Found 196 hits with Last Name = 'dellureficio' and Initial = 'jp' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021345
![PNG](/data/jpeg/tenK5002/BindingDB_50021345.png) (CHEMBL3287928)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nn(cc1Sc1ccc(Cl)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H16ClFN2O2S2/c1-30(27,28)20-12-2-15(3-13-20)22-21(29-19-10-4-16(23)5-11-19)14-26(25-22)18-8-6-17(24)7-9-18/h2-14H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 637 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021331
![PNG](/data/jpeg/tenK5002/BindingDB_50021331.png) (CHEMBL3287930)Show SMILES CC(C)(O)c1cnc(cn1)-c1nn(cc1Sc1ccc(Cl)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H18ClFN4OS/c1-22(2,29)20-12-25-18(11-26-20)21-19(30-17-9-3-14(23)4-10-17)13-28(27-21)16-7-5-15(24)6-8-16/h3-13,29H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50350538
![PNG](/data/jpeg/tenK5035/BindingDB_50350538.png) (CHEMBL1812717)Show SMILES CC(C)(O)c1ccc(cn1)-c1nc(oc1Sc1ccc(Cl)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H17ClFN3O2S/c1-22(2,28)17-9-5-14(11-25-17)19-21(30-18-10-6-15(23)12-26-18)29-20(27-19)13-3-7-16(24)8-4-13/h3-12,28H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021346
![PNG](/data/jpeg/tenK5002/BindingDB_50021346.png) (CHEMBL3287926)Show InChI InChI=1S/C17H13ClN2O2S/c18-12-2-4-13(5-3-12)23-16-10-19-20-17(16)11-1-6-14-15(9-11)22-8-7-21-14/h1-6,9-10H,7-8H2,(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021329
![PNG](/data/jpeg/tenK5002/BindingDB_50021329.png) (CHEMBL3287932)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc(oc1Sc1ccc(Cl)cn1)-c1ccc(F)cc1 Show InChI InChI=1S/C21H14ClFN2O3S2/c1-30(26,27)17-9-4-13(5-10-17)19-21(29-18-11-6-15(22)12-24-18)28-20(25-19)14-2-7-16(23)8-3-14/h2-12H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021344
![PNG](/data/jpeg/tenK5002/BindingDB_50021344.png) (CHEMBL3287929)Show SMILES Clc1ccc(Sc2cn(nc2-c2ccc(cc2)-c2ncon2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H14ClN5OS/c23-17-7-9-19(10-8-17)30-20-13-28(18-2-1-11-24-12-18)26-21(20)15-3-5-16(6-4-15)22-25-14-29-27-22/h1-14H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021334
![PNG](/data/jpeg/tenK5002/BindingDB_50021334.png) (CHEMBL3287931)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc(oc1Sc1ccc(Cl)cc1)-c1ccccc1 Show InChI InChI=1S/C22H16ClNO3S2/c1-29(25,26)19-13-7-15(8-14-19)20-22(28-18-11-9-17(23)10-12-18)27-21(24-20)16-5-3-2-4-6-16/h2-14H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50021330
![PNG](/data/jpeg/tenK5002/BindingDB_50021330.png) (CHEMBL3287927)Show SMILES Clc1ccc(Sc2cn(nc2-c2ccc3OCCOc3c2)-c2ccccc2)cc1 Show InChI InChI=1S/C23H17ClN2O2S/c24-17-7-9-19(10-8-17)29-22-15-26(18-4-2-1-3-5-18)25-23(22)16-6-11-20-21(14-16)28-13-12-27-20/h1-11,14-15H,12-13H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [35S]MK-499 from human ERG |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50329956
![PNG](/data/jpeg/tenK5032/BindingDB_50329956.png) (((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)c1ncnn1C |r| Show InChI InChI=1S/C35H44ClF2N5O/c1-21-14-24-27(16-29(21)36)35(17-28(24)34(5,6)32-39-20-40-41(32)7)10-12-42(13-11-35)31(44)26-19-43(33(2,3)4)18-25(26)23-9-8-22(37)15-30(23)38/h8-9,14-16,20,25-26,28H,10-13,17-19H2,1-7H3/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human MC4 receptor |
Bioorg Med Chem Lett 20: 6524-32 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.049 BindingDB Entry DOI: 10.7270/Q24M94SF |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50329959
![PNG](/data/jpeg/tenK5032/BindingDB_50329959.png) ((6-chloro-5-methyl-3-(2-(1-methyl-1H-1,2,4-triazol...)Show SMILES CN(C1C[C@H]([C@@H](C1)c1ccc(F)cc1F)C(=O)N1CCC2(C[C@@H](c3cc(C)c(Cl)cc23)C(C)(C)c2ncnn2C)CC1)C1CCOCC1 |r| Show InChI InChI=1S/C38H48ClF2N5O2/c1-23-16-30-31(20-33(23)39)38(21-32(30)37(2,3)36-42-22-43-45(36)5)10-12-46(13-11-38)35(47)29-19-26(44(4)25-8-14-48-15-9-25)18-28(29)27-7-6-24(40)17-34(27)41/h6-7,16-17,20,22,25-26,28-29,32H,8-15,18-19,21H2,1-5H3/t26?,28-,29+,32-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human MC4 receptor |
Bioorg Med Chem Lett 20: 6524-32 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.049 BindingDB Entry DOI: 10.7270/Q24M94SF |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348579
![PNG](/data/jpeg/tenK5034/BindingDB_50348579.png) (CHEMBL1801215)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CC[C@@H](O)C1 |r| Show InChI InChI=1S/C37H48ClF2N3O3/c1-22-15-26-29(17-31(22)38)37(18-30(26)36(5,6)34(46)42-12-9-24(44)19-42)10-13-41(14-11-37)33(45)28-21-43(35(2,3)4)20-27(28)25-8-7-23(39)16-32(25)40/h7-8,15-17,24,27-28,30,44H,9-14,18-21H2,1-6H3/t24-,27+,28-,30+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348554
![PNG](/data/jpeg/tenK5034/BindingDB_50348554.png) (CHEMBL1801095)Show SMILES CN(C)C(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C35H46ClF2N3O2/c1-21-15-24-27(17-29(21)36)35(18-28(24)34(5,6)32(43)39(7)8)11-13-40(14-12-35)31(42)26-20-41(33(2,3)4)19-25(26)23-10-9-22(37)16-30(23)38/h9-10,15-17,25-26,28H,11-14,18-20H2,1-8H3/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50329958
![PNG](/data/jpeg/tenK5032/BindingDB_50329958.png) ((6-chloro-5-methyl-3-(2-(1-methyl-1H-1,2,4-triazol...)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)c1ncnn1C |r| Show InChI InChI=1S/C36H44ClF2N5O2/c1-22-15-26-29(17-31(22)37)36(18-30(26)35(2,3)34-40-21-41-42(34)4)9-11-43(12-10-36)33(45)28-20-44(24-7-13-46-14-8-24)19-27(28)25-6-5-23(38)16-32(25)39/h5-6,15-17,21,24,27-28,30H,7-14,18-20H2,1-4H3/t27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human MC4 receptor |
Bioorg Med Chem Lett 20: 6524-32 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.049 BindingDB Entry DOI: 10.7270/Q24M94SF |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348574
![PNG](/data/jpeg/tenK5034/BindingDB_50348574.png) (CHEMBL1801146)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C37H48ClF2N3O3/c1-23-17-26-29(19-31(23)38)37(20-30(26)36(5,6)34(45)42-13-15-46-16-14-42)9-11-41(12-10-37)33(44)28-22-43(35(2,3)4)21-27(28)25-8-7-24(39)18-32(25)40/h7-8,17-19,27-28,30H,9-16,20-22H2,1-6H3/t27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348580
![PNG](/data/jpeg/tenK5034/BindingDB_50348580.png) (CHEMBL1801216)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CC[C@H](O)C1 |r| Show InChI InChI=1S/C37H48ClF2N3O3/c1-22-15-26-29(17-31(22)38)37(18-30(26)36(5,6)34(46)42-12-9-24(44)19-42)10-13-41(14-11-37)33(45)28-21-43(35(2,3)4)20-27(28)25-8-7-23(39)16-32(25)40/h7-8,15-17,24,27-28,30,44H,9-14,18-21H2,1-6H3/t24-,27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323446
![PNG](/data/jpeg/tenK5032/BindingDB_50323446.png) (2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophe...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C#N |r| Show InChI InChI=1S/C32H38ClF2N3O2/c1-19-13-22-25(15-26(19)33)32(40-28(22)31(5,6)18-36)9-11-37(12-10-32)29(39)24-17-38(30(2,3)4)16-23(24)21-8-7-20(34)14-27(21)35/h7-8,13-15,23-24,28H,9-12,16-17H2,1-6H3/t23-,24+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323456
![PNG](/data/jpeg/tenK5032/BindingDB_50323456.png) ((S)-(6-chloro-5-methyl-3-(2-morpholinopropan-2-yl)...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)N1CCOCC1 |r| Show InChI InChI=1S/C36H46ClF2N3O4/c1-23-18-27-30(20-31(23)37)36(46-33(27)35(2,3)42-12-16-45-17-13-42)8-10-40(11-9-36)34(43)29-22-41(25-6-14-44-15-7-25)21-28(29)26-5-4-24(38)19-32(26)39/h4-5,18-20,25,28-29,33H,6-17,21-22H2,1-3H3/t28-,29+,33-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348572
![PNG](/data/jpeg/tenK5034/BindingDB_50348572.png) (CHEMBL1801144)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CCC1 |r| Show InChI InChI=1S/C36H46ClF2N3O2/c1-22-16-25-28(18-30(22)37)36(19-29(25)35(5,6)33(44)41-12-7-13-41)10-14-40(15-11-36)32(43)27-21-42(34(2,3)4)20-26(27)24-9-8-23(38)17-31(24)39/h8-9,16-18,26-27,29H,7,10-15,19-21H2,1-6H3/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348581
![PNG](/data/jpeg/tenK5034/BindingDB_50348581.png) (CHEMBL1801217)Show SMILES CO[C@@H]1CCN(C1)C(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C38H50ClF2N3O3/c1-23-16-27-30(18-32(23)39)38(19-31(27)37(5,6)35(46)43-13-10-25(20-43)47-7)11-14-42(15-12-38)34(45)29-22-44(36(2,3)4)21-28(29)26-9-8-24(40)17-33(26)41/h8-9,16-18,25,28-29,31H,10-15,19-22H2,1-7H3/t25-,28+,29-,31+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348578
![PNG](/data/jpeg/tenK5034/BindingDB_50348578.png) (CHEMBL1801150)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CC[C@H](F)C1 |r| Show InChI InChI=1S/C37H47ClF3N3O2/c1-22-15-26-29(17-31(22)38)37(18-30(26)36(5,6)34(46)43-12-9-24(40)19-43)10-13-42(14-11-37)33(45)28-21-44(35(2,3)4)20-27(28)25-8-7-23(39)16-32(25)41/h7-8,15-17,24,27-28,30H,9-14,18-21H2,1-6H3/t24-,27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323458
![PNG](/data/jpeg/tenK5032/BindingDB_50323458.png) ((S)-(6-chloro-3-(2-((S)-3-hydroxypyrrolidin-1-yl)p...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)N1CC[C@H](O)C1 |r| Show InChI InChI=1S/C36H46ClF2N3O4/c1-22-16-27-30(18-31(22)37)36(46-33(27)35(2,3)42-11-6-25(43)19-42)9-12-40(13-10-36)34(44)29-21-41(24-7-14-45-15-8-24)20-28(29)26-5-4-23(38)17-32(26)39/h4-5,16-18,24-25,28-29,33,43H,6-15,19-21H2,1-3H3/t25-,28-,29+,33-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348577
![PNG](/data/jpeg/tenK5034/BindingDB_50348577.png) (CHEMBL1801149)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C37H47ClF3N3O2/c1-22-15-26-29(17-31(22)38)37(18-30(26)36(5,6)34(46)43-12-9-24(40)19-43)10-13-42(14-11-37)33(45)28-21-44(35(2,3)4)20-27(28)25-8-7-23(39)16-32(25)41/h7-8,15-17,24,27-28,30H,9-14,18-21H2,1-6H3/t24-,27+,28-,30+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348575
![PNG](/data/jpeg/tenK5034/BindingDB_50348575.png) (CHEMBL1801147)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1C[C@@H]2C[C@H]1CO2 |r| Show InChI InChI=1S/C38H48ClF2N3O3/c1-22-13-27-30(16-32(22)39)38(17-31(27)37(5,6)35(46)44-18-25-15-24(44)21-47-25)9-11-42(12-10-38)34(45)29-20-43(36(2,3)4)19-28(29)26-8-7-23(40)14-33(26)41/h7-8,13-14,16,24-25,28-29,31H,9-12,15,17-21H2,1-6H3/t24-,25-,28-,29+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323457
![PNG](/data/jpeg/tenK5032/BindingDB_50323457.png) ((S)-(6-chloro-5-methyl-3-(2-(pyrrolidin-1-yl)propa...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)N1CCCC1 |r| Show InChI InChI=1S/C36H46ClF2N3O3/c1-23-18-27-30(20-31(23)37)36(45-33(27)35(2,3)42-12-4-5-13-42)10-14-40(15-11-36)34(43)29-22-41(25-8-16-44-17-9-25)21-28(29)26-7-6-24(38)19-32(26)39/h6-7,18-20,25,28-29,33H,4-5,8-17,21-22H2,1-3H3/t28-,29+,33-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50329957
![PNG](/data/jpeg/tenK5032/BindingDB_50329957.png) (((3R,4R)-1-tert-butyl-3-(2,4-difluorophenyl)piperi...)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CCN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)c1ncnn1C |r| Show InChI InChI=1S/C36H46ClF2N5O/c1-22-16-26-28(18-30(22)37)36(19-29(26)35(5,6)33-40-21-41-42(33)7)11-14-43(15-12-36)32(45)25-10-13-44(34(2,3)4)20-27(25)24-9-8-23(38)17-31(24)39/h8-9,16-18,21,25,27,29H,10-15,19-20H2,1-7H3/t25-,27+,29+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human MC4 receptor |
Bioorg Med Chem Lett 20: 6524-32 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.049 BindingDB Entry DOI: 10.7270/Q24M94SF |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348576
![PNG](/data/jpeg/tenK5034/BindingDB_50348576.png) (CHEMBL1801148)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CCCC1 |r| Show InChI InChI=1S/C37H48ClF2N3O2/c1-23-17-26-29(19-31(23)38)37(20-30(26)36(5,6)34(45)42-13-7-8-14-42)11-15-41(16-12-37)33(44)28-22-43(35(2,3)4)21-27(28)25-10-9-24(39)18-32(25)40/h9-10,17-19,27-28,30H,7-8,11-16,20-22H2,1-6H3/t27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348573
![PNG](/data/jpeg/tenK5034/BindingDB_50348573.png) (CHEMBL1801145)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CC(F)(F)C1 |r| Show InChI InChI=1S/C36H44ClF4N3O2/c1-21-13-24-27(15-29(21)37)35(16-28(24)34(5,6)32(46)43-19-36(40,41)20-43)9-11-42(12-10-35)31(45)26-18-44(33(2,3)4)17-25(26)23-8-7-22(38)14-30(23)39/h7-8,13-15,25-26,28H,9-12,16-20H2,1-6H3/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50329961
![PNG](/data/jpeg/tenK5032/BindingDB_50329961.png) (((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)Show SMILES Cc1nnc(o1)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C35H43ClF2N4O2/c1-20-14-24-27(16-29(20)36)35(17-28(24)34(6,7)32-40-39-21(2)44-32)10-12-41(13-11-35)31(43)26-19-42(33(3,4)5)18-25(26)23-9-8-22(37)15-30(23)38/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human MC4 receptor |
Bioorg Med Chem Lett 20: 6524-32 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.049 BindingDB Entry DOI: 10.7270/Q24M94SF |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323441
![PNG](/data/jpeg/tenK5032/BindingDB_50323441.png) (2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)C#N |r| Show InChI InChI=1S/C33H38ClF2N3O3/c1-20-14-24-27(16-28(20)34)33(42-30(24)32(2,3)19-37)8-10-38(11-9-33)31(40)26-18-39(22-6-12-41-13-7-22)17-25(26)23-5-4-21(35)15-29(23)36/h4-5,14-16,22,25-26,30H,6-13,17-18H2,1-3H3/t25-,26+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348584
![PNG](/data/jpeg/tenK5034/BindingDB_50348584.png) (CHEMBL1801214)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)N1CCC(F)(F)C1 |r| Show InChI InChI=1S/C37H46ClF4N3O2/c1-22-15-25-28(17-30(22)38)36(18-29(25)35(5,6)33(47)44-14-11-37(41,42)21-44)9-12-43(13-10-36)32(46)27-20-45(34(2,3)4)19-26(27)24-8-7-23(39)16-31(24)40/h7-8,15-17,26-27,29H,9-14,18-21H2,1-6H3/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348585
![PNG](/data/jpeg/tenK5034/BindingDB_50348585.png) (CHEMBL1801142)Show SMILES CCN(C)C(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C36H48ClF2N3O2/c1-9-40(8)33(44)35(6,7)29-19-36(28-18-30(37)22(2)16-25(28)29)12-14-41(15-13-36)32(43)27-21-42(34(3,4)5)20-26(27)24-11-10-23(38)17-31(24)39/h10-11,16-18,26-27,29H,9,12-15,19-21H2,1-8H3/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348560
![PNG](/data/jpeg/tenK5034/BindingDB_50348560.png) (CHEMBL1801118)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NC1CC1 |r| Show InChI InChI=1S/C36H46ClF2N3O2/c1-21-15-25-28(17-30(21)37)36(18-29(25)35(5,6)33(44)40-23-8-9-23)11-13-41(14-12-36)32(43)27-20-42(34(2,3)4)19-26(27)24-10-7-22(38)16-31(24)39/h7,10,15-17,23,26-27,29H,8-9,11-14,18-20H2,1-6H3,(H,40,44)/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348582
![PNG](/data/jpeg/tenK5034/BindingDB_50348582.png) (CHEMBL1801218)Show SMILES CO[C@H]1CCN(C1)C(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C38H50ClF2N3O3/c1-23-16-27-30(18-32(23)39)38(19-31(27)37(5,6)35(46)43-13-10-25(20-43)47-7)11-14-42(15-12-38)34(45)29-22-44(36(2,3)4)21-28(29)26-9-8-24(40)17-33(26)41/h8-9,16-18,25,28-29,31H,10-15,19-22H2,1-7H3/t25-,28-,29+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323455
![PNG](/data/jpeg/tenK5032/BindingDB_50323455.png) ((S)-(6-chloro-3-(2-(ethylamino)propan-2-yl)-5-meth...)Show SMILES CCNC(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H44ClF2N3O3/c1-5-38-33(3,4)31-25-16-21(2)29(35)18-28(25)34(43-31)10-12-39(13-11-34)32(41)27-20-40(23-8-14-42-15-9-23)19-26(27)24-7-6-22(36)17-30(24)37/h6-7,16-18,23,26-27,31,38H,5,8-15,19-20H2,1-4H3/t26-,27+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323453
![PNG](/data/jpeg/tenK5032/BindingDB_50323453.png) ((S)-(6-chloro-3-(2-(dimethylamino)propan-2-yl)-5-m...)Show SMILES CN(C)C(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H44ClF2N3O3/c1-21-16-25-28(18-29(21)35)34(43-31(25)33(2,3)38(4)5)10-12-39(13-11-34)32(41)27-20-40(23-8-14-42-15-9-23)19-26(27)24-7-6-22(36)17-30(24)37/h6-7,16-18,23,26-27,31H,8-15,19-20H2,1-5H3/t26-,27+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323459
![PNG](/data/jpeg/tenK5032/BindingDB_50323459.png) ((S)-(6-chloro-3-(2-(3,3-difluoropyrrolidin-1-yl)pr...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)N1CCC(F)(F)C1 |r| Show InChI InChI=1S/C36H44ClF4N3O3/c1-22-16-26-29(18-30(22)37)35(47-32(26)34(2,3)44-13-10-36(40,41)21-44)8-11-42(12-9-35)33(45)28-20-43(24-6-14-46-15-7-24)19-27(28)25-5-4-23(38)17-31(25)39/h4-5,16-18,24,27-28,32H,6-15,19-21H2,1-3H3/t27-,28+,32-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348569
![PNG](/data/jpeg/tenK5034/BindingDB_50348569.png) (CHEMBL1801127)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NC1CCOCC1 |r| Show InChI InChI=1S/C38H50ClF2N3O3/c1-23-17-27-30(19-32(23)39)38(20-31(27)37(5,6)35(46)42-25-9-15-47-16-10-25)11-13-43(14-12-38)34(45)29-22-44(36(2,3)4)21-28(29)26-8-7-24(40)18-33(26)41/h7-8,17-19,25,28-29,31H,9-16,20-22H2,1-6H3,(H,42,46)/t28-,29+,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348553
![PNG](/data/jpeg/tenK5034/BindingDB_50348553.png) (CHEMBL1801093)Show SMILES CN(C(C)=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C35H46ClF2N3O2/c1-21-15-25-28(17-30(21)36)35(18-29(25)34(6,7)39(8)22(2)42)11-13-40(14-12-35)32(43)27-20-41(33(3,4)5)19-26(27)24-10-9-23(37)16-31(24)38/h9-10,15-17,26-27,29H,11-14,18-20H2,1-8H3/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348556
![PNG](/data/jpeg/tenK5034/BindingDB_50348556.png) (CHEMBL1801097)Show SMILES CNC(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H44ClF2N3O2/c1-20-14-23-26(16-28(20)35)34(17-27(23)33(5,6)31(42)38-7)10-12-39(13-11-34)30(41)25-19-40(32(2,3)4)18-24(25)22-9-8-21(36)15-29(22)37/h8-9,14-16,24-25,27H,10-13,17-19H2,1-7H3,(H,38,42)/t24-,25+,27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348571
![PNG](/data/jpeg/tenK5034/BindingDB_50348571.png) (CHEMBL1801143)Show SMILES CCN(CC)C(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C37H50ClF2N3O2/c1-9-41(10-2)34(45)36(7,8)30-20-37(29-19-31(38)23(3)17-26(29)30)13-15-42(16-14-37)33(44)28-22-43(35(4,5)6)21-27(28)25-12-11-24(39)18-32(25)40/h11-12,17-19,27-28,30H,9-10,13-16,20-22H2,1-8H3/t27-,28+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348568
![PNG](/data/jpeg/tenK5034/BindingDB_50348568.png) (CHEMBL1801126)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NCCO |r| Show InChI InChI=1S/C35H46ClF2N3O3/c1-21-15-24-27(17-29(21)36)35(18-28(24)34(5,6)32(44)39-11-14-42)9-12-40(13-10-35)31(43)26-20-41(33(2,3)4)19-25(26)23-8-7-22(37)16-30(23)38/h7-8,15-17,25-26,28,42H,9-14,18-20H2,1-6H3,(H,39,44)/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348565
![PNG](/data/jpeg/tenK5034/BindingDB_50348565.png) (CHEMBL1801123)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NCCF |r| Show InChI InChI=1S/C35H45ClF3N3O2/c1-21-15-24-27(17-29(21)36)35(18-28(24)34(5,6)32(44)40-12-11-37)9-13-41(14-10-35)31(43)26-20-42(33(2,3)4)19-25(26)23-8-7-22(38)16-30(23)39/h7-8,15-17,25-26,28H,9-14,18-20H2,1-6H3,(H,40,44)/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323440
![PNG](/data/jpeg/tenK5032/BindingDB_50323440.png) (2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)Show SMILES Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)CO)c2cc1Cl)C(C)(C)C#N |r| Show InChI InChI=1S/C32H38ClF2N3O3/c1-19-12-22-25(14-26(19)33)32(41-28(22)30(2,3)17-36)8-10-37(11-9-32)29(40)24-16-38(31(4,5)18-39)15-23(24)21-7-6-20(34)13-27(21)35/h6-7,12-14,23-24,28,39H,8-11,15-16,18H2,1-5H3/t23-,24+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348558
![PNG](/data/jpeg/tenK5034/BindingDB_50348558.png) (CHEMBL1801116)Show SMILES CCNC(=O)C(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C35H46ClF2N3O2/c1-8-39-32(43)34(6,7)28-18-35(27-17-29(36)21(2)15-24(27)28)11-13-40(14-12-35)31(42)26-20-41(33(3,4)5)19-25(26)23-10-9-22(37)16-30(23)38/h9-10,15-17,25-26,28H,8,11-14,18-20H2,1-7H3,(H,39,43)/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50323454
![PNG](/data/jpeg/tenK5032/BindingDB_50323454.png) ((S)-(6-chloro-5-methyl-3-(2-(methylamino)propan-2-...)Show SMILES CNC(C)(C)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C33H42ClF2N3O3/c1-20-15-24-27(17-28(20)34)33(42-30(24)32(2,3)37-4)9-11-38(12-10-33)31(40)26-19-39(22-7-13-41-14-8-22)18-25(26)23-6-5-21(35)16-29(23)36/h5-6,15-17,22,25-26,30,37H,7-14,18-19H2,1-4H3/t25-,26+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells |
Bioorg Med Chem Lett 20: 4895-900 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.068 BindingDB Entry DOI: 10.7270/Q2TB172P |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348570
![PNG](/data/jpeg/tenK5034/BindingDB_50348570.png) (CHEMBL1801141)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NC(C)(C)CO |r| Show InChI InChI=1S/C37H50ClF2N3O3/c1-22-15-25-28(17-30(22)38)37(18-29(25)36(7,8)33(46)41-35(5,6)21-44)11-13-42(14-12-37)32(45)27-20-43(34(2,3)4)19-26(27)24-10-9-23(39)16-31(24)40/h9-10,15-17,26-27,29,44H,11-14,18-21H2,1-8H3,(H,41,46)/t26-,27+,29-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50314765
![PNG](/data/jpeg/tenK5031/BindingDB_50314765.png) (CHEMBL1093305 | trans-N-(2-((S)-1'-((3S,4R)-1-tert...)Show SMILES CC(=O)NC(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in CHO cells |
Bioorg Med Chem Lett 20: 2106-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.058 BindingDB Entry DOI: 10.7270/Q2QC03NP |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50314765
![PNG](/data/jpeg/tenK5031/BindingDB_50314765.png) (CHEMBL1093305 | trans-N-(2-((S)-1'-((3S,4R)-1-tert...)Show SMILES CC(=O)NC(C)(C)[C@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 |r| Show InChI InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50021344
![PNG](/data/jpeg/tenK5002/BindingDB_50021344.png) (CHEMBL3287929)Show SMILES Clc1ccc(Sc2cn(nc2-c2ccc(cc2)-c2ncon2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H14ClN5OS/c23-17-7-9-19(10-8-17)30-20-13-28(18-2-1-11-24-12-18)26-21(20)15-3-5-16(6-4-15)22-25-14-29-27-22/h1-14H | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH lysate using AMCAA as substrate by fluorescence assay |
ACS Med Chem Lett 5: 717-21 (2014)
Article DOI: 10.1021/ml5001239 BindingDB Entry DOI: 10.7270/Q2JQ12KN |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50348567
![PNG](/data/jpeg/tenK5034/BindingDB_50348567.png) (CHEMBL1801125)Show SMILES Cc1cc2[C@H](CC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C(C)(C)C)c2cc1Cl)C(C)(C)C(=O)NCC(F)(F)F |r| Show InChI InChI=1S/C35H43ClF5N3O2/c1-20-13-23-26(15-28(20)36)34(16-27(23)33(5,6)31(46)42-19-35(39,40)41)9-11-43(12-10-34)30(45)25-18-44(32(2,3)4)17-24(25)22-8-7-21(37)14-29(22)38/h7-8,13-15,24-25,27H,9-12,16-19H2,1-6H3,(H,42,46)/t24-,25+,27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation counting |
Bioorg Med Chem Lett 20: 4399-405 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.062 BindingDB Entry DOI: 10.7270/Q23F4Q07 |
More data for this Ligand-Target Pair | |