223 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28051871	100	Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.	Instituto De Qu£Mica M£Dica (Iqm-Csic)
27876250	60	Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH	Jagiellonian University Medical College
27919657	24	Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor.	The Scripps Research Institute
27810243	87	Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.	Astrazeneca
27994732	56	Development of	Tokyo Medical and Dental University
27665178	42	Development of 6-arylcoumarins as nonsteroidal progesterone antagonists. Structure-activity relationships and fluorescence properties.	Ochanomizu University
27326332	66	Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.	Bristol-Myers Squibb
26988801	55	Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.	Jagiellonian University Medical College
26897089	39	Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.	Vitae Pharmaceuticals
26683992	25	2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.	Eli Lilly
26407012	80	Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.	Astrazeneca
26218343	76	Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.	Eli Lilly
25978072	53	Synthesis and Biological Evaluation of Cyclopentaquinoline Derivatives as Nonsteroidal Glucocorticoid Receptor Antagonists.	TBA
25879485	60	Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.	Seragon Pharmaceuticals
25941555	75	Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.	Merck Research Laboratories
25706100	65	2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.	TBA
25599836	14	Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.	Boehringer Ingelheim (Canada)
25121964	18	3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration.	Novartis Institutes For Biomedical Research
24980053	153	Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.	Bristol-Myers Squibb
25516791	177	Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.	Boehringer Ingelheim Pharmaceuticals
25305688	41	Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.	Phenex Pharmaceuticals
24755427	107	The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.	Astrazeneca
24745969	36	Identification of the first potent, selective and bioavailable PPARa antagonist.	Inception Sciences
24738581	81	Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.	Pfizer
24630411	38	Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.	Merck Research Laboratories
24656565	73	Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.	Boehringer Ingelheim Pharmaceuticals
24506830	91	Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.	Boehringer Ingelheim Pharmaceuticals
24446728	30	Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.	Eli Lilly
24239189	85	Substituted phenyl as a steroid A-ring mimetic: providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands.	Boehringer Ingelheim Pharmaceuticals
24215891	107	Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.	Boehringer Ingelheim Pharmaceuticals
24157365	23	Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.	Pfizer
24011644	81	Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.	Bristol-Myers Squibb
23953070	146	Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.	Ironwood Pharmaceuticals
23916594	92	Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.	Bristol-Myers Squibb
23958516	61	Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.	Takeda Pharmaceutical
23777778	101	Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.	Merck Research Laboratories
23582449	20	Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.	Institute of Organic Synthesis
23466604	36	Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.	Universit£
23403082	28	Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.	Broad Institute of Mit and Harvard
23199485	34	Macrolactonolides: a novel class of anti-inflammatory compounds.	Glaxosmithkline
17616395	43	Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics.	Glaxosmithkline
15999989	7	Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an"agreement docking" method.	Glaxosmithkline
22917520	45	Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents.	Zydus Research Centre
22280402	12	"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.	Trinity College
21257309	98	Discovery of a potent series of non-steroidal nona-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity.	Glaxosmithkline
21129964	28	Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.	Merck Research Laboratories
20812681	24	Synthesis and biochemical characterization of a series of 17a-perfluoroalkylated estradiols as selective ligands for estrogen receptora.	Charles University In Prague
20727743	64	Discovery of quinolines as selective glucocorticoid receptor agonists.	Bayer Schering Pharma
20469868	176	Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.	Glaxosmithkline
20202837	51	The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.	Medicines Research Centre
19592247	26	Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.	Glaxosmithkline
18952422	5	The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.	Glaxosmithkline
18038970	122	Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.	Glaxosmithkline
16821781	106	Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series.	Glaxosmithkline
23131342	55	Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.	Corcept Therapeutics
23079530	27	Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.	Pfizer
22866979	19	Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.	Pfizer
22079253	16	Discovery of selective glucocorticoid receptor modulator MK-5932.	Merck Research Laboratories
22465636	125	Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).	Merck Research Laboratories
21073190	135	Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists.	Bristol-Myers Squibb
20875743	90	Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela	Pfizer
21158453	12	Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators.	Trinity College Dublin
20735001	145	Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.	Boehringer Ingelheim Pharmaceuticals
20684563	176	Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.	H. Lundbeck
20672822	108	Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.	Pfizer
20672820	92	Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.	Pfizer
20638844	25	1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.	Pfizer
20510622	142	Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.	Chinese Academy of Sciences
20427184	36	5-Functionalized indazoles as glucocorticoid receptor agonists.	Amri
20355713	3	Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.	University of Illinois
20334371	20	Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators.	Trinity College
19863083	25	The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.	Wyeth Research
20047280	174	Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.	Bristol-Myers Squibb
19217285	32	Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.	Johnson and Johnson Pharmaceutical Research and Development
19610652	26	Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.	University of Texas Southwestern Medical Center
19321341	101	Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators.	Bristol-Myers Squibb
18722119	55	1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.	Wyeth Research
18504132	51	7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.	Wyeth Research
18412397	3	Alkaloids from the Australian rainforest tree Ochrosia moorei.	Griffith University
16643060	3	Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor.	Merlion Pharmaceuticals
18490170	3	High-throughput evaluation of relative cell permeability between peptoids and peptides.	University of Texas Southwestern Medical Center
18513967	103	Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.	Ligand Pharmaceuticals
18032610	4	Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.	Ligand Pharmaceuticals
18318463	53	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).	Wyeth Research
18226897	128	1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity.	Corcept Therapeutics
17855092	18	Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.	Rti International
17822897	69	2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists.	Corcept Therapeutics
17258455	22	Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist.	Johnson & Johnson Pharmaceutical Research & Development
17692519	108	Identification of dissociated non-steroidal glucocorticoid receptor agonists.	Boehringer Ingelheim Pharmaceuticals
17317167	50	Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists.	Johnson and Johnson Pharmaceutical Research and Development
17118655	73	Alpha-methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands.	Boehringer Ingelheim Pharmaceuticals
17169557	20	Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists.	Johnson and Johnson Pharmaceutical Research and Development
17070047	36	Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.	Abbott Laboratories
16987661	38	Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists.	Abbott Laboratories
17181172	94	Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.	Boehringer Ingelheim Pharmaceuticals
16250653	22	Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.	Universit£
16112571	93	Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand.	Boehringer Ingelheim Pharmaceuticals
15456242	30	11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.	The Pennsylvania State University
15293993	172	Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.	Abbott Laboratories
15261266	39	Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.	Abbott Laboratories
15261265	38	Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator-statin hybrids.	Abbott Laboratories
12238914	48	6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.	Women'S Health Research Institute
12036351	31	Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists.	Pfizer
10212133	93	5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.	Ligand Pharmaceuticals
9667968	18	Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.	Ligand Pharmaceuticals
8627601	169	Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.	Ligand Pharmaceuticals
2061919	5	Dexamethasone 21-(beta-isothiocyanatoethyl) thioether: a new affinity label for glucocorticoid receptors.	Niddk
15080982	122	Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.	Abbott Laboratories
12657271	71	Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.	Wyeth Research
12824023	6	An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.	Abbott Laboratories
12781198	108	Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.	Ligand Pharmaceuticals
12781197	59	Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.	Ligand Pharmaceuticals
10743938	103	Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.	Ligand Pharmaceuticals
9873735	111	5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.	Ligand Pharmaceuticals
22260770	12	Synthesis and antihormonal properties of novel 11ß-benzoxazole-substituted steroids.	Research Triangle Institute
22197391	44	Steroidal C-21 heteroaryl thioethers (Part 2): discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids).	Merck Research Laboratories
22074142	89	Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.	Takeda Pharmaceutical
21944381	42	Steroidal C-21 mercapto derivatives as dissociated steroids: discovery of an inhaled dissociated steroid.	Merck Research Laboratories
21963986	162	Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.	Boehringer Ingelheim Pharmaceuticals
21899328	244	Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791	Bristol-Myers Squibb
21916484	41	6-arylcoumarins as novel nonsteroidal type progesterone antagonists: an example with receptor-binding-dependent fluorescence.	Ochanomizu University
21880489	15	Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.	Pfizer
21786805	130	Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.	Vitae Pharmaceuticals
21324689	74	Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.	Ligand Pharmaceuticals
21349714	118	Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation.	Ligand Pharmaceuticals
21316964	108	Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.	Ligand Pharmaceuticals
24900294	72	Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids	TBA
19364854	24	Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.	Monash University (Parkville Campus)
21115247	64	Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.	Ligand Pharmaceuticals
20864344	110	Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.	Vitae Pharmaceuticals
20813948	63	Spiroindolones, a potent compound class for the treatment of malaria.	Swiss Tropical and Public Health Institute
20638278	145	Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.	Phenex Pharmaceuticals
20465278	27	Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).	Amgen
20462217	17	Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.	Pfizer
20430618	21	Optimisation of a pyrazole series of progesterone antagonists; Part 1.	Pfizer
20408553	27	Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.	Pfizer
19595590	49	Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.	Glaxosmithkline
19606870	53	Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).	Merck Research Laboratories
19239259	66	Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.	Pfizer
19019676	94	Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.	Medicines Research Centre
18691892	52	Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.	Merck Research Laboratories
18553958	28	A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.	Ligand Pharmaceuticals
18334300	3	Expanding the repertoire of small molecule transcriptional activation domains.	University of Michigan
18038968	26	(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.	Eli Lilly
17703938	55	Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.	Ligand Pharmaceuticals
17681796	21	5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist.	Wyeth Research
17587578	45	Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.	Argenta Discovery
17583952	5	Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum.	Griffith University
17553679	148	5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.	Ligand Pharmaceuticals
16759088	38	The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.	University of Innsbruck
16263276	2	A concise asymmetric route for the synthesis of a novel class of glucocorticoid mimetics containing a trifluoromethyl-substituted alcohol.	Boehringer Ingelheim Pharmaceuticals
15911283	62	Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.	Merck Research Laboratories
15808489	60	Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.	Merck Research Laboratories
15380227	66	Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands.	University of California San Francisco
15261264	47	Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.	Abbott Laboratories
15081010	66	Discovery of novel nonsteroidal glucocorticoid receptor modulators.	Abbott Laboratories
15026058	61	Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.	Abbott Laboratories
12954062	140	5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.	Ligand Pharmaceuticals
12657272	47	Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists.	Wyeth Research
12620078	132	Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.	Abbott Laboratories
11728194	98	Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.	Abbott Laboratories
11520196	81	Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.	Abbott Laboratories
11170650	4	Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.	Glaxo Wellcome Research and Development
30596500	182	Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.	Pharmaron-Beijing
10633034	5	Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.	Glaxo Wellcome Research and Development
31274313	95	Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).	Oric Pharmaceuticals
31940200	62	Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.	Genomics Institute of The Novartis Research Foundation (Gnf)
10230628	95	Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.	Ligand Pharmaceuticals
31185168	144	Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.	Rti International
9871534	95	New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.	Ligand Pharmaceuticals
9784110	81	5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.	Ligand Pharmaceuticals
31104995	22	Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.	Merck
30929949	2	Profiling withanolide A for therapeutic targets in neurodegenerative diseases.	University of Basel
9464360	145	5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.	Ligand Pharmaceuticals
30594433	90	Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies.	Inception Sciences
30384041	18	Discovery of a subnanomolar and selective spirocyclic agonist of the glucocorticoid receptor.	European Institute of Chemistry and Biology (Iecb)
30359818	2	Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease.	Guangzhou University of Chinese Medicine
31729873	43	Structure-Based and Property-Driven Optimization of	Global Discovery Chemistry
31188592	39	Why Some Targets Benefit from beyond Rule of Five Drugs.	Boston University
26568144	8	Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia.	Eli Lilly
26546213	56	1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.	Corcept Therapeutics
30144697	66	Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-? agonists (SERBAs).	Marquette University
29424542	138	Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.	Astrazeneca
29741897	62	Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.	TBA
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