28-13-2-3-13)21-27-10-14(9-26)34(21)32-22/h6-7,10,13,15,18,35H,2-5,11H2,1H3,(H,30,36)(H2,28,29,31,32)/t15-,18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.720n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142843
PNG
(US8940736, 428)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC(F)F)CC3)c2Cl)C#N)nn2c(cnc12)C#N
Show InChI InChI=1S/C21H21ClF2N10/c1-2-27-19-20-28-11-14(10-26)34(20)31-21(30-19)29-15-7-13(9-25)8-16(18(15)22)33-5-3-32(4-6-33)12-17(23)24/h7-8,11,17H,2-6,12H2,1H3,(H2,27,29,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.740n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142814
PNG
(US8940736, 274)
Show SMILES CC1(COC1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C24H26ClF2N9O/c1-24(12-37-13-24)35-6-4-34(5-7-35)18-9-14(20(26)27)8-17(19(18)25)31-23-32-21(30-15-2-3-15)22-29-11-16(10-28)36(22)33-23/h8-9,11,15,20H,2-7,12-13H2,1H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.75n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142804
PNG
(US8940736, 221)
Show SMILES OCC1(CO)CC(C1)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C27H30ClN9O2/c28-23-21(17-3-5-36(6-4-17)19-9-27(10-19,14-38)15-39)7-16(11-29)8-22(23)33-26-34-24(32-18-1-2-18)25-31-13-20(12-30)37(25)35-26/h7-8,13,17-19,38-39H,1-6,9-10,14-15H2,(H2,32,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.760n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142824
PNG
(US8940736, 348)
Show SMILES CCNc1nc(Nc2cc(cc(C3CCNCC3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-]
Show InChI InChI=1S/C20H20ClN9/c1-3-25-18-19-26-11-16(23-2)30(19)29-20(28-18)27-15-9-12(10-22)8-14(17(15)21)13-4-6-24-7-5-13/h8-9,11,13,24H,3-7H2,1H3,(H2,25,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.760n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142837
PNG
(US8940736, 409)
Show SMILES Clc1c(NC2CCN(CC2)C2COC2)cc(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C24H25ClN10O/c25-21-19(29-16-3-5-34(6-4-16)18-12-36-13-18)7-14(9-26)8-20(21)31-24-32-22(30-15-1-2-15)23-28-11-17(10-27)35(23)33-24/h7-8,11,15-16,18,29H,1-6,12-13H2,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.820n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142776
PNG
(US8940736, 23)
Show SMILES CN1CC2(C1)CN(C2)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C22H21ClN10/c1-31-9-22(10-31)11-32(12-22)17-5-13(6-24)4-16(18(17)23)28-21-29-19(27-14-2-3-14)20-26-8-15(7-25)33(20)30-21/h4-5,8,14H,2-3,9-12H2,1H3,(H2,27,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.870n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142780
PNG
(US8940736, 60)
Show SMILES COC(=O)N1CCC(CC1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C27H30ClN11O2/c1-41-27(40)38-6-4-19(5-7-38)36-8-10-37(11-9-36)22-13-17(14-29)12-21(23(22)28)33-26-34-24(32-18-2-3-18)25-31-16-20(15-30)39(25)35-26/h12-13,16,18-19H,2-11H2,1H3,(H2,32,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.930n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142833
PNG
(US8940736, 396)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(CC2)C2COC2)nn2c(cnc12)C#N
Show InChI InChI=1S/C24H25N11O/c1-2-27-22-23-28-12-17(10-25)35(23)32-24(30-22)29-15-3-4-21-19(9-15)20(11-26)31-34(21)16-5-7-33(8-6-16)18-13-36-14-18/h3-4,9,12,16,18H,2,5-8,13-14H2,1H3,(H2,27,29,30,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.940n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142781
PNG
(US8940736, 65)
Show SMILES CS(=O)(=O)CCN1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H25ClN10O2S/c1-37(35,36)9-8-32-4-6-33(7-5-32)19-11-15(12-25)10-18(20(19)24)29-23-30-21(28-16-2-3-16)22-27-14-17(13-26)34(22)31-23/h10-11,14,16H,2-9H2,1H3,(H2,28,29,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 0.990n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142808
PNG
(US8940736, 252)
Show SMILES CO[C@@H]1CN(C[C@@H]1NC(=O)OC)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F |r|
Show InChI InChI=1S/C23H24ClF2N9O3/c1-37-17-10-34(9-15(17)31-23(36)38-2)16-6-11(19(25)26)5-14(18(16)24)30-22-32-20(29-12-3-4-12)21-28-8-13(7-27)35(21)33-22/h5-6,8,12,15,17,19H,3-4,9-10H2,1-2H3,(H,31,36)(H2,29,30,32,33)/t15-,17+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.17n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142791
PNG
(US8940736, 150)
Show SMILES COC(=O)N[C@@H]1CN(C[C@@H]1C)C1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C28H32ClN11O2/c1-16-14-39(15-22(16)35-28(41)42-2)19-5-7-38(8-6-19)23-10-17(11-30)9-21(24(23)29)34-27-36-25(33-18-3-4-18)26-32-13-20(12-31)40(26)37-27/h9-10,13,16,18-19,22H,3-8,14-15H2,1-2H3,(H,35,41)(H2,33,34,36,37)/t16-,22+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.31n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142819
PNG
(US8940736, 314)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)cc(cc1N1CCN(C2COC2)C(C1)C(=O)N1CCOCC1)C#N
Show InChI InChI=1S/C28H30ClN11O3/c1-31-23-13-32-26-25(33-18-2-3-18)35-28(36-40(23)26)34-20-10-17(12-30)11-21(24(20)29)38-4-5-39(19-15-43-16-19)22(14-38)27(41)37-6-8-42-9-7-37/h10-11,13,18-19,22H,2-9,14-16H2,(H2,33,34,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.32n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142837
PNG
(US8940736, 409)
Show SMILES Clc1c(NC2CCN(CC2)C2COC2)cc(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C24H25ClN10O/c25-21-19(29-16-3-5-34(6-4-16)18-12-36-13-18)7-14(9-26)8-20(21)31-24-32-22(30-15-1-2-15)23-28-11-17(10-27)35(23)33-24/h7-8,11,15-16,18,29H,1-6,12-13H2,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.32n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142825
PNG
(US8940736, 364)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCC(CC3)NC[C@@H](C)O)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C23H27ClN10O/c1-4-27-21-22-29-13-19(26-3)34(22)32-23(31-21)30-17-9-15(11-25)10-18(20(17)24)33-7-5-16(6-8-33)28-12-14(2)35/h9-10,13-14,16,28,35H,4-8,12H2,1-2H3,(H2,27,30,31,32)/t14-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.33n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142804
PNG
(US8940736, 221)
Show SMILES OCC1(CO)CC(C1)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C27H30ClN9O2/c28-23-21(17-3-5-36(6-4-17)19-9-27(10-19,14-38)15-39)7-16(11-29)8-22(23)33-26-34-24(32-18-1-2-18)25-31-13-20(12-30)37(25)35-26/h7-8,13,17-19,38-39H,1-6,9-10,14-15H2,(H2,32,33,34,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.34n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142807
PNG
(US8940736, 238)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1C1CCN(CC1)C(=O)OC1COC1)C#N
Show InChI InChI=1S/C25H24ClN9O3/c26-21-19(15-3-5-34(6-4-15)25(36)38-18-12-37-13-18)7-14(9-27)8-20(21)31-24-32-22(30-16-1-2-16)23-29-11-17(10-28)35(23)33-24/h7-8,11,15-16,18H,1-6,12-13H2,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.35n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142780
PNG
(US8940736, 60)
Show SMILES COC(=O)N1CCC(CC1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C27H30ClN11O2/c1-41-27(40)38-6-4-19(5-7-38)36-8-10-37(11-9-36)22-13-17(14-29)12-21(23(22)28)33-26-34-24(32-18-2-3-18)25-31-16-20(15-30)39(25)35-26/h12-13,16,18-19H,2-11H2,1H3,(H2,32,33,34,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.35n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142799
PNG
(US8940736, 179)
Show SMILES O[C@@H]1CN(CC[C@H]1NC(=O)OC1COC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C25H25ClN10O4/c26-21-18(31-24-33-22(30-14-1-2-14)23-29-9-15(8-28)36(23)34-24)5-13(7-27)6-19(21)35-4-3-17(20(37)10-35)32-25(38)40-16-11-39-12-16/h5-6,9,14,16-17,20,37H,1-4,10-12H2,(H,32,38)(H2,30,31,33,34)/t17-,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.36n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142800
PNG
(US8940736, 184)
Show SMILES CN1CCN(CC(=O)N[C@@H]2CCN(C[C@H]2O)c2cc(cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C#N)CC1 |r|
Show InChI InChI=1S/C28H33ClN12O2/c1-38-6-8-39(9-7-38)16-24(43)34-20-4-5-40(15-23(20)42)22-11-17(12-30)10-21(25(22)29)35-28-36-26(33-18-2-3-18)27-32-14-19(13-31)41(27)37-28/h10-11,14,18,20,23,42H,2-9,15-16H2,1H3,(H,34,43)(H2,33,35,36,37)/t20-,23-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.37n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142826
PNG
(US8940736, 374)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@@H]4[C@@H](C3)OCCN4C3COC3)c2Cl)C#N)nn2c(cnc12)C#N |r|
Show InChI InChI=1S/C25H27ClN10O2/c1-2-29-23-24-30-11-16(10-28)36(24)33-25(32-23)31-18-7-15(9-27)8-20(22(18)26)34-4-3-19-21(12-34)38-6-5-35(19)17-13-37-14-17/h7-8,11,17,19,21H,2-6,12-14H2,1H3,(H2,29,31,32,33)/t19-,21-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.37n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142782
PNG
(US8940736, 108)
Show SMILES FC1(F)CC(C1)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)c1Cl)C#N
Show InChI InChI=1S/C25H25ClF2N10/c1-30-20-13-31-23-22(33-15-2-3-15)35-24(36-38(20)23)34-18-8-14(12-29)9-19(21(18)26)37-6-4-16(5-7-37)32-17-10-25(27,28)11-17/h8-9,13,15-17,32H,2-7,10-11H2,(H2,33,34,35,36)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.37n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142836
PNG
(US8940736, 408)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC3)C3COC3)c2Cl)C#N)nn2c(cnc12)C#N
Show InChI InChI=1S/C22H23ClN10O/c1-2-26-20-21-27-11-15(10-25)33(21)30-22(29-20)28-17-7-14(9-24)8-18(19(17)23)32-5-3-31(4-6-32)16-12-34-13-16/h7-8,11,16H,2-6,12-13H2,1H3,(H2,26,28,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.39n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142843
PNG
(US8940736, 428)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC(F)F)CC3)c2Cl)C#N)nn2c(cnc12)C#N
Show InChI InChI=1S/C21H21ClF2N10/c1-2-27-19-20-28-11-14(10-26)34(20)31-21(30-19)29-15-7-13(9-25)8-16(18(15)22)33-5-3-32(4-6-33)12-17(23)24/h7-8,11,17H,2-6,12H2,1H3,(H2,27,29,30,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.39n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142776
PNG
(US8940736, 23)
Show SMILES CN1CC2(C1)CN(C2)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C22H21ClN10/c1-31-9-22(10-31)11-32(12-22)17-5-13(6-24)4-16(18(17)23)28-21-29-19(27-14-2-3-14)20-26-8-15(7-25)33(20)30-21/h4-5,8,14H,2-3,9-12H2,1H3,(H2,27,28,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.40n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142819
PNG
(US8940736, 314)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc([N+]#[C-])n3n2)cc(cc1N1CCN(C2COC2)C(C1)C(=O)N1CCOCC1)C#N
Show InChI InChI=1S/C28H30ClN11O3/c1-31-23-13-32-26-25(33-18-2-3-18)35-28(36-40(23)26)34-20-10-17(12-30)11-21(24(20)29)38-4-5-39(19-15-43-16-19)22(14-38)27(41)37-6-8-42-9-7-37/h10-11,13,18-19,22H,2-9,14-16H2,(H2,33,34,35,36)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.40n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142814
PNG
(US8940736, 274)
Show SMILES CC1(COC1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C24H26ClF2N9O/c1-24(12-37-13-24)35-6-4-34(5-7-35)18-9-14(20(26)27)8-17(19(18)25)31-23-32-21(30-15-2-3-15)22-29-11-16(10-28)36(22)33-23/h8-9,11,15,20H,2-7,12-13H2,1H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.42n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142824
PNG
(US8940736, 348)
Show SMILES CCNc1nc(Nc2cc(cc(C3CCNCC3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-]
Show InChI InChI=1S/C20H20ClN9/c1-3-25-18-19-26-11-16(23-2)30(19)29-20(28-18)27-15-9-12(10-22)8-14(17(15)21)13-4-6-24-7-5-13/h8-9,11,13,24H,3-7H2,1H3,(H2,25,27,28,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.42n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142840
PNG
(US8940736, 419)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(F)c(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C26H30FN9O/c1-25(2)10-18(11-26(3,4)35(25)5)37-21-9-19(27)15(12-28)8-20(21)32-24-33-22(31-16-6-7-16)23-30-14-17(13-29)36(23)34-24/h8-9,14,16,18H,6-7,10-11H2,1-5H3,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.43n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142833
PNG
(US8940736, 396)
Show SMILES CCNc1nc(Nc2ccc3n(nc(C#N)c3c2)C2CCN(CC2)C2COC2)nn2c(cnc12)C#N
Show InChI InChI=1S/C24H25N11O/c1-2-27-22-23-28-12-17(10-25)35(23)32-24(30-22)29-15-3-4-21-19(9-15)20(11-26)31-34(21)16-5-7-33(8-6-16)18-13-36-14-18/h3-4,9,12,16,18H,2,5-8,13-14H2,1H3,(H2,27,29,30,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.44n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142781
PNG
(US8940736, 65)
Show SMILES CS(=O)(=O)CCN1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H25ClN10O2S/c1-37(35,36)9-8-32-4-6-33(7-5-32)19-11-15(12-25)10-18(20(19)24)29-23-30-21(28-16-2-3-16)22-27-14-17(13-26)34(22)31-23/h10-11,14,16H,2-9H2,1H3,(H2,28,29,30,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.44n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142809
PNG
(US8940736, 253)
Show SMILES CN1CC(C1)N1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C24H27ClF2N10/c1-34-12-17(13-34)35-4-6-36(7-5-35)19-9-14(21(26)27)8-18(20(19)25)31-24-32-22(30-15-2-3-15)23-29-11-16(10-28)37(23)33-24/h8-9,11,15,17,21H,2-7,12-13H2,1H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.5n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142798
PNG
(US8940736, 176)
Show SMILES COCCOC(=O)N[C@@H]1CCN(C[C@H]1O)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C25H27ClN10O4/c1-39-6-7-40-25(38)32-17-4-5-35(13-20(17)37)19-9-14(10-27)8-18(21(19)26)31-24-33-22(30-15-2-3-15)23-29-12-16(11-28)36(23)34-24/h8-9,12,15,17,20,37H,2-7,13H2,1H3,(H,32,38)(H2,30,31,33,34)/t17-,20-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.53n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142785
PNG
(US8940736, 119)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)NC1CC(C1)C#N)C#N |(.17,-2.05,;1.5,-2.82,;1.5,-4.36,;.17,-5.13,;-1.16,-4.36,;-1.16,-2.82,;-2.5,-2.05,;-2.5,-.51,;-1.16,.26,;-.39,1.59,;.38,.26,;-3.83,-2.82,;-5.3,-2.35,;-6.2,-3.59,;-5.3,-4.84,;-6.07,-6.17,;-6.84,-7.51,;-3.83,-4.36,;-2.5,-5.13,;2.84,-5.13,;4.17,-4.36,;4.17,-2.82,;2.84,-2.05,;2.84,-.51,;4.17,.26,;4.17,1.8,;2.84,2.57,;1.5,1.8,;1.5,.26,;2.84,4.11,;1.5,4.88,;1.1,6.36,;-.38,5.97,;.01,4.48,;-1.72,6.74,;-3.05,7.51,;5.5,-5.13,;6.84,-5.9,)|
Show InChI InChI=1S/C26H26ClN11/c27-23-21(34-26-35-24(33-17-1-2-17)25-31-14-20(13-30)38(25)36-26)9-16(12-29)10-22(23)37-5-3-18(4-6-37)32-19-7-15(8-19)11-28/h9-10,14-15,17-19,32H,1-8H2,(H2,33,34,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.53n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142785
PNG
(US8940736, 119)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)NC1CC(C1)C#N)C#N |(.17,-2.05,;1.5,-2.82,;1.5,-4.36,;.17,-5.13,;-1.16,-4.36,;-1.16,-2.82,;-2.5,-2.05,;-2.5,-.51,;-1.16,.26,;-.39,1.59,;.38,.26,;-3.83,-2.82,;-5.3,-2.35,;-6.2,-3.59,;-5.3,-4.84,;-6.07,-6.17,;-6.84,-7.51,;-3.83,-4.36,;-2.5,-5.13,;2.84,-5.13,;4.17,-4.36,;4.17,-2.82,;2.84,-2.05,;2.84,-.51,;4.17,.26,;4.17,1.8,;2.84,2.57,;1.5,1.8,;1.5,.26,;2.84,4.11,;1.5,4.88,;1.1,6.36,;-.38,5.97,;.01,4.48,;-1.72,6.74,;-3.05,7.51,;5.5,-5.13,;6.84,-5.9,)|
Show InChI InChI=1S/C26H26ClN11/c27-23-21(34-26-35-24(33-17-1-2-17)25-31-14-20(13-30)38(25)36-26)9-16(12-29)10-22(23)37-5-3-18(4-6-37)32-19-7-15(8-19)11-28/h9-10,14-15,17-19,32H,1-8H2,(H2,33,34,35,36)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.56n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142791
PNG
(US8940736, 150)
Show SMILES COC(=O)N[C@@H]1CN(C[C@@H]1C)C1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C28H32ClN11O2/c1-16-14-39(15-22(16)35-28(41)42-2)19-5-7-38(8-6-19)23-10-17(11-30)9-21(24(23)29)34-27-36-25(33-18-3-4-18)26-32-13-20(12-31)40(26)37-27/h9-10,13,16,18-19,22H,3-8,14-15H2,1-2H3,(H,35,41)(H2,33,34,36,37)/t16-,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 1.61n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142805
PNG
(US8940736, 224)
Show SMILES FC(F)(F)CCN1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H23ClF3N9/c25-20-18(15-3-6-36(7-4-15)8-5-24(26,27)28)9-14(11-29)10-19(20)33-23-34-21(32-16-1-2-16)22-31-13-17(12-30)37(22)35-23/h9-10,13,15-16H,1-8H2,(H2,32,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.05n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142830
PNG
(US8940736, 392)
Show SMILES C[C@@H](O)Cn1nc(C#N)c2cc(Nc3nc(Nc4nc(C)n(C)n4)c4ncc([N+]#[C-])n4n3)ccc12 |r|
Show InChI InChI=1S/C21H19N13O/c1-11(35)10-33-16-6-5-13(7-14(16)15(8-22)29-33)26-21-28-18(27-20-25-12(2)32(4)30-20)19-24-9-17(23-3)34(19)31-21/h5-7,9,11,35H,10H2,1-2,4H3,(H2,26,27,28,30,31)/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.47n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142842
PNG
(US8940736, 423)
Show SMILES Fc1cc(OC2CCNCC2)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C21H20FN9O/c22-16-8-18(32-15-3-5-25-6-4-15)17(7-12(16)9-23)28-21-29-19(27-13-1-2-13)20-26-11-14(10-24)31(20)30-21/h7-8,11,13,15,25H,1-6H2,(H2,27,28,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.75n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142821
PNG
(US8940736, 327)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@@H](NC(=O)OC)[C@H](O)C3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23ClN10O3/c1-4-26-19-20-27-10-17(25-2)33(20)31-21(30-19)28-14-7-12(9-24)8-15(18(14)23)32-6-5-13(16(34)11-32)29-22(35)36-3/h7-8,10,13,16,34H,4-6,11H2,1,3H3,(H,29,35)(H2,26,28,30,31)/t13-,16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.95n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142815
PNG
(US8940736, 276)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCC(CC1)C1COC1
Show InChI InChI=1S/C24H25ClF2N8O/c25-20-18(31-24-32-22(30-16-1-2-16)23-29-10-17(9-28)35(23)33-24)7-14(21(26)27)8-19(20)34-5-3-13(4-6-34)15-11-36-12-15/h7-8,10,13,15-16,21H,1-6,11-12H2,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.01n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142813
PNG
(US8940736, 269)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCN(CC1)C1(CS(=O)(=O)c2ccccc2)COC1
Show InChI InChI=1S/C30H30ClF2N9O3S/c31-25-23(37-29-38-27(36-20-6-7-20)28-35-15-21(14-34)42(28)39-29)12-19(26(32)33)13-24(25)40-8-10-41(11-9-40)30(16-45-17-30)18-46(43,44)22-4-2-1-3-5-22/h1-5,12-13,15,20,26H,6-11,16-18H2,(H2,36,37,38,39)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.16n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142812
PNG
(US8940736, 268)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCN(CC1)C1(COC1)C#N
Show InChI InChI=1S/C24H23ClF2N10O/c25-19-17(32-23-33-21(31-15-1-2-15)22-30-10-16(9-28)37(22)34-23)7-14(20(26)27)8-18(19)35-3-5-36(6-4-35)24(11-29)12-38-13-24/h7-8,10,15,20H,1-6,12-13H2,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.21n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142808
PNG
(US8940736, 252)
Show SMILES CO[C@@H]1CN(C[C@@H]1NC(=O)OC)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F |r|
Show InChI InChI=1S/C23H24ClF2N9O3/c1-37-17-10-34(9-15(17)31-23(36)38-2)16-6-11(19(25)26)5-14(18(16)24)30-22-32-20(29-12-3-4-12)21-28-8-13(7-27)35(21)33-22/h5-6,8,12,15,17,19H,3-4,9-10H2,1-2H3,(H,31,36)(H2,29,30,32,33)/t15-,17+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3.83n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142828
PNG
(US8940736, 390)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC3)C3COC3)c2Cl)C(F)F)nn2c(cnc12)[N+]#[C-]
Show InChI InChI=1S/C22H24ClF2N9O/c1-3-27-20-21-28-10-17(26-2)34(21)31-22(30-20)29-15-8-13(19(24)25)9-16(18(15)23)33-6-4-32(5-7-33)14-11-35-12-14/h8-10,14,19H,3-7,11-12H2,1H3,(H2,27,29,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.53n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142821
PNG
(US8940736, 327)
Show SMILES CCNc1nc(Nc2cc(cc(N3CC[C@@H](NC(=O)OC)[C@H](O)C3)c2Cl)C#N)nn2c(cnc12)[N+]#[C-] |r|
Show InChI InChI=1S/C22H23ClN10O3/c1-4-26-19-20-27-10-17(25-2)33(20)31-21(30-19)28-14-7-12(9-24)8-15(18(14)23)32-6-5-13(16(34)11-32)29-22(35)36-3/h7-8,10,13,16,34H,4-6,11H2,1,3H3,(H,29,35)(H2,26,28,30,31)/t13-,16-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.71n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142811
PNG
(US8940736, 267)
Show SMILES CN1CC(CN2CCN(CC2)c2cc(cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C(F)F)C1
Show InChI InChI=1S/C25H29ClF2N10/c1-35-12-15(13-35)14-36-4-6-37(7-5-36)20-9-16(22(27)28)8-19(21(20)26)32-25-33-23(31-17-2-3-17)24-30-11-18(10-29)38(24)34-25/h8-9,11,15,17,22H,2-7,12-14H2,1H3,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4.72n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142844
PNG
(US8940736, 433)
Show SMILES Clc1cnc(nc1Nc1nc(NC2CC2)c2ncc([N+]#[C-])n2n1)C#N
Show InChI InChI=1S/C14H9ClN10/c1-17-10-6-19-13-12(20-7-2-3-7)23-14(24-25(10)13)22-11-8(15)5-18-9(4-16)21-11/h5-7H,2-3H2,(H2,18,20,21,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.10n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142805
PNG
(US8940736, 224)
Show SMILES FC(F)(F)CCN1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H23ClF3N9/c25-20-18(15-3-6-36(7-4-15)8-5-24(26,27)28)9-14(11-29)10-19(20)33-23-34-21(32-16-1-2-16)22-31-13-17(12-30)37(22)35-23/h9-10,13,15-16H,1-8H2,(H2,32,33,34,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.87n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142810
PNG
(US8940736, 263)
Show SMILES COC1CN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C23H24ClF2N9O/c1-36-16-10-33(11-16)15-8-34(9-15)18-5-12(20(25)26)4-17(19(18)24)30-23-31-21(29-13-2-3-13)22-28-7-14(6-27)35(22)32-23/h4-5,7,13,15-16,20H,2-3,8-11H2,1H3,(H2,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5.96n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142815
PNG
(US8940736, 276)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCC(CC1)C1COC1
Show InChI InChI=1S/C24H25ClF2N8O/c25-20-18(31-24-32-22(30-16-1-2-16)23-29-10-17(9-28)35(23)33-24)7-14(21(26)27)8-19(20)34-5-3-13(4-6-34)15-11-36-12-15/h7-8,10,13,15-16,21H,1-6,11-12H2,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.04n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142811
PNG
(US8940736, 267)
Show SMILES CN1CC(CN2CCN(CC2)c2cc(cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C(F)F)C1
Show InChI InChI=1S/C25H29ClF2N10/c1-35-12-15(13-35)14-36-4-6-37(7-5-36)20-9-16(22(27)28)8-19(21(20)26)32-25-33-23(31-17-2-3-17)24-30-11-18(10-29)38(24)34-25/h8-9,11,15,17,22H,2-7,12-14H2,1H3,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6.16n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142830
PNG
(US8940736, 392)
Show SMILES C[C@@H](O)Cn1nc(C#N)c2cc(Nc3nc(Nc4nc(C)n(C)n4)c4ncc([N+]#[C-])n4n3)ccc12 |r|
Show InChI InChI=1S/C21H19N13O/c1-11(35)10-33-16-6-5-13(7-14(16)15(8-22)29-33)26-21-28-18(27-20-25-12(2)32(4)30-20)19-24-9-17(23-3)34(19)31-21/h5-7,9,11,35H,10H2,1-2,4H3,(H2,26,27,28,30,31)/t11-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7.54n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142828
PNG
(US8940736, 390)
Show SMILES CCNc1nc(Nc2cc(cc(N3CCN(CC3)C3COC3)c2Cl)C(F)F)nn2c(cnc12)[N+]#[C-]
Show InChI InChI=1S/C22H24ClF2N9O/c1-3-27-20-21-28-10-17(26-2)34(21)31-22(30-20)29-15-8-13(19(24)25)9-16(18(15)23)33-6-4-32(5-7-33)14-11-35-12-14/h8-10,14,19H,3-7,11-12H2,1H3,(H2,27,29,30,31)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142803
PNG
(US8940736, 218)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC(CC[C@H]1N)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C33H45ClN10OSi/c1-33(2,3)46(4,5)45-28-16-23(8-9-26(28)37)43-12-10-21(11-13-43)25-14-20(17-35)15-27(29(25)34)40-32-41-30(39-22-6-7-22)31-38-19-24(18-36)44(31)42-32/h14-15,19,21-23,26,28H,6-13,16,37H2,1-5H3,(H2,39,40,41,42)/t23?,26-,28-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.18n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142803
PNG
(US8940736, 218)
Show SMILES CC(C)(C)[Si](C)(C)O[C@@H]1CC(CC[C@H]1N)N1CCC(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C33H45ClN10OSi/c1-33(2,3)46(4,5)45-28-16-23(8-9-26(28)37)43-12-10-21(11-13-43)25-14-20(17-35)15-27(29(25)34)40-32-41-30(39-22-6-7-22)31-38-19-24(18-36)44(31)42-32/h14-15,19,21-23,26,28H,6-13,16,37H2,1-5H3,(H2,39,40,41,42)/t23?,26-,28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.54n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142840
PNG
(US8940736, 419)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(F)c(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C26H30FN9O/c1-25(2)10-18(11-26(3,4)35(25)5)37-21-9-19(27)15(12-28)8-20(21)32-24-33-22(31-16-6-7-16)23-30-14-17(13-29)36(23)34-24/h8-9,14,16,18H,6-7,10-11H2,1-5H3,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8.62n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142810
PNG
(US8940736, 263)
Show SMILES COC1CN(C1)C1CN(C1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C(F)F
Show InChI InChI=1S/C23H24ClF2N9O/c1-36-16-10-33(11-16)15-8-34(9-15)18-5-12(20(25)26)4-17(19(18)24)30-23-31-21(29-13-2-3-13)22-28-7-14(6-27)35(22)32-23/h4-5,7,13,15-16,20H,2-3,8-11H2,1H3,(H2,29,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.61n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142842
PNG
(US8940736, 423)
Show SMILES Fc1cc(OC2CCNCC2)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C21H20FN9O/c22-16-8-18(32-15-3-5-25-6-4-15)17(7-12(16)9-23)28-21-29-19(27-13-1-2-13)20-26-11-14(10-24)31(20)30-21/h7-8,11,13,15,25H,1-6H2,(H2,27,28,29,30)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9.80n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142839
PNG
(US8940736, 418)
Show SMILES CC1(C)CC(CC(C)(C)N1)Oc1cc(F)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C25H28FN9O/c1-24(2)9-17(10-25(3,4)34-24)36-20-8-18(26)19(7-14(20)11-27)31-23-32-21(30-15-5-6-15)22-29-13-16(12-28)35(22)33-23/h7-8,13,15,17,34H,5-6,9-10H2,1-4H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 13.1n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142813
PNG
(US8940736, 269)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCN(CC1)C1(CS(=O)(=O)c2ccccc2)COC1
Show InChI InChI=1S/C30H30ClF2N9O3S/c31-25-23(37-29-38-27(36-20-6-7-20)28-35-15-21(14-34)42(28)39-29)12-19(26(32)33)13-24(25)40-8-10-41(11-9-40)30(16-45-17-30)18-46(43,44)22-4-2-1-3-5-22/h1-5,12-13,15,20,26H,6-11,16-18H2,(H2,36,37,38,39)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 13.9n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142812
PNG
(US8940736, 268)
Show SMILES FC(F)c1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(c1)N1CCN(CC1)C1(COC1)C#N
Show InChI InChI=1S/C24H23ClF2N10O/c25-19-17(32-23-33-21(31-15-1-2-15)22-30-10-16(9-28)37(22)34-23)7-14(20(26)27)8-18(19)35-3-5-36(6-4-35)24(11-29)12-38-13-24/h7-8,10,15,20H,1-6,12-13H2,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15.3n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142783
PNG
(US8940736, 115)
Show SMILES CC(C)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H27ClN10/c1-14(2)29-17-5-7-34(8-6-17)20-10-15(11-26)9-19(21(20)25)31-24-32-22(30-16-3-4-16)23-28-13-18(12-27)35(23)33-24/h9-10,13-14,16-17,29H,3-8H2,1-2H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 15.5n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142839
PNG
(US8940736, 418)
Show SMILES CC1(C)CC(CC(C)(C)N1)Oc1cc(F)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C25H28FN9O/c1-24(2)9-17(10-25(3,4)34-24)36-20-8-18(26)19(7-14(20)11-27)31-23-32-21(30-15-5-6-15)22-29-13-16(12-28)35(22)33-23/h7-8,13,15,17,34H,5-6,9-10H2,1-4H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 16.0n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142838
PNG
(US8940736, 415)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(F)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C26H30FN9O/c1-25(2)10-18(11-26(3,4)35(25)5)37-21-9-19(27)20(8-15(21)12-28)32-24-33-22(31-16-6-7-16)23-30-14-17(13-29)36(23)34-24/h8-9,14,16,18H,6-7,10-11H2,1-5H3,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 19.7n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142789
PNG
(US8940736, 132)
Show SMILES COCCNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H27ClN10O/c1-36-9-6-28-16-4-7-34(8-5-16)20-11-15(12-26)10-19(21(20)25)31-24-32-22(30-17-2-3-17)23-29-14-18(13-27)35(23)33-24/h10-11,14,16-17,28H,2-9H2,1H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20.9n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142786
PNG
(US8940736, 126)
Show SMILES FC(F)(F)CNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H22ClF3N10/c24-19-17(33-22-34-20(32-15-1-2-15)21-30-11-16(10-29)37(21)35-22)7-13(9-28)8-18(19)36-5-3-14(4-6-36)31-12-23(25,26)27/h7-8,11,14-15,31H,1-6,12H2,(H2,32,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20.9n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142844
PNG
(US8940736, 433)
Show SMILES Clc1cnc(nc1Nc1nc(NC2CC2)c2ncc([N+]#[C-])n2n1)C#N
Show InChI InChI=1S/C14H9ClN10/c1-17-10-6-19-13-12(20-7-2-3-7)23-14(24-25(10)13)22-11-8(15)5-18-9(4-16)21-11/h5-7H,2-3H2,(H2,18,20,21,22,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 23.1n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142789
PNG
(US8940736, 132)
Show SMILES COCCNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H27ClN10O/c1-36-9-6-28-16-4-7-34(8-5-16)20-11-15(12-26)10-19(21(20)25)31-24-32-22(30-17-2-3-17)23-29-14-18(13-27)35(23)33-24/h10-11,14,16-17,28H,2-9H2,1H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 24.9n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142838
PNG
(US8940736, 415)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(F)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc1C#N
Show InChI InChI=1S/C26H30FN9O/c1-25(2)10-18(11-26(3,4)35(25)5)37-21-9-19(27)20(8-15(21)12-28)32-24-33-22(31-16-6-7-16)23-30-14-17(13-29)36(23)34-24/h8-9,14,16,18H,6-7,10-11H2,1-5H3,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 25.5n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142786
PNG
(US8940736, 126)
Show SMILES FC(F)(F)CNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H22ClF3N10/c24-19-17(33-22-34-20(32-15-1-2-15)21-30-11-16(10-29)37(21)35-22)7-13(9-28)8-18(19)36-5-3-14(4-6-36)31-12-23(25,26)27/h7-8,11,14-15,31H,1-6,12H2,(H2,32,33,34,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 29.9n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142783
PNG
(US8940736, 115)
Show SMILES CC(C)NC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C24H27ClN10/c1-14(2)29-17-5-7-34(8-6-17)20-10-15(11-26)9-19(21(20)25)31-24-32-22(30-16-3-4-16)23-28-13-18(12-27)35(23)33-24/h9-10,13-14,16-17,29H,3-8H2,1-2H3,(H2,30,31,32,33)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 31.0n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142841
PNG
(US8940736, 420)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(OC2CC(C)(C)N(C)C(C)(C)C2)c(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C36H50N10O2/c1-33(2)15-25(16-34(3,4)44(33)9)47-28-14-29(48-26-17-35(5,6)45(10)36(7,8)18-26)27(13-22(28)19-37)41-32-42-30(40-23-11-12-23)31-39-21-24(20-38)46(31)43-32/h13-14,21,23,25-26H,11-12,15-18H2,1-10H3,(H2,40,41,42,43)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 46.6n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142841
PNG
(US8940736, 420)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Oc1cc(OC2CC(C)(C)N(C)C(C)(C)C2)c(cc1Nc1nc(NC2CC2)c2ncc(C#N)n2n1)C#N
Show InChI InChI=1S/C36H50N10O2/c1-33(2)15-25(16-34(3,4)44(33)9)47-28-14-29(48-26-17-35(5,6)45(10)36(7,8)18-26)27(13-22(28)19-37)41-32-42-30(40-23-11-12-23)31-39-21-24(20-38)46(31)43-32/h13-14,21,23,25-26H,11-12,15-18H2,1-10H3,(H2,40,41,42,43)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 60.1n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142801
PNG
(US8940736, 189)
Show SMILES CO[C@@H]1CN(CC[C@H]1NC(=O)OC)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C24H25ClN10O3/c1-37-19-12-34(6-5-16(19)31-24(36)38-2)18-8-13(9-26)7-17(20(18)25)30-23-32-21(29-14-3-4-14)22-28-11-15(10-27)35(22)33-23/h7-8,11,14,16,19H,3-6,12H2,1-2H3,(H,31,36)(H2,29,30,32,33)/t16-,19-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 61.2n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142823
PNG
(US8940736, 347)
Show SMILES [C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cccc(n3)C#N)nn12
Show InChI InChI=1S/C15H11N9/c1-17-12-8-18-14-13(20-9-5-6-9)22-15(23-24(12)14)21-11-4-2-3-10(7-16)19-11/h2-4,8-9H,5-6H2,(H2,19,20,21,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 81.6n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142788
PNG
(US8940736, 131)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)N(CC1CC1)CC1CC1)C#N
Show InChI InChI=1S/C29H33ClN10/c30-26-24(35-29-36-27(34-21-5-6-21)28-33-15-23(14-32)40(28)37-29)11-20(13-31)12-25(26)38-9-7-22(8-10-38)39(16-18-1-2-18)17-19-3-4-19/h11-12,15,18-19,21-22H,1-10,16-17H2,(H2,34,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 85.7n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142788
PNG
(US8940736, 131)
Show SMILES Clc1c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)cc(cc1N1CCC(CC1)N(CC1CC1)CC1CC1)C#N
Show InChI InChI=1S/C29H33ClN10/c30-26-24(35-29-36-27(34-21-5-6-21)28-33-15-23(14-32)40(28)37-29)11-20(13-31)12-25(26)38-9-7-22(8-10-38)39(16-18-1-2-18)17-19-3-4-19/h11-12,15,18-19,21-22H,1-10,16-17H2,(H2,34,35,36,37)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 91.6n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha'


(Homo sapiens (Human))		BDBM142787
PNG
(US8940736, 130)
Show SMILES FC(F)CNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H23ClF2N10/c24-20-17(7-13(9-27)8-18(20)35-5-3-14(4-6-35)29-12-19(25)26)32-23-33-21(31-15-1-2-15)22-30-11-16(10-28)36(22)34-23/h7-8,11,14-15,19,29H,1-6,12H2,(H2,31,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 154n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142823
PNG
(US8940736, 347)
Show SMILES [C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cccc(n3)C#N)nn12
Show InChI InChI=1S/C15H11N9/c1-17-12-8-18-14-13(20-9-5-6-9)22-15(23-24(12)14)21-11-4-2-3-10(7-16)19-11/h2-4,8-9H,5-6H2,(H2,19,20,21,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 174n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142787
PNG
(US8940736, 130)
Show SMILES FC(F)CNC1CCN(CC1)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N
Show InChI InChI=1S/C23H23ClF2N10/c24-20-17(7-13(9-27)8-18(20)35-5-3-14(4-6-35)29-12-19(25)26)32-23-33-21(31-15-1-2-15)22-30-11-16(10-28)36(22)34-23/h7-8,11,14-15,19,29H,1-6,12H2,(H2,31,32,33,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 178n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
Casein kinase II subunit alpha


(Homo sapiens (Human))		BDBM142801
PNG
(US8940736, 189)
Show SMILES CO[C@@H]1CN(CC[C@H]1NC(=O)OC)c1cc(cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl)C#N |r|
Show InChI InChI=1S/C24H25ClN10O3/c1-37-19-12-34(6-5-16(19)31-24(36)38-2)18-8-13(9-26)7-17(20(18)25)30-23-32-21(29-14-3-4-14)22-28-11-15(10-27)35(22)33-23/h7-8,11,14,16,19H,3-6,12H2,1-2H3,(H,31,36)(H2,29,30,32,33)/t16-,19-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 220n/an/an/an/a7.430



Bristol-Myers Squibb Company

US Patent


Assay Description
The effectiveness of compounds of the present invention as inhibitors of protein kinases can be readily tested by assays known to those skilled in th...

US Patent US8940736 (2015)


BindingDB Entry DOI: 10.7270/Q2QV3K72
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%