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Compile Data Set for Download or QSAR

Found 277 hits with Last Name = 'tsuge' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249779
PNG
(3-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(c1)C#N |r,c:3|
Show InChI InChI=1S/C22H16F2N4/c1-14-22(17-5-8-19(23)9-6-17,18-7-10-20(24)26-13-18)28-21(27-14)16-4-2-3-15(11-16)12-25/h2-11,13-14H,1H3,(H,27,28)/t14-,22-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249739
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-methyl-4,5-dihyd...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C22H16F2N4/c1-14-22(16-2-6-18(23)7-3-16,17-4-8-19(24)9-5-17)28-21(27-14)20-12-15(13-25)10-11-26-20/h2-12,14H,1H3,(H,27,28)/t14-/m0/s1
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1n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249806
PNG
(4-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1ccnc(c1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)14-8-9-25-18(10-14)11-24/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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1n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249777
PNG
(2-{(4S,5S)-4-(4-Fluorophenyl)-5-methyl-4-[6-(methy...)
Show SMILES COc1ccc(cn1)[C@@]1(N=C(N[C@H]1C)c1cc(ccn1)C#N)c1ccc(F)cc1 |r,c:10|
Show InChI InChI=1S/C22H18FN5O/c1-14-22(16-3-6-18(23)7-4-16,17-5-8-20(29-2)26-13-17)28-21(27-14)19-11-15(12-24)9-10-25-19/h3-11,13-14H,1-2H3,(H,27,28)/t14-,22-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249758
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249833
PNG
(6-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(=O)[nH]1 |r,c:3|
Show InChI InChI=1S/C20H16F2N4O/c1-12-20(13-5-8-15(21)9-6-13,14-7-10-17(22)23-11-14)26-19(24-12)16-3-2-4-18(27)25-16/h2-12H,1H3,(H,24,26)(H,25,27)/t12-,20-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249775
PNG
(2-[(4R,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21+/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249830
PNG
(4-Chloro-2-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(Cl)ccn1 |r,c:3|
Show InChI InChI=1S/C20H15ClF2N4/c1-12-20(13-2-5-16(22)6-3-13,14-4-7-18(23)25-11-14)27-19(26-12)17-10-15(21)8-9-24-17/h2-12H,1H3,(H,26,27)/t12-,20-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249757
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-methyl-4,5-dihyd...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cnccn1 |r,c:3|
Show InChI InChI=1S/C20H16F2N4/c1-13-20(14-2-6-16(21)7-3-14,15-4-8-17(22)9-5-15)26-19(25-13)18-12-23-10-11-24-18/h2-13H,1H3,(H,25,26)/t13-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249737
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cc(ccn1)C#N)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C21H14F2N4/c22-17-5-1-15(2-6-17)21(16-3-7-18(23)8-4-16)13-26-20(27-21)19-11-14(12-24)9-10-25-19/h1-11H,13H2,(H,26,27)
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2n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249865
PNG
(2-Fluoro-5-[(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cnsn1 |r,c:3|
Show InChI InChI=1S/C17H13F2N5S/c1-10-17(11-2-5-13(18)6-3-11,12-4-7-15(19)20-8-12)23-16(22-10)14-9-21-25-24-14/h2-10H,1H3,(H,22,23)/t10-,17-/m0/s1
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2n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249832
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cnccn1 |r,c:3|
Show InChI InChI=1S/C19H15F2N5/c1-12-19(13-2-5-15(20)6-3-13,14-4-7-17(21)24-10-14)26-18(25-12)16-11-22-8-9-23-16/h2-12H,1H3,(H,25,26)/t12-,19-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249869
PNG
(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21
Show InChI InChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29)
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2.40n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249803
PNG
(2-Fluoro-5-{(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(c1)S(C)(=O)=O |r,c:3|
Show InChI InChI=1S/C22H19F2N3O2S/c1-14-22(16-6-9-18(23)10-7-16,17-8-11-20(24)25-13-17)27-21(26-14)15-4-3-5-19(12-15)30(2,28)29/h3-14H,1-2H3,(H,26,27)/t14-,22-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249829
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES COc1ccnc(c1)C1=N[C@@]([C@H](C)N1)(c1ccc(F)cc1)c1ccc(F)nc1 |r,t:9|
Show InChI InChI=1S/C21H18F2N4O/c1-13-21(14-3-6-16(22)7-4-14,15-5-8-19(23)25-12-15)27-20(26-13)18-11-17(28-2)9-10-24-18/h3-13H,1-2H3,(H,26,27)/t13-,21-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249754
PNG
(2-[(5S)-5-Ethyl-4,4-bis(4-fluorophenyl)-4,5-dihydr...)
Show SMILES CC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:4|
Show InChI InChI=1S/C23H18F2N4/c1-2-21-23(16-3-7-18(24)8-4-16,17-5-9-19(25)10-6-17)29-22(28-21)20-13-15(14-26)11-12-27-20/h3-13,21H,2H2,1H3,(H,28,29)/t21-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249756
PNG
(2-[(5R)-4,4-Bis(4-fluorophenyl)-5-(hydroxymethyl)-...)
Show SMILES OC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:4|
Show InChI InChI=1S/C22H16F2N4O/c23-17-5-1-15(2-6-17)22(16-3-7-18(24)8-4-16)20(13-29)27-21(28-22)19-11-14(12-25)9-10-26-19/h1-11,20,29H,13H2,(H,27,28)/t20-/m0/s1
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3n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249776
PNG
(2-[(5S)-4,4-Bis(6-fluoro-3-pyridyl)-5-methyl-4,5-d...)
Show SMILES C[C@@H]1NC(=NC1(c1ccc(F)nc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C20H14F2N6/c1-12-20(14-2-4-17(21)25-10-14,15-3-5-18(22)26-11-15)28-19(27-12)16-8-13(9-23)6-7-24-16/h2-8,10-12H,1H3,(H,27,28)/t12-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249804
PNG
(5-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cncc(c1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(16-2-5-18(22)6-3-16,17-4-7-19(23)26-12-17)28-20(27-13)15-8-14(9-24)10-25-11-15/h2-8,10-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249807
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1nccc(n1)C#N |r,c:3|
Show InChI InChI=1S/C20H14F2N6/c1-12-20(13-2-5-15(21)6-3-13,14-4-7-17(22)25-11-14)28-19(26-12)18-24-9-8-16(10-23)27-18/h2-9,11-12H,1H3,(H,26,28)/t12-,20-/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249866
PNG
(2-Fluoro-5-[(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1nccs1 |r,c:3|
Show InChI InChI=1S/C18H14F2N4S/c1-11-18(12-2-5-14(19)6-3-12,13-4-7-15(20)22-10-13)24-16(23-11)17-21-8-9-25-17/h2-11H,1H3,(H,23,24)/t11-,18-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249738
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cnccn1)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C19H14F2N4/c20-15-5-1-13(2-6-15)19(14-3-7-16(21)8-4-14)12-24-18(25-19)17-11-22-9-10-23-17/h1-11H,12H2,(H,24,25)
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4.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249831
PNG
(2-((4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C(N)=O |r,c:3|
Show InChI InChI=1S/C21H17F2N5O/c1-12-21(14-2-5-16(22)6-3-14,15-4-7-18(23)26-11-15)28-20(27-12)17-10-13(19(24)29)8-9-25-17/h2-12H,1H3,(H2,24,29)(H,27,28)/t12-,21-/m0/s1
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5.10n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249805
PNG
(6-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(n1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(14-5-8-16(22)9-6-14,15-7-10-19(23)25-12-15)28-20(26-13)18-4-2-3-17(11-24)27-18/h2-10,12-13H,1H3,(H,26,28)/t13-,21-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249755
PNG
(2-[(5S)-4,4-Bis(4-fluorophenyl)-5-propyl-4,5-dihyd...)
Show SMILES CCC[C@@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:5|
Show InChI InChI=1S/C24H20F2N4/c1-2-3-22-24(17-4-8-19(25)9-5-17,18-6-10-20(26)11-7-18)30-23(29-22)21-14-16(15-27)12-13-28-21/h4-14,22H,2-3H2,1H3,(H,29,30)/t22-/m0/s1
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8.60n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM86733
PNG
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)
Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8|
Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249778
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-5-methyl-4-(6-oxo-1,...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(=O)[nH]c1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H16FN5O/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(28)25-12-16)27-20(26-13)18-10-14(11-23)8-9-24-18/h2-10,12-13H,1H3,(H,25,28)(H,26,27)/t13-,21-/m0/s1
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145n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249740
PNG
(2-[(5R)-4,4-Bis(4-fluorophenyl)-5-methyl-4,5-dihyd...)
Show SMILES C[C@H]1NC(=NC1(c1ccc(F)cc1)c1ccc(F)cc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C22H16F2N4/c1-14-22(16-2-6-18(23)7-3-16,17-4-8-19(24)9-5-17)28-21(27-14)20-12-15(13-25)10-11-26-20/h2-12,14H,1H3,(H,27,28)/t14-/m1/s1
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300n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in mouse LMtk- cells


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258232
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ncc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-22-25-15-19(16-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,25,26,27,30)
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n/an/a 0.570n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298636
PNG
(1-(Methylsulfonyl)-N-[4-(phenylcarbonyl)phenyl]-1,...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H27N3O4S/c1-35(33,34)30-19-27(23-9-5-6-10-24(23)30)15-17-29(18-16-27)26(32)28-22-13-11-21(12-14-22)25(31)20-7-3-2-4-8-20/h2-14H,15-19H2,1H3,(H,28,32)
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n/an/a 0.680n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258191
PNG
(1-(Methylsulfonyl)-N-(6-phenylpyridin-3-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(nc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(21-9-5-6-10-23(21)29)13-15-28(16-14-25)24(30)27-20-11-12-22(26-17-20)19-7-3-2-4-8-19/h2-12,17H,13-16,18H2,1H3,(H,27,30)
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n/an/a 0.820n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258194
PNG
(1-(Methylsulfonyl)-N-(2-phenylpyrimidin-5-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cnc(nc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-19-15-25-22(26-16-19)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,27,30)
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n/an/a 0.860n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258151
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyridin-2-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(21-9-5-6-10-22(21)29)13-15-28(16-14-25)24(30)27-23-12-11-20(17-26-23)19-7-3-2-4-8-19/h2-12,17H,13-16,18H2,1H3,(H,26,27,30)
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n/an/a 0.960n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258193
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrazin-2-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cnc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(19-9-5-6-10-21(19)29)11-13-28(14-12-24)23(30)27-22-16-25-20(15-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,26,27,30)
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n/an/a 0.970n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298625
PNG
(1-(Methylsulfonyl)-N-(3-phenylisoxazol-5-yl)-1,2-d...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cc(no2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H24N4O4S/c1-32(29,30)27-16-23(18-9-5-6-10-20(18)27)11-13-26(14-12-23)22(28)24-21-15-19(25-31-21)17-7-3-2-4-8-17/h2-10,15H,11-14,16H2,1H3,(H,24,28)
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n/an/a 1.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298628
PNG
(1-(Methylsulfonyl)-N-(3-phenyl-1H-pyrazol-5-yl)-1,...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cc(n[nH]2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H25N5O3S/c1-32(30,31)28-16-23(18-9-5-6-10-20(18)28)11-13-27(14-12-23)22(29)24-21-15-19(25-26-21)17-7-3-2-4-8-17/h2-10,15H,11-14,16H2,1H3,(H2,24,25,26,29)
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n/an/a 1.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298649
PNG
(CHEMBL573860 | N-[1-(3-Fluorophenyl)-1H-imidazol-4...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cn(cn2)-c2cccc(F)c2)c2ccccc12
Show InChI InChI=1S/C23H24FN5O3S/c1-33(31,32)29-15-23(19-7-2-3-8-20(19)29)9-11-27(12-10-23)22(30)26-21-14-28(16-25-21)18-6-4-5-17(24)13-18/h2-8,13-14,16H,9-12,15H2,1H3,(H,26,30)
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n/an/a 1.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249737
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cc(ccn1)C#N)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C21H14F2N4/c22-17-5-1-15(2-6-17)21(16-3-7-18(23)8-4-16)13-26-20(27-21)19-11-14(12-24)9-10-25-19/h1-11H,13H2,(H,26,27)
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n/an/a 2n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249758
PNG
(2-[(4S,5S)-4-(4-Fluorophenyl)-4-(6-fluoro-3-pyridy...)
Show SMILES C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cc(ccn1)C#N |r,c:3|
Show InChI InChI=1S/C21H15F2N5/c1-13-21(15-2-5-17(22)6-3-15,16-4-7-19(23)26-12-16)28-20(27-13)18-10-14(11-24)8-9-25-18/h2-10,12-13H,1H3,(H,27,28)/t13-,21-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant neuropeptide Y5 receptor expressed in CHO-K1 cells coexpressing Gqi5 assessed as inhibition of NPY-induced i...


J Med Chem 52: 3385-96 (2009)


Article DOI: 10.1021/jm900110t
BindingDB Entry DOI: 10.7270/Q2DN450G
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298646
PNG
(1-(Ethylsulfonyl)-N-[1-(3-methoxyphenyl)-1H-imidaz...)
Show SMILES CCS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cn(cn2)-c2cccc(OC)c2)c2ccccc12
Show InChI InChI=1S/C25H29N5O4S/c1-3-35(32,33)30-17-25(21-9-4-5-10-22(21)30)11-13-28(14-12-25)24(31)27-23-16-29(18-26-23)19-7-6-8-20(15-19)34-2/h4-10,15-16,18H,3,11-14,17H2,1-2H3,(H,27,31)
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n/an/a 2n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50258149
PNG
(1-(Methylsulfonyl)-N-[4-(pyridin-3-yl)phenyl]-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2cccnc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(22-6-2-3-7-23(22)29)12-15-28(16-13-25)24(30)27-21-10-8-19(9-11-21)20-5-4-14-26-17-20/h2-11,14,17H,12-13,15-16,18H2,1H3,(H,27,30)
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n/an/a 2.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298627
PNG
(1-(Methylsulfonyl)-N-(5-phenyl-1,3-thiazol-2-yl)-1...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ncc(s2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H24N4O3S2/c1-32(29,30)27-16-23(18-9-5-6-10-19(18)27)11-13-26(14-12-23)22(28)25-21-24-15-20(31-21)17-7-3-2-4-8-17/h2-10,15H,11-14,16H2,1H3,(H,24,25,28)
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n/an/a 2.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298632
PNG
(1-(Methylsulfonyl)-N-[4-(1,3-thiazol-2-yl)phenyl]-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2nccs2)c2ccccc12
Show InChI InChI=1S/C23H24N4O3S2/c1-32(29,30)27-16-23(19-4-2-3-5-20(19)27)10-13-26(14-11-23)22(28)25-18-8-6-17(7-9-18)21-24-12-15-31-21/h2-9,12,15H,10-11,13-14,16H2,1H3,(H,25,28)
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n/an/a 2.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298624
PNG
(1-(Methylsulfonyl)-N-(1-phenyl-1H-imidazol-4-yl)-1...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cn(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H25N5O3S/c1-32(30,31)28-16-23(19-9-5-6-10-20(19)28)11-13-26(14-12-23)22(29)25-21-15-27(17-24-21)18-7-3-2-4-8-18/h2-10,15,17H,11-14,16H2,1H3,(H,25,29)
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n/an/a 2.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249738
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cnccn1)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C19H14F2N4/c20-15-5-1-13(2-6-15)19(14-3-7-16(21)8-4-14)12-24-18(25-19)17-11-22-9-10-23-17/h1-11H,12H2,(H,24,25)
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n/an/a 2.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells assessed as inhibition of ne...


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298621
PNG
(1-(Methylsulfonyl)-N-(quinolin-6-yl)-1,2-dihydro-1...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc3ncccc3c2)c2ccccc12
Show InChI InChI=1S/C23H24N4O3S/c1-31(29,30)27-16-23(19-6-2-3-7-21(19)27)10-13-26(14-11-23)22(28)25-18-8-9-20-17(15-18)5-4-12-24-20/h2-9,12,15H,10-11,13-14,16H2,1H3,(H,25,28)
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n/an/a 2.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298635
PNG
(1-(Methylsulfonyl)-N-(4-phenoxyphenyl)-1,2-dihydro...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(Oc3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O4S/c1-34(31,32)29-19-26(23-9-5-6-10-24(23)29)15-17-28(18-16-26)25(30)27-20-11-13-22(14-12-20)33-21-7-3-2-4-8-21/h2-14H,15-19H2,1H3,(H,27,30)
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n/an/a 2.60n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298637
PNG
(CHEMBL574996 | N-(4-Acetylphenyl)-1-(methylsulfony...)
Show SMILES CC(=O)c1ccc(NC(=O)N2CCC3(CN(c4ccccc34)S(C)(=O)=O)CC2)cc1
Show InChI InChI=1S/C22H25N3O4S/c1-16(26)17-7-9-18(10-8-17)23-21(27)24-13-11-22(12-14-24)15-25(30(2,28)29)20-6-4-3-5-19(20)22/h3-10H,11-15H2,1-2H3,(H,23,27)
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n/an/a 2.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50249867
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(c1)C#N)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C22H15F2N3/c23-19-8-4-17(5-9-19)22(18-6-10-20(24)11-7-18)14-26-21(27-22)16-3-1-2-15(12-16)13-25/h1-12H,14H2,(H,26,27)
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n/an/a 2.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50298630
PNG
(1-(methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)spiro...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2cscn2)c2ccccc12
Show InChI InChI=1S/C23H24N4O3S2/c1-32(29,30)27-15-23(19-4-2-3-5-21(19)27)10-12-26(13-11-23)22(28)25-18-8-6-17(7-9-18)20-14-31-16-24-20/h2-9,14,16H,10-13,15H2,1H3,(H,25,28)
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n/an/a 2.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human neuropeptide Y5 receptor


Bioorg Med Chem 17: 5015-26 (2009)


Article DOI: 10.1016/j.bmc.2009.05.064
BindingDB Entry DOI: 10.7270/Q2KK9BT2
More data for this
Ligand-Target Pair
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