Compile Data Set for Download or QSAR

Found 1107 hits with Last Name = 'ohno' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM29994 (2-Cyclohexylcarbonylbenzimidazole, 7e) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@]1(CC)CC[C@@](C)(O)CC1 |r,wU:20.23,25.29,wD:20.22,25.28,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,;3.2,3.85,;3.97,5.18,;4.29,2.76,;4.84,4.2,;6.37,4.44,;5.83,2.84,;6.66,1.54,;5.96,.17,;5.96,-1.37,;7.45,-.23,;4.42,.1,;3.59,1.39,)| Show InChI InChI=1S/C23H33ClN4O2/c1-4-23(8-6-22(3,30)7-9-23)20(29)21-25-17-14-16(24)19(15-18(17)26-21)28-12-10-27(5-2)11-13-28/h14-15,30H,4-13H2,1-3H3,(H,25,26)/t22-,23-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	2.40	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29988 (benzimidazole analogue, 7h | benzimidazole derivat...) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)N(C)C(C)=O)nc2cc1Cl |r,wU:14.15,18.22,wD:14.14,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;3.2,3.85,;4.29,2.76,;4.84,4.2,;3.59,1.39,;4.42,.1,;5.96,.17,;6.66,1.54,;5.83,2.84,;6.79,-1.12,;6.09,-2.49,;8.33,-1.05,;9.17,-2.34,;9.04,.32,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,)| Show InChI InChI=1S/C23H34ClN5OS/c1-5-28-10-12-29(13-11-28)21-15-20-19(14-18(21)24)25-22(26-20)31-23(3)8-6-17(7-9-23)27(4)16(2)30/h14-15,17H,5-13H2,1-4H3,(H,25,26)/t17-,23-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296914 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C23H27ClFN5/c1-14(2)22-20(13-28-17-8-7-16(25)11-17)29-23(21-19(24)5-4-10-26-21)30(22)18-9-6-15(3)27-12-18/h4-6,9-10,12,14,16-17,28H,7-8,11,13H2,1-3H3/t16-,17+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29992 (2-Cyclohexylcarbonylbenzimidazole, 7c) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@]1(C)CC[C@@](C)(O)CC1 |r,wU:20.23,24.28,wD:20.22,24.27,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,;3.2,3.85,;3.97,5.18,;4.29,2.76,;4.84,4.2,;5.83,2.84,;6.66,1.54,;5.96,.17,;5.96,-1.37,;7.45,-.23,;4.42,.1,;3.59,1.39,)| Show InChI InChI=1S/C22H31ClN4O2/c1-4-26-9-11-27(12-10-26)18-14-17-16(13-15(18)23)24-20(25-17)19(28)21(2)5-7-22(3,29)8-6-21/h13-14,29H,4-12H2,1-3H3,(H,24,25)/t21-,22-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	1.30	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29990 (2-Cyclohexylcarbonylbenzimidazole, 7b) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1C)C(=O)[C@@]1(C)CC[C@@H](CC1)NC(=O)OC |r,wU:20.23,24.30,wD:20.22,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,;3.2,3.85,;3.97,5.18,;4.29,2.76,;4.84,4.2,;3.59,1.39,;4.42,.1,;5.96,.17,;6.66,1.54,;5.83,2.84,;6.79,-1.12,;8.33,-1.05,;9.04,.32,;9.17,-2.34,;10.71,-2.26,)| Show InChI InChI=1S/C24H35N5O3/c1-5-28-10-12-29(13-11-28)20-15-19-18(14-16(20)2)26-22(27-19)21(30)24(3)8-6-17(7-9-24)25-23(31)32-4/h14-15,17H,5-13H2,1-4H3,(H,25,31)(H,26,27)/t17-,24-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	5.30	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296914 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C23H27ClFN5/c1-14(2)22-20(13-28-17-8-7-16(25)11-17)29-23(21-19(24)5-4-10-26-21)30(22)18-9-6-15(3)27-12-18/h4-6,9-10,12,14,16-17,28H,7-8,11,13H2,1-3H3/t16-,17+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296912 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-ethyl-1-(6-...) Show SMILES CCc1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C22H25ClFN5/c1-3-20-19(13-27-16-8-7-15(24)11-16)28-22(21-18(23)5-4-10-25-21)29(20)17-9-6-14(2)26-12-17/h4-6,9-10,12,15-16,27H,3,7-8,11,13H2,1-2H3/t15-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29987 (benzimidazole analogue, 7e | benzimidazole derivat...) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NC(=O)OC)nc2cc1Cl |r,wU:14.15,18.22,wD:14.14,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;3.2,3.85,;4.29,2.76,;4.84,4.2,;3.59,1.39,;4.42,.1,;5.96,.17,;6.66,1.54,;5.83,2.84,;6.79,-1.12,;8.33,-1.05,;9.04,.32,;9.17,-2.34,;10.71,-2.26,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,)| Show InChI InChI=1S/C22H32ClN5O2S/c1-4-27-9-11-28(12-10-27)19-14-18-17(13-16(19)23)25-20(26-18)31-22(2)7-5-15(6-8-22)24-21(29)30-3/h13-15H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t15-,22-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	0.720	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558265 (N-Methyl-3-[[methyl-[3-[[6-(1-H-pyrazol-5-yl)-3-py...) Show SMILES CC(=O)Oc1cc(CO)ccc1F Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558426 (Methyl 4-hydroxy-4-[3-[[6-(1-H-pyrazol-5-yl)-3-pyr...) Show SMILES COC(=O)N1CCC(O)(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296912 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-ethyl-1-(6-...) Show SMILES CCc1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C22H25ClFN5/c1-3-20-19(13-27-16-8-7-15(24)11-16)28-22(21-18(23)5-4-10-25-21)29(20)17-9-6-14(2)26-12-17/h4-6,9-10,12,15-16,27H,3,7-8,11,13H2,1-2H3/t15-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558427 (US11365192, Example 51-2) Show SMILES CCOC(=O)C(C)(C)n1ccc(CCCCO)n1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296911 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-methyl-1-(6...) Show SMILES Cc1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C21H23ClFN5/c1-13-5-8-17(11-25-13)28-14(2)19(12-26-16-7-6-15(23)10-16)27-21(28)20-18(22)4-3-9-24-20/h3-5,8-9,11,15-16,26H,6-7,10,12H2,1-2H3/t15-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558428 (1-[4-Hydroxy-4-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridin...) Show SMILES CC(=O)N1CCC(O)(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296915 ((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C19H24F3N3/c1-11(2)19-18(10-23-16-5-4-13(20)7-16)24-12(3)25(19)17-8-14(21)6-15(22)9-17/h6,8-9,11,13,16,23H,4-5,7,10H2,1-3H3/t13-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296913 (CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...) Show SMILES CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 Show InChI InChI=1S/C23H28ClN5/c1-15(2)22-20(14-27-17-7-4-5-8-17)28-23(21-19(24)9-6-12-25-21)29(22)18-11-10-16(3)26-13-18/h6,9-13,15,17,27H,4-5,7-8,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558214 (2,3-Difluoro-5-[3-[[6-(1H-pyrazol-5-yl)-3-pyridiny...) Show SMILES Oc1cc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc(F)c1F Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558439 (N-Methyl-N-[[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]o...) Show SMILES CN(CC12CC(COc3ccc(nc3)-c3ccn[nH]3)(C1)C2)S(C)(=O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558313 (2-[3-[[6-(5-Isothiazolyl)-3-pyridinyl]oxymethyl]ph...) Show SMILES OC(=O)Cc1cccc(COc2ccc(nc2)-c2ccns2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296930 ((1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-me...) Show SMILES COCCc1nc(CN[C@H]2CC[C@@H](F)C2)n(C(C)C)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H29ClFN3O/c1-14(2)26-20(13-24-18-9-8-17(23)12-18)25-19(10-11-27-3)21(26)15-4-6-16(22)7-5-15/h4-7,14,17-18,24H,8-13H2,1-3H3/t17-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29989 (2-Cyclohexylcarbonylbenzimidazole, 7a) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@@]1(C)CC[C@@H](CC1)NC(=O)OC |r,wU:20.23,24.30,wD:20.22,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,;3.2,3.85,;3.97,5.18,;4.29,2.76,;4.84,4.2,;3.59,1.39,;4.42,.1,;5.96,.17,;6.66,1.54,;5.83,2.84,;6.79,-1.12,;8.33,-1.05,;9.04,.32,;9.17,-2.34,;10.71,-2.26,)| Show InChI InChI=1S/C23H32ClN5O3/c1-4-28-9-11-29(12-10-28)19-14-18-17(13-16(19)24)26-21(27-18)20(30)23(2)7-5-15(6-8-23)25-22(31)32-3/h13-15H,4-12H2,1-3H3,(H,25,31)(H,26,27)/t15-,23-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	7.5	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558338 (US11365192, Example 42-16) Show SMILES CN(C)C(=O)\C=C\c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558218 (2-Methyl-5-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxyme...) Show SMILES Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558269 (US11365192, Example 23-6) Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM50591500 (CHEMBL5195099) Show SMILES N#Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01089 BindingDB Entry DOI: 10.7270/Q2MK6HW6
					More data for this Ligand-Target Pair
Neuraminidase (Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)	BDBM50222711 (CHEMBL350985) Show SMILES [H][C@@]1(C[C@H](O)[C@H](O)CO1)[C@]1([H])OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O |c:13| Show InChI InChI=1S/C14H22N4O7/c1-5(19)17-11-6(18-14(15)16)2-10(13(22)23)25-12(11)9-3-7(20)8(21)4-24-9/h2,6-9,11-12,20-21H,3-4H2,1H3,(H,17,19)(H,22,23)(H4,15,16,18)/t6-,7-,8+,9+,11+,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.84	n/a	n/a	n/a	n/a	n/a	n/a
Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory concentration against influenza A virus sialidase A/PR/8/34				Bioorg Med Chem Lett 13: 669-73 (2003) BindingDB Entry DOI: 10.7270/Q2P84F3T
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558316 (US11365192, Example 40-2) Show SMILES CC(C)OC(=O)c1ccc(CCO)cc1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558216 (US11365192, Example 11-3) Show SMILES CCOC(=O)c1cc(CBr)ccc1Cl Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296930 ((1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-me...) Show SMILES COCCc1nc(CN[C@H]2CC[C@@H](F)C2)n(C(C)C)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H29ClFN3O/c1-14(2)26-20(13-24-18-9-8-17(23)12-18)25-19(10-11-27-3)21(26)15-4-6-16(22)7-5-15/h4-7,14,17-18,24H,8-13H2,1-3H3/t17-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558552 (US11365192, Example 75-7 | US11365192, Example 75-...) Show SMILES OC(=O)C1CCc2ccc(COc3ccc(nc3)-c3[nH]ncc3Cl)cc2O1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558188 (1-Acetyl-4-[8-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]ox...) Show SMILES CC(=O)N1CCC(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)(CC1)C(O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558451 (1,1,1-Trifluoro-N-[[3-[[6-(1-H-pyrazol-5-yl)-3-pyr...) Show SMILES FC(F)(F)S(=O)(=O)NCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558443 (2,2-Difluoro-2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridiny...) Show SMILES OC(=O)C(F)(F)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296915 ((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...) Show SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C19H24F3N3/c1-11(2)19-18(10-23-16-5-4-13(20)7-16)24-12(3)25(19)17-8-14(21)6-15(22)9-17/h6,8-9,11,13,16,23H,4-5,7,10H2,1-3H3/t13-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558158 (US11365192, Example 1-63) Show SMILES CC(C)(CCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296911 ((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-methyl-1-(6...) Show SMILES Cc1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 |r| Show InChI InChI=1S/C21H23ClFN5/c1-13-5-8-17(11-25-13)28-14(2)19(12-26-16-7-6-15(23)10-16)27-21(28)20-18(22)4-3-9-24-20/h3-5,8-9,11,15-16,26H,6-7,10,12H2,1-2H3/t15-,16+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558294 (3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]p...) Show SMILES OC(=O)c1cccc(c1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558529 (US11365192, Example 72-6) Show SMILES OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCS(=O)(=O)CC1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558114 (US11365192, Example 1-19) Show SMILES OC(=O)c1cccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296913 (CHEMBL561396 | N-((2-(3-chloropyridin-2-yl)-5-isop...) Show SMILES CC(C)c1c(CNC2CCCC2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1 Show InChI InChI=1S/C23H28ClN5/c1-15(2)22-20(14-27-17-7-4-5-8-17)28-23(21-19(24)9-6-12-25-21)29(22)18-11-10-16(3)26-13-18/h6,9-13,15,17,27H,4-5,7-8,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558295 (US11365192, Example 31-2) Show SMILES OC(=O)c1ccc(cc1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558315 (2-[3-[[6-(5-Oxazolyl)-3-pyridinyl]oxymethyl]phenyl...) Show SMILES OC(=O)Cc1cccc(COc2ccc(nc2)-c2cnco2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM29991 (2-Cyclohexylcarbonylbenzimidazole, 9) Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)C1(C)CCC(=O)CC1 Show InChI InChI=1S/C21H27ClN4O2/c1-3-25-8-10-26(11-9-25)18-13-17-16(12-15(18)22)23-20(24-17)19(28)21(2)6-4-14(27)5-7-21/h12-13H,3-11H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	38	n/a	n/a	7.4	37
Banyu Pharmaceutical Co.					Assay Description Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...				Bioorg Med Chem Lett 19: 3096-9 (2009) Article DOI: 10.1016/j.bmcl.2009.04.023 BindingDB Entry DOI: 10.7270/Q24J0CFR
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558440 (1,1,1-Trifluoro-3-[3-[[6-(1H-pyrazol-5-yl)-3-pyrid...) Show SMILES OC(Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(F)(F)F Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558311 (2-[3-[[6-(1H-Pyrazol-4-yl)-3-pyridinyl]oxymethyl]p...) Show SMILES CCOC(=O)C(C)(C)OCCCCOCCCCO Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558219 (US11365192, Example 12-2) Show SMILES Oc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50296929 (CHEMBL562663 | N-((5-(4-chlorophenyl)-1-isopropyl-...) Show SMILES CC(C)n1c(CNC2CCCC2)nc(C)c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H26ClN3/c1-13(2)23-18(12-21-17-6-4-5-7-17)22-14(3)19(23)15-8-10-16(20)11-9-15/h8-11,13,17,21H,4-7,12H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 4611-6 (2009) Article DOI: 10.1016/j.bmcl.2009.06.095 BindingDB Entry DOI: 10.7270/Q2TM7B4V
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558342 (US11365192, Example 42-20) Show SMILES Fc1cc(OCc2cccc(CCC(=O)NC3COC3)c2)cnc1-c1ccn[nH]1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4A11 (Homo sapiens)	BDBM558231 (US11365192, Example 18-2) Show SMILES OC(=O)c1ccc(nc1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair
Cytochrome P450 4F2 (Homo sapiens (Human))	BDBM558533 (1,1-Dioxo-3-[8-[6-(1H-pyrazol-5-yl)pyridin-3-yl]ox...) Show SMILES OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CS(=O)(=O)C1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In the CYP4F2 inhibition test, the reaction solution containing each compound [final concentration of 50 mM, KPO4 (pH 7.4), 2.5 μM luciferine de...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PN98V9
					More data for this Ligand-Target Pair

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