The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27914948 |
36 |
Triazolopyridine ethers as potent, orally active mGlu |
Bristol-Myers Squibb |
| 27908761 |
55 |
Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. |
Eli Lilly |
| 27836401 |
57 |
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. |
Eli Lilly |
| 27579727 |
33 |
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM). |
Janssen Pharmaceutica |
| 26985321 |
54 |
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI. |
Merck Research Laboratories |
| 26814576 |
146 |
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. |
University of Copenhagen |
| 26810316 |
29 |
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis. |
Merck Research Laboratories |
| 26684851 |
86 |
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia. |
Janssen Pharmaceutica |
| 26475522 |
81 |
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators. |
Vanderbilt University Medical Center |
| 26313429 |
155 |
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective |
Eli Lilly |
| 26231155 |
53 |
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. |
Massachusetts General Hospital |
| 25958247 |
22 |
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers. |
Univ. Rouen |
| 25699154 |
4 |
Allosteric modulators: an emerging concept in drug discovery. |
Therachem Research Medilab (India) |
| 25683622 |
86 |
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). |
Janssen Pharmaceutica |
| 25032784 |
33 |
Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor. |
Janssen-Cilag |
| 24914612 |
36 |
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). |
Vanderbilt University Medical Center |
| 24794112 |
50 |
Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs. |
Vanderbilt University Medical Center |
| 24735492 |
98 |
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence. |
Sanford-Burnham Medical Research Institute |
| 23947773 |
79 |
Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor. |
Janssen Pharmaceutica |
| 23718281 |
7 |
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). |
Vanderbilt University Medical Center |
| 23675965 |
64 |
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. |
Eli Lilly |
| 21232953 |
29 |
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones. |
Janssen-Cilag |
| 20005096 |
112 |
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2. |
Glaxosmithkline |
| 19932615 |
17 |
Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor. |
Janssen-Cilag |
| 22992024 |
21 |
Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging. |
Janssen-Cilag |
| 22607673 |
34 |
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. |
Vanderbilt University Medical Center |
| 23072213 |
32 |
Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
Janssen-Cilag |
| 23009245 |
53 |
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence. |
Sanford-Burnham Medical Research Institute |
| 22318160 |
12 |
Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo. |
Massachusetts General Hospital |
| 22352782 |
17 |
Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor. |
Janssen-Cilag |
| 22981332 |
58 |
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. |
Vanderbilt University Medical Center |
| 22148748 |
23 |
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. |
Vanderbilt University Medical Center |
| 22364337 |
38 |
Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. |
Janssen-Cilag |
| 21207959 |
69 |
Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. |
National Institute of Mental Health |
| 21155570 |
16 |
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. |
Sanford-Burnham Medical Research Institute |
| 20218620 |
81 |
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. |
Universite Paris Descartes |
| 19042134 |
30 |
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. |
Universit£ |
| 18578478 |
60 |
Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. |
Universite Blaise Pascal |
| 18578477 |
77 |
Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. |
Universite Blaise Pascal |
| 18374569 |
65 |
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. |
F. Hoffmann-La Roche |
| 18348906 |
5 |
Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist. |
Taisho Pharmaceutical |
| 18338843 |
57 |
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid. |
Universit£ |
| 18096387 |
31 |
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. |
F. Hoffmann-La Roche |
| 17489573 |
16 |
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain. |
Eli Lilly |
| 17725337 |
40 |
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs. |
Universit£ |
| 17350267 |
48 |
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. |
Universit£ |
| 16213710 |
32 |
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. |
Universit£ |
| 16078848 |
6 |
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist. |
Eli Lilly |
| 12109902 |
15 |
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. |
Parc Club Orsay Universit£ |
| 10893301 |
270 |
Ligands for glutamate receptors: design and therapeutic prospects. |
The Royal Danish School of Pharmacy |
| 9572889 |
39 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. |
Georgetown University Medical Center |
| 9357538 |
38 |
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors. |
Royal Danish School of Pharmacy |
| 8759641 |
48 |
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. |
Royal Danish School of Pharmacy |
| 7738999 |
88 |
Metabotropic glutamate receptors: novel targets for drug development. |
Cns Research |
| 11720869 |
9 |
Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors. |
Universit£ |
| 9871513 |
1 |
Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation. |
Georgetown University Medical Center |
| 9873471 |
111 |
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. |
Eli Lilly |
| 21688779 |
84 |
Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. |
Lundbeck Research Usa |
| 19443219 |
39 |
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. |
Vanderbilt University Medical Center |
| 21366332 |
60 |
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis. |
Pfizer |
| 24900255 |
19 |
Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK Profile |
TBA |
| 20971004 |
126 |
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. |
F. Hoffmann-La Roche |
| 21105727 |
10 |
Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. |
Domain Therapeutics |
| 21036612 |
10 |
1,2,3-triazolyl amino acids as AMPA receptor ligands. |
The University of Adelaide |
| 20638290 |
9 |
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. |
The University of Adelaide |
| 20409708 |
65 |
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts. |
Merck Research Laboratories |
| 19931453 |
59 |
Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity. |
Novartis Institutes For Biomedical Research |
| 19692242 |
30 |
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders. |
Tsukuba Research Institute |
| 19674894 |
34 |
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. |
Tsukuba Research Institute |
| | 10 |
Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA) |
TBA |
| 19537763 |
24 |
Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. |
Vanderbilt University Medical Center |
| 19328692 |
47 |
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization. |
Pfizer |
| 18812259 |
21 |
3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators. |
Pfizer |
| 17964783 |
39 |
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1. |
F. Hoffmann-La Roche |
| 17571866 |
49 |
Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography. |
National Institute of Mental Health |
| 17376693 |
36 |
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors. |
The Danish University of Pharmaceutical Sciences |
| 17228865 |
30 |
Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors. |
Eli Lilly |
| 16828551 |
12 |
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
Faust Pharmaceuticals |
| 16809035 |
15 |
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists. |
Abbott Laboratories |
| 16392801 |
8 |
Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3. |
The Danish University of Pharmaceutical Sciences |
| 16190758 |
30 |
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. |
Università |
| 16005222 |
26 |
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia. |
Merck Research Laboratories |
| 15887967 |
24 |
Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. |
Eli Lilly |
| 15745798 |
25 |
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators. |
Merck Research Laboratories |
| 15501058 |
23 |
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators. |
Merck Research Laboratories |
| 15454221 |
19 |
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones. |
Merck Research Laboratories |
| 15317467 |
105 |
Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. |
Taisho Pharmaceutical |
| 15149652 |
34 |
SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide. |
Eli Lilly |
| 14711315 |
72 |
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. |
Eli Lilly |
| 12852748 |
4 |
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. |
Eli Lilly |
| 12825948 |
13 |
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids. |
Università |
| 12213064 |
33 |
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid. |
The Royal Danish School of Pharmacy |
| 11831912 |
43 |
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. |
The Royal Danish School of Pharmacy |
| 11123999 |
42 |
Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. |
Taisho Pharmaceutical |
| 10888329 |
22 |
Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. |
Università |
| 10465539 |
14 |
Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists. |
F. Hoffmann-La Roche |
| 10229625 |
16 |
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
Parc Club Orsay Université |
| 10090786 |
33 |
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors |
Eli Lilly |
| 9873392 |
6 |
Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist. |
Università |
| 9873391 |
15 |
Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid. |
Royal Danish School of Pharmacy |
| 9871538 |
22 |
(2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist. |
Eli Lilly |
| 9464367 |
24 |
2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. |
Eli Lilly |
| 9464366 |
30 |
2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution. |
Eli Lilly |
| 9301676 |
14 |
Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
Université |
| 8709120 |
17 |
(S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. |
Università |
| 8667369 |
121 |
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. |
Università |
| 7562903 |
10 |
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. |
Università |
| 29350927 |
102 |
Synthesis and Pharmacological Characterization of C4 |
TBA |
| 26010139 |
34 |
Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety. |
Tehran University of Medical Sciences |
| 24636345 |
25 |
Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors. |
Birla Institute of Technology |
| 17480064 |
53 |
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). |
Pfizer |
| 16451048 |
7 |
Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. |
Sunesis |
| 16376544 |
10 |
The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors. |
Santhera Pharmaceuticals |
| 8171040 |
10 |
L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. |
Merck Research Laboratories |
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