The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28284808 |
7 |
Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.![EBI](/images/logo_chembl.png) |
University of Paris |
27789138 |
355 |
Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.![EBI](/images/logo_chembl.png) |
Abbvie Bioresearch Center |
28109791 |
44 |
Identification of a selective inhibitor of transforming growth factorß-activated kinase 1 by biosensor-based screening of focused libraries.![EBI](/images/logo_chembl.png) |
Chugai Pharmaceutical |
27876318 |
38 |
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.![EBI](/images/logo_chembl.png) |
Gilead Sciences |
27527804 |
109 |
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK).![EBI](/images/logo_chembl.png) |
Teva Branded Pharmaceutical Products R & D |
27003761 |
120 |
Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
27117263 |
51 |
Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKC¿ inhibitors.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
26762835 |
342 |
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).![EBI](/images/logo_chembl.png) |
Icahn School of Medicine At Mount Sinai |
26318056 |
25 |
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.![EBI](/images/logo_chembl.png) |
Universit£ |
26318067 |
34 |
Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors.![EBI](/images/logo_chembl.png) |
Hanyang University |
26222319 |
192 |
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
25007344 |
73 |
Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorß (PDGF-Rß) guided by water thermodynamics.![EBI](/images/logo_chembl.png) |
Christian-Albrechts-University of Kiel |
26071372 |
89 |
Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.![EBI](/images/logo_chembl.png) |
Astellas Pharma |
25835317 |
63 |
Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer.![EBI](/images/logo_chembl.png) |
Sichuan University |
25369539 |
116 |
SAR156497, an exquisitely selective inhibitor of aurora kinases.![EBI](/images/logo_chembl.png) |
Sanofi |
25180654 |
29 |
Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.![EBI](/images/logo_chembl.png) |
University of Paris |
25000588 |
72 |
Discovery of selective and orally bioavailable protein kinase C¿ (PKC¿) inhibitors from a fragment hit.![EBI](/images/logo_chembl.png) |
Abbvie Bioresearch Center |
24980703 |
296 |
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
24139169 |
175 |
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
24904961 |
27 |
Synthesis and in vivo SAR study of indolin-2-one-based multi-targeted inhibitors as potential anticancer agents.![EBI](/images/logo_chembl.png) |
Qilu Pharmaceutical |
24819116 |
135 |
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expo![EBI](/images/logo_chembl.png) |
Pfizer |
24792811 |
19 |
Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity.![EBI](/images/logo_chembl.png) |
Nanjing University |
24780592 |
2 |
Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.![EBI](/images/logo_chembl.png) |
Roswell Park Cancer Institute |
24569110 |
11 |
Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk.![EBI](/images/logo_chembl.png) |
University of Zurich |
24432909 |
13 |
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.![EBI](/images/logo_chembl.png) |
Pfizer |
24479418 |
39 |
Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia.![EBI](/images/logo_chembl.png) |
Heinrich Heine Universit£T |
24328302 |
94 |
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.![EBI](/images/logo_chembl.png) |
Heinrich-Heine-Universit£T D£Sseldorf |
24157370 |
22 |
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.![EBI](/images/logo_chembl.png) |
Chugai Pharmaceutical |
24100158 |
148 |
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
23973211 |
145 |
Fragment-based discovery of focal adhesion kinase inhibitors.![EBI](/images/logo_chembl.png) |
Merck |
23937569 |
22 |
Selectivity data: assessment, predictions, concordance, and implications.![EBI](/images/logo_chembl.png) |
Eli Lilly |
23845217 |
30 |
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.![EBI](/images/logo_chembl.png) |
University of Paris |
23755884 |
23 |
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
23673215 |
19 |
Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity.![EBI](/images/logo_chembl.png) |
Nanjing University |
22819505 |
46 |
Discovery and characterization of novel allosteric FAK inhibitors.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
23414845 |
44 |
Structure-based discovery of cellular-active allosteric inhibitors of FAK.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
23394126 |
170 |
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).![EBI](/images/logo_chembl.png) |
Exelixis |
23249297 |
75 |
Trimeric hemibastadin congener from the marine sponge Ianthella basta.![EBI](/images/logo_chembl.png) |
Heinrich-Heine University |
23391364 |
78 |
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.![EBI](/images/logo_chembl.png) |
Nanjing University |
23294348 |
66 |
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.![EBI](/images/logo_chembl.png) |
Merck Serono |
23153798 |
46 |
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.![EBI](/images/logo_chembl.png) |
Pfizer |
22726925 |
216 |
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.![EBI](/images/logo_chembl.png) |
Cellzome |
24900538 |
27 |
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.![EBI](/images/logo_chembl.png) |
TBA |
22980219 |
55 |
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
22564207 |
44 |
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase.![EBI](/images/logo_chembl.png) |
Cephalon |
22439974 |
79 |
Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
22560627 |
70 |
2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.![EBI](/images/logo_chembl.png) |
Technische Universit£T Braunschweig |
22372864 |
25 |
Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.![EBI](/images/logo_chembl.png) |
Hanmi Research Center |
21353571 |
26 |
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.![EBI](/images/logo_chembl.png) |
Hanyang University |
20000469 |
179 |
Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.![EBI](/images/logo_chembl.png) |
Boehringer Ingelheim Pharmaceuticals |
19648005 |
41 |
Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.![EBI](/images/logo_chembl.png) |
Amgen |
18183025 |
12060 |
A quantitative analysis of kinase inhibitor selectivity.![EBI](/images/logo_chembl.png) |
Ambit Biosciences |
19610618 |
41 |
Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.![EBI](/images/logo_chembl.png) |
University of South Florida |
19320489 |
125 |
Discovery and development of aurora kinase inhibitors as anticancer agents.![EBI](/images/logo_chembl.png) |
Vertex Pharmaceuticals |
18077425 |
197 |
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.![EBI](/images/logo_chembl.png) |
Harvard Medical School |
17983756 |
55 |
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.![EBI](/images/logo_chembl.png) |
Osi Pharmaceuticals |
16451062 |
46 |
Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.![EBI](/images/logo_chembl.png) |
Astrazeneca |
22377675 |
44 |
Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.![EBI](/images/logo_chembl.png) |
Westf£Lische Wilhelms-Universit£T M£Nster |
22269278 |
50 |
Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.![EBI](/images/logo_chembl.png) |
Chugai Pharmaceutical |
22136433 |
67 |
7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.![EBI](/images/logo_chembl.png) |
Ludwig-Maximilians University of Munich |
22204902 |
9 |
Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.![EBI](/images/logo_chembl.png) |
Institute of The Sir Mortimer Jewish General Hospital |
22169263 |
73 |
Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.![EBI](/images/logo_chembl.png) |
Cephalon |
22014550 |
337 |
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).![EBI](/images/logo_chembl.png) |
Ansaris |
22003817 |
71 |
Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
21982797 |
128 |
9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp.![EBI](/images/logo_chembl.png) |
Peking University |
22014755 |
36 |
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.![EBI](/images/logo_chembl.png) |
Hanyang University |
22037378 |
31824 |
Comprehensive analysis of kinase inhibitor selectivity.![EBI](/images/logo_chembl.png) |
Ambit Biosciences |
21936542 |
143 |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.![EBI](/images/logo_chembl.png) |
Novartis Institute For Biomedical Research |
21741249 |
32 |
Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.![EBI](/images/logo_chembl.png) |
Heinrich Heine Universit£T |
19428251 |
38 |
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.![EBI](/images/logo_chembl.png) |
Pfizer |
21470862 |
110 |
NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
21391610 |
139 |
Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.![EBI](/images/logo_chembl.png) |
Vertex Pharmaceuticals |
21035334 |
55 |
Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.![EBI](/images/logo_chembl.png) |
Martin-Luther-University Halle-Wittenberg |
20965724 |
57 |
Identification of potent ITK inhibitors through focused compound library design including structural information.![EBI](/images/logo_chembl.png) |
Nycomed |
20873740 |
111 |
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
20832307 |
43 |
Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.![EBI](/images/logo_chembl.png) |
Hoffmann-La Roche |
20833055 |
44 |
Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
19654408 |
2521 |
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).![EBI](/images/logo_chembl.png) |
Ambit Biosciences |
19039322 |
50 |
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.![EBI](/images/logo_chembl.png) |
Center For Molecular Medicine of The Austrian Academy of Sciences |
20218623 |
68 |
Emerging targets in osteoporosis disease modification.![EBI](/images/logo_chembl.png) |
Amgen |
20141146 |
234 |
Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors.![EBI](/images/logo_chembl.png) |
Nerviano Medical Sciences |
19211246 |
320 |
N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.![EBI](/images/logo_chembl.png) |
4Sc |
19097792 |
24 |
Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.![EBI](/images/logo_chembl.png) |
Astrazeneca R&D Boston |
19053831 |
39 |
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.![EBI](/images/logo_chembl.png) |
Institute of General Genetics |
19035792 |
85 |
Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.![EBI](/images/logo_chembl.png) |
Glaxosmithkline |
18951788 |
61 |
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.![EBI](/images/logo_chembl.png) |
Pfizer |
18529047 |
156 |
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.![EBI](/images/logo_chembl.png) |
Eberhard-Karls University |
17395594 |
10 |
Cellular characterization of a novel focal adhesion kinase inhibitor.![EBI](/images/logo_chembl.png) |
University of Virginia |
17149885 |
20 |
Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor.![EBI](/images/logo_chembl.png) |
Eberhard-Karls University |
16524731 |
77 |
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.![EBI](/images/logo_chembl.png) |
Genomics Institute of The Novartis Research Foundation |
16458503 |
54 |
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.![EBI](/images/logo_chembl.png) |
Genomics Institute of The Novartis Research Foundation |
16366598 |
51 |
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.![EBI](/images/logo_chembl.png) |
Johnson & Johnson Pharmaceutical Research and Development |
16134929 |
22 |
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.![EBI](/images/logo_chembl.png) |
Bristol-Myers Squibb |
16111887 |
104 |
New dual inhibitors of EGFR and HER2 protein tyrosine kinases.![EBI](/images/logo_chembl.png) |
Bristol-Myers Squibb Pharmaceutical Research Institute |
15711537 |
653 |
A small molecule-kinase interaction map for clinical kinase inhibitors.![EBI](/images/logo_chembl.png) |
Ambit Biosciences |
15615512 |
21 |
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.![EBI](/images/logo_chembl.png) |
Bristol-Myers Squibb Pharmaceutical Research Institute |
14592495 |
60 |
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).![EBI](/images/logo_chembl.png) |
Bristol-Myers Squibb Pharmaceutical Research Institute |
31757666 |
314 |
Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors.![EBI](/images/logo_chembl.png) |
Merck |
27515719 |
8 |
Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK.![EBI](/images/logo_chembl.png) |
Anhui Agricultural University |
31009559 |
50 |
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
28528303 |
171 |
Discovery of a potent dual ALK and EGFR T790M inhibitor.![EBI](/images/logo_chembl.png) |
Harvard Medical School |
32292541 |
9 |
Bifunctional Pyrimidines as Modulators of Focal Adhesion Kinase.![EBI](/images/logo_chembl.png) |
Usona Institute |
31693351 |
473 |
Discovery of 4![EBI](/images/logo_chembl.png) |
TBA |
31129452 |
10 |
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.![EBI](/images/logo_chembl.png) |
Peking University Health Science Center |
30978560 |
7 |
Structure-based modification of carbonyl-diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells.![EBI](/images/logo_chembl.png) |
The First Affiliated Hospital of Dalian Medical University |
30763817 |
39 |
Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach.![EBI](/images/logo_chembl.png) |
University of Naples Federico Ii |
30987781 |
88 |
Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.![EBI](/images/logo_chembl.png) |
Southeast University |
30384048 |
365 |
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.![EBI](/images/logo_chembl.png) |
University of Florida |
30340900 |
37 |
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.![EBI](/images/logo_chembl.png) |
Korea University |
31526603 |
379 |
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.![EBI](/images/logo_chembl.png) |
Takeda Pharmaceutical |
31550660 |
40 |
Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.![EBI](/images/logo_chembl.png) |
Shenyang Pharmaceutical University |
26505898 |
123 |
Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.![EBI](/images/logo_chembl.png) |
Novartis Institutes For Biomedical Research |
21889345 |
11 |
Synthesis, biological evaluation and molecular docking studies of 1,3,4-thiadiazole derivatives containing 1,4-benzodioxan as potential antitumor agents.![EBI](/images/logo_chembl.png) |
Nanjing University |
19271717 |
96 |
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.![EBI](/images/logo_chembl.png) |
Heinrich-Heine-Universitat |
18494522 |
244 |
Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.![EBI](/images/logo_chembl.png) |
Heinrich-Heine-Universit£T |
30480444 |
85 |
Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.![EBI](/images/logo_chembl.png) |
Sichuan University/Collaborative Innovation Center of Biotherapy |
29578342 |
35 |
Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors.![EBI](/images/logo_chembl.png) |
Yunnan University |
30082069 |
359 |
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.![EBI](/images/logo_chembl.png) |
Vertex Pharmaceuticals |
29945794 |
193 |
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.![EBI](/images/logo_chembl.png) |
Vertex Pharmaceuticals |
29549836 |
47 |
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors.![EBI](/images/logo_chembl.png) |
Universit£ |
29102081 |
7 |
Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines.![EBI](/images/logo_chembl.png) |
Dalian Medical University |
28576633 |
10 |
Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity.![EBI](/images/logo_chembl.png) |
Dalian Medical University |
28259529 |
31 |
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.![EBI](/images/logo_chembl.png) |
The Ohio State University |
28431353 |
26 |
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.![EBI](/images/logo_chembl.png) |
Wuhan University of Technology |
28412530 |
2 |
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.![EBI](/images/logo_chembl.png) |
Punjabi University |
28363444 |
10 |
Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors.![EBI](/images/logo_chembl.png) |
Nanjing University |
18821258 |
11 |
Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors.![BDB](/images/logo_bindingdb.png) |
Centre D'Etudes Et De Recherche Sur Le MÉDicament De Normandie |
19549076 |
26 |
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes.![BDB](/images/logo_bindingdb.png) |
Universita Degli Studi Di Firenze |
1982626 |
30 |
Neurochemical profile of eltoprazine.![BDB](/images/logo_bindingdb.png) |
Duphar |