Found 162 hits with Last Name = 'bruge' and Initial = 'd' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313441
(3-(dimethylamino)-N-(((2R,4aS,5R,10bS)-9-isopropyl...)Show SMILES CC(C)c1ccc2N[C@H]([C@@H]3CC[C@H](CNS(=O)(=O)CCCN(C)C)O[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C27H39N3O3S/c1-19(2)21-11-14-25-24(17-21)27-23(26(29-25)20-9-6-5-7-10-20)13-12-22(33-27)18-28-34(31,32)16-8-15-30(3)4/h5-7,9-11,14,17,19,22-23,26-29H,8,12-13,15-16,18H2,1-4H3/t22-,23+,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313446
(CHEMBL1096003 | N-(((2R,4aS,5R,10bS)-9-chloro-7-fl...)Show SMILES CN(C)CCS(=O)(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3c(F)cc(Cl)cc3[C@H]2O1)c1ccccc1 |r| Show InChI InChI=1S/C23H29ClFN3O3S/c1-28(2)10-11-32(29,30)26-14-17-8-9-18-21(15-6-4-3-5-7-15)27-22-19(23(18)31-17)12-16(24)13-20(22)25/h3-7,12-13,17-18,21,23,26-27H,8-11,14H2,1-2H3/t17-,18+,21+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313442
(1-((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3c(F)cc(Br)cc3[C@H]2O1)c1ccccc1 |r| Show InChI InChI=1S/C20H22BrFN2O/c1-23-11-14-7-8-15-18(12-5-3-2-4-6-12)24-19-16(20(15)25-14)9-13(21)10-17(19)22/h2-6,9-10,14-15,18,20,23-24H,7-8,11H2,1H3/t14-,15+,18+,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313437
(1-((2R,4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(C)(C)C)c1ccccc1 |r| Show InChI InChI=1S/C24H32N2O/c1-24(2,3)17-10-13-21-20(14-17)23-19(12-11-18(27-23)15-25-4)22(26-21)16-8-6-5-7-9-16/h5-10,13-14,18-19,22-23,25-26H,11-12,15H2,1-4H3/t18-,19+,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313430
(2-(methylamino)-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(t...)Show SMILES CNCCS(=O)(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C23H28F3N3O3S/c1-27-11-12-33(30,31)28-14-17-8-9-18-21(15-5-3-2-4-6-15)29-20-10-7-16(23(24,25)26)13-19(20)22(18)32-17/h2-7,10,13,17-18,21-22,27-29H,8-9,11-12,14H2,1H3/t17-,18+,21+,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313435
(4-((2R,4aS,5R,10bS)-2-((methylamino)methyl)-9-(tri...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccc(O)cc1 |r| Show InChI InChI=1S/C21H23F3N2O2/c1-25-11-15-7-8-16-19(12-2-5-14(27)6-3-12)26-18-9-4-13(21(22,23)24)10-17(18)20(16)28-15/h2-6,9-10,15-16,19-20,25-27H,7-8,11H2,1H3/t15-,16+,19+,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313444
(CHEMBL1085692 | N-(((2R,4aS,5R,10bS)-9-bromo-7-flu...)Show SMILES CN(C)CCCC(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3c(F)cc(Br)cc3[C@H]2O1)c1ccccc1 |r| Show InChI InChI=1S/C25H31BrFN3O2/c1-30(2)12-6-9-22(31)28-15-18-10-11-19-23(16-7-4-3-5-8-16)29-24-20(25(19)32-18)13-17(26)14-21(24)27/h3-5,7-8,13-14,18-19,23,25,29H,6,9-12,15H2,1-2H3,(H,28,31)/t18-,19+,23+,25+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313439
(1-((2R,4aS,5R,10bS)-9-tert-butyl-5-(thiophen-2-yl)...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(C)(C)C)c1cccs1 |r| Show InChI InChI=1S/C22H30N2OS/c1-22(2,3)14-7-10-18-17(12-14)21-16(9-8-15(25-21)13-23-4)20(24-18)19-6-5-11-26-19/h5-7,10-12,15-16,20-21,23-24H,8-9,13H2,1-4H3/t15-,16+,20-,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313434
((2R,4aS,5R,10bS)-2-((1H-1,2,4-triazol-1-yl)methyl)...)Show SMILES FC(F)(F)c1ccc2N[C@H]([C@@H]3CC[C@H](Cn4cncn4)O[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C22H21F3N4O/c23-22(24,25)15-6-9-19-18(10-15)21-17(20(28-19)14-4-2-1-3-5-14)8-7-16(30-21)11-29-13-26-12-27-29/h1-6,9-10,12-13,16-17,20-21,28H,7-8,11H2/t16-,17+,20+,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313443
(CHEMBL1082249 | N-(2-(((2R,4aS,5R,10bS)-9-bromo-7-...)Show SMILES CC(=O)NCCNC[C@H]1CC[C@H]2[C@@H](Nc3c(F)cc(Br)cc3[C@H]2O1)c1ccccc1 |r| Show InChI InChI=1S/C23H27BrFN3O2/c1-14(29)27-10-9-26-13-17-7-8-18-21(15-5-3-2-4-6-15)28-22-19(23(18)30-17)11-16(24)12-20(22)25/h2-6,11-12,17-18,21,23,26,28H,7-10,13H2,1H3,(H,27,29)/t17-,18+,21+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313431
(3-amino-N-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(...)Show SMILES CN(C[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1)S(=O)(=O)CCCN |r| Show InChI InChI=1S/C24H30F3N3O3S/c1-30(34(31,32)13-5-12-28)15-18-9-10-19-22(16-6-3-2-4-7-16)29-21-11-8-17(24(25,26)27)14-20(21)23(19)33-18/h2-4,6-8,11,14,18-19,22-23,29H,5,9-10,12-13,15,28H2,1H3/t18-,19+,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313445
(2-(((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,...)Show SMILES OCCNC[C@H]1CC[C@H]2[C@@H](Nc3c(F)cc(Cl)cc3[C@H]2O1)c1ccccc1 |r| Show InChI InChI=1S/C21H24ClFN2O2/c22-14-10-17-20(18(23)11-14)25-19(13-4-2-1-3-5-13)16-7-6-15(27-21(16)17)12-24-8-9-26/h1-5,10-11,15-16,19,21,24-26H,6-9,12H2/t15-,16+,19+,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313428
(1-(2-(dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-...)Show SMILES CN(C)CCNC(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C25H31F3N4O2/c1-32(2)13-12-29-24(33)30-15-18-9-10-19-22(16-6-4-3-5-7-16)31-21-11-8-17(25(26,27)28)14-20(21)23(19)34-18/h3-8,11,14,18-19,22-23,31H,9-10,12-13,15H2,1-2H3,(H2,29,30,33)/t18-,19+,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313440
(1-((2R,4aS,5R,10bS)-9-cyclopropyl-5-phenyl-3,4,4a,...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C1CC1)c1ccccc1 |r| Show InChI InChI=1S/C23H28N2O/c1-24-14-18-10-11-19-22(16-5-3-2-4-6-16)25-21-12-9-17(15-7-8-15)13-20(21)23(19)26-18/h2-6,9,12-13,15,18-19,22-25H,7-8,10-11,14H2,1H3/t18-,19+,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313427
(1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-...)Show SMILES OCCCNC(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C24H28F3N3O3/c25-24(26,27)16-7-10-20-19(13-16)22-18(21(30-20)15-5-2-1-3-6-15)9-8-17(33-22)14-29-23(32)28-11-4-12-31/h1-3,5-7,10,13,17-18,21-22,30-31H,4,8-9,11-12,14H2,(H2,28,29,32)/t17-,18+,21+,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178285
(CHEMBL3813865)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cn[nH]c1 Show InChI InChI=1S/C16H15N7/c1-2-11-4-14(23-16(17)22-11)13-8-19-15-12(13)3-9(5-18-15)10-6-20-21-7-10/h3-8H,2H2,1H3,(H,18,19)(H,20,21)(H2,17,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313429
(2-(dimethylamino)ethyl((2R,4aS,5R,10bS)-5-phenyl-9...)Show SMILES CN(C)CCOC(=O)NC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C25H30F3N3O3/c1-31(2)12-13-33-24(32)29-15-18-9-10-19-22(16-6-4-3-5-7-16)30-21-11-8-17(25(26,27)28)14-20(21)23(19)34-18/h3-8,11,14,18-19,22-23,30H,9-10,12-13,15H2,1-2H3,(H,29,32)/t18-,19+,22+,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313409
(4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexah...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccc(O)c(F)c1 |r| Show InChI InChI=1S/C22H26FNO2/c1-22(2,3)14-7-8-18-16(12-14)21-15(5-4-10-26-21)20(24-18)13-6-9-19(25)17(23)11-13/h6-9,11-12,15,20-21,24-25H,4-5,10H2,1-3H3/t15-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313438
(2-((((2R,4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a...)Show SMILES CCN(CCO)C[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(C)(C)C)c1ccccc1 |r| Show InChI InChI=1S/C27H38N2O2/c1-5-29(15-16-30)18-21-12-13-22-25(19-9-7-6-8-10-19)28-24-14-11-20(27(2,3)4)17-23(24)26(22)31-21/h6-11,14,17,21-22,25-26,28,30H,5,12-13,15-16,18H2,1-4H3/t21-,22+,25+,26+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313432
(CHEMBL1093087 | N1-phenyl-N1-(((2R,4aS,5R,10bS)-5-...)Show SMILES NCCN(C[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C28H30F3N3O/c29-28(30,31)20-11-14-25-24(17-20)27-23(26(33-25)19-7-3-1-4-8-19)13-12-22(35-27)18-34(16-15-32)21-9-5-2-6-10-21/h1-11,14,17,22-23,26-27,33H,12-13,15-16,18,32H2/t22-,23+,26+,27+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313426
(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4...)Show SMILES NC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C20H21F3N2O/c21-20(22,23)13-6-9-17-16(10-13)19-15(8-7-14(11-24)26-19)18(25-17)12-4-2-1-3-5-12/h1-6,9-10,14-15,18-19,25H,7-8,11,24H2/t14-,15+,18+,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313418
((4aS,5R,10bS)-9-tert-butyl-5-(thiophen-2-yl)-3,4,4...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1cccs1 |r| Show InChI InChI=1S/C20H25NOS/c1-20(2,3)13-8-9-16-15(12-13)19-14(6-4-10-22-19)18(21-16)17-7-5-11-23-17/h5,7-9,11-12,14,18-19,21H,4,6,10H2,1-3H3/t14-,18+,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313407
(4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexah...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H27NO2/c1-22(2,3)15-8-11-19-18(13-15)21-17(5-4-12-25-21)20(23-19)14-6-9-16(24)10-7-14/h6-11,13,17,20-21,23-24H,4-5,12H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM17053
(BX-320 | N-(3-{[5-bromo-2-({3-[(pyrrolidin-1-ylcar...)Show SMILES CC(C)(C(N)=O)C(=O)NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br Show InChI InChI=1S/C23H31BrN8O3/c1-23(2,19(25)33)20(34)27-10-6-9-26-18-17(24)14-28-21(31-18)29-15-7-5-8-16(13-15)30-22(35)32-11-3-4-12-32/h5,7-8,13-14H,3-4,6,9-12H2,1-2H3,(H2,25,33)(H,27,34)(H,30,35)(H2,26,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| MMDB
PDB
Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDK1 assessed as PtdIns-3,4-P2-mediated AKT2 activation using biotin-ARRRDGGGAQPFRPRAATF as substrate after 2 hrs by ... |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313406
(3-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexah...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1cccc(O)c1 |r| Show InChI InChI=1S/C22H27NO2/c1-22(2,3)15-9-10-19-18(13-15)21-17(8-5-11-25-21)20(23-19)14-6-4-7-16(24)12-14/h4,6-7,9-10,12-13,17,20-21,23-24H,5,8,11H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178291
(CHEMBL3814140)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C21H24N8/c1-2-15-8-19(28-21(22)27-15)18-11-25-20-17(18)7-13(9-24-20)14-10-26-29(12-14)16-3-5-23-6-4-16/h7-12,16,23H,2-6H2,1H3,(H,24,25)(H2,22,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313436
(1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluor...)Show SMILES CNC[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccc(F)cc1 |r| Show InChI InChI=1S/C21H22F4N2O/c1-26-11-15-7-8-16-19(12-2-5-14(22)6-3-12)27-18-9-4-13(21(23,24)25)10-17(18)20(16)28-15/h2-6,9-10,15-16,19-20,26-27H,7-8,11H2,1H3/t15-,16+,19+,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313433
(CHEMBL1084431 | N-(2-aminoethyl)-4-methyl-N-(((2R,...)Show SMILES Cc1ccc(cc1)C(=O)N(CCN)C[C@H]1CC[C@H]2[C@@H](Nc3ccc(cc3[C@H]2O1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C30H32F3N3O2/c1-19-7-9-21(10-8-19)29(37)36(16-15-34)18-23-12-13-24-27(20-5-3-2-4-6-20)35-26-14-11-22(30(31,32)33)17-25(26)28(24)38-23/h2-11,14,17,23-24,27-28,35H,12-13,15-16,18,34H2,1H3/t23-,24+,27+,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178290
(CHEMBL3814770)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(CCN(C)C)c1 Show InChI InChI=1S/C20H24N8/c1-4-15-8-18(26-20(21)25-15)17-11-23-19-16(17)7-13(9-22-19)14-10-24-28(12-14)6-5-27(2)3/h7-12H,4-6H2,1-3H3,(H,22,23)(H2,21,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178293
(CHEMBL3815046)Show SMILES CCCCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C23H28N8/c1-2-3-4-17-10-21(30-23(24)29-17)20-13-27-22-19(20)9-15(11-26-22)16-12-28-31(14-16)18-5-7-25-8-6-18/h9-14,18,25H,2-8H2,1H3,(H,26,27)(H2,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178287
(CHEMBL3814785)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(C)c1 Show InChI InChI=1S/C17H17N7/c1-3-12-5-15(23-17(18)22-12)14-8-20-16-13(14)4-10(6-19-16)11-7-21-24(2)9-11/h4-9H,3H2,1-2H3,(H,19,20)(H2,18,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313401
((4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl...)Show SMILES Fc1cc(cc2[C@H]3OCCC[C@H]3[C@@H](Nc12)c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C19H17F4NO/c20-15-10-12(19(21,22)23)9-14-17(15)24-16(11-5-2-1-3-6-11)13-7-4-8-25-18(13)14/h1-3,5-6,9-10,13,16,18,24H,4,7-8H2/t13-,16-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313408
(4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexah...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C22H27NO3/c1-22(2,3)14-7-8-17-16(12-14)21-15(5-4-10-26-21)20(23-17)13-6-9-18(24)19(25)11-13/h6-9,11-12,15,20-21,23-25H,4-5,10H2,1-3H3/t15-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313391
((4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,...)Show SMILES FC(F)(F)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C19H18F3NO/c20-19(21,22)13-8-9-16-15(11-13)18-14(7-4-10-24-18)17(23-16)12-5-2-1-3-6-12/h1-3,5-6,8-9,11,14,17-18,23H,4,7,10H2/t14-,17-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178292
(CHEMBL3813933)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(CC(C)C)c1 Show InChI InChI=1S/C20H23N7/c1-4-15-6-18(26-20(21)25-15)17-9-23-19-16(17)5-13(7-22-19)14-8-24-27(11-14)10-12(2)3/h5-9,11-12H,4,10H2,1-3H3,(H,22,23)(H2,21,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178284
(CHEMBL3814317)Show InChI InChI=1S/C17H15N5O/c1-2-11-7-14(22-17(18)21-11)13-9-20-16-12(13)6-10(8-19-16)15-4-3-5-23-15/h3-9H,2H2,1H3,(H,19,20)(H2,18,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313419
((4aS,5R,10bS)-9-tert-butyl-5-(thiophen-3-yl)-3,4,4...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccsc1 |r| Show InChI InChI=1S/C20H25NOS/c1-20(2,3)14-6-7-17-16(11-14)19-15(5-4-9-22-19)18(21-17)13-8-10-23-12-13/h6-8,10-12,15,18-19,21H,4-5,9H2,1-3H3/t15-,18-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313387
((4aS,5R,10bS)-9-ethyl-5-phenyl-3,4,4a,5,6,10b-hexa...)Show SMILES CCc1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C20H23NO/c1-2-14-10-11-18-17(13-14)20-16(9-6-12-22-20)19(21-18)15-7-4-3-5-8-15/h3-5,7-8,10-11,13,16,19-21H,2,6,9,12H2,1H3/t16-,19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313389
((4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-...)Show SMILES CC(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C21H25NO/c1-14(2)16-10-11-19-18(13-16)21-17(9-6-12-23-21)20(22-19)15-7-4-3-5-8-15/h3-5,7-8,10-11,13-14,17,20-22H,6,9,12H2,1-2H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178283
(CHEMBL3814154)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1ccc(N)nc1 Show InChI InChI=1S/C18H17N7/c1-2-12-6-15(25-18(20)24-12)14-9-23-17-13(14)5-11(8-22-17)10-3-4-16(19)21-7-10/h3-9H,2H2,1H3,(H2,19,21)(H,22,23)(H2,20,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313414
((4aS,5R,10bS)-9-tert-butyl-5-(2-fluorophenyl)-3,4,...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1F |r| Show InChI InChI=1S/C22H26FNO/c1-22(2,3)14-10-11-19-17(13-14)21-16(8-6-12-25-21)20(24-19)15-7-4-5-9-18(15)23/h4-5,7,9-11,13,16,20-21,24H,6,8,12H2,1-3H3/t16-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178286
(CHEMBL3814539)Show SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1ccn[nH]1 Show InChI InChI=1S/C16H15N7/c1-2-10-6-14(22-16(17)21-10)12-8-19-15-11(12)5-9(7-18-15)13-3-4-20-23-13/h3-8H,2H2,1H3,(H,18,19)(H,20,23)(H2,17,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313415
((4aS,5R,10bS)-9-tert-butyl-5-(4-fluorophenyl)-3,4,...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H26FNO/c1-22(2,3)15-8-11-19-18(13-15)21-17(5-4-12-25-21)20(24-19)14-6-9-16(23)10-7-14/h6-11,13,17,20-21,24H,4-5,12H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313390
((4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C22H27NO/c1-22(2,3)16-11-12-19-18(14-16)21-17(10-7-13-24-21)20(23-19)15-8-5-4-6-9-15/h4-6,8-9,11-12,14,17,20-21,23H,7,10,13H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313420
((4aS,5R,10bS)-9-tert-butyl-5-(5-chlorothiophen-2-y...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccc(Cl)s1 |r| Show InChI InChI=1S/C20H24ClNOS/c1-20(2,3)12-6-7-15-14(11-12)19-13(5-4-10-23-19)18(22-15)16-8-9-17(21)24-16/h6-9,11,13,18-19,22H,4-5,10H2,1-3H3/t13-,18+,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313390
((4aS,5R,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C22H27NO/c1-22(2,3)16-11-12-19-18(14-16)21-17(10-7-13-24-21)20(23-19)15-8-5-4-6-9-15/h4-6,8-9,11-12,14,17,20-21,23H,7,10,13H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313416
((4aS,5R,10bS)-9-tert-butyl-5-(3-fluorophenyl)-3,4,...)Show SMILES CC(C)(C)c1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1cccc(F)c1 |r| Show InChI InChI=1S/C22H26FNO/c1-22(2,3)15-9-10-19-18(13-15)21-17(8-5-11-25-21)20(24-19)14-6-4-7-16(23)12-14/h4,6-7,9-10,12-13,17,20-21,24H,5,8,11H2,1-3H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313388
((4aS,5R,10bS)-5-phenyl-9-propyl-3,4,4a,5,6,10b-hex...)Show SMILES CCCc1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C21H25NO/c1-2-7-15-11-12-19-18(14-15)21-17(10-6-13-23-21)20(22-19)16-8-4-3-5-9-16/h3-5,8-9,11-12,14,17,20-22H,2,6-7,10,13H2,1H3/t17-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
3-phosphoinositide-dependent protein kinase 1
(Homo sapiens (Human)) | BDBM50178277
(CHEMBL3814554)Show InChI InChI=1S/C14H16N6/c15-5-1-3-9-7-12(20-14(16)19-9)11-8-18-13-10(11)4-2-6-17-13/h2,4,6-8H,1,3,5,15H2,(H,17,18)(H2,16,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA
Curated by ChEMBL
| Assay Description
Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount method |
Bioorg Med Chem Lett 26: 3073-80 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.005
BindingDB Entry DOI: 10.7270/Q2M61N5R |
More data for this
Ligand-Target Pair | |
Kinesin-like protein KIF11
(Homo sapiens (Human)) | BDBM50313386
((4aS,5R,10bS)-9-methyl-5-phenyl-3,4,4a,5,6,10b-hex...)Show SMILES Cc1ccc2N[C@H]([C@@H]3CCCO[C@@H]3c2c1)c1ccccc1 |r| Show InChI InChI=1S/C19H21NO/c1-13-9-10-17-16(12-13)19-15(8-5-11-21-19)18(20-17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,15,18-20H,5,8,11H2,1H3/t15-,18-,19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono
Curated by ChEMBL
| Assay Description
Inhibition of ATPase activity of human recombinant EG5 assessed as ATP hydrolysis by pyruvate kinase-lactate dehydrogenase coupled assay |
Bioorg Med Chem Lett 20: 1491-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.110
BindingDB Entry DOI: 10.7270/Q2KD1ZWN |
More data for this
Ligand-Target Pair | |
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