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Compile Data Set for Download or QSAR

Found 80 hits with Last Name = 'masukawa' and Initial = 'k'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088982
PNG
(CHEMBL160253 | CHEMBL367004 | N-[1-(1-Carbamimidoy...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)CCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H32N6O6S/c1-13(17(28)24-15-8-5-10-26(19(15)30)20(21)22)23-18(29)16(12-27)25-33(31,32)11-9-14-6-3-2-4-7-14/h2-4,6-7,13,15-16,19,25,27,30H,5,8-12H2,1H3,(H3,21,22)(H,23,29)(H,24,28)/t13-,15-,16+,19?/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088978
PNG
(CHEMBL176515 | N-[1-(1-Carbamimidoyl-2-hydroxy-pip...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C19H30N6O6S/c1-12(16(27)23-14-8-5-9-25(18(14)29)19(20)21)22-17(28)15(10-26)24-32(30,31)11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,24,26,29H,5,8-11H2,1H3,(H3,20,21)(H,22,28)(H,23,27)/t12-,14-,15+,18?/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088984
PNG
(2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hyd...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C18H28N6O6S/c1-11(15(26)22-13-8-5-9-24(17(13)28)18(19)20)21-16(27)14(10-25)23-31(29,30)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,17,23,25,28H,5,8-10H2,1H3,(H3,19,20)(H,21,27)(H,22,26)/t11-,13-,14+,17?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088979
PNG
(CHEMBL366666 | {(R)-2-[2-((S)-1-Carbamimidoyl-2-hy...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)C2CCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C21H30N6O6/c22-20(23)27-9-4-7-14(18(27)30)24-17(29)16-8-10-26(16)19(31)15(11-28)25-21(32)33-12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,28,30H,4,7-12H2,(H3,22,23)(H,24,29)(H,25,32)/t14-,15+,16?,18?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088985
PNG
(CHEMBL369042 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES NC(=N)N1CCCC(NC(=O)[C@H]2CCCN2C(=O)C(CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C22H32N6O6/c23-21(24)28-11-4-8-15(19(28)31)25-18(30)17-9-5-10-27(17)20(32)16(12-29)26-22(33)34-13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,29,31H,4-5,8-13H2,(H3,23,24)(H,25,30)(H,26,33)/t15?,16?,17-,19?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088977
PNG
(CHEMBL177557 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14-,15+,18?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088987
PNG
(CHEMBL174813 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(C)COC(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C17H32N6O6/c1-9(2)8-29-17(28)22-12(7-24)14(26)20-10(3)13(25)21-11-5-4-6-23(15(11)27)16(18)19/h9-12,15,24,27H,4-8H2,1-3H3,(H3,18,19)(H,20,26)(H,21,25)(H,22,28)/t10-,11-,12+,15?/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088986
PNG
(CHEMBL433809 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES NC(=N)N1CCC[C@@H](NC(=O)[C@H]2CCCCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C23H34N6O6/c24-22(25)29-12-6-9-16(20(29)32)26-19(31)18-10-4-5-11-28(18)21(33)17(13-30)27-23(34)35-14-15-7-2-1-3-8-15/h1-3,7-8,16-18,20,30,32H,4-6,9-14H2,(H3,24,25)(H,26,31)(H,27,34)/t16-,17-,18-,20?/m1/s1
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n/an/a 101n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088985
PNG
(CHEMBL369042 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES NC(=N)N1CCCC(NC(=O)[C@H]2CCCN2C(=O)C(CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C22H32N6O6/c23-21(24)28-11-4-8-15(19(28)31)25-18(30)17-9-5-10-27(17)20(32)16(12-29)26-22(33)34-13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,29,31H,4-5,8-13H2,(H3,23,24)(H,25,30)(H,26,33)/t15?,16?,17-,19?/m1/s1
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n/an/a 125n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50073630
PNG
(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Show SMILES OC(=O)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+
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n/an/a 130n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50073630
PNG
(2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]...)
Show SMILES OC(=O)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+
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n/an/a 150n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 250n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088981
PNG
(CHEMBL425850 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(O)[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C21H32N6O6/c1-12(17(29)25-15-9-6-10-27(19(15)31)20(22)23)24-18(30)16(13(2)28)26-21(32)33-11-14-7-4-3-5-8-14/h3-5,7-8,12-13,15-16,19,28,31H,6,9-11H2,1-2H3,(H3,22,23)(H,24,30)(H,25,29)(H,26,32)/t12-,13?,15-,16+,19?/m0/s1
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n/an/a 261n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088978
PNG
(CHEMBL176515 | N-[1-(1-Carbamimidoyl-2-hydroxy-pip...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C19H30N6O6S/c1-12(16(27)23-14-8-5-9-25(18(14)29)19(20)21)22-17(28)15(10-26)24-32(30,31)11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,24,26,29H,5,8-11H2,1H3,(H3,20,21)(H,22,28)(H,23,27)/t12-,14-,15+,18?/m0/s1
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n/an/a 275n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088352
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCN2CCN(CC2)C(N)=NC(N)=N)C1=O)C(=O)c1c(C)cccc1C3(C)O |w:26.28|
Show InChI InChI=1S/C30H40N8O6/c1-14-6-5-7-16-18(14)23(39)20-17(30(16,2)44)12-15-19(24(20)40)25(41)21(26(42)22(15)36(3)4)27(43)34-13-37-8-10-38(11-9-37)29(33)35-28(31)32/h5-7,15,17,19-22,44H,8-13H2,1-4H3,(H,34,43)(H5,31,32,33,35)/t15-,17+,19?,20?,21?,22+,30?/m1/s1
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n/an/a 300n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088982
PNG
(CHEMBL160253 | CHEMBL367004 | N-[1-(1-Carbamimidoy...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)CCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H32N6O6S/c1-13(17(28)24-15-8-5-10-26(19(15)30)20(21)22)23-18(29)16(12-27)25-33(31,32)11-9-14-6-3-2-4-7-14/h2-4,6-7,13,15-16,19,25,27,30H,5,8-12H2,1H3,(H3,21,22)(H,23,29)(H,24,28)/t13-,15-,16+,19?/m0/s1
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n/an/a 367n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50056908
PNG
((1R,3R,4S,5R)-3,4-Bis-[(E)-3-(3,4-dihydroxy-phenyl...)
Show SMILES O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088979
PNG
(CHEMBL366666 | {(R)-2-[2-((S)-1-Carbamimidoyl-2-hy...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)C2CCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C21H30N6O6/c22-20(23)27-9-4-7-14(18(27)30)24-17(29)16-8-10-26(16)19(31)15(11-28)25-21(32)33-12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,28,30H,4,7-12H2,(H3,22,23)(H,24,29)(H,25,32)/t14-,15+,16?,18?/m0/s1
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n/an/a 482n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088358
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCNC(CO)(CO)CO)C1=O)C(=O)c1c(C)cccc1C3(C)O
Show InChI InChI=1S/C28H37N3O9/c1-13-6-5-7-15-17(13)22(35)19-16(27(15,2)40)8-14-18(23(19)36)24(37)20(25(38)21(14)31(3)4)26(39)29-12-30-28(9-32,10-33)11-34/h5-7,14,16,18-21,30,32-34,40H,8-12H2,1-4H3,(H,29,39)/t14-,16+,18?,19?,20?,21+,27?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 600n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM23408
PNG
(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Show SMILES Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
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n/an/a 600n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088359
PNG
(3,5-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-1,4...)
Show SMILES OC1C(CC(O)(CC1OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O)OC(=O)\C=C/c1ccc(O)c(O)c1 |(5.46,-3.6,;5.46,-2.24,;6.59,-.7,;8.81,-.7,;9.95,-2.24,;9.95,-3.8,;8.81,-3.69,;6.59,-3.69,;6.59,-5.2,;7.98,-5.83,;9.35,-5.13,;7.98,-7.41,;9.28,-8.06,;10.55,-7.19,;10.55,-5.53,;11.74,-4.69,;13.18,-5.43,;14.54,-4.77,;13.18,-7.23,;14.57,-7.85,;11.91,-7.88,;9.95,-.68,;11.38,.16,;8.79,.5,;6.63,.6,;4.99,1.65,;3.59,.89,;4.99,3.31,;3.7,4.06,;2.43,3.26,;2.43,1.78,;1.1,1.09,;-.16,1.85,;-1.52,1.15,;-.16,3.31,;-1.48,4.11,;1.14,4.04,)|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(30)36-19-11-25(35,24(33)34)12-20(23(19)32)37-22(31)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-29,32,35H,11-12H2,(H,33,34)/b7-3-,8-4-
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n/an/a 640n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088359
PNG
(3,5-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-1,4...)
Show SMILES OC1C(CC(O)(CC1OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O)OC(=O)\C=C/c1ccc(O)c(O)c1 |(5.46,-3.6,;5.46,-2.24,;6.59,-.7,;8.81,-.7,;9.95,-2.24,;9.95,-3.8,;8.81,-3.69,;6.59,-3.69,;6.59,-5.2,;7.98,-5.83,;9.35,-5.13,;7.98,-7.41,;9.28,-8.06,;10.55,-7.19,;10.55,-5.53,;11.74,-4.69,;13.18,-5.43,;14.54,-4.77,;13.18,-7.23,;14.57,-7.85,;11.91,-7.88,;9.95,-.68,;11.38,.16,;8.79,.5,;6.63,.6,;4.99,1.65,;3.59,.89,;4.99,3.31,;3.7,4.06,;2.43,3.26,;2.43,1.78,;1.1,1.09,;-.16,1.85,;-1.52,1.15,;-.16,3.31,;-1.48,4.11,;1.14,4.04,)|
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(30)36-19-11-25(35,24(33)34)12-20(23(19)32)37-22(31)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-29,32,35H,11-12H2,(H,33,34)/b7-3-,8-4-
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n/an/a 660n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088356
PNG
(1,3-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-4,5...)
Show SMILES OC1CC(CC(OC(=O)\C=C/c2ccc(O)c(O)c2)C1O)(OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3-,8-4-
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n/an/a 680n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088981
PNG
(CHEMBL425850 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(O)[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C21H32N6O6/c1-12(17(29)25-15-9-6-10-27(19(15)31)20(22)23)24-18(30)16(13(2)28)26-21(32)33-11-14-7-4-3-5-8-14/h3-5,7-8,12-13,15-16,19,28,31H,6,9-11H2,1-2H3,(H3,22,23)(H,24,30)(H,25,29)(H,26,32)/t12-,13?,15-,16+,19?/m0/s1
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n/an/a 699n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM22984
PNG
((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Show SMILES COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r|
Show InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
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n/an/a 900n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088352
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCN2CCN(CC2)C(N)=NC(N)=N)C1=O)C(=O)c1c(C)cccc1C3(C)O |w:26.28|
Show InChI InChI=1S/C30H40N8O6/c1-14-6-5-7-16-18(14)23(39)20-17(30(16,2)44)12-15-19(24(20)40)25(41)21(26(42)22(15)36(3)4)27(43)34-13-37-8-10-38(11-9-37)29(33)35-28(31)32/h5-7,15,17,19-22,44H,8-13H2,1-4H3,(H,34,43)(H5,31,32,33,35)/t15-,17+,19?,20?,21?,22+,30?/m1/s1
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n/an/a 900n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088977
PNG
(CHEMBL177557 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14-,15+,18?/m0/s1
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n/an/a 904n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50041419
PNG
(1,2,5,8-tetrahydroxy-9,10-anthracenedione | 1,2,5,...)
Show SMILES Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088353
PNG
(5-(3,4-Dihydroxy-phenyl)-3-hydroxy-pentanoic acid ...)
Show SMILES OC(CCc1ccc(O)c(O)c1)CC(=O)O[C@H]1Cc2cc(O)c(O)cc2O[C@H]1c1ccc(O)c(O)c1
Show InChI InChI=1S/C26H26O10/c27-16(4-1-13-2-5-17(28)19(30)7-13)11-25(34)35-24-10-15-9-21(32)22(33)12-23(15)36-26(24)14-3-6-18(29)20(31)8-14/h2-3,5-9,12,16,24,26-33H,1,4,10-11H2/t16?,24-,26-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088349
PNG
(2',3,3',4,4'-pentahydroxychalcone | 3-(3,4-Dihydro...)
Show SMILES Oc1ccc(CCC(=O)c2ccc(O)c(O)c2O)cc1O
Show InChI InChI=1S/C15H14O6/c16-10(9-3-6-12(18)15(21)14(9)20)4-1-8-2-5-11(17)13(19)7-8/h2-3,5-7,17-21H,1,4H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088356
PNG
(1,3-Bis-[3-(3,4-dihydroxy-phenyl)-acryloyloxy]-4,5...)
Show SMILES OC1CC(CC(OC(=O)\C=C/c2ccc(O)c(O)c2)C1O)(OC(=O)\C=C/c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3-,8-4-
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n/an/a 1.08E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088358
PNG
(4-Dimethylamino-3,6,12-trihydroxy-6,10-dimethyl-1,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NCNC(CO)(CO)CO)C1=O)C(=O)c1c(C)cccc1C3(C)O
Show InChI InChI=1S/C28H37N3O9/c1-13-6-5-7-15-17(13)22(35)19-16(27(15,2)40)8-14-18(23(19)36)24(37)20(25(38)21(14)31(3)4)26(39)29-12-30-28(9-32,10-33)11-34/h5-7,14,16,18-21,30,32-34,40H,8-12H2,1-4H3,(H,29,39)/t14-,16+,18?,19?,20?,21+,27?/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088984
PNG
(2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hyd...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C18H28N6O6S/c1-11(15(26)22-13-8-5-9-24(17(13)28)18(19)20)21-16(27)14(10-25)23-31(29,30)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,17,23,25,28H,5,8-10H2,1H3,(H3,19,20)(H,21,27)(H,22,26)/t11-,13-,14+,17?/m0/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088350
PNG
(CHEMBL430786 | Sodium; 1-[N'-(4-dimethylamino-3,6,...)
Show SMILES CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)C2C(=O)C(C(=O)NNC2(CCCC2)C([O-])=O)C1=O)C(=O)c1c(C)cccc1C3(C)O
Show InChI InChI=1S/C29H35N3O8/c1-13-8-7-9-15-17(13)22(33)19-16(28(15,2)40)12-14-18(23(19)34)24(35)20(25(36)21(14)32(3)4)26(37)30-31-29(27(38)39)10-5-6-11-29/h7-9,14,16,18-21,31,40H,5-6,10-12H2,1-4H3,(H,30,37)(H,38,39)/p-1/t14-,16+,18?,19?,20?,21+,28?/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM23408
PNG
(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Show SMILES Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088353
PNG
(5-(3,4-Dihydroxy-phenyl)-3-hydroxy-pentanoic acid ...)
Show SMILES OC(CCc1ccc(O)c(O)c1)CC(=O)O[C@H]1Cc2cc(O)c(O)cc2O[C@H]1c1ccc(O)c(O)c1
Show InChI InChI=1S/C26H26O10/c27-16(4-1-13-2-5-17(28)19(30)7-13)11-25(34)35-24-10-15-9-21(32)22(33)12-23(15)36-26(24)14-3-6-18(29)20(31)8-14/h2-3,5-9,12,16,24,26-33H,1,4,10-11H2/t16?,24-,26-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50088987
PNG
(CHEMBL174813 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(C)COC(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C17H32N6O6/c1-9(2)8-29-17(28)22-12(7-24)14(26)20-10(3)13(25)21-11-5-4-6-23(15(11)27)16(18)19/h9-12,15,24,27H,4-8H2,1-3H3,(H3,18,19)(H,20,26)(H,21,25)(H,22,28)/t10-,11-,12+,15?/m0/s1
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n/an/a 1.46E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human Plasmin enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088349
PNG
(2',3,3',4,4'-pentahydroxychalcone | 3-(3,4-Dihydro...)
Show SMILES Oc1ccc(CCC(=O)c2ccc(O)c(O)c2O)cc1O
Show InChI InChI=1S/C15H14O6/c16-10(9-3-6-12(18)15(21)14(9)20)4-1-8-2-5-11(17)13(19)7-8/h2-3,5-7,17-21H,1,4H2
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088360
PNG
(2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...)
Show SMILES Oc1cc2cccc(O)c(=O)c2c(O)c1O
Show InChI InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM50088355
PNG
(10-(4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-...)
Show SMILES C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)OC1C[C@@](O)(Cc2c(O)c3C(=O)c4cccc(O)c4C(=O)c3c(O)c12)C(=O)CO
Show InChI InChI=1S/C26H27NO11/c1-9-21(31)12(27)5-16(37-9)38-14-7-26(36,15(30)8-28)6-11-18(14)25(35)20-19(23(11)33)22(32)10-3-2-4-13(29)17(10)24(20)34/h2-4,9,12,14,16,21,28-29,31,33,35-36H,5-8,27H2,1H3/t9-,12-,14?,16-,21+,26-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Integrase


(Human immunodeficiency virus 1)		BDBM22984
PNG
((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Show SMILES COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r|
Show InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer

J Med Chem 43: 2100-14 (2000)


BindingDB Entry DOI: 10.7270/Q27D2VTS
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50088983
PNG
(CHEMBL177251 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES C[C@@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14+,15-,18?/m1/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50088984
PNG
(2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hyd...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C18H28N6O6S/c1-11(15(26)22-13-8-5-9-24(17(13)28)18(19)20)21-16(27)14(10-25)23-31(29,30)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,17,23,25,28H,5,8-10H2,1H3,(H3,19,20)(H,21,27)(H,22,26)/t11-,13-,14+,17?/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50088979
PNG
(CHEMBL366666 | {(R)-2-[2-((S)-1-Carbamimidoyl-2-hy...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)C2CCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C21H30N6O6/c22-20(23)27-9-4-7-14(18(27)30)24-17(29)16-8-10-26(16)19(31)15(11-28)25-21(32)33-12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,28,30H,4,7-12H2,(H3,22,23)(H,24,29)(H,25,32)/t14-,15+,16?,18?/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50088987
PNG
(CHEMBL174813 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(C)COC(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C17H32N6O6/c1-9(2)8-29-17(28)22-12(7-24)14(26)20-10(3)13(25)21-11-5-4-6-23(15(11)27)16(18)19/h9-12,15,24,27H,4-8H2,1-3H3,(H3,18,19)(H,20,26)(H,21,25)(H,22,28)/t10-,11-,12+,15?/m0/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human t-PA enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50088983
PNG
(CHEMBL177251 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES C[C@@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14+,15-,18?/m1/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50

Bioorg Med Chem Lett 10: 983-7 (2000)


BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
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