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Compile Data Set for Download or QSAR

Found 86 hits with Last Name = 'pohlmann' and Initial = 'j'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))		BDBM7842
PNG
(BAY 59-7939 Analog 17 | US8822458, 46)
Show SMILES Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H18BrN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 0.400n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130530
PNG
(US8822458, 127)
Show SMILES Fc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Br)s2)OC1=O |r|
Show InChI InChI=1S/C19H17BrFN3O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10H2,(H,22,26)/t12-/m0/s1
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n/an/a 0.700n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7840
PNG
(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 0.700n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Homo sapiens (Human))		BDBM130532
PNG
(US8822458, 129)
Show SMILES Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCCC1=O |r|
Show InChI InChI=1S/C20H20BrN3O4S/c21-17-9-8-16(29-17)19(26)22-11-15-12-24(20(27)28-15)14-6-4-13(5-7-14)23-10-2-1-3-18(23)25/h4-9,15H,1-3,10-12H2,(H,22,26)/t15-/m0/s1
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n/an/a 1n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12998
PNG
(5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Show SMILES FC(F)(F)c1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C20H17ClF3N3O5S/c21-16-4-3-15(33-16)18(29)25-8-12-9-27(19(30)32-12)11-1-2-14(13(7-11)20(22,23)24)26-5-6-31-10-17(26)28/h1-4,7,12H,5-6,8-10H2,(H,25,29)/t12-/m0/s1
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n/an/a 1n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12997
PNG
(5-Chloro-N-({(5S)-3-[3-fluoro-4-(3-oxomorpholin-4-...)
Show SMILES Fc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H17ClFN3O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10H2,(H,22,26)/t12-/m0/s1
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n/an/a 1.40n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7840
PNG
(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 1.40n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Coagulation factor X


(Homo sapiens (Human))		BDBM130531
PNG
(US8822458, 128)
Show SMILES Fc1cc(ccc1N1CCCC1=O)N1C[C@H](CNC(=O)c2ccc(Br)s2)OC1=O |r|
Show InChI InChI=1S/C19H17BrFN3O4S/c20-16-6-5-15(29-16)18(26)22-9-12-10-24(19(27)28-12)11-3-4-14(13(21)8-11)23-7-1-2-17(23)25/h3-6,8,12H,1-2,7,9-10H2,(H,22,26)/t12-/m0/s1
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n/an/a 2n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12999
PNG
(BAY 59-7939 Analog 14 | N-({(5S)-3-[3-Amino-4-(3-o...)
Show SMILES Nc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H19ClN4O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10,21H2,(H,22,26)/t12-/m0/s1
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n/an/a 2.5n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM8299
PNG
(US8822458, 162)
Show SMILES Fc1cc(ccc1N1CCCCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C20H19ClFN3O4S/c21-17-7-6-16(30-17)19(27)23-10-13-11-25(20(28)29-13)12-4-5-15(14(22)9-12)24-8-2-1-3-18(24)26/h4-7,9,13H,1-3,8,10-11H2,(H,23,27)/t13-/m0/s1
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n/an/a 2.80n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130533
PNG
(US8822458, 130)
Show SMILES Fc1cc(ccc1N1CCCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H17ClFN3O4S/c20-16-6-5-15(29-16)18(26)22-9-12-10-24(19(27)28-12)11-3-4-14(13(21)8-11)23-7-1-2-17(23)25/h3-6,8,12H,1-2,7,9-10H2,(H,22,26)/t12-/m0/s1
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n/an/a 3.30n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7552
PNG
(BAY 59-7939 Analog 11 | US8822458, 17)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O |r|
Show InChI InChI=1S/C19H18ClN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 4n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130527
PNG
(US8822458, 56)
Show SMILES Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O |r|
Show InChI InChI=1S/C19H18BrN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 4n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7552
PNG
(BAY 59-7939 Analog 11 | US8822458, 17)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O |r|
Show InChI InChI=1S/C19H18ClN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 4n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7841
PNG
(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Show SMILES Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C20H21N3O5S/c1-13-2-7-17(29-13)19(25)21-10-16-11-23(20(26)28-16)15-5-3-14(4-6-15)22-8-9-27-12-18(22)24/h2-7,16H,8-12H2,1H3,(H,21,25)/t16-/m0/s1
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n/an/a 4.20n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7841
PNG
(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Show SMILES Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C20H21N3O5S/c1-13-2-7-17(29-13)19(25)21-10-16-11-23(20(26)28-16)15-5-3-14(4-6-15)22-8-9-27-12-18(22)24/h2-7,16H,8-12H2,1H3,(H,21,25)/t16-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13008
PNG
(4-Amino-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorphol...)
Show SMILES Nc1cc(sc1Cl)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H19ClN4O5S/c20-17-14(21)7-15(30-17)18(26)22-8-13-9-24(19(27)29-13)12-3-1-11(2-4-12)23-5-6-28-10-16(23)25/h1-4,7,13H,5-6,8-10,21H2,(H,22,26)/t13-/m0/s1
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n/an/a 8.5n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130529
PNG
(US8822458, 126)
Show SMILES NC1CCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-8-13-10-25(19(27)28-13)12-1-2-15(14(21)7-12)24-6-5-11(22)9-24/h1-4,7,11,13H,5-6,8-10,22H2,(H,23,26)
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n/an/a 13n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7839
PNG
(US8822458, 43)
Show SMILES Brc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C19H18BrN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)
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n/an/a 14n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13005
PNG
(4-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Show SMILES Clc1ccc(cc1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C21H20ClN3O5/c22-15-3-1-14(2-4-15)20(27)23-11-18-12-25(21(28)30-18)17-7-5-16(6-8-17)24-9-10-29-13-19(24)26/h1-8,18H,9-13H2,(H,23,27)/t18-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13004
PNG
(5-Bromo-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)p...)
Show SMILES Brc1ccc(o1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H18BrN3O6/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13010
PNG
(5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Show SMILES Clc1ccc(nc1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C20H19ClN4O5/c21-13-1-6-17(22-9-13)19(27)23-10-16-11-25(20(28)30-16)15-4-2-14(3-5-15)24-7-8-29-12-18(24)26/h1-6,9,16H,7-8,10-12H2,(H,23,27)/t16-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12990
PNG
(5-Chloro-N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphen...)
Show SMILES Fc1cc(ccc1N1CCOCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H19ClFN3O4S/c20-17-4-3-16(29-17)18(25)22-10-13-11-24(19(26)28-13)12-1-2-15(14(21)9-12)23-5-7-27-8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1
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n/an/a 32n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7633
PNG
(US8822458, 37)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(Cl)c1 |r|
Show InChI InChI=1S/C19H19Cl2N3O4S/c20-14-9-12(1-2-15(14)23-5-7-27-8-6-23)24-11-13(28-19(24)26)10-22-18(25)16-3-4-17(21)29-16/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1
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n/an/a 33n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130526
PNG
(US8822458, 55)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOC1=O |r|
Show InChI InChI=1S/C18H16ClN3O5S/c19-15-6-5-14(28-15)16(23)20-9-13-10-22(18(25)27-13)12-3-1-11(2-4-12)21-7-8-26-17(21)24/h1-6,13H,7-10H2,(H,20,23)/t13-/m0/s1
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n/an/a 40n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12992
PNG
(5-Chloro-N-{[(5S)-3-(3-fluoro-4-pyrrolidin-1-ylphe...)
Show SMILES Fc1cc(ccc1N1CCCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H19ClFN3O3S/c20-17-6-5-16(28-17)18(25)22-10-13-11-24(19(26)27-13)12-3-4-15(14(21)9-12)23-7-1-2-8-23/h3-6,9,13H,1-2,7-8,10-11H2,(H,22,25)/t13-/m0/s1
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n/an/a 40n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7629
PNG
(US8822458, 18)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1 |r|
Show InChI InChI=1S/C19H20ClN3O3S/c20-17-8-7-16(27-17)18(24)21-11-15-12-23(19(25)26-15)14-5-3-13(4-6-14)22-9-1-2-10-22/h3-8,15H,1-2,9-12H2,(H,21,24)/t15-/m0/s1
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n/an/a 40n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7495
PNG
(BAY 59-7939 Analog 7 | US8822458, 2)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1 |r|
Show InChI InChI=1S/C19H20ClN3O4S/c20-17-6-5-16(28-17)18(24)21-11-15-12-23(19(25)27-15)14-3-1-13(2-4-14)22-7-9-26-10-8-22/h1-6,15H,7-12H2,(H,21,24)/t15-/m0/s1
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n/an/a 43n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7495
PNG
(BAY 59-7939 Analog 7 | US8822458, 2)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1 |r|
Show InChI InChI=1S/C19H20ClN3O4S/c20-17-6-5-16(28-17)18(24)21-11-15-12-23(19(25)27-15)14-3-1-13(2-4-14)22-7-9-26-10-8-22/h1-6,15H,7-12H2,(H,21,24)/t15-/m0/s1
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n/an/a 43n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130540
PNG
(US8822458, 137)
Show SMILES NC1CCCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1S/C20H22ClFN4O3S/c21-18-6-5-17(30-18)19(27)24-9-14-11-26(20(28)29-14)13-3-4-16(15(22)8-13)25-7-1-2-12(23)10-25/h3-6,8,12,14H,1-2,7,9-11,23H2,(H,24,27)
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n/an/a 44n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7845
PNG
(US8822458, 98)
Show SMILES CC(=O)N(C1CC1)c1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1S/C20H20ClN3O4S/c1-12(25)24(15-6-7-15)14-4-2-13(3-5-14)23-11-16(28-20(23)27)10-22-19(26)17-8-9-18(21)29-17/h2-5,8-9,15-16H,6-7,10-11H2,1H3,(H,22,26)
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n/an/a 50n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130536
PNG
(US8822458, 133)
Show SMILES OC1CCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1S/C19H19ClFN3O4S/c20-17-4-3-16(29-17)18(26)22-8-13-10-24(19(27)28-13)11-1-2-15(14(21)7-11)23-6-5-12(25)9-23/h1-4,7,12-13,25H,5-6,8-10H2,(H,22,26)
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n/an/a 62n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12993
PNG
(5-Chloro-N-({(5S)-3-[4-(dimethylamino)phenyl]-2-ox...)
Show SMILES CN(C)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C17H18ClN3O3S/c1-20(2)11-3-5-12(6-4-11)21-10-13(24-17(21)23)9-19-16(22)14-7-8-15(18)25-14/h3-8,13H,9-10H2,1-2H3,(H,19,22)/t13-/m0/s1
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n/an/a 74n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12993
PNG
(5-Chloro-N-({(5S)-3-[4-(dimethylamino)phenyl]-2-ox...)
Show SMILES CN(C)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C17H18ClN3O3S/c1-20(2)11-3-5-12(6-4-11)21-10-13(24-17(21)23)9-19-16(22)14-7-8-15(18)25-14/h3-8,13H,9-10H2,1-2H3,(H,19,22)/t13-/m0/s1
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n/an/a 74n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7648
PNG
(US8822458, 40)
Show SMILES CN(C)S(=O)(=O)c1ccc(cc1Cl)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C17H17Cl2N3O5S2/c1-21(2)29(25,26)14-5-3-10(7-12(14)18)22-9-11(27-17(22)24)8-20-16(23)13-4-6-15(19)28-13/h3-7,11H,8-9H2,1-2H3,(H,20,23)/t11-/m0/s1
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n/an/a 90n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM12988
PNG
(5-Chloro-N-{[(5S)-3-(3-fluoro-4-thiomorpholin-4-yl...)
Show SMILES Fc1cc(ccc1N1CCSCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H19ClFN3O3S2/c20-17-4-3-16(29-17)18(25)22-10-13-11-24(19(26)27-13)12-1-2-15(14(21)9-12)23-5-7-28-8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1
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n/an/a 90n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13011
PNG
(6-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Show SMILES Clc1ccc(cn1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C20H19ClN4O5/c21-17-6-1-13(9-22-17)19(27)23-10-16-11-25(20(28)30-16)15-4-2-14(3-5-15)24-7-8-29-12-18(24)26/h1-6,9,16H,7-8,10-12H2,(H,23,27)/t16-/m0/s1
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n/an/a 94n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130535
PNG
(US8822458, 132)
Show SMILES Fc1cc(ccc1N1CCC1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1S/C18H17ClFN3O3S/c19-16-5-4-15(27-16)17(24)21-9-12-10-23(18(25)26-12)11-2-3-14(13(20)8-11)22-6-1-7-22/h2-5,8,12H,1,6-7,9-10H2,(H,21,24)
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n/an/a 120n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130520
PNG
(US8822458, 48)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(cc1F)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C21H22ClFN4O5S/c22-18-4-3-17(33-18)20(30)24-10-14-11-27(21(31)32-14)13-1-2-16(15(23)9-13)25-5-7-26(8-6-25)19(29)12-28/h1-4,9,14,28H,5-8,10-12H2,(H,24,30)/t14-/m0/s1
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n/an/a 120n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130525
PNG
(US8822458, 54)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCCC2)c(c1)C#N |r|
Show InChI InChI=1S/C20H19ClN4O3S/c21-18-6-5-17(29-18)19(26)23-11-15-12-25(20(27)28-15)14-3-4-16(13(9-14)10-22)24-7-1-2-8-24/h3-6,9,15H,1-2,7-8,11-12H2,(H,23,26)/t15-/m0/s1
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n/an/a 130n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7532
PNG
(BAY 59-7939 Analog 10 | US8822458, 11)
Show SMILES Fc1cc(ccc1N1CCNCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-10-13-11-25(19(27)28-13)12-1-2-15(14(21)9-12)24-7-5-22-6-8-24/h1-4,9,13,22H,5-8,10-11H2,(H,23,26)/t13-/m0/s1
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n/an/a 140n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7532
PNG
(BAY 59-7939 Analog 10 | US8822458, 11)
Show SMILES Fc1cc(ccc1N1CCNCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-10-13-11-25(19(27)28-13)12-1-2-15(14(21)9-12)24-7-5-22-6-8-24/h1-4,9,13,22H,5-8,10-11H2,(H,23,26)/t13-/m0/s1
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n/an/a 140n/an/an/an/a8.325



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM8298
PNG
(US8822458, 160)
Show SMILES Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCS1(=O)=O
Show InChI InChI=1S/C18H18ClN3O5S2/c19-16-7-6-15(28-16)17(23)20-10-14-11-21(18(24)27-14)12-2-4-13(5-3-12)22-8-1-9-29(22,25)26/h2-7,14H,1,8-11H2,(H,20,23)
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n/an/a 140n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7654
PNG
(US8822458, 42)
Show SMILES Cc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O
Show InChI InChI=1S/C20H21N3O4S/c1-13-4-9-17(28-13)19(25)21-11-16-12-23(20(26)27-16)15-7-5-14(6-8-15)22-10-2-3-18(22)24/h4-9,16H,2-3,10-12H2,1H3,(H,21,25)
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US Patent
n/an/a 160n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM130523
PNG
(US8822458, 52)
Show SMILES NC1CCN(C1)c1ccc(cn1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C18H20ClN5O3S/c19-15-3-2-14(28-15)17(25)22-8-13-10-24(18(26)27-13)12-1-4-16(21-7-12)23-6-5-11(20)9-23/h1-4,7,11,13H,5-6,8-10,20H2,(H,22,25)/t11?,13-/m0/s1
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US Patent
n/an/a 190n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13012
PNG
(5-Chloro-N-methyl-N-({(5S)-2-oxo-3-[4-(3-oxomorpho...)
Show SMILES CN(C[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O)C(=O)c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C20H20ClN3O5S/c1-22(19(26)16-6-7-17(21)30-16)10-15-11-24(20(27)29-15)14-4-2-13(3-5-14)23-8-9-28-12-18(23)25/h2-7,15H,8-12H2,1H3/t15-/m0/s1
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n/an/a 197n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7847
PNG
(US8822458, 15)
Show SMILES Fc1cc(ccc1N1CCS(=O)(=O)CC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H19ClFN3O5S2/c20-17-4-3-16(30-17)18(25)22-10-13-11-24(19(26)29-13)12-1-2-15(14(21)9-12)23-5-7-31(27,28)8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1
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US Patent
n/an/a 210n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7631
PNG
(US8822458, 19)
Show SMILES CCN(CC)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Show InChI InChI=1S/C19H22ClN3O3S/c1-3-22(4-2)13-5-7-14(8-6-13)23-12-15(26-19(23)25)11-21-18(24)16-9-10-17(20)27-16/h5-10,15H,3-4,11-12H2,1-2H3,(H,21,24)/t15-/m0/s1
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n/an/a 270n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM13009
PNG
(2-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Show SMILES Clc1ncc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C18H17ClN4O5S/c19-17-21-8-14(29-17)16(25)20-7-13-9-23(18(26)28-13)12-3-1-11(2-4-12)22-5-6-27-10-15(22)24/h1-4,8,13H,5-7,9-10H2,(H,20,25)/t13-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



Bayer HealthCare AG



Assay Description
The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...

J Med Chem 48: 5900-8 (2005)


Article DOI: 10.1021/jm050101d
BindingDB Entry DOI: 10.7270/Q2J38QR6
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM7842
PNG
(BAY 59-7939 Analog 17 | US8822458, 46)
Show SMILES Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Show InChI InChI=1S/C19H18BrN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 300n/an/an/an/an/a25



Bayer Intellectual Property GmbH

US Patent


Assay Description
The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...

US Patent US8822458 (2014)


BindingDB Entry DOI: 10.7270/Q2VH5MJ2
More data for this
Ligand-Target Pair
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