Found 179 hits with Last Name = 'benakli' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359261
(CHEMBL1923617)Show SMILES CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C30H41ClN4O4/c1-5-20(2)27-30(38)35(4)21(3)28(36)34-25(19-22-12-14-24(31)15-13-22)29(37)33-16-8-10-23-9-6-7-11-26(23)39-18-17-32-27/h6-7,9,11-15,20-21,25,27,32H,5,8,10,16-19H2,1-4H3,(H,33,37)(H,34,36)/t20-,21+,25+,27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50002694
(MOTILIN)Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@H](-[#6]-[#6]-[#16]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r| Show InChI InChI=1S/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)/t64-,65+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80+,81-,82-,83-,84-,85-,86-,96-,97-,98-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359239
(CHEMBL1923629)Show SMILES C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C33H45FN4O4/c1-22-21-36-30(26-11-5-4-6-12-26)33(41)38(3)23(2)31(39)37-28(20-24-15-17-27(34)18-16-24)32(40)35-19-9-13-25-10-7-8-14-29(25)42-22/h7-8,10,14-18,22-23,26,28,30,36H,4-6,9,11-13,19-21H2,1-3H3,(H,35,40)(H,37,39)/t22-,23-,28-,30+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359250
(CHEMBL1923640)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NC[C@H]2CCc3cccc(CCCNC(=O)[C@@H](Cc4ccc(F)cc4)NC1=O)c3O2)C1CC1 |r| Show InChI InChI=1S/C31H39FN4O4/c1-19-29(37)35-26(17-20-8-13-24(32)14-9-20)30(38)33-16-4-7-22-5-3-6-23-12-15-25(40-28(22)23)18-34-27(21-10-11-21)31(39)36(19)2/h3,5-6,8-9,13-14,19,21,25-27,34H,4,7,10-12,15-18H2,1-2H3,(H,33,38)(H,35,37)/t19-,25-,26-,27+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359252
(CHEMBL1923642)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2cc(F)ccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C29H36F2N4O4/c1-18-27(36)34-24(16-19-5-10-22(30)11-6-19)28(37)33-13-3-4-20-9-12-23(31)17-25(20)39-15-14-32-26(21-7-8-21)29(38)35(18)2/h5-6,9-12,17-18,21,24,26,32H,3-4,7-8,13-16H2,1-2H3,(H,33,37)(H,34,36)/t18-,24-,26+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359259
(CHEMBL1923610)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C29H38N4O4/c1-20-27(34)32-24(19-21-9-4-3-5-10-21)28(35)31-16-8-12-22-11-6-7-13-25(22)37-18-17-30-26(23-14-15-23)29(36)33(20)2/h3-7,9-11,13,20,23-24,26,30H,8,12,14-19H2,1-2H3,(H,31,35)(H,32,34)/t20-,24-,26+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214268
((5R,8R,11S)-8-(propan-2-yl)-11-(pyrrolidin-1-ylmet...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](CN2CCCC2)NC1=O Show InChI InChI=1S/C33H44F3N5O4/c1-22(2)29-32(44)39-27(21-41-16-5-6-17-41)30(42)38-14-8-11-24-10-3-4-13-28(24)45-18-15-37-26(31(43)40-29)20-23-9-7-12-25(19-23)33(34,35)36/h3-4,7,9-10,12-13,19,22,26-27,29,37H,5-6,8,11,14-18,20-21H2,1-2H3,(H,38,42)(H,39,44)(H,40,43)/t26-,27+,29-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359238
(CHEMBL1923628)Show SMILES C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)c(C)c2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C31H41FN4O4/c1-19-16-22(11-14-25(19)32)17-26-30(38)33-15-7-9-23-8-5-6-10-27(23)40-20(2)18-34-28(24-12-13-24)31(39)36(4)21(3)29(37)35-26/h5-6,8,10-11,14,16,20-21,24,26,28,34H,7,9,12-13,15,17-18H2,1-4H3,(H,33,38)(H,35,37)/t20-,21-,26-,28+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359238
(CHEMBL1923628)Show SMILES C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)c(C)c2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C31H41FN4O4/c1-19-16-22(11-14-25(19)32)17-26-30(38)33-15-7-9-23-8-5-6-10-27(23)40-20(2)18-34-28(24-12-13-24)31(39)36(4)21(3)29(37)35-26/h5-6,8,10-11,14,16,20-21,24,26,28,34H,7,9,12-13,15,17-18H2,1-4H3,(H,33,38)(H,35,37)/t20-,21-,26-,28+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359237
(CHEMBL1923627)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(C)cc2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C30H40N4O4/c1-20-10-12-22(13-11-20)19-25-29(36)32-16-6-8-23-7-4-5-9-26(23)38-18-17-31-27(24-14-15-24)30(37)34(3)21(2)28(35)33-25/h4-5,7,9-13,21,24-25,27,31H,6,8,14-19H2,1-3H3,(H,32,36)(H,33,35)/t21-,25-,27+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214270
(1-{[(5R,8R,11S)-5-[(4-chlorophenyl)methyl]-6,9,12-...)Show SMILES [#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2ccc(Cl)cc2)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O Show InChI InChI=1S/C29H40ClN7O4/c1-18(2)25-28(40)36-23(17-35-29(31)32)26(38)34-13-5-7-20-6-3-4-8-24(20)41-15-14-33-22(27(39)37-25)16-19-9-11-21(30)12-10-19/h3-4,6,8-12,18,22-23,25,33H,5,7,13-17H2,1-2H3,(H,34,38)(H,36,40)(H,37,39)(H4,31,32,35)/t22-,23+,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214264
(1-{[(5R,8R,11S)-6,9,12-trioxo-8-(propan-2-yl)-5-{[...)Show SMILES [#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2cccc(c2)C(F)(F)F)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O Show InChI InChI=1S/C30H40F3N7O4/c1-18(2)25-28(43)39-23(17-38-29(34)35)26(41)37-12-6-9-20-8-3-4-11-24(20)44-14-13-36-22(27(42)40-25)16-19-7-5-10-21(15-19)30(31,32)33/h3-5,7-8,10-11,15,18,22-23,25,36H,6,9,12-14,16-17H2,1-2H3,(H,37,41)(H,39,43)(H,40,42)(H4,34,35,38)/t22-,23+,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214266
((5R,8R,11S)-11-[(methylamino)methyl]-8-(propan-2-y...)Show SMILES CNC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C30H40F3N5O4/c1-19(2)26-29(41)37-24(18-34-3)27(39)36-13-7-10-21-9-4-5-12-25(21)42-15-14-35-23(28(40)38-26)17-20-8-6-11-22(16-20)30(31,32)33/h4-6,8-9,11-12,16,19,23-24,26,34-35H,7,10,13-15,17-18H2,1-3H3,(H,36,39)(H,37,41)(H,38,40)/t23-,24+,26-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359233
(CHEMBL1923623)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2F)NC1=O)C1CC1 |r| Show InChI InChI=1S/C29H37FN4O4/c1-19-27(35)33-24(18-22-9-3-5-11-23(22)30)28(36)32-15-7-10-20-8-4-6-12-25(20)38-17-16-31-26(21-13-14-21)29(37)34(19)2/h3-6,8-9,11-12,19,21,24,26,31H,7,10,13-18H2,1-2H3,(H,32,36)(H,33,35)/t19-,24-,26+/m1/s1 | PDB
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| 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359282
(CHEMBL1923609)Show SMILES CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C30H42N4O4/c1-5-21(2)27-30(37)34(4)22(3)28(35)33-25(20-23-12-7-6-8-13-23)29(36)32-17-11-15-24-14-9-10-16-26(24)38-19-18-31-27/h6-10,12-14,16,21-22,25,27,31H,5,11,15,17-20H2,1-4H3,(H,32,36)(H,33,35)/t21-,22+,25+,27-/m0/s1 | PDB
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| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359236
(CHEMBL1923626)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(cc2)C(F)(F)F)NC1=O)C1CC1 |r| Show InChI InChI=1S/C30H37F3N4O4/c1-19-27(38)36-24(18-20-9-13-23(14-10-20)30(31,32)33)28(39)35-15-5-7-21-6-3-4-8-25(21)41-17-16-34-26(22-11-12-22)29(40)37(19)2/h3-4,6,8-10,13-14,19,22,24,26,34H,5,7,11-12,15-18H2,1-2H3,(H,35,39)(H,36,38)/t19-,24-,26+/m1/s1 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359235
(CHEMBL1923625)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C29H37FN4O4/c1-19-27(35)33-24(18-20-9-13-23(30)14-10-20)28(36)32-15-5-7-21-6-3-4-8-25(21)38-17-16-31-26(22-11-12-22)29(37)34(19)2/h3-4,6,8-10,13-14,19,22,24,26,31H,5,7,11-12,15-18H2,1-2H3,(H,32,36)(H,33,35)/t19-,24-,26+/m1/s1 | PDB
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| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50199368
((9R,12R,15S)-12-isopropyl-9-(4-methoxy-benzyl)-15-...)Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(OC)cc2)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C31H44N4O5/c1-5-9-25-29(36)33-17-8-11-23-10-6-7-12-27(23)40-19-18-32-26(20-22-13-15-24(39-4)16-14-22)30(37)35-28(21(2)3)31(38)34-25/h6-7,10,12-16,21,25-26,28,32H,5,8-9,11,17-20H2,1-4H3,(H,33,36)(H,34,38)(H,35,37)/t25-,26+,28+/m0/s1 | PDB
Reactome pathway
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50199372
((9R,12R,15S)-12-isopropyl-9-naphthalen-1-ylmethyl-...)Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2cccc3ccccc23)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C34H44N4O4/c1-4-11-28-32(39)36-19-10-16-25-13-6-8-18-30(25)42-21-20-35-29(33(40)38-31(23(2)3)34(41)37-28)22-26-15-9-14-24-12-5-7-17-27(24)26/h5-9,12-15,17-18,23,28-29,31,35H,4,10-11,16,19-22H2,1-3H3,(H,36,39)(H,37,41)(H,38,40)/t28-,29+,31+/m0/s1 | PDB
Reactome pathway
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| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359247
(CHEMBL1923637)Show SMILES CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@@H](N1)C1CC1 |r| Show InChI InChI=1S/C30H39FN4O4/c1-19-18-39-26-9-5-4-7-22(26)8-6-16-32-29(37)25(17-21-10-14-24(31)15-11-21)34-28(36)20(2)35(3)30(38)27(33-19)23-12-13-23/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H3,(H,32,37)(H,34,36)/t19?,20-,25-,27+/m1/s1 | PDB
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50199359
((9R,12R,15S)-9-benzo[b]thiophen-3-ylmethyl-12-isop...)Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2csc3ccccc23)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C32H42N4O4S/c1-4-10-25-30(37)34-16-9-12-22-11-5-7-14-27(22)40-18-17-33-26(31(38)36-29(21(2)3)32(39)35-25)19-23-20-41-28-15-8-6-13-24(23)28/h5-8,11,13-15,20-21,25-26,29,33H,4,9-10,12,16-19H2,1-3H3,(H,34,37)(H,35,39)(H,36,38)/t25-,26+,29+/m0/s1 | PDB
Reactome pathway
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359249
(CHEMBL1923639)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCC(C)(C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C31H41FN4O4/c1-20-28(37)35-25(18-21-11-15-24(32)16-12-21)29(38)33-17-7-9-22-8-5-6-10-26(22)40-31(2,3)19-34-27(23-13-14-23)30(39)36(20)4/h5-6,8,10-12,15-16,20,23,25,27,34H,7,9,13-14,17-19H2,1-4H3,(H,33,38)(H,35,37)/t20-,25-,27+/m1/s1 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214272
((5R,8R,11S)-11-(aminomethyl)-8-(propan-2-yl)-5-{[3...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](CN)NC1=O Show InChI InChI=1S/C29H38F3N5O4/c1-18(2)25-28(40)36-23(17-33)26(38)35-12-6-9-20-8-3-4-11-24(20)41-14-13-34-22(27(39)37-25)16-19-7-5-10-21(15-19)29(30,31)32/h3-5,7-8,10-11,15,18,22-23,25,34H,6,9,12-14,16-17,33H2,1-2H3,(H,35,38)(H,36,40)(H,37,39)/t22-,23+,25-/m1/s1 | PDB
Reactome pathway
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359262
(CHEMBL1923621)Show SMILES C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C30H39ClN4O4/c1-19-18-33-27(23-12-13-23)30(38)35(3)20(2)28(36)34-25(17-21-10-14-24(31)15-11-21)29(37)32-16-6-8-22-7-4-5-9-26(22)39-19/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H3,(H,32,37)(H,34,36)/t19-,20-,25-,27+/m1/s1 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359260
(CHEMBL1923611)Show SMILES CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C29H40N4O4/c1-4-11-24-29(36)33(3)21(2)27(34)32-25(20-22-12-6-5-7-13-22)28(35)31-17-10-15-23-14-8-9-16-26(23)37-19-18-30-24/h5-9,12-14,16,21,24-25,30H,4,10-11,15,17-20H2,1-3H3,(H,31,35)(H,32,34)/t21-,24+,25-/m1/s1 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214250
((5R,8R,11S)-5-[(4-chlorophenyl)methyl]-11-[(dimeth...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O Show InChI InChI=1S/C30H42ClN5O4/c1-20(2)27-30(39)34-25(19-36(3)4)28(37)33-15-7-9-22-8-5-6-10-26(22)40-17-16-32-24(29(38)35-27)18-21-11-13-23(31)14-12-21/h5-6,8,10-14,20,24-25,27,32H,7,9,15-19H2,1-4H3,(H,33,37)(H,34,39)(H,35,38)/t24-,25+,27-/m1/s1 | PDB
Reactome pathway
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359256
(CHEMBL1923502 | ULIMORELIN)Show SMILES C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C30H39FN4O4/c1-19-18-33-27(23-12-13-23)30(38)35(3)20(2)28(36)34-25(17-21-10-14-24(31)15-11-21)29(37)32-16-6-8-22-7-4-5-9-26(22)39-19/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H3,(H,32,37)(H,34,36)/t19-,20-,25-,27+/m1/s1 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214255
((5R,8R,11S)-11-[(5-methyl-1H-1,2,3-triazol-1-yl)me...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2nncc2C)NC1=O Show InChI InChI=1S/C32H40F3N7O4/c1-20(2)28-31(45)39-26(19-42-21(3)18-38-41-42)29(43)37-13-7-10-23-9-4-5-12-27(23)46-15-14-36-25(30(44)40-28)17-22-8-6-11-24(16-22)32(33,34)35/h4-6,8-9,11-12,16,18,20,25-26,28,36H,7,10,13-15,17,19H2,1-3H3,(H,37,43)(H,39,45)(H,40,44)/t25-,26+,28-/m1/s1 | PDB
Reactome pathway
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214260
((5R,8R,11S)-5-[(3-chlorophenyl)methyl]-8-(propan-2...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2cccn2)NC1=O Show InChI InChI=1S/C31H39ClN6O4/c1-21(2)28-31(41)36-26(20-38-16-7-14-35-38)29(39)34-13-6-10-23-9-3-4-12-27(23)42-17-15-33-25(30(40)37-28)19-22-8-5-11-24(32)18-22/h3-5,7-9,11-12,14,16,18,21,25-26,28,33H,6,10,13,15,17,19-20H2,1-2H3,(H,34,39)(H,36,41)(H,37,40)/t25-,26+,28-/m1/s1 | PDB
Reactome pathway
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359251
(CHEMBL1923641)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NC[C@@H]2CCc3cccc(CCCNC(=O)[C@@H](Cc4ccc(F)cc4)NC1=O)c3O2)C1CC1 |r| Show InChI InChI=1S/C31H39FN4O4/c1-19-29(37)35-26(17-20-8-13-24(32)14-9-20)30(38)33-16-4-7-22-5-3-6-23-12-15-25(40-28(22)23)18-34-27(21-10-11-21)31(39)36(19)2/h3,5-6,8-9,13-14,19,21,25-27,34H,4,7,10-12,15-18H2,1-2H3,(H,33,38)(H,35,37)/t19-,25+,26-,27+/m1/s1 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214253
((5R,8R,11S)-8-(propan-2-yl)-11-[(pyrimidin-2-ylami...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2ncccn2)NC1=O Show InChI InChI=1S/C33H40F3N7O4/c1-21(2)28-31(46)42-26(20-41-32-39-14-7-15-40-32)29(44)38-13-6-10-23-9-3-4-12-27(23)47-17-16-37-25(30(45)43-28)19-22-8-5-11-24(18-22)33(34,35)36/h3-5,7-9,11-12,14-15,18,21,25-26,28,37H,6,10,13,16-17,19-20H2,1-2H3,(H,38,44)(H,42,46)(H,43,45)(H,39,40,41)/t25-,26+,28-/m1/s1 | PDB
Reactome pathway
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214274
((5R,8R,11S)-11-[(5-methyl-1H-1,2,3,4-tetrazol-1-yl...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2nnnc2C)NC1=O Show InChI InChI=1S/C31H39F3N8O4/c1-19(2)27-30(45)37-25(18-42-20(3)39-40-41-42)28(43)36-13-7-10-22-9-4-5-12-26(22)46-15-14-35-24(29(44)38-27)17-21-8-6-11-23(16-21)31(32,33)34/h4-6,8-9,11-12,16,19,24-25,27,35H,7,10,13-15,17-18H2,1-3H3,(H,36,43)(H,37,45)(H,38,44)/t24-,25+,27-/m1/s1 | PDB
Reactome pathway
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359234
(CHEMBL1923624)Show SMILES C[C@H]1N(C)C(=O)[C@@H](NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(F)c2)NC1=O)C1CC1 |r| Show InChI InChI=1S/C29H37FN4O4/c1-19-27(35)33-24(18-20-7-5-10-23(30)17-20)28(36)32-14-6-9-21-8-3-4-11-25(21)38-16-15-31-26(22-12-13-22)29(37)34(19)2/h3-5,7-8,10-11,17,19,22,24,26,31H,6,9,12-16,18H2,1-2H3,(H,32,36)(H,33,35)/t19-,24-,26+/m1/s1 | PDB
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214261
((5R,8R,11S)-11-[(4,5-dimethyl-1H-1,2,3-triazol-1-y...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NCCOc2ccccc2CCCNC(=O)[C@H](Cn2nnc(C)c2C)NC1=O Show InChI InChI=1S/C33H42F3N7O4/c1-20(2)29-32(46)39-27(19-43-22(4)21(3)41-42-43)30(44)38-14-8-11-24-10-5-6-13-28(24)47-16-15-37-26(31(45)40-29)18-23-9-7-12-25(17-23)33(34,35)36/h5-7,9-10,12-13,17,20,26-27,29,37H,8,11,14-16,18-19H2,1-4H3,(H,38,44)(H,39,46)(H,40,45)/t26-,27+,29-/m1/s1 | PDB
Reactome pathway
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359281
(CHEMBL1923608)Show SMILES CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C30H42N4O4/c1-21(2)19-26-30(37)34(4)22(3)28(35)33-25(20-23-11-6-5-7-12-23)29(36)32-16-10-14-24-13-8-9-15-27(24)38-18-17-31-26/h5-9,11-13,15,21-22,25-26,31H,10,14,16-20H2,1-4H3,(H,32,36)(H,33,35)/t22-,25-,26+/m1/s1 | PDB
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214251
((5R,8R,11S)-5-[(3-chlorophenyl)methyl]-11-[(dimeth...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CN(C)C)NC1=O Show InChI InChI=1S/C30H42ClN5O4/c1-20(2)27-30(39)34-25(19-36(3)4)28(37)33-14-8-11-22-10-5-6-13-26(22)40-16-15-32-24(29(38)35-27)18-21-9-7-12-23(31)17-21/h5-7,9-10,12-13,17,20,24-25,27,32H,8,11,14-16,18-19H2,1-4H3,(H,33,37)(H,34,39)(H,35,38)/t24-,25+,27-/m1/s1 | PDB
Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214276
(3-[(5R,8R,11S)-5-[(3-chlorophenyl)methyl]-6,9,12-t...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CCC(N)=N)NC1=O Show InChI InChI=1S/C30H41ClN6O4/c1-19(2)27-30(40)36-23(12-13-26(32)33)28(38)35-14-6-9-21-8-3-4-11-25(21)41-16-15-34-24(29(39)37-27)18-20-7-5-10-22(31)17-20/h3-5,7-8,10-11,17,19,23-24,27,34H,6,9,12-16,18H2,1-2H3,(H3,32,33)(H,35,38)(H,36,40)(H,37,39)/t23-,24+,27+/m0/s1 | PDB
Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214262
((5R,8R,11S)-5-[(4-chlorophenyl)methyl]-11-[(methyl...)Show SMILES CNC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C29H40ClN5O4/c1-19(2)26-29(38)34-24(18-31-3)27(36)33-14-6-8-21-7-4-5-9-25(21)39-16-15-32-23(28(37)35-26)17-20-10-12-22(30)13-11-20/h4-5,7,9-13,19,23-24,26,31-32H,6,8,14-18H2,1-3H3,(H,33,36)(H,34,38)(H,35,37)/t23-,24+,26-/m1/s1 | PDB
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| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359269
(CHEMBL1923620)Show SMILES CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C31H43FN4O4/c1-6-20(2)28-31(39)36(5)22(4)29(37)35-26(18-23-13-15-25(32)16-14-23)30(38)33-17-9-11-24-10-7-8-12-27(24)40-21(3)19-34-28/h7-8,10,12-16,20-22,26,28,34H,6,9,11,17-19H2,1-5H3,(H,33,38)(H,35,37)/t20-,21+,22+,26+,28-/m0/s1 | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214267
(1-{2-[(5R,8R,11S)-5-[(3-chlorophenyl)methyl]-6,9,1...)Show SMILES [#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2cccc(Cl)c2)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O Show InChI InChI=1S/C30H42ClN7O4/c1-19(2)26-29(41)37-23(12-14-36-30(32)33)27(39)35-13-6-9-21-8-3-4-11-25(21)42-16-15-34-24(28(40)38-26)18-20-7-5-10-22(31)17-20/h3-5,7-8,10-11,17,19,23-24,26,34H,6,9,12-16,18H2,1-2H3,(H,35,39)(H,37,41)(H,38,40)(H4,32,33,36)/t23-,24+,26+/m0/s1 | PDB
Reactome pathway
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359267
(CHEMBL1923618)Show SMILES CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C30H41FN4O4/c1-5-9-25-30(38)35(4)21(3)28(36)34-26(18-22-13-15-24(31)16-14-22)29(37)32-17-8-11-23-10-6-7-12-27(23)39-20(2)19-33-25/h6-7,10,12-16,20-21,25-26,33H,5,8-9,11,17-19H2,1-4H3,(H,32,37)(H,34,36)/t20-,21-,25+,26-/m1/s1 | PDB
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359232
(CHEMBL1923622)Show SMILES C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C30H40N4O4/c1-20-19-32-27(24-15-16-24)30(37)34(3)21(2)28(35)33-25(18-22-10-5-4-6-11-22)29(36)31-17-9-13-23-12-7-8-14-26(23)38-20/h4-8,10-12,14,20-21,24-25,27,32H,9,13,15-19H2,1-3H3,(H,31,36)(H,33,35)/t20-,21-,25-,27+/m1/s1 | PDB
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| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359265
(CHEMBL1923614)Show SMILES CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O |r| Show InChI InChI=1S/C31H44N4O4/c1-5-21(3)28-31(38)34-25(6-2)30(37)35-26(19-23-13-8-7-9-14-23)29(36)32-18-12-16-24-15-10-11-17-27(24)39-22(4)20-33-28/h7-11,13-15,17,21-22,25-26,28,33H,5-6,12,16,18-20H2,1-4H3,(H,32,36)(H,34,38)(H,35,37)/t21-,22+,25+,26+,28-/m0/s1 | PDB
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214273
((5R,8R,11S)-5-[(3-chlorophenyl)methyl]-8-(propan-2...)Show SMILES CC(C)[C@H]1NC(=O)[C@@H](Cc2cccc(Cl)c2)NCCOc2ccccc2CCCNC(=O)[C@H](CNc2nccs2)NC1=O Show InChI InChI=1S/C31H39ClN6O4S/c1-20(2)27-30(41)37-25(19-36-31-35-14-16-43-31)28(39)34-12-6-9-22-8-3-4-11-26(22)42-15-13-33-24(29(40)38-27)18-21-7-5-10-23(32)17-21/h3-5,7-8,10-11,14,16-17,20,24-25,27,33H,6,9,12-13,15,18-19H2,1-2H3,(H,34,39)(H,35,36)(H,37,41)(H,38,40)/t24-,25+,27-/m1/s1 | PDB
Reactome pathway
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359283
(CHEMBL1923616)Show SMILES CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O |r| Show InChI InChI=1S/C31H44N4O4/c1-5-22(2)28-31(38)35(4)23(3)29(36)34-26(18-17-24-12-7-6-8-13-24)30(37)33-19-11-15-25-14-9-10-16-27(25)39-21-20-32-28/h6-10,12-14,16,22-23,26,28,32H,5,11,15,17-21H2,1-4H3,(H,33,37)(H,34,36)/t22-,23+,26+,28-/m0/s1 | PDB
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214257
((5R,8R,11S)-5-[(3-chlorophenyl)methyl]-11-[(4,5-di...)Show SMILES [#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2cccc(Cl)c2)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6]-2\[#7]-[#6]-[#6]-[#7]-2)-[#7]-[#6]-1=O Show InChI InChI=1S/C31H42ClN7O4/c1-20(2)27-30(42)38-25(19-37-31-35-13-14-36-31)28(40)34-12-6-9-22-8-3-4-11-26(22)43-16-15-33-24(29(41)39-27)18-21-7-5-10-23(32)17-21/h3-5,7-8,10-11,17,20,24-25,27,33H,6,9,12-16,18-19H2,1-2H3,(H,34,40)(H,38,42)(H,39,41)(H2,35,36,37)/t24-,25+,27-/m1/s1 | PDB
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| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50199397
((9R,12R,15S)-9-(4-hydroxy-benzyl)-12-isopropyl-15-...)Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2ccc(O)cc2)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C30H42N4O5/c1-4-8-24-28(36)32-16-7-10-22-9-5-6-11-26(22)39-18-17-31-25(19-21-12-14-23(35)15-13-21)29(37)34-27(20(2)3)30(38)33-24/h5-6,9,11-15,20,24-25,27,31,35H,4,7-8,10,16-19H2,1-3H3,(H,32,36)(H,33,38)(H,34,37)/t24-,25+,27+/m0/s1 | PDB
Reactome pathway
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Appetite-regulating hormone
(Homo sapiens (Human)) | BDBM50359248
(CHEMBL1923638)Show SMILES C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1 |r| Show InChI InChI=1S/C30H39FN4O4/c1-19-18-33-27(23-12-13-23)30(38)35(3)20(2)28(36)34-25(17-21-10-14-24(31)15-11-21)29(37)32-16-6-8-22-7-4-5-9-26(22)39-19/h4-5,7,9-11,14-15,19-20,23,25,27,33H,6,8,12-13,16-18H2,1-3H3,(H,32,37)(H,34,36)/t19-,20+,25+,27-/m0/s1 | PDB
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| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay |
J Med Chem 54: 8305-20 (2011)
Article DOI: 10.1021/jm2007062
BindingDB Entry DOI: 10.7270/Q2930TK0 |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50199347
((9R,12R,15S)-9-benzyl-12-isopropyl-15-propyl-6,7,8...)Show SMILES CCC[C@@H]1NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NCCOc2ccccc2CCCNC1=O)C(C)C Show InChI InChI=1S/C30H42N4O4/c1-4-11-24-28(35)32-17-10-15-23-14-8-9-16-26(23)38-19-18-31-25(20-22-12-6-5-7-13-22)29(36)34-27(21(2)3)30(37)33-24/h5-9,12-14,16,21,24-25,27,31H,4,10-11,15,17-20H2,1-3H3,(H,32,35)(H,33,37)(H,34,36)/t24-,25+,27+/m0/s1 | PDB
Reactome pathway
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| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]motilin from human MOTR |
J Med Chem 49: 7190-7 (2006)
Article DOI: 10.1021/jm0606600
BindingDB Entry DOI: 10.7270/Q2251JZH |
More data for this
Ligand-Target Pair | |
Motilin receptor
(Homo sapiens (Human)) | BDBM50214269
(1-{[(5R,8R,11S)-5-[(3-chlorophenyl)methyl]-6,9,12-...)Show SMILES [#6]-[#6](-[#6])-[#6@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2cccc(Cl)c2)-[#7]-[#6]-[#6]-[#8]-c2ccccc2-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6]-1=O Show InChI InChI=1S/C29H40ClN7O4/c1-18(2)25-28(40)36-23(17-35-29(31)32)26(38)34-12-6-9-20-8-3-4-11-24(20)41-14-13-33-22(27(39)37-25)16-19-7-5-10-21(30)15-19/h3-5,7-8,10-11,15,18,22-23,25,33H,6,9,12-14,16-17H2,1-2H3,(H,34,38)(H,36,40)(H,37,39)(H4,31,32,35)/t22-,23+,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
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PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-motilin from human motilin receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 4187-90 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.043
BindingDB Entry DOI: 10.7270/Q2GF0T62 |
More data for this
Ligand-Target Pair | |
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