Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuraminidase (Influenza B virus (B/Lee/40)) | BDBM4707 (3-(2,2-diaminoimino)-4-methylcarboxamidobenzoate |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description In vitro inhibitory activity of the compound against B/Lee/40 Influenza B Neuraminidase. | J Med Chem 42: 2332-43 (1999) Article DOI: 10.1021/jm980707k BindingDB Entry DOI: 10.7270/Q25B01NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pyruvate kinase PKM (Homo sapiens (Human)) | BDBM50455474 (CHEMBL4218770) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nankai University Curated by ChEMBL | Assay Description Irreversible binding affinity to recombinant human PKM2 expressed in Escherichia coli BL21 | J Med Chem 61: 4155-4164 (2018) Article DOI: 10.1021/acs.jmedchem.8b00241 BindingDB Entry DOI: 10.7270/Q2C82CWR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336257 (4-(3-fluorobenzylidene)-1,7-bis(4-hydroxy-3-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336258 (4-(4-fluorobenzylidene)-1,7-bis(4-hydroxy-3-methox...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336261 (4-(4-hydroxy-3-methoxybenzylidene)-1,7-bis(4-hydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336259 (4-(5-(3,4-dimethoxyphenyl)-2-(-3-(3,4-dimethoxyphe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336251 (1,7-bis(4-fluorophenyl)-5-hydroxyhepta-1,4,6-trien...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336256 (4-(3,4-dimethoxybenzylidene)-1,7-bis(4-hydroxy-3-m...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50067040 (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM36371 (5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of IDO1 (unknown origin) | Eur J Med Chem 138: 199-211 (2017) Article DOI: 10.1016/j.ejmech.2017.06.039 BindingDB Entry DOI: 10.7270/Q2C25012 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336272 (Acemetacin | CHEMBL189171 | [1-(4-Chloro-benzoyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336254 (5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(1H-pyrr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50059989 ((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336264 (3-((5-nitrofuran-2-yl)methylene)pentane-2,4-dione ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336252 (1-(3,4-dimethoxyphenyl)-5-hydroxy-7-(4-hydroxyphen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human)) | BDBM50241727 ((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of IDO1 (unknown origin) | Eur J Med Chem 138: 199-211 (2017) Article DOI: 10.1016/j.ejmech.2017.06.039 BindingDB Entry DOI: 10.7270/Q2C25012 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336268 (CHEMBL1669738 | diethyl 2,5-diacetylhexa-2,4-diene...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336272 (Acemetacin | CHEMBL189171 | [1-(4-Chloro-benzoyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336267 (CHEMBL1669737 | ethyl 2-(3-nitrobenzylidene)-3-oxo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336253 (5-hydroxy-7-(5-(hydroxymethyl)furan-2-yl)-1-(4-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 7.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50012899 ((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50295287 (2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | 8.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336271 (4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)-hexa-3,5-d...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336263 (3-(3-nitrobenzylidene)pentane-2,4-dione | CHEMBL16...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50027952 (5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336260 (4-(hydroxymethylene)-1,7-bis(4-methoxyphenyl)hepta...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.09E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50012899 ((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.39E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336266 (CHEMBL1669736 | ethyl 2-(4-nitrobenzylidene)-3-oxo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.59E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytidine deaminase (Homo sapiens (Human)) | BDBM50087289 (1-beta-D-Arabinofuranosylcytosine | 4-Amino-1-beta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PubMed | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibitory constant was measured on cytidine/deoxycytidine deaminase | J Med Chem 34: 2607-15 (1991) BindingDB Entry DOI: 10.7270/Q23F4Q8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50027952 (5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336262 (3-(4-methoxybenzylidene)pentane-2,4-dione | CHEMBL...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM54705 (CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 3.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50297424 ((E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid et...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM54705 (CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50022271 (2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of glyoxalase 1 | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336265 (2-(3-nitrobenzylidene)malonic acid | CHEMBL1669735) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50022271 (2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.43E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50295287 (2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | 1.01E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336270 (3-(4-fluorophenyl)acrylamide | CHEMBL1669739) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.39E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336255 (1,7-di(furan-2-yl)-5-hydroxyhepta-1,4,6-trien-3-on...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytidine deaminase (Homo sapiens (Human)) | BDBM50007155 (4-Amino-1-(3-hydroxy-5-hydroxymethyl-4-methylene-t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.60E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibitory constant was measured on cytidine/deoxycytidine deaminase | J Med Chem 34: 2607-15 (1991) BindingDB Entry DOI: 10.7270/Q23F4Q8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoylglutathione lyase (Homo sapiens (Human)) | BDBM50336269 (CHEMBL1669711 | methyl 3-(4-fluorophenyl)acrylate) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.91E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis | Bioorg Med Chem 19: 1189-96 (2011) Article DOI: 10.1016/j.bmc.2010.12.039 BindingDB Entry DOI: 10.7270/Q2222V2X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 15 member 1 (Homo sapiens (Human)) | BDBM50519221 (CHEMBL4460144) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 2.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian Medical University Curated by ChEMBL | Assay Description Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake by LC-MS/MS analysis | J Med Chem 62: 7708-7721 (2019) Article DOI: 10.1021/acs.jmedchem.9b00358 BindingDB Entry DOI: 10.7270/Q2CZ3BJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytidine deaminase (Homo sapiens (Human)) | BDBM50421893 (CHEMBL10128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 7.69E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibitory constant was measured on cytidine/deoxycytidine deaminase | J Med Chem 34: 2607-15 (1991) BindingDB Entry DOI: 10.7270/Q23F4Q8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytidine deaminase (Homo sapiens (Human)) | BDBM50007156 (4-Amino-5-fluoro-1-(4-hydroxy-5-hydroxymethyl-3-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.51E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibitory constant was measured on cytidine/deoxycytidine deaminase | J Med Chem 34: 2607-15 (1991) BindingDB Entry DOI: 10.7270/Q23F4Q8T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 15 member 1 (Homo sapiens (Human)) | BDBM50519220 (CHEMBL2229108) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | 3.60E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian Medical University Curated by ChEMBL | Assay Description Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake by LC-MS/MS analysis | J Med Chem 62: 7708-7721 (2019) Article DOI: 10.1021/acs.jmedchem.9b00358 BindingDB Entry DOI: 10.7270/Q2CZ3BJ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50576403 (CHEMBL4872605) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of RET wild type (unknown origin) | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128149 BindingDB Entry DOI: 10.7270/Q2JM2FFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Irreversible inhibition of recombinant BTK (unknown origin) incubated for 1 hr by FRET assay | Bioorg Med Chem Lett 26: 3052-9 (2016) Article DOI: 10.1016/j.bmcl.2016.05.014 BindingDB Entry DOI: 10.7270/Q2VT1V1T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |
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